Published Articles Using MLAB

 

This file contains a list of published articles reporting work involving the use of MLAB.

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1972

Authors: Cooper, Herbert L.
Title: Studies on RNA Metabolism During Lymphocyte Activation
Source: Transplant. Rev. 11 (1972) 3-38
Description: nonlinear least squares fit


1973

Authors: Adelman, William J.; Palti, Yoram; Senft, Joseph P.
Title: Potassium Ion Accumulation in a Periaxonal Space and its Effect on the Measurement of Membrane Potassium Ion Conductance
Source: J. Membrane Biol. 13 (1973) 387-410
Description: least squares curve fit



Authors: Cooper, Herbert L.
Title: Analysis of Precursor Pool Labeling Kinetics Without Pool Size Measurements: A Computer Assisted Approach
Source: Anal. Biochem. 53 (1973) 49-63
Description: ode curve fitting



Authors: Dunn, Ben M.; DiBello, Carlo; Anfinsen, Christian B.
Title: The pH Dependence of the Steady State Kinetic Parameters for Staphylococcal Nuclease-catalyzed Hydrolysis of Deoxythymidine-3'-phosphate-5'-p-nitro-phenylphosphate in H2O and D2O
Source: J. Biol. Chem. 248 (1973) 4769
Description: curve-fitting



Authors: Fitzhugh, R.; Cole, K.S.
Title: Voltage and Current Clamp Transients with Membrane Dielectric Loss
Source: Biophys. J. 13 (1973) 1125-1140
Description: numerical integration of odes on DEC-10



Authors: Gross, Michael; Folk, J.E.
Title: Mapping of the Active Sites of Transglutaminases. I. Activity of the Guinea Pig Liver Enzyme Toward Aliphatic Amides
Source: J. Biol. Chem. 248 (1973) 1301-1306
Description: PDP10 MLAB, kinetic experiments reciprocal velocities plotted vs reciprocal substrate concentrations, fit to models.



Authors: Gross, Michael; Folk, J.E.
Title: Mapping of the Active Sites of Transglutaminases. II. Activity of the Guinea Pig Liver Enzyme Toward Methylglutamine Peptide Derivatives
Source: J. Biol. Chem. 248 (1973) 6534-6540
Description: PDP10 MLAB, reciprocal plots fit to models.



Authors: Pommier, Jacques; Sokoloff, Louis; Nunez, Jacques
Title: Enzymatic Iodination of Protein: Kinetics of Iodine Formation and Protein Iodination Catalyzed by Horse-Radish Peroxidase
Source: Eur. J. Biochem. 38 (1973) 497-506
Description: curve-fitting


1974

Authors: Chung, Soo Il; Lewis, Marc S.; Folk, J.E.
Title: Relationships of the Catalytic Properties of Human Plasma and Platelet Transglutaminases (Activated Blood Coagulation Factor XIII) to Their Subunit Structures
Source: J. Biol. Chem. 249 (1974) 940-950
Description: curve-fitting and graphics



Authors: Lewis, Marc S.; Krieg, Laura C.; Kirk, William D.
Title: The Molecular Weight and Detergent Binding of Bovine Rhodopsin
Source: Exp. Eye Res. 18 (1974) 29-40
Description: curve-fitting and graphics



Authors: Marini, Mario A.; Martin, Charles J.; Berger, Robert L.; Forlani, Luciano
Title: A Proposed Solution for the Determination of the Ionization Constants of Sets of Ionizing Groups in Proteins
Source: Biopolymers 13 (1974) 891-902
Description: curve-fitting


1975

Authors: Allen, Larry M.; Creaven, Patrick J.
Title: Comparison of the Human Pharmacokinetics of VM-26 and VP-16, Two Antineoplastic Epipodophyllotoxin Glucopyranoside Derivatives
Source: Eur. J. Cancer 11 (1975) 697-707
Description: renal clearances evaluated using DEC10 MLAB.



Authors: Allen, Larry M.; Creaven, Patrick J.
Title: Pharmacokinetics of Ifosfamide
Source: Clin. Pharm. 17 (1975) 492-498
Description: DEC10 MLAB fit parameters in ode model to data.


pages 192-218; ACS Symposium Series, volume 19
Authors: Carhart, R.E.; Johnson, S.M.; Smith, D.H.; Buchanan, B.G.; Dromey, R.G.; Lederberg, J.
Title: Networking and a Collaborative Research Community: a Case Study Using the DENDRAL Programs
Source: Computer Networking and Chemistry, Chapter 13 (1975)



Authors: Catt, K.J.; Dufau, Maria L.; Neaves, William B.; Walsh, Patrick C.; Wilson, Jean D.
Title: LH-hCG Receptors and Testosterone Content During Differentiation of the Testes in the Rabbit Embryo
Source: Endocrin. 97 (1975) 1157
Description: curve-fitting binding curves on PDP-10



Authors: Chignell, Colin F.; Starkweather, Donnas K.; Sinha, Birandra K.
Title: A Spin Label Study of Egg White Avidin
Source: J. Biol. Chem. 250 (1975) 5622-5630
Description: ESR spectra manipulated in the form of matrices



Authors: Detwiler, Peter B.; Fuortes, M.G.F.
Title: Responses of Hair Cells in the Statocyst of Hermissenda
Source: J. Physiol. 251 (1975) 107
Description: curve-fitting



Authors: Dunn, Ben M.; Chaiken, Irwin M.
Title: Relationship Between Alpha-Helical Propensity and Formation of the Ribonuclease-S Complex
Source: J. Mol. Biol. 95 (1975) 497-511
Description: constant amount of RNAase-S-(21-124) was assayed with increasing portions of synthetic-(1-15) peptides. The resulting curves were fit to equation 5 by non-linear least square procedure.



Authors: Ehrenstein, Gerald; Gilbert, Daniel L.; Lipicky, Raymond
Title: Does Phospholipid Flip-Flop Affect Axon Potassium Channels?
Source: Biophys. J. 15 (1975) 847
Description: curve fit hyperbolic secant functions to experimental points



Authors: Gillin, Frances D.; Nossal, Nancy G.
Title: T4 DNA Polymerase Has a Lower Apparent Km For Deoxynucleoside Triphosphates Complementary Rather Than Noncomplementary to the Template
Source: Bioc. Bioph. R 64 (1975) 457-464
Description: PDP10 MLAB, Michaelis constants.



Authors: Gross, Michael; Whetzel, Norma K.; Folk, J.E.
Title: The Extended Active Site of Guinea Pig Liver Transglutaminase
Source: J. Biol. Chem. 250 (1975) 4648-4655
Description: curve-fitting; PDP-10



Authors: Hendler, Richard W.; Towne, David W.; Shrager, Richard I.
Title: Redox Properties of b-Type Cytochromes in Escherichia Coli and Rat Liver Mitochondria and Techniques for Their Analysis
Source: Biochim. Biophys. Acta 376 (1975) 42-62
Description: accumulated data was analyzed by MLAB; DEC-10



Authors: Ketelslegers, Jean-Marie; Knott, Gary D.; Catt, Kevin J.
Title: Kinetics of Gonadotropin Binding by Receptors of the Rat Testis. Analysis by a Nonlinear Curve-Fitting Method
Source: Biochem. 14 (1975) 3075
Description: curve-fitting odes; PDP-10



Authors: Ketley, Jeanne N.; Habig, William H.; Jakoby, William B.
Title: Binding of Nonsubstrate Ligands to the Glutathione S-Transferases
Source: J. Biol. Chem. 250 (1975) 8670-8673
Description: curves for experimental points calculated; PDP digital computer



Authors: Klee, Claude B.; Kirk, Kenneth L.; Cohen, Louis A.; McPhie, Peter
Title: Histidine Ammonia-lyase: The Use of 4-Fluorohistidine in Identification of the Rate-Determining Step
Source: J. Biol. Chem. 250 (1975) 5033-5040
Description: estimate kinetic constants by fitting data; DEC-10



Authors: Latoure, R.; Alvarez, O.; Ehrenstein, G.; Espinoza, M.; Reyes, J.
Title: The Nature of the Voltage-Dependent Conductance of the Hemoyanin Channel
Source: J. Membrane Biol. 25 (1975) 163-182
Description: curve-fitting



Authors: Taniuchi, Hiroshi; Bohnert, Janice L.
Title: The Mechanism of Stabilization of the Structure of Nuclease-T' by Binding of Ligands
Source: J. Biol. Chem. 250 (1975) 2388-2394
Description: best fit of algebraic equations


1976


Title: Lack of in Vivo Transformation of Human Growth Hormone to Its Activated Isohormonesin Peripheral Tissues of the Rhesus Monkey
Source: J. Clin. Endocr. Metab. 43 (1976) 1009
Description: 2 compartmental exponential model
Authors: Baumann, Gerhard; Hodges, Gary
Title: Meeting Programs
Source: J. Chem. Inf. Comp. Sci. 16 (1976) 183-186



Authors: Bina-Stein, Minou; Stein, Arnold
Title: Allosteric Interpretation of Mg2+ Binding to the Denaturable Escherichia coli tRNA Glu2
Source: Biochem. 15 (1976) 3912
Description: curve-fitting, PDP-10



Authors: Callis, James; Hoehn, Holger
Title: Flow-Fluorometric Diagnosis of Euploid and Aneuploid Human Lymphocytes
Source: Am. J. Hum. Genetics 28 (1976) 577-584
Description: fit to sum of gaussians



Authors: Chaiken, Irwin M.; Taylor, Hope C.
Title: Analysis of Ribonuclease-Nucleotide Interactions by Quantitative Affinity Chromatography
Source: J. Biol. Chem. 251 (1976) 2044-2048
Description: fit data to relation involving elution volume, void volume, dissociation constants.



Authors: Craine, Jonathan E.; Peterkofsky, Alan
Title: Studies on Arginyl-tRNA Synthetase from Escherichia coli B Dual Roles of Metals in Enzyme Catalysis
Source: J. Biol. Chem. 251 (1976) 241-246
Description: fit to Michaelis Menten equation, PDP-10



Authors: Creaven, P.J.; Cohen, M.H.; Allen, L.M.
Title: Methotrexate Plasma Decay Kinetics: Possible Alteration in Patients Undergoing Gut Sterilization
Source: Br. J. Cancer 34 (1976) 571-575
Description: fit mono- and bi-exponential functions on DEC-10



Authors: Egan, William
Title: Intermolecular Association in Adenosine 5'-Monophosphate. An 2-H Nuclear Magnetic Resonance Investigation
Source: JACS 98 (1976) 4091-4093
Description: analysis of (eta, T1, [AMP]) data sets in terms of monomer-dimer equilibrium.



Authors: Gillin, Francis D.; Nossal, Nancy G.
Title: Control of Mutation Frequency by Bacteriophage T4 DNA Polymerase
Source: J. Biol. Chem. 251 (1976) 5225
Description: find Km and Vmax by fitting DNA polymerase assays



Authors: Harosi, Ferenc I.
Title: Spectral Relations of Core Pigments in Goldfish
Source: J. Gen. Physiol. 68 (1976) 65
Description: curve-fitting sums of gaussians



Authors: Lewis, Marc S.; Knott, Gary D.
Title: Simulation Studies of Self-Associating Systems: Descrimination Between Specific and Isodemic Associations
Source: Biophys. Ch. 5 (1976) 171-183
Description: DEC10 MLAB.



Authors: Murphy, Dennis L.; Donnelly, Cynthia H.; Miller, Leonard; Wyatt, Richard J.
Title: Platelet Monamine Oxidase in Chronic Schizophrenia
Source: Arch. Gen. Psych. 33 (1976) 1377
Description: Michaelis constants and maximum velocities by curve-fitting



Authors: Nelson, R.L.
Title: The Utility of Pharmacokinetics to the Pharmaceutical Industry
Source: J. Clin. Pharm. 16 (1976) 565
Description: reviews packages including NONLIN, MLAB



Authors: Nelson, Robert L.; Allen, Larry M.; Creaven, Patrick J.
Title: Pharmacokinetics of Divided-Dose Ifosfamide
Source: Clin. Pharm. 19 (1976) 365
Description: fit plasma decay of unchanged ifosfamide; DEC-10



Authors: Parsegian, V. Adrian; Brenner, Stephen L.
Title: The Role of Long Range Forces in Ordered Arrays of Tobacco Mosaic Virus
Source: Nature 259 (1976) 632
Description: data fitted to form of damped linear oscillators



Authors: Protzel, Alberto; Sridhara, S.; Levenbook, Leo
Title: Ribosomal Replacement and Degradation During Metamorphosis of the Blowfly, Calliphora vicina
Source: Insect Biochem. 6 (1976) 571-578
Description: constant plus exponential fit



Authors: Rhee, S.G.; Chock, P.B.
Title: Mechanistic Studies of Glutamine Synthetase from Escherichia coli: Kinetic Evidence for Two Reaction Intermediates in Biosynthetic Reaction
Source: Proc. Natl. Acad. Sci. USA 73 (1976) 476
Description: curve-fitting and graphics



Authors: Rhee, S.G.; Chock, P.B.
Title: Mechanistic Studies of Glutamine Synthetase from Escherichia coli: Kinetics of ADP and Orthophosphate Binding to the Unadenylated Enzyme
Source: Biochem. 15 (1976) 1755-1760



Authors: Shinohara, Toshimichi; Piatigorsky, Joram
Title: Quantitation of Delta-Crystallin Messenger RNA During Lens Induction in Chick Embryos
Source: Proc. Natl. Acad. Sci. 73 (1976) 2808-2812
Description: Linear regression using PDP10 MLAB, molecules of Delta-Crystallin mRNA per lens cell vs. time.



Authors: Tack, B.F.; Prahl, J.W.
Title: Third Component of Human Complement: Purification from Plasma and Physiochemical Characterization
Source: Biochem. 15 (1976) 4513-4521
Description: PDP10 MLAB, linear least squares fit.



Authors: Tsien, R.W.; Weingart, R.
Title: Isotropic Effect of Cyclic AMP in Calf Ventricular Muscle Studied by a Cut End Method
Source: J. Physiol. 260 (1976) 117-119
Description: fit to sum of two error functions



Authors: White, F.H.
Title: Studies on Secondary Structure in Chicken Egg-White Lysozyme after Reductive Cleavage of Disulphide Bonds
Source: Biochem. 15 (1976) 2906-2912



Authors: Winslow, Robert M.; Swenberg, Mei-Lei; Gross, Erhard; Chervenick, Paul A.; Buchman, Robert R.; Anderson, W. French
Title: Hemoglobin McKees Rocks (Alpha2 Beta2 145 Tyr->Term)
Source: J. Clin. Inv. 57 (1976) 772-781
Description: curve fit hemolysate data, Pressure of O2 versus O2 content data.



Authors: Zelenka, Peggy; Piatigorsky, Joram
Title: Reiteration Frequency of delta-Crystallin DNA in Lens and Non-lens Tissues of Chick Embryos
Source: J. Biol. Chem. 251 (1976) 4294-4298
Description: graphics and curve-fitting


1977

Authors: Abe, Takashi; Chung, Soo Il; DiAugustine, Richard P.; Folk, J.E.
Title: Rabbit Liver Transglutaminase: Physical, Chemical, and Catalytic Properties
Source: Biochem. 16 (1977) 5495
Description: Michaelis Menten constants



Authors: Chock, P.B.; Stadtman, E.R.
Title: Superiority of Interconvertible Enzyme Cascades in Metabolic Regulation: Analysis of Multicyclic Systems
Source: Proc. Natl. Acad. Sci. USA 74 (1977) 2766
Description: curve-fitting and graphics



Authors: Donnelly, Cynthia H.; Murphy, Dennis L.
Title: Substrate- and Inhibitor-Related Characteristics of Human Platelet Monoamine Oxidase
Source: Biochem. Pharm. 26 (1977) 853-858
Description: Michalis constants



Authors: Fenton, John W., II; Fasco, Michael J.; Stacknow, Anne B.; Aronson, David L.; Young, Andrew M.; Finlayson, John S.
Title: Human Thrombosis: Production, Evaluation, and Properties of Alpha-Thrombin
Source: J. Biol. Chem. 252 (1977) 3587-3598
Description: curve-fitting, PDP 10



Authors: Fjellstedt, Thorsten A.; Schlesselman, James J.
Title: A Simple Statistical Method for Use in Kinetic Analysis Based on Lineweaver-Burk Plots
Source: Anal. Bioch. 80 (1977) 224
Description: Michaelis-Menten eqtn, statistics, used calculator-not MLAB



Authors: Formisano, Silvestro; Johnson, Michael L.; Edelhoch, Harold
Title: Thermodynamics of the Self-Association of Glucagon
Source: Proc. Natl. Acad. Sci. USA 74 (1977) 3340-3344
Description: curve-fitting



Authors: Gross, Michael; Whetzel, Norma K.; Folk, J.E.
Title: Amine Binding Sites in Acyl Intermediates of Transglutaminases
Source: J. Biol. Chem. 252 (1977) 3752-3759
Description: curve-fitting



Authors: Heck, H.A.; Dyer, R.L.; Scott, A.C.; Anbar, M.
Title: Determination and Disposition of Trifluralin in the Rat. Separation by Sequential High-Pressure Liquid Chromotography and Quantitation by Field Ionization Mass Spectrometry
Source: J. Agric. Food. Chem. 25 (1977) 901-908



Authors: Heller, S.R.; Milne, G.W.A.; Feldman, R.J.
Title: A Computer-Based Chemical Information System
Source: Science 195 (1977) 253-259
Description: MLAB as part of chemical information system.



Authors: Hendler, R.W.
Title: Automated Electrode Potentiometry of Postassium Ferricyanide and Respiratory Components
Source: Anal. Chem. 49 (1977) 1914-1918
Description: Nernst equation.



Authors: Highet, Robert J.; Chou, Feng-te E.
Title: The Dependence of Phenol-Dienone Tautomerism Upon the Hydrogen Bonding Characteristics of the Solvent: 3,5-Dipyrrolidinophenol
Source: JACS 99 (1977) 3538
Description: linear regression



Authors: Hodgkin, A.L.; O'bryan, Paul M.
Title: Internal Recording of the Early Receptor Potential in Turtle Cones
Source: J. Physiol. 267 (1977) 737-766
Description: curve-fitting to exponential model



Authors: Humphrey, Richard L.; Karpetsky, Timothy P.; Neuwelt, Edward A.; Levy, Carl C.
Title: Levels of Serum Ribonuclease as an Indicator of Renal Insufficiency in Patients with Leukemia
Source: Cancer Res. 37 (1977) 2015-2022
Description: curve-fitting



Authors: Karpetsky, Timothy P.; Humphrey, Richard L.; Levy, Carl C.
Title: Influence of Renal Insufficiency on Levels of Serum Ribonuclease in Patients with Multiple Myeloma
Source: JNCI 58 (1977) 875-880
Description: units RNase activity per ml per min fit to A+B/(C (ml/min)).



Authors: Klee, Claude B.; LaJohn, Lawrence E.; Kirk, Kenneth L.; Cohen, Louis A.
Title: 2-Fluorourocanic Acid, A Potent Reversible Inhibitor of Urocanase
Source: Biochem. Biophys. Res. Comm. 75 (1977) 674
Description: least squares fit of model with kinetic constants



Authors: Knights, Ralph J.; Gross, Michael; Folk, J.E.
Title: Identification and Quantitative Analysis of Alkyl Isocyanates as Their Urea Derivatives
Source: Anal. Biochem. 77 (1977) 176-184
Description: ode fits on DEC-10


pages 26-45, ACS Symposium Series, volume 54.
Authors: Milne, G.W.A.; Heller, S.R.
Title: The NIH-EPA Chemical Information System
Source: Computer-Assisted Structure Elucidation, Chapter 3 (1977)



Authors: Mittelstaedt, W.; Still, G.S.; Duerbeck, H.; Fuehr, F.
Title: Extraction and Identification of the Major Metabolite of [carbonyl-C14] methabenzthiazuron After Degradation in the soil
Source: J. Agric. Food Chem. 25 (1977) 908-912



Authors: Norton, Larry; Simon, Richard
Title: Growth Curve of an Experimental Solid Tumor Following Radiotherapy
Source: JNCI 58 (1977) 1735-1741
Description: curve-fitting odes on DEC-10



Authors: Parsegian, V.A.; Weiss, G.H.; Shrader, M.E.
Title: Macroscopic Continuum Model of Influence of Hydrocarbon Contaminant on Forces Causing Wetting of Gold by Water
Source: J. Coll. and Interface Sci. 61 (1977) 356
Description: curve-fitting



Authors: Rao, K. Gurudath; Becker, Edwin D.; Rao, C.N.R.
Title: Effect of Lithium Ion on the Torsional Barrier in Amides
Source: J.C.S. Chem. Comm 1977 (1977) 350-351
Description: digitized NMR spectra, curve-fitting, Arrhenius plots, Gutowsky-Holm equation



Authors: Sokoloff, Louis; Reivich, M.; Kennedy, C.; DesRosiers, M. H.; Patlak, C.S.; Pettigrew, K.D.; Sakurada, O.; Shinohara, M.
Title: The [14-C] Deoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization: Theory, Procedure, and Normal Values in the Conscious and Anethetized Albino Rat
Source: J. Neurochem. 28 (1977) 897-916
Description: least square fit of rate constants in compartmental model



Authors: Stadtman, E.R.; Chock, P.B.
Title: Superiority of Interconvertible Enzyme Cascades in Metabolic Regulation: Analysis of Monocyclic Systems
Source: Proc. Natl. Acad. Sci. 74 (1977) 2761-2765
Description: fit parameters in steady state solutions of chemical kinetics rate differential equations.



Authors: Taniuchi, Hiroshi; Parker, Diana S.; Bohnert, Janice L.
Title: Study of Equilibration of the System Involving Two Alternative, Enzymatically Active Complementing Structures Simultaneously Formed from Two Overlapping Fragments of Staphylococcal Nuclease
Source: J. Biol. Chem. 252 (1977) 125-140
Description: least squares fit on PDP-10



Authors: Taylor, Hope C.; Chaiken, Irwin M.
Title: Active Site Ligand Binding by an Inactive Ribonuclease S Analogue
Source: J. Biol. Chem. 252 (1977) 6991
Description: fit elution data to Michaelis-Menten equation



Authors: Tsuruhara, Tsuneo; Dufau, Maria L.; Cigorraga, Selva; Catt, Kevin J.
Title: Hormonal Regulation of Testicular Luteinizing Hormone Receptors Effects of Cyclic AMP and Testosterone Responses in Isolated Leydig Cells
Source: J. Biol. Chem. 252 (1977) 9002-9009
Description: Scatchard analysis of binding data



Authors: Weiss, Gary B.; Anderson, W. French
Title: The Problem of Nuclease Activity in Nucleic Acid Hybridization Reactions. Theoretical Considerations
Source: Biophys. Chem. 6 (1977) 337-344
Description: system of odes representing competition of nucleic acid digestion and hybridization was solved on DEC PDP-10



Authors: Wiggert, Barbara; Bergsma, Donald R.; Helmsen, Ralph J.; Alligood, James; Lewis, Marc; Chader, Gerald J.
Title: Retinol Receptors in Corneal Epithelium, Stroma, and Endothelium
Source: Biochim. Biophys. Acta 491 (1977) 104-113
Description: least squares parameter estimation, odes, DEC-10



Authors: Winslow, Robert M.; Swenberg, Mei-Lie; Berger, Robert L.; Shrager, Richard I.; Luzzana, Massimo; Samaja, Michele; Bernardi, Luigi Rossi
Title: Oxygen Equilibrium Curve of Normal Human Blood and Its Evaluation by Adair's Equation
Source: J. Biol. Chem. 252 (1977) 2331-2337
Description: curve-fitting odes



Authors: Wolfe, N. Lee; Zepp, Richard G.; Gordon, John A.; Baughman, George L.; Cline, David M.
Title: Kinetics of Chemical Degradation of Malathion in Water
Source: Env. Sci. Tec. 11 (1977) 88-93
Description: rate constants obtained by curve-fitting


1978

Authors: Adelman, William J.; French, Robert J.
Title: Blocking of the Squid Axon Potassium Channel by External Caesium Ions
Source: J. Physiol. 276 (1978) 13-25
Description: non linear least squares curve-fitting, DEC PDP-10



Authors: Ahmad, F.; McPhie, P.
Title: Thermodynamics of the Denaturation of Pespinogen by Urea
Source: Biochem. 17 (1978) 241-246



Authors: Allen, Larry M.
Title: Comparison of Uptake and Binding of Two Epipodophyllotoxin Glucopyramosides, 4'-Demethyl Epipodophyllotoxin Thenylidene-Beta-D-Glucoside and 4'-Demethyl Epipodophyllotoxin Ethylidene-Beta-D-Glucoside, in the L1210 Leukemia Cell
Source: Cancer Res. 38 (1978) 2549-2554
Description: kinetics of transport VM-26 and VP-16 using DEC10 MLAB nonlinear least squares of efflux of VM26 and VP-16.



Authors: Auer, Henry E.; Thompson, Thomas N.
Title: Actinomycin D-deoxynucleotide Interactions: Binding Isotherms at the Benzenoid and Quinoid Portions of the Drug
Source: Proc. Natl. Acad. Sci. USA 75 (1978) 4729
Description: curve-fitting



Authors: Berger, Robert L.
Title: Some Problems Concerning Mixers and Detectors for Stopped Flow Kinetic Studies
Source: Biophys. J. 24 (1978) 2-20
Description: determined correct rate constants to make kinetic data fit curve.



Authors: Bina-Stein, Minou
Title: Folding of 140-Base Pair Length DNA by a Core of Arnine-Rich Histones
Source: J. Biol. Chem. 253 (1978) 5213-5219
Description: digitized melt data analysis



Authors: Brigham, Brain A.; Bunn, Paul A.; Minna, John D.; Cohen, Martin H.; Ihde, Daniel C.; Shackney, Stanley E.
Title: Growth Rates of Small Cell Bronchogenic Carcinomas
Source: Cancer 42 (1978) 2880
Description: fit tumor growth data to exponential model



Authors: Carnahan, J.E.; Jenner, E.L.; Wat, E.K.W.
Title: Prevention of Ozone Injury to Plants by a New Protectant Chemical
Source: Phytopathology 68 (1978) 1225
Description: least squares fit of data to dose response function



Authors: Cigorraga, Selva B.; Dufau, Maria L.; Catt, Kevin J.
Title: Regulation of Luteinizing Hormone Receptors and Steroidogenesis in Gonadotropin-desensitized Leydig Cells
Source: J. Biol. Chem. 253 (1978) 4297
Description: Scatchard analysis, solving odes



Authors: Coppola, Richard; Tabor, Richard; Buchsbaum, Monte S.
Title: Signal to Noise Ratio and Response Variability Measurements in Single Trial Evoked Potentials
Source: EEG and Clin. Neurophys. 44 (1978) 214-222
Description: curve-fitting and simulations



Authors: Darvey, Ivan G.; Walker, E. J.
Title: A Procedure for Obtaining Initial Estimates of Parameters Appearing in Steady-State Rate or Equilibrium Binding Equations
Source: Can. J. of Biochem. 56 (1978) 697
Description: weighted least squares fit with continued fractions



Authors: Deibler, Gladys E.; Driscoll, Bernard F.; Kies, Marian W.
Title: Immunochemical and Biochemical Studies Demonstrating the Identity of a Bovine Spinal Cord Protein (SCP) and a Basic Protein of Bovine Peripheral Myelin (BF)
Source: J. Neurochem. 30 (1978) 401-412
Description: best fit analysis of CD curves



Authors: DeLean, A.; Munson, P.J.; Rodbard, D.
Title: Simultaneous Analysis of Families of Sigmoidal Curves: Application to Bioassay, Radioligand Assay, and Physiological Dose-Response Curves
Source: Am. J. Physiol. 235 (1978) E97-E102
Description: fit logistic, doesn't use MLAB



Authors: Dufau, Maria L.; Horner, Kathleen A.; Hayashi, Keiko; Tsuruhara, Tsuneo; Conn, P. Michael; Catt, Kevin J.
Title: Actions of Choleragen and Gonadotropin in Isolated Leydig Cells
Source: J. Biol. Chem. 253 (1978) 3721-3729
Description: Scatchard analysis, fitting odes, PDP-10



Authors: Eaton, William A.; Hanson, Louise Karle; Stephens, P.J.; Sutherland, J.C.; Dunn, J.B.R.
Title: Optical Spectra of Oxy- and Deoxyhemoglobin
Source: JACS 100 (1978) 4991-5003
Description: fit spectra to sum of gaussians



Authors: Elchisak, M.A.; Polinsky, R.J.; Ebert, M.H.; Powers, K.J.; Kopin, Irwin J.
Title: Contribution of Plasma Homovanillic Acid (HVA) to Urine and Cerebrospinal Fluid HVA in the Monkey and its Pharmacokinetic Disposition
Source: Life Sciences 23 (1978) 2339-2348
Description: nonlinear least squares fitting, bi-exponential function



Authors: Emlen, Wodruff; Mannik, Mart
Title: Kinetics and Mechanisms for Removal of Circulating Single Stranded DNA in Mice
Source: J. Exp. Med. 147 (1978) 684
Description: clearance kinetics curve analysis



Authors: Formisano, Silvestro; Johnson, Michael L.; Edelhoch, Harold
Title: Effects of Hofmeister Salts on the Self-Association of Glucagon
Source: Biochem. 17 (1978) 1468
Description: best fit of titration curves



Authors: Hobbs, Ann S.; Dunham, Philip B.
Title: Interactions of External Alkali Metal Ions with the Na-K Pump of Human Erythrocytes
Source: J. Gen. Physiol. 72 (1978) 381
Description: best fit solutions to Hill equation



Authors: Johnson, Michael J.; Formisano, Silvestro; Edelhoch, Harold
Title: Self-association of Glucagon as Measured by the Optical Properties of Rhodamine 6G
Source: J. Biol. Chem. 253 (1978) 1353
Description: least squares fit to find equilibrium constants



Authors: Kahn, C. Ronald; Goldfine, Ira D.; Neville, David M., Jr.; De Meyts, Pierre
Title: Alterations in Insulin Binding Induced by Charges in Vitro in the Levels of Glucocorticoids and Growth Hormone
Source: Endocrin. 103 (1978) 1054
Description: Scatchard analysis, best fits, PDP-10



Authors: Ketelslegers, Jean-Marie; Catt, Kevin J.
Title: Follitropin Receptors in Rat Testis. Characterization with Enzymatically 125-I-Labeled Human Follitropin
Source: Bioc. Biop. A 541 (1978) 360-371
Description: binding data were corrected for maximum binding activity of tracer and analyzed with MLAB.



Authors: Ketelslegers, J.M.; Hetzel, W.D.; Sherins, Richard J.; Catt, K.J.
Title: Developmental Changes in Testicular Gonadotropin Receptors: Plasma Gonadotropins and Plasma Testosterone in the Rat
Source: Endocrin. 103 (1978) 212
Description: Scatchard plots, linear and non-linear regression



Authors: Maghuin-Rogister, Guy; Closset, Jean; Combarnous, Yves; Hennen, Georges; Dechanne, Charles; Ketelslegers, Jean-Marie
Title: Study of Follitropin Receptors in Testis Using a Homologous System
Source: Eur. J. Biochem. 86 (1978) 121-131
Description: Scatchard analysis



Authors: Mittag, Thomas W.; Tormay, A.; Massa, T.
Title: Heterogeneity of Acetylcholine Receptors in Denervated Muscle. Interactions of Receptors with Immunoglobin from Patients with Myasthenia Gravis
Source: Mol. Pharm. 14 (1978) 60-68
Description: linear and non-linear regression



Authors: Ohno, K.; Pettigrew, K.D.; Rapoport, S.I.
Title: Lower Limits of Cereborvascular Permeability to Nonelectrolytes in the Conscious Rat
Source: Am. J. Physiol. 235 (1978) H299-H307
Description: nonlinear regression of plasma concentration-time curves



Authors: Pang, K. Sandy; Gillette, James R.
Title: Kinetics of Metabolite Formation and Elimination in the Perfused Rat Liver Preparation: Differences Between the Elimination of Preformed Acetaminophen and Acetaminophen Formed from Phenacetin
Source: J. Pharm. Exp 207 (1978) 178-194
Description: predicted time-cours for decay of [14-C]-phenacetin and the appearance of [14-C]-acetaminophen



Authors: Pelsor, Francis R.; Allen, Larry M.; Creaven, Patrick J.
Title: Multicompartment Pharmacokinetic Model of 4'-Demethylepipodophyllo Toxin 9-(4,6-0-Ethylidene-beta-D-glucopyranoside) in Humans
Source: J. Pharm. Sciences 67 (1978) 1106-1108
Description: non-linear least squares regression



Authors: Podesta, E.J.; Dufau, M.L.; Catt, K.J.
Title: Cyclic Adenosine 3',5'-Monophosphate Dependent Protein Kinase of Rat Leydig Cells: Physical Characteristics of Two Holoenzymes and Their Subunits
Source: Biochem. 17 (1978) 1566
Description: Scatchard analysis, ode fitting



Authors: Ramu, A.; Fusner, J.E.; Blaschke, T.; Glaubiger, D.L.
Title: Probenecid Inhibition of Methotrexate-Cerebrospinal Fluid Pharmacokinetics in Dogs
Source: Cancer Treat. Rep. 62 (1978) 1465
Description: regression on PDP-11



Authors: Ramu, Avner; Glaubiger, Daniel; Ramu, Nili P.; Eldridge, Noreen; Blaschke, Terrence
Title: Probenecid Inhibition of Methotrexate Excretion from Cerebrospinal Fluid in Dogs
Source: J. Pharm. Biopharm. 6 (1978) 389
Description: fit CSF MTX concentration to biexponential decay function



Authors: Ramu, Avner; Rosenbaum, James; Blaschke, Terrence F.
Title: Disposition of Acetone Following Acute Acetone Intoxication
Source: Western J. of Med. 129 (1978) 429
Description: disappearance curves fit to get 1/2-life, nonlinear regression



Authors: Resnik, Judith A.; Malaba, Franco E.; Colburn, Theodore R.; Murray, George C.; Smith, T.G., Jr.
Title: A Novel Rapid Scanning Microspectophotometer and its Use in Measuring Rhodopsin Photoproduct and Pathways and Kinetics in Frog Retinas
Source: J. Opt. Soc. Am. 68 (1978) 937
Description: multiexponential model



Authors: Rhee, S.G.; Park, R.; Chock, P.B.; Stadtman, E.R.
Title: Allosteric Regulation of Monocyclic Interconvertible Enzyme Cascade Systems: Use of Escherichia coli Glutamine Synthetase as an Experimental Model
Source: Proc. Natl. Acad. Sci. USA 75 (1978) 3138-3142
Description: simulated curves



Authors: Sperling, Richard; Furie, Barbara C.; Blumenstein, Michael; Keyt, Bruce; Furie, Bruce
Title: Metal Binding Properites of gamma-Carboxyglutamic Acid
Source: J. Biol. Chem. 253 (1978) 3898
Description: fit titration data



Authors: Stoller, Ronald G.; Myers, Charles E.; Chabner, Bruce A.
Title: Analysis of Lytidine Decaminese and Tetrahydrouridine Interaction by Use of Ligand Techniques
Source: Biochem. Pharm. 27 (1978) 53
Description: rate constants for binding by curve-fitting



Authors: Tinker, David O.; Purdon, A. David; Wei, Jane; Mason, Eileen
Title: Kinetics of Hydrolysis of Dispersions of Saturated Phosphatidylcholines by Crotalus atrox Phospholipase A2'
Source: Can. J. Bioch. 56 (1978) 552-558
Description: reaction progress curves fit to cubic equation in time.



Authors: Wood, William I.; Peterson, David O.; Bloch, Konrad
Title: Subunit Structure of Mycobacterium smegmatis Fatty Acid Synthetase Evidence for Identical Multifunctional Polypeptide Chains
Source: J. Biol. Chem. 253 (1978) 2650-2655
Description: graphs


1979

Authors: Baumann, Gerhard
Title: Metabolic Clearance Rates of Isohormones of Human Growth Hormone in Man
Source: J. Clin. End. 49 (1979) 495
Description: 2 and 3 compartment exponential models



Authors: Berg, G.G.; Miles, E.F.
Title: Mechanisms of Inhibition of Active Transport ATPases by Mercurials
Source: Chem.-Biol. Interactions 27 (1979) 199-219
Description: transformations, curve-fitting, plotting; DEC-10



Authors: Bina-Stein, Minou; Thoren, Marilyn; Salzman, Norman; Thomson, John A.
Title: Rapid Sequence Determination of Late Simian Virus 40 16S mRNA Leader by Using Inhibitions of Reverse Transcriptase
Source: Proc. Natl. Acad. Sci. USA 76 (1979) 731
Description: non-linear regression, mobilities of DNA markers were fitted to a polynomial, DEC-10



Authors: Bjornsson, Thorir D.; Meffin, Peter J.; Swezey, Sarah; Blaschke, Terrence F.
Title: Clofibrate Displaces Warfarin from Plasma Proteins
Source: J. of Pharm. Exp. 210 (1979) 316
Description: best-fit of biexponential decay function



Authors: Bjornsson, Thorir D.; Meffin, Peter J.; Swezey, Sarah; Blaschke, Terrence F.
Title: Effects of Clofibrate and Warfarin Alone and in Combination on the Disposition of Vitamin K
Source: J. of Pharm. Exp. 210 (1979) 322
Description: best-fit of biexponential decay function



Authors: Boobis, Susan W.; Chignell, Colin F.
Title: Effect of Protein Concentration on the Binding of Drugs to Human Serum Albumin. I. Sulfadiazine, Salicylate, and Phenybutazone
Source: Biochem. Pharm. 28 (1979) 751-756
Description: Scatchard analysis, PDP-10



Authors: Bunow, Barry; Line, Bruce R.; Horton, Martha R.; Weiss, George H.
Title: Regional Ventilatory Clearance by Xenon Scintigraphy: A Critical Evaluation of Two Estimation Procedures
Source: J. Nucl. Med. 20 (1979) 703-710
Description: parameter estimation using curve-fitting



Authors: Butrimovitz, Gerald P.; Purdy, William C.
Title: Resolution of Age-Dependent Reference Intervals: Polynomial Regression Methodology with Applicability to Plasma Zinc Levels in Childhood Population
Source: Clin. Biochem. 12 (1979) 33-36
Description: polynomial regression



Authors: Chen, Betty; Chrambach, Andreas; Rodbard, David
Title: Continuous Optical Scanning in Polyacrylamide Gel Electrophoresis: Estimation of the Apparent Diffusion Coefficient of Beta-Lactoglobulin B
Source: Anal. Biodchem. 9b (1979) 120-130
Description: non-linear least squares curve fit



Authors: Cheng, Sheue-yann; Morone, Stefania; Robbins, Jacob
Title: Effect of Deglycosylation on the Binding and Immunoreactivity of Human Thyroxine-Binding Globulin
Source: J. Biol. Chem. 254 (1979) 8830-8835
Description: Michaelis-Menten equation



Authors: Davis, Austine; Parr, Gary R.; Taniuchi, Hiroshi
Title: A Kinetic Study of the Folding of Nuclease B. A Possible Precursor of Staphyloccocal Nuclease A
Source: Biochim. Biophys. Acta 578 (1979) 505-510
Description: kinetic rate constants by curve-fitting, PDP-10



Authors: DiChiro, Giovanni D.; Arimitsu, Tetsuo; Brooks, Rodney A.; Morganthaler, David G.; Johnston, Gerald S.; Jones, A. Eric; Keller, Mark R.
Title: Computed Tomography Profiles of Periventricular Hypodensity in Hydrocephalus and Leukoencephalopathy
Source: Radiology 130 (1979) 661
Description: curve fitting to piece-wise constant/exponential function



Authors: Edelhoch, Harold; Irace, Gaetano; Johnson, Michael L.; Michot, Jean Luc; Nunez, Jacques
Title: The Effects of Thioureylene Compounds (Goitrogens) on Lactoperoxidase Activity
Source: J. Biol. Chem. 254 (1979) 11822-11830
Description: fit data to odes.



Authors: Elchisak, M.A.; Polinsky, R.J.; Ebert, M.H.; Modlin, L.T.; Kopin, I.J.
Title: Kinetics of Homovanillic Acid and Determination of its Production Rate in the Rhesus Monkey
Source: Life Sciences 24 (1979) 1493-1502
Description: decline in serum concentration in time fit to polyexponential functions



Authors: Ginder, Gordon D.; Wood, William I.; Felsenfeld, Gary
Title: Isolation and Characterization of Recombinant Clones Containing the Chicken Adult beta-Globulin Gene
Source: J. Biol. Chem. 254 (1979) 8099
Description: least squares curve-fitting



Authors: Greco, William R.; Hakala, Marie T.
Title: Evaluation of Methods for Estimating the Dissociation Constant of Tight Binding Enzyme Inhibitors
Source: J. Biol. Chem. 254 (1979) 12104-12109
Description: MLAB used for study.


Chapter 15 (1979) pages 233-258, ACS Symposium Series, volume 99.
Authors: Guarino, A.M.; Arnold, S.T.
Title: Xenobiotic Transport Mechanisms and Pharmacokinetics in the Dogfish Shark
Source: Pesticide and Xenobiotic Metabolism in Aquatic Organisms,


ACS Symposium Series, volume 94.
Authors: Heller, S.R.; Milne, G.W.
Title: Use of the NIH-EPA Chemical Information System in Support of the Toxic Substances Control Act
Source: Monitoring Toxic Substances, Chapter 16 (1979) pages 255-280.



Authors: Hoffer, J.A.; Stein, R.B.; Gordon, T.
Title: Differential Atrophy of Sensory and Motor Fibers Following Section of Cat Peripheral Nerves
Source: Brain Res. 178 (1979) 347-361
Description: curve fit exponential plus constant function



Authors: Hruska, Robert E.; Kennedy, Shawn; Silbergeld, Ellen K.
Title: Quantitative Aspects of Normal Locomotion in Rats
Source: Life Sciences 25 (1979) 171-180
Description: curve fit quadratic and logarithmic functions



Authors: Jaillon, Patrice; Rubin, Peter; Yee, YinGail; Ball, Robert; Kates, Robert; Harrison, Donald; Blaschke, Terrence
Title: Influence of Congestive Heart Failure on Prazosin Kinetics
Source: Clin. Pharm. Ther. 25 (1979) 790
Description: blood prazosin conc-time fit to monexponential decay function



Authors: Jennrich, Robert I.; Ralston, Mary L.
Title: Fitting Nonlinear Models to Data
Source: Ann. Rev. Biophys. Bioeng. 8 (1979) 195-238
Description: review of curve-fitting programs



Authors: Klee, Claude B.; Crouch, Thomas H.; Krinks, Marie H.
Title: Subunit Structure and Catalytic Properties of Bovine Brain Ca2+-Dependent Cyclic Nucleotide Phosphodiesterase
Source: Biochem. 18 (1979) 722-729
Description: Michaelis Menten equation, PDP-10



Authors: Knott, Gary D.
Title: MLAB - A Mathematical Modeling Tool
Source: Comput. Math Prog. Biom. 10 (1979) 271-280



Authors: Land, Charles E.; McGregor, Douglas H.
Title: Breast Cancer Incidence Among Atomic Bomb Survivors: Implication for Radiobiologic Risk at Low Doses
Source: JNCI 62 (1979) 17-21
Description: curve-fit quadratic times gaussian



Authors: Liacouras, A.S.; Anderson, E.P.
Title: Uridine-Cytidine Kinase IV. Kinetics of the Competition Between 5-Azacytidine and the Two Natural Substrates
Source: Mol. Pharm. 15 (1979) 331-340
Description: modified michaelis-menten equation



Authors: Marino, D.F.; Wolfe, F.; Ingle, J.D.
Title: Determination of Cobalt by Lophine Chemiluminescence
Source: Anal. Chem. 51 (1979) 2051-2053



Authors: Michot, Jean Luc; Nunez, Jacques; Johnson, Michael L.; Irace, Gaetano; Edelhoch, Harold
Title: Iodide Binding and Regulation of Lactoperoxidase Activity Toward Thyroid Goitrogens
Source: J. Biol. Chem. 254 (1979) 2205-2209
Description: curve-fitting odes



Authors: Morrow, P.E.; Gibb, F.R.; Better, H.; Kilpper, R.W.
Title: Pulmonary Retention of Neuron-Activated Coal Dust
Source: Arch. Env. Health 34 (1979) 178
Description: curve-fit sum of exponentials



Authors: Neil, E. Andrew; Meffin, Peter J.; Gregory, Peter B.; Blaschke, Terrence F.
Title: Enhanced Bioavailability and Decreased Clearance of Analgesics in Patients with Cirrhosis
Source: Gastroent. 77 (1979) 96
Description: blood conc.-time data fit to biexponential decay function



Authors: Nelson, R.L.; Dyke, R.W.; Root, M.A.
Title: Clinical Pharmacokinetics of Vindesine
Source: Cancer Chemo. Pharm. 2 (1979) 243
Description: fiting odes, DEC-10



Authors: Ohno, K.; Pettigrew, K.D.; Rapoport, S.I.
Title: Local Cerebral Blood Flow in the Conscious Rat as Measured with 14-C-Antipyrine, 14-C-Iodoantipyrine, and 3-H-Nicotine
Source: Stroke 10 (1979) 62-67
Description: 14-C-Antipyrine or 14-C-Iodoantipyrine in plasma vs. time, fit to triexponential model.



Authors: Pang, K. Sandy; Stobl, Kristina; Gillette, James R.
Title: A Method for the Estimation of the Fraction of a Precursor that is Converted to a Metabolite in Rat in Vivo with Phenacetin and Acetominophen
Source: Drug Metab. 7 (1979) 366
Description: half-lives found by curve-fitting



Authors: Pesek, J.J.; Blair, B.A.
Title: Determination of C8 and Heavier Molecular Weight Alkylbenzenes in Petroleum
Source: Anal. Chem. 51 (1979) 2048-2050



Authors: Raiford, D.S.; Fisk, C.L.; Becker, E.D.
Title: Calibration of Methanol and Ethylene Glycol Nuclear Magnetic Resonance Thermometers
Source: Anal. Chem. 51 (1979) 2050-2051



Authors: Rakhit, Gupa; Chignell, Colin F.
Title: A Spin Label Study of Horseradish Peroxidase
Source: Biochim. Biophys. Acta 580 (1979) 108-119
Description: curve-fitting and graphics, DEC-10



Authors: Rapoport, Stanley I.; Ohno, Kikuo; Pettigrew, Karen D.
Title: Blood-Brain Barrier Permeability in Senescent Rats
Source: J. Gerontol. 34 (1979) 162-169
Description: multiexponential decay curve fit for plasma concentration of 14-C, brain concentration fit to more complicated exponential function.



Authors: Rapoport, S.I.; Ohno, K.; Pettigrew, K.D.
Title: Drug Entry Into Brain
Source: Brain Research 172 (1979) 354-359
Description: 3 or 4 term exponential function fit to plasma concentration data.



Authors: Rapoport, Stanley I.; Pettigrew, Karen D.
Title: A Heterogenous, Pore-Vesicle Membrane Model for Protein Transfer from Blood to Cerebrospinal Fluid at the Choroid Plexus
Source: Microvascular Research 18 (1979) 105-119
Description: permeability coefficient of a solute of radius, a, function of a, fit to data.



Authors: Richman, Paul G.; Klee, Claude B.
Title: Specific Perturbation by Ca2+ of Tyrosyl Residue 138 of Calmodulin
Source: J. Biol. Chem. 254 (1979) 5372-5376
Description: Henderson-Hasselbach equations



Authors: Rubin, Peter; Yee, Yin-Gail; Anderson, Malcolm; Blaschke, Terrence
Title: Prazosin First-Pass Metabolism and Hepatic Extraction in the Dog
Source: J. Cardiovasc. Pharm. 1 (1979) 641-647
Description: fit biexponential function



Authors: Swann, Alan C.; Albers, R. Wayne
Title: (Na+,K+)-Adenosine Triphosphate of Mammalian Brain
Source: J. Biol. Chem. 254 (1979) 4540-4544
Description: curve-fitting, simulations



Authors: Tack, Brian F.; Morris, Sam C.; Prahl, James W.
Title: Third Component of Human Complement: Structural Analysis of the Polypeptide Chains of C3 and C3b
Source: Biochem. 18 (1979) 1497-1503
Description: ultracentrifuge data analysis, linear regression, PDP10 MLAB.



Authors: Tanabe, K.; Bohn, E.W.; Wilson, S.H.
Title: Steady State Kinetics of Mouse DNA Polymerase Beta
Source: Biochem. 18 (1979) 3401-3406
Description: kinetic constants evaluated by curve-fitting



Authors: Thakur, Ajit K.; Rodbard, David
Title: Graphical Aids to Interpretation of Scatchard Plots and Dose-Response Curves
Source: J. Theor. Biol. 80 (1979) 383-403
Description: curve-fitting



Authors: Tinker, David O.; Wei, Jane
Title: Heterogeneous Catalysis by Phospholipase A2: Formulation of a Kinetic Description of Surface Effects
Source: Can. J. Bioch. 57 (1979) 97-106
Description: ode rate equations fit to data.



Authors: Williams, Leah A.; Piatigorsky, Joram
Title: Comparative and Evolutionary Aspects of delta-Crystallin in the Vertebrate Lens
Source: Eur. J. Biochem. 100 (1979) 349-357
Description: least squares fit


1980

Authors: Aronoff, George R.; Szwed, James J.; Nelson, Robert L.; Maneus, Edwin L.; Kleit, Stuart A.
Title: Hypoxanthine-Arabinoside Pharmacokinetics After Adenine Arabinoside Administration to a Patient with Renal Failure
Source: Antimicrobial Agents and Chemo. 18 (1980) 212-214
Description: plasma concentration- time data fit to multi-exponential decay model



Authors: Bina, Minou; Strutevant, Julian M.; Stein, Arnold
Title: Stability of DNA in Nucleosomes
Source: Proc. Natl. Acad. Sci. 77 (1980) 4044-4047
Description: excess heat capacity vs temp in degrees C fit to sum of Gaussians.



Authors: Chikira, Makato; Kon, Hideo; Smith, Kevin M.
Title: Concentration- and Solvent-Dependent Electron Spin Resonance Signals and Dimer Formation of High-Spin Iron (III) Porphyrins
Source: JCS Dalton (1980) 526
Description: calculation and simulation of dimer esr spectra



Authors: Choie, David D.; del Campo, Anthony A.; Guarino, Anthony M.
Title: Subcellular Localization of cis-Dichlorodiammineplatinum (II) in Rat Kidney and Liver
Source: Toxicol. and Appl. Pharm. 55 (1980) 245-252
Description: estimate half-life of tissue platinum in kidney and liver



Authors: Crouch, Thomas H.; Klee, Claude B.
Title: Positive Cooperative Binding of Calcium to Bovine Brain Calmodulin
Source: Biochem. 19 (1980) 3692-3698
Description: ultracentrifuge data analysis



Authors: Davies, P.J.A.; Wallach, D.; Willingham, M.; Pastan, I.; Lewis, M.S.
Title: Self-Association of Chicken Gizzard Filamin and Heavy Merofilamin
Source: Biochem. 19 (1980) 1366-1372



Authors: Dubois, Michel; Sato, Susumu; Lees, David E.; Bull, Joan M.; Smith, Rosalie; White, Billy G.; Moore, Henry; Macnamara, Thomas E.
Title: Electroencephalographic Changes During Whole Body Hyperthermia in Humans
Source: EEG and Clin. Neur. 50 (1980) 486-495
Description: 3D net graphics of spectral intensity over duration of hypothermia



Authors: Dutcher, John S.; Jones, Roy B.; Boyd, Michael R.
Title: A Sensitive and Specific Assay for Pentamethylmelamine in Plasma: Applicability to Clinical Studies
Source: Canc. Treat Rep. 64 (1980) 99-104
Description: 2-compartment model



Authors: Erlichman, Charles; Strong, John M.; Chabner, Bruce A.
Title: Application of a Simple Competitive Protein-Binding Assay Technique to the Pharmacokinetics of N-(Phosphonacetyl)-L-Aspartate in Humans
Source: Canc. Res. 40 (1980) 1902
Description: Scatchard analysis, 2 compartment model



Authors: Gandour, R.D.; Coyne, M.; Stella, V.J.; Schowen, R.L.
Title: Proton Inventory of Phthalic Anhydride Hydrolysis. Comments on Analysis of Proton-Inventory Data
Source: J. Org. Chem. 45 (1980) 1733-1737



Authors: Giacomini, Kathleen M.; Giacomini, John C.; Swezey, Sarah E.; Harrison, Donald C.; Nelson, Wendel L.; Burke, Terrence R., Jr.; Blaschke, Terrence
Title: The Stereoselective Disposition of Disopyramide in the Dog
Source: J. Cardiov. Pharm. 2 (1980) 825-832
Description: 2 compartment model, clearance rates



Authors: Goldberg, Itzhak D.; Stemerman, Michael B.; Pansil, Bernard J.; Fuhro, Robert L.
Title: In Vivo Aortic Muscle Cell Growth Kinetics
Source: Circ. Res. 47 (1980) 182
Description: intimal growth curves fit to appropriate function



Authors: Gorman, Jeffrey J.; Folk, J.E.
Title: Structural Features of Glutamine Substrates for Human Plasma Factor XIIIa (Activated Blood Coagulation Factor XIII)
Source: J. Biol. Chem. 255 (1980) 419-427
Description: Michaelis-Menten equation



Authors: Graves, S.W.; Fox, J.A.; Babior, B.M.
Title: Deamination of 2-aminopropanol by Ethanolamine Ammonia- lyase, an Ado Cbl-requiring enzyme. Kinetics and Isotope Effects for the R and S Enantiomers of the Substrate
Source: Biochem. 19 (1980) 3630-3633



Authors: Greco, William R.; Hakala, Marie T.
Title: Cellular Pharmacokinetics of Lipophilic Diamino Pyrimidine Antifolates
Source: J. Pharm. Exp. 212 (1980) 39
Description: plasma concentration curves fit to mono- or bi-exponential decay curves, Michaelis Menten equation



Authors: Greco, William R.; Hakala, Marie T.
Title: Biochemical Pharmacology of Lipophilic Diaminopyrimidine Antifolates in Mouse and Human Cells in Vitro
Source: Mol. Pharm. 18 (1980) 521-528
Description: nonlinear regression



Authors: Gullo, John J.; Litterst, Charles L.; Maguire, Patrick J.; Sikic, Branimir I.; Hoth, Daniel F.; Woolley, Paul V., III
Title: Pharmacokinetics and Protein Binding of cis-Dichlorodiammine Platinum (II) Administered as a One Hour or as a Twenty Hour Infusion
Source: Canc. Chemo. Pharm. 5 (1980) 21-26
Description: 1 and 2 compartment models



Authors: Guttman, Rita; Lewis, Stephen; Rinzel, John
Title: Control of Repetitive Firing in Squid Axon Membrane as a Model for a Neuroneoscillator
Source: J. Physiol. 305 (1980) 377-395
Description: transient trajectories computed using differential equation solver



Authors: Hobbs, Ann S.; Albers, R. Wayne; Froehlich, Jeffrey P.
Title: Potassium-Induced Changes in Phosphorylation and Dephosphorylation of (Na+ K+)-ATPase Observed in the Transient State
Source: J. Biol. Chem. 255 (1980) 3395-3402
Description: curve fitting.



Authors: Hobbs, Ann S.; Froehlich, Jeffrey P.; Albers, R. Wayne
Title: Inhibition by Vanadate of the Reactions Catalyzed by the (Na+ K+)-Stimulated ATPase
Source: J. Biol. Chem. 255 (1980) 5724-5727
Description: single exponential fits of phosphorylation of (Na+ K+)-ATPase after equilibration with various concentrations of vanadate vs time.



Authors: Hunston, D.L.; Zakin, J.L.
Title: Flow-Assisted Degradation in Dilute Polystyrene Solutions
Source: Polymer Eng. Sci. 20 (1980) 517-523
Description: loss of drag reduction through mechanical degradation modeled by exponential function.



Authors: Jackson, Meyer B.; Berkowitz, Steven A.
Title: Nucleation and the Kinetics of Microtubule Assembly
Source: Proc. Natl. Acad. Sci. USA 77 (1980) 7302-7305
Description: fit thermodynamic parameters in system of odes



Authors: Johnson, Michael L.; Lippoldt, Roland E.; Gershengorn, Marvin C.; Robbins, Jacob; Edelhoch, Harold
Title: Molecular Transitions of Human Thyroxine-Binding Globulin
Source: Arch. Biochem. Biophys. 200 (1980) 288-295
Description: bi-exponential decay model



Authors: Karpetsky, Timothy; Shriver, Kren K.; Levy, Carl C.
Title: Covalent Linkage of Poly(A) to RNA Produces a Molecule Altered in Both Structure and Susceptibility to Ribonuclease-Mediated Hydrolysis
Source: J. Biol. Chem. 255 (1980) 2713-2721
Description: thermodynamic parameters-standard enthalpies and entropies, experimental results for melting various polynucleotides, measure absorbance at 260nm vs reciprocal of temperature in degrees K.



Authors: Kates, Robert E.; Jaillon, Patrice
Title: A Model to Describe Myocaridal Drug Disposition in the Dog
Source: J. Pharm. and Exp. Ther. 214 (1980) 31
Description: 3 compartment model, differential equations



Authors: Kates, Robert E.; Jaillon, Patrice; Rubenson, David S.; Winkle, Roger A.
Title: Intravenous N-Acetylprocainamide Disposition Kinetics in Coronary Artery Disease
Source: Clin. Pharm. and Ther. 28 (1980) 52
Description: 3 compartment model



Authors: Keller, Charles A.; Doherty, Richard A.
Title: Lead and Calcium Distributions in Blood, Plasma, and Milk of the Lactating Mouse
Source: J. Lab. Clin. Med. 95 (1980) 81
Description: 2- and 3-compartment exponential models



Authors: Keller, Charles A.; Doherty, Richard A.
Title: Distribution and Excretion of Lead in Young and Adult Female Mice
Source: Env. Res. 21 (1980) 217-228
Description: whole body retention fit to tri-exponential decay, linear regression



Authors: Kris-Etherton, P.M.; Cooper, A.D.
Title: Studies on the Etiology of the Hyperlipemia in Rats Fed an Atherogenic Diet
Source: J. Lipid Res. 21 (1980) 435
Description: fit linear, exponential models



Authors: Land, Charles E.; Boice, John D.; Shore, Ray E.; Norman, James E.; Tokunaga, M.
Title: Breast Cancer Risk from Low-Dose Exposures to Ionizing Radiation: Results of Parallel Analysis of Three Exposed Populations of Women
Source: JNCI 65 (1980) 353
Description: fit dose-response data to product of quadratic and gaussian



Authors: Levine, R.F.; Bunn, P.A., Jr.; Hazzard, K.C.; Schlan, M.L.
Title: Flow Cytometric Analysis of Megakaryocyte Ploidy. Comparison with Feulgen Microdensitometry and Discovery that 8N is the Dominant Ploidy Class in Guinea Pig and Monkey Marrow
Source: Blood 56 (1980) 210
Description: fit gaussian to experimental frequency distribution



Authors: Levy, Carl C.; Karpetsky, Timothy
Title: The Purification and Properties of Chicken Liver RNase
Source: J. Biol. Chem. 255 (1980) 2153-2159
Description: values of kinetic constants were obtained by fitting reciprocal of enzyme activity equation to data.



Authors: Litterst, Charles L.
Title: In Vitro Hepatic Drug Metabolism and Microsomal Enzyme Induction in Genetically Obese Rats
Source: Biochem. Pharm. 29 (1980) 289-296
Description: linear regression of enzyme specific activity vs. substrate concentration



Authors: Marini, M.A.; Marti, G.E.; Berger, R.L.; Martin, C.J.
Title: Potentiometric Titration Curves of Oxidized and Reduced Horse Heart Cytochrome c
Source: Biopolymers 19 (1980) 885-898
Description: titration curves



Authors: Mendelson, Carole R.; Johnston, John M.
Title: Estrogen Binding in Human Fetal Lung Tissue Cytosol
Source: Endocrin. 106 (1980) 368
Description: fit binding affinity and conc. of binding sites



Authors: Milne, G.W.A.; Heller, S.R.
Title: NIH/EPA Chemical Information System
Source: J. Chem. Inf. 20 (1980) 204-211
Description: MLAB as part of chemical information system.



Authors: Nandi, Pradip K.; Pretorius, Harold T.; Lippoldt, Roland E.; Johnson, Michael L.; Edelhoch, Harold
Title: Molecular Properties of the Reassembled Coat Protein of Coated Vesicles
Source: Biochem. 19 (1980) 5917-5921
Description: ultracentrifuge-sedimentation equilibrium data analysis



Authors: Nelson, R.L.; Dyke, R.W.; Root, M.A.
Title: Comparative Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Patients with Cancer
Source: Canc. Treat. Rev. 7 supplement (1980) 17-24
Description: 3 compartment open model, differential equation



Authors: Newton, Carol M.
Title: Biomathematics in Oncology: Modeling of Cellular Systems
Source: Ann. Rev. Biophys. Bioeng. 39 (1980) 341-379
Description: review of computer programs



Authors: Ohno, K.; Chiueh, C.C.; Burns, E.M.; Pettigrew, K.D.; Rapoport, S.I.
Title: Cerebrovascular Integrity in Protein-Deprived Rats
Source: Brain Res. Bull. 5 (1980) 251-255
Description: fit brain concentration data with exponential function



Authors: Pang, K. Sandy; Gillette, James R.
Title: Metabolite Pharmacokinetics: Methods for Simultaneous Estimates of Elimination Rate Constants of a Drug and its Metabolite
Source: Drug Metab. and Disp. 8 (1980) 39
Description: simulation of decay of a precursor and its metabolite



Authors: Parr, Gary R.; Taniuchi, Hiroshi
Title: An Investigation of Ordered Complex Formation with Chemically Modified Fragments of Cytochrome c
Source: J. Biol. Chem. 255 (1980) 2616-2623
Description: dimerization equilibrium constants from Pasternack equation.



Authors: Rafferty, C.N.; Muellenberg, C.G.; Shichi, H.
Title: Tryptophan in Bovine Rhodopsin: its Content, Spectral Properties, and Environment
Source: Biochem. 19 (1980) 2145-2151



Authors: Rapoport, S.I.; Klee, W.A.; Pettigrew, K.D.; Ohno, K.
Title: Entry of Opioid Peptides into the Central Nervous System
Source: Science 207 (1980) 84-86
Description: fit plasma and brain concentrations vs time to exponential models.



Authors: Roberts, Rowena L.; Szaniszlo, Paul J.
Title: Yeast-Phase Cell Cycle of the Polymorphic Fungus Wangiella dermatitidis
Source: J. Bact. 144 (1980) 721-731
Description: fit sum of gaussians to experimental frequency distribution



Authors: Rubin, P.; Jackson, G.; Blaschke, T.
Title: Studies on the Clinical Pharmacology of Prazosin. II The Influence of Indomethacin and of Propranolol on the Action and Disposition of Prazosin
Source: Br. J. Clin. Pharm. 10 (1980) 33-39
Description: fit plasma concentration-time data to monoexponential decay



Authors: Shindo, H.; Wooten, J.B.; Pheiffer, B.H.; Zimmerman, S.B.
Title: Nonuniform Backbone Conformation of Deoxyribonucleic Acid Indicated by Phosphorous-31 Nuclear Magnetic Resonance Chemical Shift Anisotropy
Source: Biochem. 19 (1980) 518-526



Authors: Siddic, Zahid H.; Mimnaugh, Edward G.; Trush, Michael A.; Gram, Theodore E.
Title: The Effect of Vitamin A Deficiency on Hepatic, Renal and Pulmonary Glutathione S-Transferase Activities in the Rat
Source: Biochem. J. 188 (1980) 889-893
Description: fit Michaelis Mentent equation, Km, Vmax



Authors: Strobl, Jeannine; Monaco, Marie E.; Lippman, Marc E.
Title: The Role of Intracellular Equilibria and the Effects of Antiestrogens on Estrogen-Receptor Dissociation Kinetics from Perfused Cultures of Human Breast Cancer Cells
Source: Endocrin. 107 (1980) 450
Description: fit dissociation curves to mono- and bi-phasic exponential decay functions



Authors: Sumida, Michihiro; Wang, Taitzer; Schwartz, Arnold; Younkin, Casey; Froehlich, Jeffrey P.
Title: The Ca2+-ATPase Partial Reactions in Cardiac and Skeletal Sarcoplasmic Reticulum
Source: J. Biol. Chem. 255 (1980) 1497-1503
Description: fit to sum of exponentially decreasing functions



Authors: Swann, A.C.; Albers, R. Wayne
Title: (Na+,K+)-ATPase of Mammalian Brain: Differential Effects on Cation Affinities of Phosphorylation by ATP and Acetylphosphate
Source: Arch. Bioch. 203 (1980) 422-427
Description: computer simulations.



Authors: Swann, Alan C.; Marini, James L.; Sheard, Michael H.; Maas, James W.
Title: Effects of Chronic Dietary Lithium on Activity and Regulation of (Na+,K+)-Adenosine Triphosphate in Rat Brain
Source: Bioch. Pharm. 29 (1980) 2819-2823
Description: fit Hill coefficients.



Authors: Thakur, Ajit; Munson, Peter J.; Hunston, Donald L.; Rodbard, David
Title: Characterization of Ligand-Binding Systems by Continuous Affinity Distributions of Arbitrary Shape
Source: Analytical Biochemistry 102 (1980) 240-254
Description: curve fitting.



Authors: Tinker, David O.; Low, Rosita; Lucassen, Maria
Title: Heterogenous Catalysis by Phospholipase A2: Mechanism of Hydrolysis of Gel Phase Phosphatidylcholine
Source: Can. J. Bioch. 58 (1980) 898-912
Description: fitting of experimental data to kinetic models using MLAB, three models.



Authors: Turner, N.H.; Murday, J.S.; Rameker, D.E.
Title: Quantitative Determination of Surface Composition of Sulfur Bearing Anion Mixtures by Auger Electron Spectroscopy
Source: Anal. Chem. 52 (1980) 84-92
Description: fit linear combination of lineshape functions



Authors: Vallerga, S.; Covacci, R.; Pottala, E.W.
Title: Artificial Cone Repsonses: A Computer-Driven Hardware Model
Source: Vis. Res. 20 (1980) 453-457
Description: reconstruction of cone responses as odes



Authors: Vreman, Hendrik J.; Assomul, Vinod M.; Kaiser, Bruce A.; Blaschke, Terrance F.; Weiner, Michael W.
Title: Acetate Metabolism and Acid-Base Homeostasis During Hemodialysis- Influence of Dialyzer Efficiency and Rate of Acetate Metabolism
Source: Kidney Int. 18 (1980) S12
Description: 1st order and nonlinear compartmental models fit to plasma acetate concentrations



Authors: Zelenka, Peggy S.
Title: Changes in Phosphatidylinositol Metabolism During Differentiation of Lens Epithelial Cells into Lens Fiber Cells in the Embryonic Chick
Source: J. Biol. Chem. 255 (1980) 1296-1300
Description: ode model in which derivative of radioactivity counts is proportional to specific activity of precursor and radioactivity.


1981

Authors: Behe, M.; Zimmerman, S.; Felsenfeld, G.
Title: Changes in the Helical Repeat of Poly(dG-m5dC).Poly(dG-m5dC) and Poly(dG-dC).Poly(dG-dC) Associated with the B-Z Transition
Source: Nature 293 (1981) 233
Description: autocorrelation analysis and fitting tracings to a single damped sinusoidal curve



Authors: Bunn, Paul A., Jr.; Edelson, Richard; Ford, Sharon S.; Shackney, Stanley E.
Title: Patterns of Cell Proliferation and Cell Migration in the Sezary Syndrome
Source: Blood 57 (1981) 452
Description: least squares curve fit



Authors: Campbell, M.C.W.; Hughes, A.
Title: An Analytic, Gradient, Index Schematic Lens and Eye for the Rat Which Predicts Aberration for Finite Pupils
Source: Vis. Res. 21 (1981) 1129-1148
Description: curve fitting



Authors: Carlisle, David M.; Blaschke, Terrence F.
Title: Vitamin K1, Vitamin K1 Epoxide, and Warfarin Interrelationships in the Dog
Source: Biochem. Pharm. 30 (1981) 2931-2936
Description: biexponential model for plasma concentration-time data



Authors: Cheng, Sheue-yann; Rakhit, Gupa; Erard, Francois; Robbins, Jacob; Chignell, Colin F.
Title: A Spin Label Study of the Thyroid Hormone-Binding Sites in Human Plasma Thyroxine Transport Proteins
Source: J. Biol. Chem. 256 (1981) 831-836
Description: least squares curve fit



Authors: Collins, Jerry M.
Title: Inert Gas Exchange of Subcutaneous and Intraperitoneal Gas Pockets in Piglets
Source: Resp. Physiol. 46 (1981) 391-404
Description: fitting odes



Authors: Czernichow, P.; Vandalem, J.L.; Hennen, G.
Title: Transient Neonatal Hyperthyrotropinemia: A Factitious Syndrome Due to the Heterophilic Antibodies in the Plasma of Infants and Their Mothers
Source: J. Clin. Endocrin. and Metab. 53 (1981) 387
Description: Scatchard plots and analysis



Authors: Dower, Steven K.; DeLisi, Charles P.; Titus, Julie A.; Segal, David M.
Title: Mechanisms of Binding of Multivalent Immune Complexes to Fc Receptors. 1. Equilibrium Binding
Source: Biochem. 20 (1981) 6326-6334
Description: ligand binding model



Authors: Dower, Steven K.; Segal, David M.
Title: C1q Binding to Antibody-Coated Cells: Predictions From a Simple Multivalent Binding Model
Source: Mol. Immunol. 18 (1981) 823-829
Description: DEC10 MLAB, root of sixth-power equation.



Authors: Dower, Steven K.; Titus, Julie A.; DeLisi, Charles; Segal, David M.
Title: Mechanism of Binding of Multivalent Immune Complexes to Fc Receptors. 2. Kinetics of Binding
Source: Biochem. 20 (1981) 6335-6340
Description: biexponential model for dissociation reaction, bi-(1-exponential) model for association reactions.



Authors: Duffel, Michael W.; Jakoby, William B.
Title: On the Mechanism of Aryl Sulfotransferase
Source: J. Biol. Chem. 256 (1981) 11123-11127
Description: kinetics



Authors: French, Robert J.; Shoukimes, Jonathan J.
Title: Blockage of Squid Axon Potassium Conductance by Internal Tetra-N-Alkylammonium Ions of Various Sizes
Source: Biophys. J. 34 (1981) 271
Description: analysis and curve-fitting



Authors: Green, F.J.; Lavelle, K.J.; Aronoff, G.R.; Vander Zanden, J.; Brier, G.L.
Title: Management of Amkacin Overdose
Source: Am. J. Kid. Dis. 1 (1981) 110
Description: biexponential decay model



Authors: Holford, Nicholas H.G.; Coates, Peter E.; Guentert, Theodore W.; Riegelman, Sidney; Sheiner, Lewis B.
Title: The Effect of Quinidine and its Metabolites on the Electrocardiogram and Systolic Time Intervals: Concentration-Effect Relationships
Source: Br. J. Clin. Pharm. 11 (1981) 187-195
Description: 2-compartment model of plama quinidine concentration data



Authors: Ihde, Daniel C.; Dutcher, John S.; Young, Robert C.; Cordes, Rosemarie S.; Barlock, Audrey L.; Hubbard, Susan M.; Jones, Roy B.; Boyd, Michael R.
Title: Phase I Trial of Pentamethylmelamine: A Clinical and Pharmacologic Study
Source: Canc. Treat. Rep. 65 (1981) 753-762
Description: 2- and 3-compartment models



Authors: Karpetsky, Timothy P.; Shriver, Kren K.; Levy, Carl C.
Title: Poly(adenylic acid) in Small Amounts, Free or Covalently Linked to Substrate, Protects RNA from Hydrolysis by Ribonuclease
Source: Biochem. J. 193 (1981) 311-324
Description: curve-fit Michaelis-Menten equation



Authors: Kates, Robert E.; Keefe, Deborah L.D.; Schwarz, Janice; Harapat, Sandra; Kirsten, Edward B.; Harrison, Donald C.
Title: Verapamil Disposition Kinetics in Chronic Atrial Fibrilation
Source: Clin. Pharm. and Ther. 30 (1981) 44
Description: 3-compartment model



Authors: Landrum, P.F.; Crosby, D.G.
Title: The Disposition of p-Nitroanisole by the Sea Urchin, Strongylocentrotus purpuratus
Source: Ecotox. and Env. Safety 5 (1981) 225-239
Description: 2-compartment model



Authors: Marini, M.A.; Martin, C.J.; Forlani, L.
Title: Analysis of the Potentiometric Titration of Reduced Horse Heart Cytochrome c
Source: Biopolymers 20 (1981) 2243-2252
Description: fit pK ionization constants



Authors: McManus, M.E.; Monks, A.; Collins, J.M.; White, R.; Strong, J.M.
Title: Nonlinear Pharmacokinetics of Misonidazole and Desmethylmisonidazole in the Isolated Perfused Rat Liver
Source: J. Pharm. Exp. 219 (1981) 669
Description: Michaelis Menten kinetics



Authors: Morris, Catherine; Lecar, Harold
Title: Voltage Oscillations in the Barnacle Giant Muscle Fiber
Source: Biophys. J. 35 (1981) 193
Description: Hodgkin-Huxley equations



Authors: Nagainis, Monica Palcic; Pu, Wenshi; Cheng, Behling; Taylor, Keith E.; Schmidt, Donald E., Jr.
Title: Effects of pH and Sulfhydryl Specific Reagents on 4-Fumarylacetoacetate Fumarylhydrolase
Source: Biochem. Biophys. Acta 657 (1981) 203-211
Description: pKa values from fitting log V vs ph curves



Authors: Ohata, M.; Fredericks, W.R.; Sundaram, U.; Rapoport, S.I.
Title: Effects of Immobilization Stress on Regional Cerebral Blood Flow in the Conscious Rat
Source: J. Cereb. Bl. Fl. 1 (1981) 187-194
Description: rising arterial whole blood concentration of 14-C-iodoantipyrine measured during intravenous infusion plotted vs time and fit to biexponential model, brain concentration fit to more complicated model involving exponentials.



Authors: Ohata, M.; Sundaram, U.; Fredericks, W.R.; London, E.D.; Rapoport, S.I.
Title: Regional Cerebral Blood Flow During Development and Ageing of the Rat Brain
Source: Brain 104 (1981) 319-332
Description: least squares fit of brain concentration data



Authors: Pang, K. Sandy; Koster, Henk; Halsema, Ina C.M.; Scholtens, Egbert; Mulder, Gerard J.
Title: Aberrant Pharmacokinetics of Harmol in the Perused Rat Liver Preparation: Sulfate and Glucuronide Conjugations
Source: J. Pharm. Exp. 219 (1981) 134
Description: Michaelis-Menten equation



Authors: Parker, Diana S.; Davis, Austine; Taniuchi, Hiroshi
Title: Further Study of the Conformation of Nuclease-(1-126) in Relation to Intrinsic Enzymatic Activity
Source: J. Biol. Chem. 256 (1981) 455-4569
Description: modified Lineweaver Burk equation



Authors: Parr, Gary R.; Taniuchi, Hiroshi
Title: Ordered Complexes of Cytochrome c Fragments
Source: J. Biol. Chem. 256 (1981) 125-132
Description: curve fit relaxation times vs. concentration



Authors: Parsegian, V. Adrian; Weiss, George H.
Title: Spectroscopic Parameters for Computation of van der Waals Forces
Source: J. Coll. I. Sc. 81 (1981) 285
Description: fit e-prime and e-double prime in Kramers-Kronig relation.



Authors: Pretorius, Harold T.; Nandi, Pradip K.; Lippoldt, Roland E.; Johnson, Michael L.; Keen, James H.; Pastan, Ira; Edelhoch, Harold E.
Title: Molecular Characterization of Human Clathrin
Source: Biochem. 20 (1981) 2777-2782
Description: sedimentation equilibrium data analysis



Authors: Roberts, R.K.; Grice, J.; Wood, L.; Petroff, V.; McGuffie, C.
Title: Cimetidine Impairs the Elimination of Theophylline and Antipyrine
Source: Gastroenterology 81 (1981) 19-21
Description: area under curve, two tailed t-test



Authors: Ross-Lee, L.M.; Eadie, M. J.; Hooper, W.D.; Bochner, F.
Title: Single-Dose Pharmacokinetics of Metoclopramide
Source: Eur. J. Clin. Pharm. 20 (1981) 465-471
Description: bi- and tri-exponential model



Authors: Sawhney, Vinod K.; Gregory, Peter B.; Swezey, Sarah E.; Blaschke, Terrence
Title: Furosemide Disposition in Cirrhotic Patients
Source: Gastroent. 81 (1981) 1012-1016
Description: biexponential model of plasma concentration data



Authors: Shindo, H.; Wooten, J.B.; Zimmerman, S.B.
Title: Geometry of the Phosphodiester Backbone in the A Form of Desoxyribonucleic Acid Determined by Phosphorous-31 Nuclear Magnetic Resonance Spectroscopy
Source: Biochem. 20 (1981) 745-750



Authors: Sligo, Jennifer H.; Charles, Bruce G.; Ravenscroft, Peter J.
Title: Oral Bioavailability of Theophylline from Hydroalcoholic and Alcohol-free Preparations
Source: Med. J. Austr. 2 (1981) 410-411
Description: biexponential function plasma conc. of theophylline



Authors: Swann, Alan C.; Albers, R. Wayne
Title: Temperature Effects on Cation Affinities of the (Na+,K+)-ATPase of Mammalian Brain
Source: Bioc. Biop. A 644 (1981) 36-40
Description: parameters of equations used to fit experimental data



Authors: Titus, Julie A.; Sharrow, Susan O.; Connolly, Janet M.; Segal, David M.
Title: Fc (IgG) Receptor Distribution in Homogeneous and Heterogeneous Cell Populations by Flow Microfluorometry
Source: Proc. Natl. Acad. Sci. USA 78 (1981) 519-523
Description: linear regression of mean fluorescence vs IgG subunits bound per cell



Authors: Woolley, Paul V., III; Luc, Phuong Van T.; Rahman, Aquilur; Korsmeyer, Susan J.; Smith, Frederick P.; Schein, Philip S.
Title: Phase I Trial and Clinical Pharmacology of 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea
Source: Canc. Res. 41 (1981) 3896-3900
Description: post-infusion data fit to 2-compartment model


1982

Authors: Abramson, Fred P.
Title: Methadone Plasma Protein Binding: Alterations in Cancer and Displacement from alpha-1-acid Glycoprotein
Source: Clin. Pharm. 32 (1982) 652
Description: least squares fit of AAG/methadone binding data



Authors: Aitken, Susan C.; Lippman, Marc E.
Title: Hormonal Regulation of Net DNA Synthesis in MCF-7 Human Breast Cancer Cells in Tissue Culture
Source: Canc. Res. 42 (1982) 1727-1735
Description: 32-P in Acid soluble pool vs. time, DEC 10, labelling kinetics



Authors: Aizenbud, Boris M.; Gershon, Nahum D.
Title: Diffusion of Molecules on Biological Membranes of Nonplanar Form
Source: Biophys. J. 38 (1982) 287
Description: 3D graphics



Authors: Alving, Barbara M.; Chung, Soo Il; Murano, Genesio; Tang, Douglas B.; Finlayson, J.S.
Title: Rabbit Fibrinogen: Time Course of Constituent Chain Production in Vivo
Source: Arch. Biochem. 217 (1982) 1-9
Description: kinetic data, 2-terms: (1-exp(-a(t-t0)))



Authors: Aronoff, George R.; Sloan, Rebecca S.; Luft, Friedrich C.
Title: Pharmacokinetics of Moxalactam in Patients with Normal and Impaired Renal Function
Source: J. Infect. Dis. 145 (1982) 365
Description: n compartment model



Authors: Bachur, Nicholas R.; Collins, Jerry M.; Kelley, James A.; van Echo, David A.; Kaplan, Richard S.; Whitacre, Margaret
Title: Diaziquone, 2,5 diaziridinyl-3,6-biscarboethoxyamino-1,4-benzo quinone, Plasma and Cerebrospinal Fluid Kinetics
Source: Clin. Pharm. 31 (1982) 650
Description: postinfusion plasma conc. fit to biexponential model



Authors: Bikle, David D.; Peck, Carl C.; Holford, Nicholas H.G.; Zolock, David T.; Morrissey, Robert L.
Title: Pharmacokinetics and Pharmacodynamics of 1,25-Dihydroxyvitamin D3 in the Chick
Source: Endocrin. 111 (1982) 939
Description: weighted least squares fit of system of odes



Authors: Bozzato, Richard P.; Tinker, David O.
Title: Effects of Membrane Fluidity and Identification of the Rate-Limiting Step in the Protein-Mediated Phosphatidycholine Exchange Reaction
Source: Can. J. Biochem. 60 (1982) 409-418
Description: curve fitting to experimental data, function with two exponentials



Authors: Chen, Raymond F.
Title: Fluorescence Lifetimes: Effect of Precision of Relaxation Times from Fluorescence Depolarization Data
Source: Anal. Lett. 15 (1982) 1383-1392
Description: DEC 10 computer and interactive language MLAB used for calculations and graphics.



Authors: Clay, John R.; Shlesinger, Michael F.
Title: Delayed Kinetics of Squid Axon Potassium Channels do not Always Superpose After Time Translation
Source: Biophys. J. 37 (1982) 677
Description: Hodgkin Huxley model



Authors: Cooper, Allen D.; Shrewsbury, M. Adeline; Erickson, Sandra K.
Title: Comparison of Binding and Removal of Remnants of Triglyceride-Rich Lipoproteins of Intestinal and Hepatic Origin by Rat Liver in Vitro
Source: Am. J. Physiol. 243 (1982) G389-G395
Description: 125I labelled hepatic VLDL in serum vs time as biexponential decay model



Authors: Creaven, Patrick J.
Title: The Clinical Pharmacology of VM26 and VP16-213: A Brief Overview
Source: Canc. Chem. Pharm. 7 (1982) 133-140
Description: bi and tri exponential fit of plasma concentrations



Authors: Elchisak, M.A.; Polinsky, R.J.; Ebert, M.H.; Kopin, I.J.
Title: Kinetics of Homovanillic Acid and Determination of Its Production Rate in Humans
Source: J. Neurochem. 38 (1982) 360
Description: nonlinear regression least squares fit of sums of 1,2,3 exponentials



Authors: Evans, W.J.; McCourtney, E.J.; Shrager, R.I.
Title: Titration Studies of Phytic Acid
Source: JAOCS 59 (1982) 189
Description: n-site Adair-type binding



Authors: Fisk, Cherie L.; Becker, Edwin D.; Miles, H. Todd; TJ Pinnavia
Title: Self-Structured Guanosine 5'-Monophosphate. A 13-C and 1-H Magnetic Resonance Study
Source: JACS 104 (1982) 3307-3314
Description: least squares regression to find T1



Authors: Giacomini, Kathleen M.; Swezey, Sarah E.; Turner-Tamiyasu, Kathleen; Blaschke, Terrence
Title: The Effect of Saturable Binding to Plasma Proteins on the Pharmacokinetic Properties of Disopyramide
Source: J. Pharm. Biopharm. 10 (1982) 1
Description: mono- and bi-exponential equation, nonlinear least squares fit



Authors: Hasegawa, Jiro; Lin, Emil T.; Williams, Roger L.; Sorgel, Fritz; Benet, Leslie Z.
Title: Pharmacokinetics of Triamterene and Its Metabolite in Man
Source: J. Pharm. Biopharm. 10 (1982) 507
Description: compartmental models



Authors: Ho, Yen-sen; Lewis, Marc; Rosenberg, Martin
Title: Purification and Properties of a Transcriptional Activator
Source: J. Biol. Chem. 257 (1982) 9128
Description: ultracentrifuge data, concentration distributions analyzed using MLAB



Authors: Hobbs, Ann S.
Title: Comparative Effects of External Monovalent Cations on Sodium Pump Activity and Ouabain Inhibition Rates in Squid Giant Axon
Source: J. Physiol. 331 (1982) 567-576
Description: rate of binding was determined graphically using MLAB



Authors: Kadoma, Masaaki; Froehlich, Jeffrey; Reeves, John; Sutko, John
Title: Kinetics of Sodium Ion Induced Calcium Ion Release in Calcium Ion Loaded Cardiac Sarcolenmal Vesicles: Determination of Initial Velocities by Stopped-Flow Spectrophotometry
Source: Biochem. 21 (1982) 1914-1918
Description: Hill equation parameters



Authors: Keefe, Deborah L.; Kates, Robert E.
Title: Myocardial Disposition and Cardiac Pharmacodynamics of Verapomil in the Dog
Source: J. Pharmacol. Thera. 270 (1982) 91
Description: 3 compartment model of plasma concentration vs. time



Authors: Lyon, Ellen Sue; Jakoby, William B.
Title: Arylamine N-Methyltranferase
Source: J. Biol. Chem. 257 (1982) 7531-7535
Description: kinetic constants



Authors: McManus, Michael E.; Long, Matti A.; Stuart, Karen; Strong, John
Title: Activation of Misonidazole by Rat Liver Microsomes and Purified NADPH-Cytochrome C Reductase
Source: Bioch. Pharm. 31 (1982) 547-552
Description: fitting data to rate equations for competitive, non-competitive, mixed, and uncompetitive inhibition mechanisms



Authors: McPhie, P
Title: Swine Pepsinogen Folding Intermediates are Highly Structured, Motile Molecules
Source: Biochem. 21 (1982) 5509-5515



Authors: Miller-Podraza, H.; Fishman, P.H.
Title: Transolocation of Newly Synthesized Gangliosides to the Cell Surface
Source: Biochem. 21 (1982) 3265-3270



Authors: Milne, G.W.A.; Fisk, C.L.; Heller, Stephen R.; Potenzone, Rudolph, Jr.
Title: Environmental Uses of the NIH-EPA Chemical Information System
Source: Science 215 (1982) 371-375
Description: MLAB as part of information system.



Authors: Mitchell, Richard R.; Gupta, Narendra K.
Title: Variability of Radionuclide Clearance Parameter Estimates
Source: Comp. Biomed. Res. 15 (1982) 387-403
Description: estimate parameters in washout and washin exponential models



Authors: Mohanakrishnan, P.; Chignell, C.F.
Title: Ion-Specific Electrode Study of Copper Binding to Serum Albumins
Source: J. Pharm. Sci. 71 (1982) 1180
Description: Nernst equation



Authors: Morrow, P.E.; Gibb, F.R.; Beiter, H.; Amato, F.; Yuile, C.; Kilpper, R.W.
Title: Pulmonary Retention of Coal Dusts
Source: Ann. Occup. Hyg. 26 (1982) 291-307
Description: compartmental model



Authors: Mossman, Kenneth L.
Title: Quantitative Radiation Dose-Response Relationships for Normal Tissues in Man
Source: Rad. Res. 91 (1982) 265-274
Description: LD50 determined by curve-fitting



Authors: Nelson, R.L.
Title: The Comparative Clinical Pharmacology and Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Human Patients With Cancer
Source: Med. Ped. Onc. 10 (1982) 115-127
Description: linear differential equations, 3 and 4 compartment models



Authors: Ohata, M.; Takei, H.; Fredericks, W.R.; Rapoport, S.I.
Title: Effects of Immobilization Stress on Cerebral Blood Flow and Cerebrovascular Permeability in Spontaneously Hypertensive Rats
Source: J. Cereb. Bl. Fl. 2 (1982) 373-379
Description: bi-exponential plus constant model of blood concentration in time



Authors: Pang, K. Sandy; Waller, Lewis; Horning, Marjorie G.; Chan, Kenneth K.
Title: Metabolite Kinetics: Formation of Acetominophen from Deuterated and Nondeuterated Phenacetin and Acetanilide on Acetaminophen Sulfation Kinetics in the Perfused Rat Liver Preparation
Source: J. Pharm. Exp. 222 (1982) 14
Description: simulated concentration of drug and metabolite species in lever vs. time



Authors: Parr, Gary R.; Taniuchi, Hiroshi
Title: A Thermodynamic Study of Ordered Complexes of Cytochrome c Fragments
Source: J. Biol. Chem. 257 (1982) 10103-10111
Description: dissociation constants obtained using MLAB from temperature fluorescence titration measurements and Richardo Vithayathil equation.



Authors: Porter, E. Victoria; Chasey, Bruce M.; Holmlund, Chester E.
Title: Purification and Kinetic Characterization of a Specific Glucokinase from Streptococcus mutans OMZ270 Cells
Source: Bioch. Biophys. Acta 709 (1982) 178
Description: Lineweaver Burk method



Authors: Ramacciotti, Carla; Pretorius, Harold T.; Line, Bruce R.; Goldman, Joel M.; Robbins, Jacob
Title: Ablation of Nonalignment Thyroid Remnants with Low Doses of Radioactive Iodine: Concise Communication
Source: J. Nucl. Med. 23 (1982) 483-489
Description: expected radiation exposure to body from radioiodine calcuated with MLAB



Authors: Rapoport, Stanley I.; Fitzhugh, Richard; Pettigrew, Karen D.; Sundaram, Uma; Ohno, Kikuo
Title: Drug Entry into and Distribution Within Brain and Cerebrospinal Fluid: [14-C] Urea Pharmacokinetics
Source: Am. J. Physiol. 242 (1982) R339-R348
Description: pharmacokinetics



Authors: Rhee, Sue Goo; Ubom, Gregory A.; Hunt, John B.; Chock, P.B.
Title: Catalytic Cycle of the Biosynthetic Reaction Catalyzed by Adenylated Glutamine Synthetase from Escherichia Coli
Source: J. Biol. Chem. 257 (1982) 289-297
Description: curve-fitting, integration, and simulation. first order rate equations, odes.



Authors: Richards, R. Henry; Vreman, Hendrik J.; Zager, Philip; Feldman, Charles; Blaschke, Terrance
Title: Acetate Metabolism in Normal Human Subjects
Source: Am. J. Kid. Dis. 2 (1982) 47
Description: 1st order and nonlinear compartmental models fit to infusion-postinfusion plasma acetate data



Authors: Sayer, J.M.; Lehr, R.E.; Whalen, D.L.; Yagi, H.; Jerina, D.M.
Title: Structure-Reactivity Indices for the Hydrolysis of Diol Epoxides of Polycyclic Aromatic Hydrocarbons
Source: Tetr. Let. 23 (1982) 4431-4434
Description: least squares slopes and intercepts for log km rate constants and reactivity indices for hydrolysis of region diol epoxides



Authors: Schilsky, Richard L.; Kelley, James A.; Ihde, Daniel C.; Howser, Dianne M.; Cordes, Rosemarie S.; Young, Robert C.
Title: Phase I Trial and Pharmacokinetics of Aziridinylbenzoquinone (NSC 182986) in Humans
Source: Canc. Res. 42 (1982) 1582-1586
Description: AZQ concentration vs. time fit to biexponential model



Authors: Setty, O.H.; Hendler, Richard W.
Title: Interference of Electron Donors in the Measurement of the Proton Gradient and Membrane Potential by Flow Dialysis
Source: J. Biochem. Biophys. Meth. 7 (1982) 35-46
Description: All computations and graphic art were performed using MLAB on DEC10 at nih



Authors: Shoemaker, D.D.; McManus, M.E.; Hoerauf, R.; Strong, J.M.
Title: Studies on the O-Demethylation of Misonidazole by Rat Liver Microsomes
Source: Canc. Trt. Rep. 66 (1982) 1343
Description: Michaelis-Menten equation paramters



Authors: Shrager, Richard I.; Hendler, Richard W.
Title: Titration of Individual Components in a Mixture with Resolution of Difference Spectra, pKs, and Redox Transitions
Source: Analytical Chem. 54 (1982) 1147-1152
Description: Henderson-Hasselbach, Nernst, Adair models.



Authors: Silber, Bernie; Holford, Nicholas H.G.; Riegelman, Sidney
Title: Stereoselective Disposition and Glucuronidation of Propranolol in Humans
Source: J. Pharm. Sci. 71 (1982) 699
Description: Michaelis Menten constants, use root function



Authors: Silverton, J.V.; Linen, W.; Miles, H.T.
Title: 2-Amino-8-methyladenosine 5'-Monophosphate Dihydrate. A Nucleotide with Syn C4'-Exo Conformation and 'Triple-Stranded' Packing
Source: JACS 104 (1982) 1081-1089
Description: extinction correction of the Zachariasen type was evaluated using MLAB



Authors: Steven, A.C.; Wall, J.; Hainfeld, J.; Steinert, P.M.
Title: Structure of Fibroblastic Intermediate Filaments: Analysis by Scanning Transmission Electron Microscopy
Source: Proc. Natl. Acad. Sci. 79 (1982) 3101-3105
Description: relative frequencies of measurement vs. linear mass density in kDal/nm fit to sum of gaussians.



Authors: Thomas, David J.; Fisher, Henry L.; Hall, Larry L.; Mushak, Paul
Title: Effects of Age and Sex on Retention of Mercury by Methyl Mercury-Treated Rats
Source: Toxicol. and App. Pharmaco. 62 (1982) 445-454
Description: decay corrected data on whole body retention of Hg were fitted to single or multiexponential functions



Authors: Tinker, David O.; Low, Rosita
Title: Thermodynamics of Mixing of Dipalmitoyl Phosphatidylcholine and Egg Phosphatidylcholine in Hydrated Bilayers
Source: Can. J. Bioch. 60 (1982) 538-548
Description: splined cubic polynomial interpolation formula, Simpson's rule, differential scanning calorimetry of aqueous mixtures fit to nonlinear function of temperature.



Authors: Wood, Alexander W.; Sayer, Jane M.; Neumark, Harold L.; Yagi, Haruhiko; Michaud, Dennis P.; Jerina, Donald M.; Conney, A.H.
Title: Mechanism of the Inhibition of Mutagenicity of a Benzo[alpha]pyrene 7,8-diol 9,10-epoxide by Riboflavin 5'-phosphate
Source: Proc. Natl. Acad. Sci. 79 (1982) 5122-5126



Authors: Wood, William I.; Felsenfeld, Gary
Title: Chromatin Structure of the Chicken Beta-Globulin Gene Region
Source: J. Biol. Chem. 257 (1982) 7730-7736
Description: curvefit


1983

Authors: Aitken, Susan C.; Lippman, Marc E.
Title: Hormonal Regulation of de Novo Pyrimidine Synthesis and Utilization in Human Breast Cancer Cells in Tissue Culture
Source: Canc. Res. 43 (1983) 4681-4690
Description: acetate labelling kinetics



Authors: Armand, J.P.; Maquet, J.P.; LeRoy, A.F.
Title: Cerebrospinal Fluid-Platinum Kinetics of Cisplatin in Man
Source: Canc. Treat. Rpts. 67 (1983) 1035
Description: platinum concentration in plasma as a function of time modelled as sum of two exponentials



Authors: Aronoff, George R.; Pottratz, Scott T.; Brier, Michael E.; Walker, Naomi E.; Fineberg, Naomi S.; Glant, Michael D.; Luft, Friedrich C.
Title: Aminoglycoside Accumulation Kinetics in Rat Renal Parenchyma
Source: Antimicr. Agents and Chemo. 23 (1983) 74-78
Description: performed pharmacokinetic analysis



Authors: Ask, Per; Levitan, Herbert; Robinson, Peter J.; Rapoport, Stanley I.
Title: Peripheral Nerve as an Osmometer: Role of Perineurium in Frog Sciatic Nerve
Source: Am. J. Physiol. 244 (1983) C75-C81
Description: fit by nonlinear least squares to experimentally observed trans. charges.



Authors: Bai, Stephen A.; Abramson, Fred P.
Title: Interaction of Phenobarbital with Propranolol in the Dog
Source: J. Pharm. Exp. 224 (1983) 62
Description: DR-1 vs time data were analyzed using MLAB



Authors: Berg, G.G.; Smith, B.S.
Title: Distribution and Elimination of Ingested Mercuric Oxide in Mice
Source: J. Am. Col. Tox. 2 (1983) 307
Description: weighted least squares fit to 3 compartment model



Authors: Botto, R.E.; Coxon, B.
Title: Nitrogen-15 Nuclear Magnetic Resonance Spectroscopy of Neomycin B and Related Aminoglycosides
Source: JACS 105 (1983) 1021-1028



Authors: Burch, Patrick G.; Starski, Donald R.
Title: The Role of Metabolism and Protein Binding in Thiopental Anesthesia
Source: Anesthesiology 58 (1983) 146-152
Description: 3 compartment mamillary model using least squares regression



Authors: Chen, C.; Knop, R.H.; Cohen, J.S.
Title: Adriamycin Inhibits the B to Z Transition of poly(dGm5dc)
Source: Biochem. 22 (1983) 5468-5471



Authors: Clay, John R.; Shlesinger, Michael F.
Title: Effects of External Cesium and Rubidium on Outward Potassium Currents in Squid Axons
Source: Biophys. J. 42 (1983) 43
Description: linear regression of current voltage relation



Authors: Closset, Jean; Smal, Jean; Gomez, Francoise; Hennen, Georges
Title: Purification of the 22000- and 20000-Molecular Weight Forms of Human Somatotropin and Characterization of Their Binding to Liver and Mammary Binding Sites
Source: Biochem. J. 214 (1983) 885-892
Description: Scatchard analysis and parallel-line assays on PDP20



Authors: Curt, Gregory A.; Kelley, James A.; Kufta, Conrad V.; Smith, Barry H.; Kornblith, Paul L.; Young, Robert C.; Collins, Jerry M.
Title: Phase II and Pharmacokinetic Study of Aziridinylbenzoquinone [2,5-Diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone, Diaziquone, NSC 182986] in High-Grade Gliomas
Source: Canc. Res. 43 (1983) 6102-6105
Description: 2-compartment, bi-exponential model



Authors: Dunn, Joseph A.; Blumberg, Peter M.
Title: Specific Binding of [20-3H] 12-Deoxyphorbol 13-Isobutyrate to Phorbol Ester Receptor Subclasses in Mouse Skin Particulate Preparations
Source: Canc. Res. 43 (1983) 4632-4637
Description: specific binding characteristics of [3H] DPB and [3H]PDBU were determined using the curve fit modelling program MLAB



Authors: Finet, M.; Godfraind, Theophile; Noel, F.
Title: The Isotropic Effect of Ouabain and its Antagonism by Dihydroouabain in Rat Isolated Atria and Ventricles in Relation to Specific Binding Sites
Source: Br. J. Pharmac. 80 (1983) 751-759
Description: Scatchard analysis, student's t test



Authors: Finley, J.; Ireton, D.; Schleidt, W.M.; Thompson, T.A.
Title: A New Look at the Features of Mallard Courtship Displays
Source: Animal Behav. 31 (1983) 348-354
Description: 3D graphics



Authors: Fram, R.J.; Egan, E.M.; Kufe, D.W.
Title: Accumulation of Leukemia Cell DNA Strand Breaks with Adriamycin and Cytosine Arabinoside
Source: Leuk. Res. 7 (1983) 243-249
Description: fit decreasing exponential



Authors: Froehlich, Jeffrey P.; Hobbs, Ann S.; Albers, R. Wayne
Title: Evidence for Parallel Pathways of Phosphoenzyme Formation in the Mechanism of ATP Hydrolysis by Electrophorus Na,K-ATPase
Source: Curr. Topics in Membr. and Trans. 19 (1983) 513
Description: simulations of time course of phosphoenzyme formation of Pi release carried out with MLAB



Authors: Gasiewicz, Thomas A.; Geiger, Lee E.; Rucci, George; Neal, Robert A.
Title: Distribution, Excretion, and Metabolism of 2,3,7,8-Tetrachloro dibenzo-p-dioxin in C57BL/6J, DBA/2J, and BGD2F1/J Mice
Source: Drug. Metab. 11 (1983) 397
Description: multiexponential models with nonlinear least squares fit



Authors: Greene, Raymond F.; Collins, Jerry M.; Jenkins, Jean F.; Speyer, James L.; Myers, Charles E.
Title: Plasma Pharmacokinetics of Adriamycin and Andriamycinol: Implications for the Design of in Vitro Experiments and Treatment Protocols
Source: Canc. Res. 43 (1983) 3417-3421
Description: biexponential model for Adriamycin plasma concentration



Authors: Grigorescu, Florin; White, Morris F.; Kahn, C. Ronald
Title: Insulin Binding and Insulin-Dependent Phosphorylation of the Insulin Receptor Solubilized from Human Erythrocytes
Source: J. Biol. Chem. 258 (1983) 13708-13716
Description: MLAB used to analyze insulin-binding data, Hill-Sipps model, 4 parameter logistic equation.



Authors: Hobbs, Ann S.; Albers, R. Wayne; Froehlich, Jeffrey P.
Title: Effects of Oligomycin on the Partial Reactions of the Sodium Plus Potassium-stimulated Adenosine Triphosphatase
Source: J. Biol. Chem. 258 (1983) 8163
Description: kinetic data were analyzed by computer simulation using MLAB



Authors: Jackson, Meyer B.; Wong, Brandon S.; Morris, Catherine E.; Lecar, Harold; Christian, Clifford N.
Title: Successive Openings of the Same Acetylcholine Receptor Channel are Correlated in Open Time
Source: Biophys. J. 42 (1983) 109-114
Description: curve fit sum of 2 exponentials



Authors: Jahnke, Ulrike; Heilmeyer, Ludwig M.G., Jr.
Title: Ca2+ and Mg2+-Dependent Complex Formation of Tropomyosing with Phosphotroponin (P1TI2C) or Dephosphotroponin (TI2C)
Source: Eur. J. Biochem. 133 (1983) 591-597
Description: degree of tropomysosin aggregation was calculated from sedimentation equation by fitting data. ultracentrifuge



Authors: Kates, Robert E.; Keefe, Deborah L.; Winkle, Roger A.
Title: Lorcainide Disposition Kinetics in Arrhythmia Patients
Source: Clin. Pharm. Ther. 33 (1983) 28
Description: 3 compartment model



Authors: Kerr, Ian G.; Jolivet, Jacques; Collins, Jerry M.; Drake, James C.; Chabner, Bruce A.
Title: Test Dose for Predicting High-Dose Methotrexate Infusions
Source: Clin. Pharm. 33 (1983) 44
Description: kinetics parameters in biexponential model



Authors: Maes, M.; De Hertogh, R.; Watrin-Granger, P.; Ketelslegers, J.M.
Title: Ontogeny of Liver Somatotropic and Lactogenic Binding Sites in Male and Female Rats
Source: Endocrin. 113 (1983) 1325
Description: curvilinear Scatchard plots derived using MLAB



Authors: Maes, Marc; Ketelsleger, Jean Marie; Underwood, Louis E.
Title: Low Plasma Somatomedin-C in Streptozotocin-Induced Diabetes Mellitus
Source: Diabetes 32 (1983) 1060
Description: scatchard plots dereived and analyzed for different binding models



Authors: Major, Pierre P.; Agarwal, Ram P.; Kufe, Donald W.
Title: Clinical Pharmacology of Arabinofuranosyladenine in Combination with Deoxycoformycin
Source: Canc. Chem. Pharm. 10 (1983) 125-128
Description: plasma concentration of ara-A were fitted to exponentially decreasing function, 1 compartment model



Authors: Marchaud, E.; Grigorescu, F.; Buysschaert, M.; De Meyts, P.; Ketelslegers, J.M.; Brems, H.; Nathan, M.C.; Lambert, A.E.
Title: The Hypoglycemic Effect of a Sulfonylurea (Gliclazide) in Moderate Type II Diabetes and Glucose Intolerance is not Accompanied by Changes in Insulin Action and Insulin Binding to Erythrocytes
Source: Mol. Physiol. 4 (1983) 83-93



Authors: McManus, Michael E.; Minchin, Rodney F.; Sanderson, Nancy; Wirth, Peter J.; Thorgeirsson, Snorri S.
Title: Kinetics of N- and C-Hydroxylations of 2-Acetylaminofluorene in Male Sprague-Dawley Rat Liver Microsomes: Implications for Carcinogenesis
Source: Canc. Res. 43 (1983) 3720-3724
Description: Michaelis-Menten equation parameters



Authors: McManus, M.E.; Minchin, R.F.; Sanderson, N.D.; Wirth, P.J.; Thorgeirsson, S.S.
Title: Kinetic Evidence for the Involvement of Multiple Forms of Human Liver Cytochrome P-450 in the Metabolism of Acetylamino Fluorene
Source: Carcinogenesis 4 (1983) 693-697
Description: general Michaelis Menten model.



Authors: Micetich, Kenneth; Zwelling, Leonard A.; Kohn, Kurt W.
Title: Quenching of DNA: Platinum (II) Monoadducts as a Possible Mechanism of Resistance to cis-Diamminedichloroplatinum (II) in L1210 Cells
Source: Canc. Res. 43 (1983) 3609-3613
Description: best fit of kinetic parameters to exponential model



Authors: Michaud, D.P.; Gupta, S.C.; Whalen, D.L.; Sayer, J.M.; Jerina, D.M.
Title: Effects of pH and Salt Concentration on the Hydrolysis of a Benzo[alpha]pyrene 7,8-diol-9,10-epoxide Catalyzed by DNA and Polyadenylic Acid
Source: Chem. Biol. Int. 44 (1983) 41-52
Description: Michaelis Menten saturation curves



Authors: Mico, Bruce A.; Branch, Richard V.; Pohl, Lance R.
Title: Formation of Electrophilic Chlorine from Carbon Tetrachloride. Involvement of Cytochrome P-450
Source: Biochem. Pharm. 32 (1983) 2357-2359
Description: Vmax, Km calculations by unweighted nonlinear least squares regression. concentration of carbon tet vs. rate of electrophile chlorine formation



Authors: Mossman, Kenneth L.
Title: Quantitative Radiation Dose-Response Relationships for Normal Tissues in Man. II. Response of the Salivary Glands During Radiotherapy
Source: Radiation Res. 95 (1983) 392-398
Description: fit 2 parameter function for dose-response data.



Authors: Newton, Dianne L.; Burke, Terrance R., Jr.; Rice, Kenner C.; Klee, Claude B.
Title: Calcium Ion-Dependent Covalent Modification of Calmodulin with Norchlorpromazine Isothiocyanate
Source: Biochem. 22 (1983) 5472-5476
Description: competitive inhibition, velocity of reaction



Authors: Nossal, R.; Weiss, G.H.; Nandi, P.K.; Lippoldt, R.E.; Edelhoch, H.
Title: Sizes and Mass Distributions of Clathrin-Coated Vesicles from Bovine Brain
Source: Arch. Biochem. 226 (1983) 593-603
Description: ultracentrifuge data analysis



Authors: Nowak, Thaddeus S., Jr.; Albright, Elizabeth B.; Munro, Hamish N.
Title: Inhibition of Aminoacyl-tRNA Synthetases by p-Chloroamphetamine and its Role in Progein Synthesis Inhibition
Source: Arch. Biochem. 225 (1983) 722-730
Description: dissociation constant for various enzyme-substrate and enzyme-inhibitor complexes were numerically evaluated by fitting rate law to experimental data.



Authors: Reddy, K.V. Subba; Hendler, Richard W.
Title: Complete Analysis of the Cytochrome Components of Beef Heart Mitochondria in Terms of Spectra and Redox Properties
Source: J. Biol. Chem. 258 (1983) 8568-8581
Description: Nernst equation



Authors: Roberts, Roderick K.; Grice, Jeffrey; McGuffie, Christine; Heilbronn, Lillian
Title: Oral Contraceptive Steroids Impair the Elimination of Theophylline
Source: J. Lab. Clin. Med. 101 (1983) 821
Description: fit concentration vs time to exponentially decreasing function



Authors: Rothman, Richard B.
Title: Analysis of Binding Surfaces: A Methodology Appropriate for the Investigation of Complex Receptor Mechanisms and Multiple Neurotransmitter Receptors
Source: Neuropeptides 4 (1983) 41-44
Description: ligand and inhibitor bind to 2 binding sites



Authors: Schulz, Pierre; Turner-Tamiyasu, Kathleen; Smith, Gabrielle; Giacomini, Kathleen M.; Blaschke, Terrence F.
Title: Amitriptyline Disposition in Young and Elderly Normal Men
Source: Clin. Pharm. 33 (1983) 360
Description: biexponential model to get half-life



Authors: Segal, David M.; Dower, Steven K.; Titus, Julie A.
Title: The FcR-Mediated Endocytosis of Model Immune Complexes by Cells from the P338D1 Mouse Macrophage Line
Source: J. Immunol. 130 (1983) 130
Description: 1st order kinetics



Authors: Steven, Alasdair; Hainfeld, James F.; Trus, Benes L.; Wall, Joseph S.; Steinert, Peter M.
Title: The Distribution of Mass in Heteropolymer Intermediate Filaments Assembled in Vitro
Source: J. Biol. Chem. 258 (1983) 8323-8329
Description: experimental histograms modelled as sums of Gaussians



Authors: Steven, Alasdair C.; Hainfeld, James F.; Trus, Benes L.; Wall, Joseph S.; Steinert, Peter M.
Title: Epidural Keratin Filaments Assembled in Vitro Have Masses-per-Unit-Length that Scale According to Average Subunit Mass
Source: J. Cell Biol. 97 (1983) 1939-1944
Description: statistical analysis and graphics



Authors: Steven, Alasdair C.; Hainfeld, James F.; Wall, Joseph S.; Steer, Clifford J.
Title: Mass Distributions of Coated Vesicles Isolated from Liver and Brain: Analysis by Scanning Transmission Electron Microscopy
Source: J. Cell Biol. 97 (1983) 1714
Description: Photographic records of stained gels were scanned with densitometer, Kolmogorov-Smirnov test, graphics



Authors: Stevens, James; Jakoby, William B.
Title: Cysteine Conjugate Beta-Lyase
Source: Mol. Pharm. 23 (1983) 761-765
Description: exponential model



Authors: Takei, Hidemori; Fredericks, Wendy R.; London, Edythe D.; Rapoport, Stanley I.
Title: Cerebral Blood Flow and Oxidative Metabolism in Conscious Fischer-344 Rats of Different Ages
Source: J. Neurochem. 40 (1983) 801
Description: concentration of 14-C-iodoantipyrine measured during intravenous infusion



Authors: Tozer, Thomas N.; Gambertoglio, John G.; Furst, Daniel E.; Avery, Denis S.; Holford, Nicholas H.G.
Title: Volume Shifts and Protein Binding Estimates Using Equilibrium Dialysis: Application to Predinsolone Binding in Humans
Source: J. Pharm. Sci. 72 (1983) 1442-1446
Description: binding parameters estimated with MLAB



Authors: Valet, Scot B.; Schwartz, Robert H.; Brooks, John G.
Title: Pharmacokinetics of Theophylline and Bioavailability of a Sustained Release Theophylline Preparation in Patients with Cystic Fibrosis
Source: Ann. Allergy 50 (1983) 161
Description: 2 compartment model for theophyline distributions



Authors: van Bohemen, Charles G.; Eliard, Pierre H.; Rousseau, Guy G.
Title: Control by Calcium Ions of Steroid Binding to the Glucocoriticoid Receptor
Source: Mol. Phys. 4 (1983) 95-110
Description: Equilibrium binding curves



Authors: van Zuiden, Paul E.A.; Erickson, Sandra K.; Cooper, Allen D.
Title: Effect of Removal of Lipoproteins of Different Composition on Hepatic 3-hydroxy-3-methylglutaryl coenzyme A Reductase Activity and Hepatic Very Low Density Lipoprotein Secretion
Source: J. Lipid Res. 24 (1983) 418
Description: 125I labelled lipoprotein, slope, y-intercept, and half-life.



Authors: Vu, Van T.; Bai, Stephen A.; Abramson, Fred P.
Title: Interactions of Phenobarbitol with Propranolol in the Dog. 2. Bioavailability, Metabolism, and Pharmacokinetics
Source: J. Pharm. Exp. 224 (1983) 55
Description: log absorbance vs time fitted to line



Authors: Wahlund, L.O.; Smedby, Y.; Saaf, J.; Schulmans, A.; Ross, S.B.; Wetterberg, L.
Title: Influence of Hemodialysis on Monoamine Oxidase Kinetics in Platelets from Chronic Schizophrenic Patients
Source: Artificial Organs 7 (1983) 334-339



Authors: Wolfenden, R.; Williams, R.
Title: Affinities of Phosphoric Acids, Esters, and Amides for Solvent Water
Source: JACS 105 (1983) 1028-1031



Authors: Zaharko, Daniel S.; Covey, Joseph M.
Title: Modulation of Deoxycytidine Metabolism in Vivo with High-Dose Thymidine in Mice
Source: JNCI 71 (1983) 1033-1039
Description: half-life from per cent dose per ml of plasma vs time



Authors: Zelenka, Peggy S.
Title: Phosphatidylcholine and Phosphatidylethanolamine Metabolism During Lens Fiber Cell Formation
Source: Biochim. Biophys. Acta 752 (1983) 145-152
Description: linear ordinary differential equation fit



Authors: Zimm, Solomon; Collins, Jerry M.; O'Neill, Dondra; Chabner, Bruce; Poplack, David G.
Title: Inhibition of First-Pass Metabolism in Cancer Chemotherapy: Interaction of 6-Mercaptopurine and Allopurinol
Source: Clin. Pharm. Ther. 34 (1983) 810
Description: plasma concentration fit to bi- and tri-exponential models


1984

Authors: Arnold, Susan T.; Jayaram, Hiremagalur N.; Harper, Gregory R.; Litterst, Charles L.; Malspeis, Louis; Desouza, John J.V.; Stoubus, Alfred E.; Ahluwalia, Gupreet S.; Wilson, Yvonne A.; Cooney, David A.; Johns, David G.
Title: The Disposition and Metabolism of Tiazofurin in Rodents, Rabbits, and Dogs
Source: Drug Metab. 12 (1984) 165
Description: 3 compartment model



Authors: Bai, Stephen A.; Abramson, Fred P.
Title: Effects of Chlorpromazine on the Disposition and Beta-Andrenergic Blocking Activity of Propranolol in the Dog
Source: J. Pharm. Biopharm. 12 (1984) 333
Description: kinetic analysis of DR-1 vs time date, statistics



Authors: Bissonnette, B.M.; Collen, M.J.; Adachi, H.; Jensen, R.T.; Gardner, J.D.
Title: Receptors for Vasoactive Intestinal Peptide and Secretin on Rat Pancreatic Acini
Source: Am. J. Physiol. 246 (1984) G710-G717
Description: data in figure 3 were fit to a model having 4 classes of binding sites using MLAB



Authors: Boykins, Robert; Phelan, Michael; Gray, Irving
Title: Modification of Glyceraldehyde-3-Phosphate Dehydrogenase, EC 1.2.1.12, Isolated from Rainbow Trout During Acclimation at 5 or 15 degrees C
Source: Comp. Biochem. Physiol. 79B (1984) 139-146
Description: nonlinear regression analysis of data points generated by enzyme activity assays, Michaelis Menten



Authors: Bristow, Michael R.; Ginsburg, Robert; Laser, Jeffrey A.; McAuley, Bruce J.; Minobe, Wayne
Title: Tissue Response Selectivity of Calcium Antagonists is not Due to Heterogeneity of [3-H]-nitrendipine Binding Sites
Source: Br. J. Pharm. 82 (1984) 309-320
Description: calculated dissociation constant and maximum binding constant using MLAB



Authors: Chen, Chu; Applegate, Kenneth; King, Weiling C.; Glomset, John A.; Norum, Kaare R.; Gjone, Egil
Title: A Study of the Small Spherical High Density Lipoproteins of Patients Afflicted with Familial Lecithin: Cholesterol Acyltransferase Deficiency
Source: J. Lipid Res. 25 (1984) 269
Description: gel scans in optical density vs. diameter, fit to sum of Gaussians



Authors: Connolly, Stuart; Lebsack, Cynthia; Winkle, Roger A.; Harrison, Donald C.; Kates, Robert E.
Title: Propafenore Disposition Kinetics in Cardiac Arrhythmia
Source: Clin. Pharm. 36 (1984) 163
Description: 2 and 3 compartment model of plasma concentration



Authors: Crettaz, Marco; Kahn, C. Ronald
Title: Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells
Source: Diabetes 33 (1984) 477
Description: Scatchard analysis



Authors: Dow, D.D.; Gill, B.J.
Title: Environmental vs Social Factors as determinants of growth in nestlings of a communally breeding bird
Source: Oecologia 63 (1984) 370-375.
Description: fit of growth of wing, bill, torso, and weight measurements to 3-parameter logistic and asymptotic regression



Authors: Dower, Steven K.; Ozato, Keiko; Segal, David M.
Title: The Interaction of Monoclonal Antibodies with MHC Class I Antigens on Mouse Spleen Cells
Source: J. Immunology 132 (1984) 751
Description: two-site binding model



Authors: Dritschilo, A.; Brennan, T.; Weichselbaum, R.R.; Mossman, K.L.
Title: Response of Human Fibroblasts to Low Dose Rate Gamma Irradiation
Source: Rad. Res. 100 (1984) 387-395
Description: survival curves



Authors: Egorin, Merrill J.; Van Echo, David A.; Tipping, Stuart J.; Olman, Eve A.; Whitacre, Margaret Y.; Thompson, Bruce W.; Aisner, Joseph
Title: Pharmacokinetics and Dosage Reduction of cis-Diammine (1,1-cyclobutanedicarboxylato) Platinum in Patients with Impaired Renal Function
Source: Canc. Res. 44 (1984) 5432-5438
Description: fit sum of 2 exponentials



Authors: Eliard, Pierre H.; Rousseau, Guy G.
Title: Thermodynamics of Steroid Binding to the Human Glucocorticoid Receptor
Source: Biochem. J. 218 (1984) 395-404
Description: 2nd order kinetics, ode rate equations, DEC 20



Authors: Ermentrout, G. Bard
Title: Period Doublings and Possible Chaos in Neural Models
Source: SIAM J. Appl. Math 44 (1984) 80
Description: Gear-Adams solver in MLAB



Authors: Eun, H.M.; Miles, E.W.
Title: Reaction of Phenylglyoxal and {p-hydroxyphenyl} glyoxal with Arginines and Cysteines in the alpha-Subunit of Tryptophan Synthase
Source: Biochem. 23 (1984) 6484-6491



Authors: Graves, P.M.; Carter, R.; Keystone, J.S.; Seeley, D.C., Jr.
Title: Drug Sensitivity and Isoenzyme Type in Cloned Lines of Plasmodium falciparum
Source: Am. J. Trop. Med. Hyg. 33 (1984) 212-219
Description: fit log-logistic distribution to effect of drug



Authors: Grigorescu, Florin; Flier, Jeffrey S.; Kahn, C. Ronald
Title: Defect in Insulin Receptor Phosphorylation in Erythrocytes and Fibroblasts Associated with Severe Insulin Resistance
Source: J. Biol. Chem. 259 (1984) 15003-15006
Description: fit logistic equation to competition-inhibition curves.



Authors: Horwitz, Barry; Duara, Ranjan; Rapoport, Stanley I.
Title: Intercorrelations of Glucose Metabolic Rates Between Brain Regions: Application to Healthy Males in a State of Reduced Sensory Input
Source: J. Cereb. Bl. Fl. 4 (1984) 484-499
Description: figure 3 is a matrix of statistically significant partial correlation coefficients made with MLAB



Authors: Hughes, L.T.; Cohen, J.S.; Szabo, A.; Niu, C.H.; Matsuura, S.
Title: Carbon-13 NMR Studies of the Molecular Dynamics of Selectively Carbon-13 Enriched Ribonuclease Complexes
Source: Biochem. 23 (1984) 4390-4394



Authors: Huguenin, Philipp N.; Jayaram, Hiremagalur N.; Kelley, James A.
Title: Reverse Phase HPLC Determination of 5,6 Dihydro-5-Azacytidine in Biological Fluids
Source: J. Liq. Chrom. 7 (1984) 1433-1453
Description: initial pharmacokinetic parameters of DHAC were calculated from rat plasma concentration. 2 compartment open model, biexponential model



Authors: Kessler, R.M.; Goble, J.C.; Bird, J.H.; Girton, M.E.; Doppman, J.L.; Rapoport, S.I.; Baranger, J.A.
Title: Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [68-Ga] EDTA
Source: J. Cereb. Bl. Fl. 4 (1984) 323-328
Description: brain concentration as linear combination of (1-exp(-ai*t))



Authors: Ketelslegers, Jean-Marie; Pirens, Guy; Maghuin-Rogister, Guy; Hennen, Georges; Frere, Jean-Marie
Title: The Choice of Erroneous Models of Hormone-Receptor Interactions: A Consequence of Illegitimate Utilization of Scatchard Graphs
Source: Biochem. Pharm. 33 (1984) 707-710
Description: Scatchard plots, hormone receptor models, differential equation models



Authors: Kinsella, James; Cujdik, Timothy; Sacktor, Bertram
Title: Na+ H+ Exchange in Isolated Renal Brush-Border Membrane Vesicles in Response to Metabolic Acidosis
Source: J. Biol. Chem. 259 (1984) 13224-13227
Description: Eadie-Scatchard plot data fit to Hill equation.



Authors: Klecker, Raymond W., Jr.; Collins, Jerry M.
Title: Quantification of Tiazofurin in Plasma by High Performance Liquid Chromotography
Source: J. Chrom. 307 (1984) 361-369
Description: bi- and tri-exponential equations for concentration-time data



Authors: Lagakos, S.W.; Schoenfeld, D.A.
Title: Properties of Proportional-Hazards Score Tests Under Misspecified Regression Models
Source: Biometrics 40 (1984) 1037-1048



Authors: LaRossa, Robert A.; Schloss, John V.
Title: The Sulfonylurea Herbicide Sulfonaturon Methyl Is an Extremely Potent and Selective Inhibitor of Acetolackte Synthase in Salmonella typhimurium
Source: J. Biol. Chem. 259 (1984) 8753-8757
Description: fit Michaelis Menten parameters



Authors: Lewis, Marc S.; Carmassi, Franco; Chung, Soo Il
Title: Cooperative Association of Plasminogen with Fibrinogen
Source: Biochem. 23 (1984) 3874-3879
Description: ultracentrifuge scans digitized and analyzed with MLAB


pages 221-244, Volume 259, ACS Symposium Series
Authors: Macalady, D.L.; Wolfe, N.L.
Title: Abiotic Hydrolysis of Sorbed Pesticides
Source: Treatment and Disposal of Pesticide Wastes, Chapter 14 (1984)



Authors: Maes, M.; Underwood, L.E.; Gerard, G.; Ketelslegers, J.M.
Title: Relationship Between Plasma Sonetomedin-C and Liver Somatogenic Binding Sites in Neonatal Rats During Malnutrition and After Short and Long Term Refeeding
Source: Endocrin. 115 (1984) 786
Description: specific binding data analyzed with MLAB



Authors: Marti, G.E.; Marini, M.A.; Sreenathan, B.R.
Title: Characterization of Phenolic Ionizations in Horse Heart Cytochrome c
Source: Biochem. 23 (1984) 6649-6654
Description: Experimental tyrosyl ionization curves, titration curves fit



Authors: Newton, Dianne L.; Oldewurtel, Mary D.; Krinks, Marie H.; Shiloach, Joseph; Klee, C.B.
Title: Agonist and Antagonist Properties of Calmodulin Fragments
Source: J. Biol. Chem. 259 (1984) 4419-4426
Description: Michaelis Menten parameters



Authors: Noel, F.; Godfraind, T.
Title: Heterogeneity of Ouabain Specific Binding Sites and (Na+ and K+)-ATPase Inhibition in Microsomes from Rat Heart
Source: Bioch. Pharm. 33 (1984) 47-53
Description: Scatchard and log concentration-effect plots, Hill equation



Authors: Phelan, Michael; Gray, Irving
Title: Modification of Glyceraldehyde-3-Phosphate Dehydrogenase, EC 1.2.1.12, Isolated from Rainbow Trout During Acclimation at 5 or 15 degrees C
Source: Comp. Biochem. Physiol. 79B (1984) 135-138
Description: nonlinear regression analysis of data points generated by enzyme activity assays, Michaelis Menten



Authors: Phillips, Robert S.; Parniak, Michael A.; Kaufman, Seymour
Title: The Interaction of Aromatic Amino Acids with Rat Liver Phenylalanine Hydroxylase
Source: J. Biol. Chem. 259 (1984) 271-277
Description: direct fit of Michaelis Menten equation



Authors: Phillips, R.S.; Parniak, M.A.; Kaufman, S.
Title: Spectroscopic Investigation of Ligand Interaction with Hepatic Phenylalanine Hydroxylase: Evidence for a Conformational Change Associated with Activation
Source: Biochem. 23 (1984) 3836-3842



Authors: Rahman, Aquilur; Goodman, Anita; Foo, Wayne; Harvey, Jimmie; Smith, Frederick P.; Schein, Philip S.
Title: Clinical Pharmacology of Daunorubicin in Phase I Patients with Solid Tumors: Development of an Analytical Methodology for Daunorubicin and Its Metabolites
Source: Semin. Oncol. 11 (1984) 36-44
Description: fit plasma concentration-time data to triexponential function.



Authors: Rothman, Richard B.; Bowen, Wayne D.; Bykov, Victor; Schumacher, Uwe K.; Pert, Candace B.; Jacobson, Arthur E.; Burke, Terrence R., Jr.; Rice, Kenner C.
Title: Preparation of Rat Brain Membranes Greatly Enriched with Either Type I Delta or Type II Delta Opiate Binding Sites Using Site Directed Alkylating Agents: Evidence for a Two-Site Allosteric Model
Source: Neuropeptides 4 (1984) 201-215
Description: saturation binding



Authors: Rothman, Richard B.; Shumacher, Uwe K.; Pert, Candace B.
Title: Effect of Beta-FNA on Opiate Delta Receptor Binding
Source: J. Neurochem. 43 (1984) 1197-1200
Description: Scatchard plots, saturation studies



Authors: Sabljic, Aleksandar
Title: Calculation of Retention Indices by Molecular Topology: Chlorinated Alkanes
Source: J. Chromatog. 314 (1984) 1-12
Description: Single and multiple linear regression analysis



Authors: Sabljic, A.
Title: Predictions of the Nature and Strength of Soil Sorption of Organic Pollutants by Molecular Topolgy
Source: J. Agric. Food Chem. 32 (1984) 243-246



Authors: Schloss, John V.; Emptage, Mark H.; Cleland, W.W.
Title: pH Profiles and Isotope Effects for Aconitases from Saccharomycopsis lipolytica, Beef Heart, and Beef Liver. alpha-Methyl-cis-aconitate and threo-D5-alpha-Methylisocitrate as Substrates
Source: Biochem. 23 (1984) 4572-4580
Description: Michaelis Menten parameters



Authors: Schurmeyer, T.H.; Avgerinos, P.C.; Gold, P.W.; Gallucci, W.T.; Tomai, T.P.; Cutler, G.B., Jr.; Loriaux, D.L.; Chrousos, G.P.
Title: Human Corticotropin-Releasing Factor in Man: Pharmacokinetic Properties and Dose-Response of Plasma Adrenocorticotropin and Cortisol Secretion
Source: J. Clin. Endocrin. 59 (1984) 1103
Description: mono- and bi-exponential fits of CRF plasma concentration



Authors: Segal, David M.; Stephany, David A.
Title: The Mechanism of Intercellular Aggregation: I. The Kinetics of the Fe Gamma Receptor-Mediated Aggregation of P388D1 Cells with Antibody-Coated Lymphocytes at 4 Degrees C
Source: J. Immunol. 132 (1984) 1924
Description: contour graphs, fit exponential model



Authors: Smith, Quentin R.; Rapoport, Stanley I.
Title: Carrier-Mediated Transport of Chloride Across the Blood-Brain Barrier
Source: J. Neurochem. 42 (1984) 754-763
Description: fit plasma concentration of tracer at different time after injection to linear combination of exponentials



Authors: Smith, Quentin R.; Takasato, Yoshio; Rapoport, Stanley I.
Title: Kinetic Analysis of L-leucine Transport Across the Blood-Brain Barrier
Source: Brain Res. 311 (9184) 167-170
Description: Michaelis Menten paramters



Authors: Steven, Alasdair C.; Hainfeld, James F.; Trus, Benes L.; Steinert, Peter M.; Wall, Joseph S.
Title: Radial Distributions of Density within Macromolecular Complexes Determined from Dark-field Electron Micrographs
Source: Proc. Natl. Acad. Sci. 81 (1984) 6363-6367
Description: analysis and graphics of one dimensional traces using MLAB



Authors: Strobl, Jeannine S.; Kasid, Atton; Huff, Karen K.; Lippman, Marc E.
Title: Kinetic Alterations in Estrogen Receptors Associated with Estrogen Receptor Processing in Human Breast Cancer Cells
Source: Endocrin. 115 (1984) 1116
Description: dissociation curves analyzed using MLAB



Authors: Sweeting, Linda M.; Becker, Edwin D.
Title: A Carbon-13 Nuclear Magnetic Resonance Spin-Lattice Relaxation Study of Hydrogen Bonding in 2-Methyl-2-Propanol. Relaxation Mechanisms
Source: J. Phys. Chem. 88 (1984) 6075-6080
Description: curve-fit to find T1, k, M0



Authors: Takasato, Yoshio; Rapoport, Stanley I.; Smith, Quentin R.
Title: An in Situ Brain Perfusion Technique to Study Cerebrovascular Transport in the Rat
Source: Am. J. Physiol. 247 (1984) H484-H493
Description: biexponential model for femoral arterial concentrations of 14-C antipyrine.



Authors: van Schrarendijk, Christiaan; Hooghe-Peters, Elisabeth L.; De Meyts, Pierre; Pipeleers, Daniel G.
Title: Identification and Characterization of Insulin Receptors on Foetal-Mouse Brain Cortical Cells
Source: Biochem. J. 220 (1984) 165-172
Description: apparent affinity constants obtained using a model for 2 class sites



Authors: Velasquez, D.J.; Morrow, P.E.
Title: Estimation of Guinea Pig Tracheobronchial Transport Rates using Compartmental Model
Source: Exp. Lung. Res. 7 (1984) 163-176
Description: modelled spatial zones in tracheal passage, characterized by varying diameter as compartments in compartmental model



Authors: Wahlund, Lars-Olof; Saaf, Jan; Ross, Suante B.; Wetterberg, Lennart
Title: Activation of Monoamine Oxidase by High Molecular Weight Fractions of Human Plasma
Source: Acta Physiol. Scand. 120 (1984) 337-341
Description: kinetic paramters Km, Vmax determined



Authors: Wahlund, L.-O.; Saaf, J.; Ross, S.B.; Wetterberg, L.; Smedby, Y.
Title: Kinetic Aspects of Human Platelet Monoamine Oxidase Thermolability
Source: Acta-Physiol. Scand. 122 (1984) 97-102



Authors: Weerasuriya, Ananda; Spangler, Robert A.; Rapoport, Stanley I.; Taylor, Robert E.
Title: AC Impedance of the Perineurium of the Frog Sciatic Nerve
Source: Biophys. J. 46 (1984) 167-174
Description: impedance data analyzed by nonlinear least squares curve fitting technique



Authors: Weir, R.L.; Padgett, W.; Daly, J.W.; Anderson, J.M.
Title: Interaction of Anticonvulsant Drugs with Adenosine Receptors in the Central Nervous System
Source: Epilepsia 25 (1984) 492-498
Description: characteristics of the [3-H] CHA binding were estimated directly using nontransformed data. single and dual site models fitted



Authors: Zelenka, Peggy S.; Vu, Ngoc-Diep
Title: Correlation Between Phosphatidylinositol Degradation and Cell Division in Embryonic Chicken Lens Epithelia
Source: Dev. Biol. 105 (1984) 325-329
Description: per cent labelled nuclei in central region of embryonic chicken lens epithelium vs. average decay rate fit with MLAB



Authors: Zimm, Solomon; Collins, Jerry M.; Curt, Gregory A.; O'Neill, Dondra; Poplack, David G.
Title: Cerebrospinal Fluid Pharmacokinetics of Intraventricular and Intravenous Aziridinylbenzoquinone
Source: Canc. Res. 44 (1984) 1698-1701
Description: monoexponential function fit to CSF disppearance curves following AZQ adminstration



Authors: Zimm, Solomon; Collins, Jerry M.; Miser, James; Chatterji, Dulal; Poplack, David G.
Title: Cytosine Arabinoside Cerebrospinal Fluid Kinetics
Source: Clin. Pharm. and Ther. 35 (1984) 826
Description: biexponential model Ara-C CSF disapperance curves



Authors: Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Ozkan, Gunay; Egan, William; Shao, Kai-liu
Title: NMR Spectroscopic Studies of Intermediary Metabolites of Cyclophosphamide
Source: J. Med. Chem. 27 (1984) 466-485
Description: fit 31-P NMR data to kinetic model.


1985

Authors: Aizenbud, Boris M.; Gershon, Nahum D.
Title: Diffusion of Molecules on Biological Membranes of Nonplanar Form
Source: Biophys. J. 48 (1985) 543-552
Description: 3D graphics



Authors: Balis, Frank M.; Lange, Beverly J.; Packer, Roger J.; Holcenberg, John S.; Ettinger, Lawrence J.; Sallan, Stephen E.; Heideman, Richard L.; Zimm, Solomon; Smithson, William A.; Cogliano-Shutta, Nancy A.; Reaman, Gregory H.; Poplack, David G.
Title: Podiatric Phase I Trial and Pharmacokinetic Study of Tiazofurin (NSC 286193)
Source: Cancer Res. 45 (1985) 5169-5172
Description: bi- and tri-exponential equations fit to plasma disappearance



Authors: Borah, B.; Chen, C.W.; Egan, W.; Miller, M.; Wlodawer, A.; Cohen, J.S.
Title: Nuclear Magnetic Resonance and Neutron Diffraction Studies of the Complex Ribonuclease A with Uridine Vanadate, a Transition-State Analog
Source: Biochem. 24 (1985) 2058-2067



Authors: Borowski, Marianne; Furie, Barbara C.; Goldsmith, George H.; Furie, Bruce
Title: Metal and Phospholipid Binding Properties of Partially Carboxylated Human Prothrombin Variants
Source: J. Biol. Chem. 260 (1985) 9258-9264
Description: data from dialysis experiments analyzed using 2 site binding model



Authors: Brenner, Dean E.; Galloway, Sherri; Cooper, John; Noone, Richard; Hande, Kenneth R.
Title: Improved High-Performance Liquid Chromatography Assay of Doxorubicin: Detection of Circulating Aglycones in Human Plasma and Comparison with Thin-Layer Chromatography
Source: Cancer Chemot. 14 (1985) 139-145
Description: 3 compartment, first order elimination kinetic model, Student's t



Authors: Bunow, B.; Segev, I.; Fleshman, J.W.
Title: Modeling the Electrical Behavior of Anatomically Complex Neurons Using a Network Analysis Program: Excitable Membrane
Source: Biol Cybern. 53 (1985) 41-56
Description: Hodgkin-Huxley equation, coefficients of polynomial



Authors: Chan, Kenneth K.; Bolger, Michael B.; Pang, K. Sandy
Title: Statistical Moment Theory in Chemical Kinetics
Source: Anal. Chem. 57 (1985) 2145-2151
Description: several sets of data on kinetic systems were generated, including 3 consecutive first order reactions, parallel first order



Authors: Chen, Raymond F.; Scott, Carrie H.
Title: Atlas of Fluorescence Spectra and Lifetimes of Dyes Attached to Protein
Source: Anal. Lett. 18 (1985) 393-421
Description: Correction and graphics, DEC10 MLAB



Authors: Cheng, Sheue-yann
Title: Structural Similarities Between the Plasma Membrane Binding Sites for L-Thyroxine and 3,3',5-Triiodo-L-Thyronine in Cultured Cells
Source: J. Receptor Res. 5 (1985) 1-26
Description: binding data were fitted to Scatchard equation



Authors: Chiueh, C.C.; Ohata, M.; Jonas, L.A.; Greenblatt, D.J.; Rapoport, S.I.
Title: Brain Uptake of Flurazepam and of N1-Desalkyl Flurazepam after Administration of Flurazepam to the Cat
Source: Drug Metab. 13 (1985) 1
Description: fit plasma conc.-time data to multiexponential equation



Authors: Chu, David T.W.; Shikawa, Hisataka; Khatra, Balwart S.; Exton, John H.
Title: Effects of Altered Thyroid Status on Beta-Adrenergic Actions on Skeletal Muscle Glycogen Metabolism
Source: J. Biol. Chem. 260 (1985) 9994-10000
Description: Receptor density and ICYP affinity quantified, DEC10 MLAB



Authors: Collins, Jerry M.; Riccardi, Riccardo; Trown, Patrick; O'Neill, Dondra; Poplack, David G.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of Recombinant Interferon Alpha A in Monkeys: Comparison of Intravenous, Intramuscular, and Intraventricular Delivery
Source: Cancer Drug Del. 2 (1985) 247-253
Description: half-times were calculated by weighted least squares regression



Authors: Cumming, J.R.; Eckert, R.T.; Evans, L.S.
Title: Kinetics of Potassium Uptake in Red Spruce Seedlings
Source: Canadian J. Bot. 63 (1985) 512-516
Description: data were fit to various models by weighted nonlinear least squares, Michaelis-Menten equation



Authors: Curt, Gregory A.; Kelley, James A.; Fine, Robert L.; Huguenin, Philipp N.; Roth, Jeri S.; Balist, Gerald; Jenkins, Jean; Collins, Jerry M.
Title: A Phase I and Pharmacokinetic Study of Dihydro-5-Azacytidine (NSC 264880)
Source: Cancer Res. 45 (1985) 3359-3363
Description: postinfusion plasma conc-time data fit to biexponential model



Authors: de Monasterio, F.M.; McCrane, E.P.; Newlander, J.K.; Schein, S.J.
Title: Density Profile of Blue-Sensitive Cones Along the Horizontal Meridian of Macaque Retina
Source: Inv. Ophthal. Vis. Sci. 26 (1985) 289-302
Description: fit of various model functions to distribution of cone densities as a function of retinal eccentricity, MLAB PDP 10



Authors: de Nayer, Phillipe; Dozin, Beatrice
Title: Thyroid Hormones and Brain Development: Modulation of the Binding Activity of the T3 Nuclear Receptor by Chromatin-Associated Factors
Source: Molecular Physiol. 7 (1985) 303-310
Description: Affinity constant of the T3 receptor was derived from a Scatchard plot of the data, weighted non-linear least squares fit



Authors: Depiereu, E.; Feytmans, E.
Title: Gradual modification of the structure of benthic invertebrate communities according to water quality of the OUrthe and Lesse rivers (Belgian Meuse)
Source: Acta Oecologia Applicata 6(1985) 81-98.
Description: cluster analysis, principal component analysis, dendrograms, histograms



Authors: Dodion, P.; Davis, T.A.; Rozencweig, M.; Crespeigne, N.; Kenis, Y.; Bachur, N.R.
Title: Human Pharmacokinetics of Esorubicin (4'-deoxydoxorubicin)
Source: Inv. New Drugs 3 (1985) 361-368
Description: esorubicin plasma conc.-time date fit to tri-exponential model



Authors: Dodion, Pierre; Egorin, Merrill J.; Engisch, Kathrin L.; Bachur, Nicholas R.
Title: Metabolism and Disposition of Menogaril (NSC 269148) in the Rabbit
Source: Cancer Res. 45 (1985) 5352-5357
Description: computer simulation of decline in plasma conce of 7-OMEN



Authors: Dodion, Pierre; Egorin, Merrill J.; Riggs, Charles E, Jr.; Ferraro, Thomas A.; Tamburini, Julie M.; Bachur, Nicholas R.
Title: Comparative Murine Metabolism and Disposition of Clas II Anthracycline Antibiotics
Source: Cancer Chemot. 15 (1985) 153-160
Description: computer modeling of plasma conc. of ACL and MST to determine peak concentration, half-life, and area under curve



Authors: Dower, Steven K.; Hefeneider, Steven H.; Alpert, Alan R.; Urdal, David L.
Title: Quantitative Measurement of Human Interleukin 2 Receptor Levels with Intact and Detergent Solubilized Human T-Cells
Source: Molec. Immunology 22 (1985) 937-947
Description: 2 site binding model, DEC10 MLAB



Authors: Dower, Steven K.; Segal, David M.
Title: Interaction of Monoclonal Antibodies with MHC Class I Antigens on Mouse Spleen Cells
Source: J. Immunology 134 (1985) 431-435
Description: 2 site binding model



Authors: Egan, Pamela C.; Costanza, Mary E.; Dodion, Pierre; Egorin, Merrill J.; Bachur, Nicholas R.
Title: Doxorubicin and Cisplatin Excretion into Human Milk
Source: Cancer Treat. Rep. 69 (1985) 1387-1389
Description: plasma and milk drug conc were modelled as single exponential



Authors: Egorin, Merrill J.; Cohen, Brian E.; Kohlhepp, Elizabeth A.; Gutierrez, Peter L.
Title: Gas-Liquid Chromatographic Analysis of N,N',N''-Triethylene Thiophosphoramide and N,N',N'' Triethylene Phosphoramide in Biological Samples
Source: J. Chromat. 343 (1985) 196-202
Description: computer modeling of plasma conc. of thioTEPA and TEPA



Authors: Ellis, John; Lenox, Robert H.
Title: Characterization of the Interactions of Gallamine with Muscarinic Receptors from Brain
Source: Biochem. Pharm. 34 (1985) 2214-2217
Description: monoexponential best fits of time course of inhibition by gallamine of muscarainic receptor binding



Authors: Fram, Robert J.; Kufe, Donald W.
Title: Effect of 1-Beta-D-Arabinofuranosyl Cytosine and Hydroxyurea on the Repair of X-Ray-Induced DNA Single-Strand Breaks in Human Leukemic Blasts
Source: Biochem. Pharm. 34 (1985) 2557-2560
Description: relative retention values were calculated for 14-C-labeled DNA at 50% elution of 3-H-internal standards treated with Gy plotted according to a decreasing exponential function.



Authors: Freund, Kurt; Mizzer, John; Dick, William; Thorpe, Colin
Title: Inactivation of General Acyl-CoA Dehydrogenase from Pig Kidney by 2-Alkynoyl Coenzyme A Derivatives: Initial Aspects
Source: Biochem. 24 (1985) 5996-6002
Description: absorbance traces fit to two sequential first order reactions where product of first reaction absorbs at 800 nm



Authors: Froehlich, Jeffrey P.; Heller, Phillip F.
Title: Transient-State Kinetics of the ADP-Insensitive Phosphoenzyme in Sarcoplasmic Reticulum: Implications for Transient-State Calcium Translocation
Source: Biochem. 24 (1985) 126-136
Description: kinetic constants of the ATPase partial reactions were determined by computer simulation of the dephosphorylation time cours



Authors: Gillis, Anne M.; Yee, Yin-Gail; Kates, Robert E.
Title: Binding of Antiarrhythmic Drugs to Purified Human Alpha-1-Acid Glycoprotein
Source: Biochem. Pharm. 34 (1985) 4279-4282
Description: fit binding parameters



Authors: Grygiel, John J.; Balis, Frank M.; Collins, Jerry M.; Lester, Cynthia M.; Poplack, David G.
Title: Pharmacokinetics of Tiazofurin in the Plasma and Cerebrospinal Fluid of Rhesus Monkeys
Source: Cancer Res. 45 (1985) 2037-2039
Description: area under curve of plasma-conc.-time, trapezoidal rule, triexponential model



Authors: Heller, Stephen R.
Title: The Chemical Information System and Spectral Databases
Source: J. Chem. Infor. 25 (1985) 224-231



Authors: Henner, W.D.; Furlong, E.A.; Kelley, S.L.; Rosowsky, A.
Title: Assay for Mitolactol and Its Bifunctional Alkylating Metabolites in Plasma
Source: J. Pharm. Sci. 74 (1985) 983
Description: concentration-time data fit to bi-exponential model



Authors: Hinesly, T.D.; Hansen, L.G.; Bray, D.J.; Redborg, K.E.
Title: Transfer of Sludge-Borne Cadmium Through Plants to Chickens
Source: J. Agric. Food Chem. 33 (1985) 173-180



Authors: Hobbs, Ann S.; Albers, R. Wayne; Froehlich, Jeffrey P.; Heller, Phillip F.
Title: ADP Stimulates Hydrolysis of the "ADP-insensitive" Phospho-enzyme in Na+, K+-ATPase and Ca2+-ATPase
Source: J. Biol. Chem. 260 (1985) 2035-2037
Description: biexponential fitting of dephosphorylation time course



Authors: Janzon, Bo; Torsten, Seeman
Title: Muscle Devitalization in High-energy Missile Wounds, and its Dependence on Energy Transfer
Source: J. Trauma 25 (1985) 138-144
Description: least squares regression analysis and plotting



Authors: Kimes, Alane S.; Sweeney, Daniel; Rapoport, Stanley I.
Title: Brain Palmitate Incorporation in Awake and Anesthetized Rats
Source: Brain Res. 341 (1985) 164-170
Description: plasma palmitate radioactivities at different times after iv injectionof [14-C] palmitate were fit to biexponential equation



Authors: Kinsella, J.L.; Freiberg, J.M.; Sacktor, B.
Title: Glucocorticoid Activation of Na+/H+ Exchange in Renal Brush Border Vesicles: Kinetic Effects
Source: Am. J. Physiol. 248 (1985) F233-F239
Description: fit rates of Na+ uptake to a Hill-type equation



Authors: Klecker, Raymond W., Jr.; Collins, Jerry M.
Title: Quantification of Suramin by Reverse-Phase Ion-Pairing High-Performance Liquid Chromatography
Source: J. Liq. Chrom. 8 (1985) 1685-1696
Description: Standard curve data fit to mx+b=y



Authors: Klecker, Raymond W.; Jenkins, Jean F.; Kinsella, Timothy J.; Fine, Robert L.; Strong, John M.; Collins, Jerry M.
Title: Clinical Pharmacology of 5-Iodo-2'-Deoxyuridine and 5-Iodouracil and Endogenous Pyrimidine Modulation
Source: Clin. Pharm. 38 (1985) 45-51
Description: fit Michaelis Menten parameters



Authors: Krumins, Solveig A.; Rodbard, David
Title: Comparative Studies of the Binding of Dimeric and Monomeric Enkephalins to Neuroblastoma-Glioma NG108-15 Cells
Source: J. Neurochem. 45 (1985) 101-107
Description: Maximum amount of a radioligand capable of binding was computed and fit to y(x) = (a-d)/(1+(x/c)^b)+d.



Authors: Lamore, P.J.J.; Verweij, C.; Brocaar, M.P.
Title: Investigations of the Residual Hearing Capacity of Severely Hearing-Impaired and Profoundly Deaf Subjects
Source: Audiology 24 (1985) 343-361
Description: curve fit hearing loss to A-B*exp(-(x-1)/c), x is frequency.



Authors: Laskey, John W.; Eders, Frank W.
Title: Hatch Weight Selection: Effect on Post-Hatch Growth in the Japanese Quail (Coturnix Coturnix Japonica)
Source: Comp. Biochem. Physiol. 82A (1985) 101-104
Description: fit data to Gompertz growth equation--Wt = W0*exp((A0/a)*(1-exp(-a*t))).



Authors: Lee, K.N.; Fesus, L.; Yancey, S.T.; Girard, J.E.; Chung, S.I.
Title: Development of Selective Inhibitors of Transglutaminase
Source: J. Biol. Chem. 260 (1985) 14689-14694
Description: DEC10 MLAB, Michaelis Menten equation.



Authors: Liberman, Ellen; Reddy, Prasad; Gazdar, Celia; Peterkofsky, Alan
Title: The Escherichia coli Adenylate Cyclase Complex
Source: J. Biol. Chem. 260 (1985) 4075-4081
Description: for studies involving the effect of varying ATP conc. on adenylated cyclase activity, data were fit to Hill equation.



Authors: Litterst, Charles L.; Roth, Jeri S.; Kelly, James A.
Title: Distribution, Elimination, Metabolism, and Bioavailability of Hexamethylenebisacetamide in Rats
Source: Inv. New Drugs 3 (1985) 263-272
Description: plasma conc. HMBA in time fit to 2-compartment model



Authors: Lucignani, G.; Nehlig, A.; Blasberg, R.; Patlak, C.S.; Anderson, L.; Fieschi, C.; Fazio, F.; Sokoloff, L.
Title: Metabolic and Kinetic Considerations in the Use of [125-I] HIPDM for Quantitative Measurement of Regional Cerebral Blood Flow
Source: J. Cereb. Bl. Flow 5 (1985) 86-96
Description: fit rate constants for [125-I] HIPDM



Authors: Lynch, Christopher J.; Blackmore, Peter F.; Charest, Robert; Exton, John H.
Title: The Relationships Between Receptor Binding Capacity for Norepinephrine, Angiotensin II, and Vasopressin and Release of Inositol Triphosphate, Ca2+ Mobilization, and Phosphorylase Activation in Rat Liver
Source: Mol. Pharm. 28 (1985) 93-99
Description: all data from concentration-response and binding experiments were calculated, curve-fitted, and plotted with MLAB



Authors: Lynch, Christopher J.; Charest, Robert; Blackmore, Peter F.; Exton, John H.
Title: Studies on the Hepatic Alpha-1-Adrenergic Receptor
Source: J. Biol. Chem. 260 (1985) 1593-1600
Description: Scatchard plots of conc. dependence of [3-H] prazosin binding were analyzed with MLAB.



Authors: Lynch, Christopher J.; Charest, Robert; Bocckino, Stephen B.; Exton, John H.; Blackmore, Peter F.
Title: Inhibition of Hepatic Alpha-1-Adrenergic Effects and Binding by Phorbol Myristate Acetate
Source: J. Biol. Chem. 260 (1985) 2844-2851
Description: Binding parameters were determined using nonlinear curve fitting.



Authors: Macalady, Donald L.; Wolfe, N. Lee
Title: Effect of Sediment Sorption and Abiotic Hydrolyses. 1. Organophosphorothioate Esters
Source: J. Agric. Food Chem. 33 (1985) 167-173
Description: values for neutral hydrolysis rate constants of chlorpyrifos were determined based on 4 lnear coupled differential rate equations.



Authors: Marini, M.A.; Evans, W.J.; Berger, R.L.
Title: Use of the Twin-Cell Differential Titration Calorimeter for Binding Studies. I. EDTA and its Calcium Complex
Source: J. Biochem. Biophys. Meth. 10 (1985) 273-285
Description: both potentiometric and thermal curves have pK' as common parameter; fit simultaneously



Authors: Marini, Mario A.; Evans, William J.; Morris, Nancy M.
Title: Calorimetric and Potentiometric Studies on the Binding of Calcium by Phytic Acid
Source: J. Appl. Biochem. 7 (1985) 180-191
Description: potentiometric and calorimetric titrations were analyzed.



Authors: Mattera, Fafael; Pitts, Barry J.R.; Entman, Mark L.; Birnbaumer, Lutz
Title: Guanine Nucleotide Regulation of a Mammalian Myocardial Muscarinic Receptor System
Source: J. Biol. Chem. 260 (1985) 7410-7421
Description: Scatchard plots, Hill coefficients, Adair-Pauling approach



Authors: McCarthy, J.F.; Jimenez, B.D.
Title: Reduction in Bioavailability to Bluegills of Polycyclic Aromatic Hydrocarbons Bound to Dissolved Humic Material
Source: Env. Tox. Chem. 4 (1985) 511-521
Description: two compartment model for fish and water, bound and free PAHs



Authors: McCarthy, J.F.; Jimenez, B.D.; Barbee, T.
Title: Effect of Dissolved Humic Material on Accumulation of Polycyclic Aromatic Hydrocarbons: Structure-Activity Relationships
Source: Aquat. Tox. 7 (1985) 15-24
Description: bioaccumulation, Michaelis-Menten kinetics.



Authors: Monks, Anne; Marquez, Victor E.; Mao, David T.; Cysyk, Richard L.
Title: Uptake of 2-Beta-D-Ribofuranosylthiazole-4-Carboxamide (Tiazofurin) and Analogues by the Facilitated Transport Mechanism of Erythrocytes
Source: Cancer Lett. 28 (1985) 1-8
Description: Kinetic parameters for transport and inhibition of transport were calculated from least squares fit of data to modified Michaelis Menten equation.



Authors: Morris, Stephen J.; Bradley, Diane; Blumenthal, Robert
Title: The Use of Cobalt Ions as a Collisional Quencher to Probe Surface Charge Stability of Fluorescently Labeled Bilayer Vesicles
Source: Bioch. Biophys. A. 818 (1985) 365-372
Description: fluorescence quenching data, change in fluorescence fit to functions with exponential factors



Authors: Morrissey, Philip J.; Sharrow, Susan O.; Kohno, Yoichi; Berzofsky, Jay A.; Singer, Alfred
Title: Correlation of Intrathymic Tolerance with Intrathymic Chimerism in Neonatally Tolerized Mice
Source: Transplantation 40 (1985) 68-72
Description: Computer enhanced resolution and curve-smoothing of immunofluorescence profiles.



Authors: Moyer, James D.; Karle, Jean M.; Malinowsky, Nancy; Marquez, Victor E.; Salom, Mohammed A.; Malspeis, Louis; Cysyk, Richard L.
Title: Inhibition of Uridine Kinase and the Salvage of Uridine by Modified Pyrimidine Necleosides
Source: Mol. Pharm. 28 (1985) 454-460
Description: Michaelis Menten equation for competitive inhibition



Authors: Nashed, Nashaat T.; Michaud, Dennis P.; Levin, Wayne; Jerina, Donald M.
Title: Properties of Liver Microsomal Cholesterol 5,6-Oxide Hydrolase
Source: Arch. Biochem. 241 (1985) 149-162
Description: fit parameters in Michaelis Menten equation



Authors: Ohata, Masahiro, Fredericks, Wendy R.; Neuwelt, Edward A.; Sundaram, Uma; Rapoport, Stanley I.
Title: [3-H] Methotrexate Loss from the Rat Brain Following Enhanced Uptake by Osmotic Opening of the Blood-Brain Barrier
Source: Cancer Res. 45 (1985) 1092-1096
Description: least squares fit of exponential model to brain concentration in time to get half-life



Authors: Ohnhaus, E.E.; McManus, M.E.; Scharz, D.M.; Thorgeirsson, S.S.
Title: Kinetics of Sparteine Metabolism in Rat and Rabbit Liver Microsomes
Source: Biochem. Pharm. 34 (1985) 439-440
Description: Michaelis Menten kinetics



Authors: Osborne, J.C.; Bengtsson-Olivecrona, G.; Lee, N.S.; Olivecrona, T.
Title: Studies on Inactivation of Lipoprotein Lipase: Role of the Dimer to Monomer Dissociation
Source: Biochem. 24 (1985) 5606-5611



Authors: Osborne, J.S.; Stanley, S.J.; Moss, J.
Title: Kinetic Mechanisms of two NAD: arginine ADP-ribosyltransferases: the Soluble, Salt-stimulated Transferase from Turkey Erythrocytes and Choleragen, a Toxin from Vibro cholerae
Source: Biochem. 24 (1985) 5235-5240



Authors: Pang, K. Sandy; Kong, Philomena; Terrell, Julia A.; Billings, Ruth E.
Title: Metabolism of Acetaminophen and Phenacetin by Isolated Rat Hepatocytes
Source: Drug Metab. 13 (1985) 42
Description: The kinetic differences in the extents of sulfation of acetominophen as a generated and preformed metabolite may be explained. predictive time course.



Authors: Penniman, C.A.
Title: Photosynthesis of Gracilaria tikuahiae McLachlan (Gigartinales, Rhodophyta) from the Great Bay Estuary, New Hampshire
Source: Botanica Marina 28 (1985) 427-435.
Description: fit of exponential model of photosynthesis efficiency to laboratory measurements.



Authors: Perez, Pilar; Bluestone, Jeffrey A.; Stephany, David A.; Segal, David M.
Title: Quantitative Measurements of the Specificity and Kinetics of Conjugate Formation Between Cloned Cytotoxic T Lymphocytes and Splenic Target CElls by Dual Parameter Flow Cytometry
Source: J. Immunology 134 (1985) 478-485
Description: computations and data fitting performed with DEC10 MLAB



Authors: Phillips, Robert S.; Miles, Edith Wilson; Cohen, Louis A.
Title: Differential Inhibition of Tryptophan Synthase and of Tryptophanase by the Two Diastereomers of 2,3-Dihydro-L-Tryptophan
Source: J. Biol. Chem. 260 (1985) 14665-14670
Description: DEC10 MLAB, 340nm absorbance vs time at 40 second intervals for pre-steady state data analyzed with MLAB.



Authors: Piantadosi, Steven
Title: A Model of Growth with First-Order Birth and Death Rates
Source: Comp. and Biomed. Res. 18 (1985) 220-232
Description: population dynamics modeled with odes



Authors: Pocchiari, M.; Munson, P.J.; Costa, T.; Gajdusek, D.C.; Gibbs, C.J., Jr.
Title: Serotoninergic System in Scrapie-Infected Hamsters
Source: J. Neurochem. 44 (1985) 862-868
Description: Michaelis Menten parameters fit with MLAB and LIGAND



Authors: Poretsky, L.; Grigorescu, F.; Seibel, M.; Moses, A.C.; Flier, J.S.
Title: Distribution and Characterization of Insulin and Insulin-Like Growth Factor I Receptors in Normal Human Ovary
Source: J. Clin. Endocrin. 61 (1985) 728-734
Description: Insulin binding data analyzed with MLAB.



Authors: Rahman, Aquilur; Smith, Frederick P.; Luc, Phuong-Van T.; Woolley, Paul V.
Title: Phase I Study and Clinical Pharmacology of 6-Diazo-5-Oxo-L-Norleucine (DON)
Source: Inv. New Drugs 3 (1985) 369-374
Description: Prophet drug modeling integrated with MLAB was used to fit plasma disappearance data for both intact drug and total radioactivity



Authors: Redmond, T.M.; Wiggert, B.; Robey, F.A.; Yen, N.N.; Lewis, M.S.; Lee, L.; Chader, G.J.
Title: Isolation and Characterization of Monkey Interphotoreceptor Retinoid-Binding Protein, a Unique Extracellular Matrix Component of the Retina
Source: Biochem. 24 (1985) 787-793



Authors: Robinson-White, Audrey; Baylin, Stephen B.; Olivecrona, Thomas; Beaven, Michael A.
Title: Binding of Diamine Oxidase Activity to Rat and Guinea Pig Microvascular Endothelial Cells
Source: J. Clin. Inv. 76 (1985) 93-100
Description: curve-fitting 2 or 3 Michaelis Menten components



Authors: Rothman, Richard B.; Bowen, Wayne D.; Herkenham, Miles; Jacobson, Arthur E.; Rice, Kenner C.; Pert, Candace B.
Title: A Quantitative Study of [3-H] D-Ala2-D-Leu5-Enkephalin Binding to Rat Brain Membranes
Source: Mol. Pharm. 27 (1985) 399-408
Description: fit data to 2 site competitive binding model, F-test



Authors: Sabljic, Aleksandar
Title: Calculation of Retention Indices by Molecular Topology Chlorinated Benzenes
Source: J. Chrom. 319 (1985) 1-8



Authors: Sayer, Jane M.; Yagi, Haruhiko; van Bladeren, Peter J.; Levin, Wayne; Jerina, Donald M.
Title: Stereoselectivity of Microsomal Epoxide Hydrolase toward Diol Epoxides and Tetrahydroepoxides Derived from Benz-[alpha]-anthracene
Source: J. Biol. Chem. 260 (1985) 1630-1640
Description: Michaelis Menten equation



Authors: Schloss, John V.; Van Dyk, Drew E.; Vasta, Julia F.; Kutny, Rusty M.
Title: Purification and Properties of Salmonella typhimurium Acetolactate Synthase Isozyme II from Escherichia coli HB101/pDU9
Source: Biochem. 24 (1985) 4952-4959
Description: kinetic data were fit to Michaelis Menten equations



Authors: Schwartz, Rochelle D.; Jackson, Jane A.; Weigert, David; Skolnick, Phil; Paul, Steven M.
Title: Characterization of Barbituate-stimulated Chloride Efflux from Rat Brain Synaptoneurosomes
Source: J. Neurosci. 5 (1985) 2963-2970
Description: the efflux of 36-Cl- measured between 5 and 300 sc can best be fit to a single exponential decay curve



Authors: Segev, I.; Fleshman, J.W.; Miller, J.P.; Bunow, B.
Title: Modeling the Electrical Behavior of Anatomically Complex Neurons Using a Network Analysis Program: Passive Membrane
Source: Biol. Cybern. 53 (1985) 27-40
Description: used SPICE from EE and CS departments at Berkeley



Authors: Senear, Donald F.; Betts, Graham; Bernhard, Sidney A.
Title: Multiple Ion-Dependent and Substrate-Dependent Na+/K+-ATPase Conformational States. Transient and Steady-State Kinetic Studies
Source: Biochem. 24 (1985) 6789-6798
Description: curve-fitting with DEC10 MLAB



Authors: Siebens, Arthur W.; Kregenow, Floyd M.
Title: Volume-Regulatory Responses of Amphiuna Red Cells in Anisotonic Media: The Effecto of Amiloride
Source: J. Gen. Physiol. 86 (1985) 527-564
Description: Kinetic analysis of Na uptake as a function extracellular Na was performed by using the method of least squares fit of data to linear transfer of Michaelis Menten equation assuming rapid equilibrium.



Authors: Smal, Jean; Closset, Jean; Hennen, Georges; de Meyts, Pierre
Title: Receptor-Binding and Down-Regulatory Properties of 22000-Mr Human Growth Hormone and Its Natural 20000-Mr Variant on Im-9 Human Lymphocytes
Source: Biochem. J. 225 (1985) 283-289
Description: Analysis of binding data performed using MLAB on PDP20



Authors: Stone, Audrey Larack; Park, Juliana Y.; Martenson, Russell E.
Title: Low-Ultraviolet Circular Dichroism Spectroscopy of Oligopeptides 1-95 and 96-168 Derived from Myelin Base Protein of Rabbit
Source: Biochem. 24 (1985) 6666-6673
Description: To determine the conformation of the oligo peptides the best fits of various matrices (each composed of 4 model CD spectra) to the experimental CD curve.



Authors: Summers, Michael F.; Byrd, R. Andrew; Gallo, Kathleen A.; Samson, Carie J.; Zon, Gerald; Egan, William
Title: Nuclear Magnetic Resonance and Circular Dichroism Studies of a Duplex-Single Stranded Hairpin Loop Equilibrium for the Oligodeoxyribonucleotide Sequence d(CGCGATTCGCG)
Source: Nucleic Acid Res. 13 (1985) 6375-6386
Description: pre-exchange lifetime was gotten from least squares fit to exponential or linear function.



Authors: Takasato, Yoshio; Momma, Serji; Smith, Quentin R.
Title: Kinetic Analysis of Cerebrovascular Isoleucine Transport from Saline and Plasma
Source: J. Neurochem. 45 (1985) 1013-1020
Description: best fit values for Vmax, Km, and Kd were obtained fro isoleucine by fitting PA - Vmax/(Km+Cpf)+Kd to the saline perfusion data with weighted nonlinear least squares.



Authors: Thraves, Peter; Mossman, Kenneth L.; Brennan, Terrance; Dritschilo, Anatoly
Title: Radiosensitization of Human Fibroblasts by 3-Aminobenzamide: An Inhibitor of Poly(ADP-Ribosylation)
Source: Radiation Res. 104 (1985) 119-127
Description: fit survival curves S = (1-(1-exp(-D/D0))^n), Student's t



Authors: van Bladeren, Peter J.; Sayer, Jane M.; Ryan, Dene E.; Thomas, Paul E.; Levin, Wayne; Jerina, Donald M.
Title: Differential Stereoselectivity of Cytochromes P-450b and P-450c in the Formation of Naphthalene and Anthracene 1,2-Oxides
Source: J. Biol. Chem. 260 (1985) 10226
Description: enzyme reaction kinetics, fit ordinary differential equations.


pages 81-91, ACS Symposium Series
Authors: Van Lier, R.B.L.
Title: The Use of Monkey Percutaneous Absorption Studies
Source: Dermal Exposure Related to Pesticide Use, Chapter 6 (1985)



Authors: Verschuure, J.; Wijngaart, W.S.I.M.; Brocaar, M.P.; Nagels, M.M.
Title: Methods of Analysis of Large Numbers of Audiograms
Source: Audiology 24 (1985) 2-14
Description: curve fitting andiograms as hyperbolic tangent functions



Authors: Yu, L.C.; Steven, A.C.; Naylor, G.R.S.; Gamble, R.C.; Podolsky, R.J.
Title: Distribution of Mass in Relaxed Frog Skeletal Muscle and its Redistribution Upon Activation
Source: Biophys. J. 47 (1985) 311-321
Description: intensities of reflection peaks found using MLAB.


1986

Authors: Abramson, Fred P.
Title: Kinetic Models of Induction: 1. Persistence of the Inducing Substance
Source: J. Pharm. Sci. 75 (1986) 223-228
Description: odes, Michaelis Menten equation.



Authors: Abramson, Fred P.; Lutz, Michael P.
Title: The Kinetics of Induction by Rifampin of Alpha-1-Acid Glycoprotein and Antipyrine Clearance in the Dog
Source: Drug Metab. 14 (1986) 46-51
Description: one compartment model with first order absorption.



Authors: Abramson, F.P.; Lutz, M.P.
Title: The Effects of Phenytoin Dosage on the Induction of Alpha-1-Acid Glycoprotein and Antipyrine Clearance in the Dog
Source: Eur. J. Drug 11 (1986) 135-143
Description: weighted fit of one compartment model, 2 odes



Authors: Agren, Hans; Mefford, Ivan N.; Rudorfer, Matthew V.; Linnoila, Markku; Potter, William Z.
Title: Interacting Neurotransmitter Systems. A Non-Experimental Approach to the 5HIAA-HVA Correlation in Human CSF
Source: J. Psych. Res. 20 (1986) 175-193
Description: nonlinear curves generated with MLAB, linear and logistic regression



Authors: Balis, Frank M.; Lester, Cynthia M.; Poplack, David G.
Title: Pharmacokinetics of Trimetrexate (NSC 352122) in Monkeys
Source: Cancer Res. 46 (1986) 169-174
Description: Plasma concentration-time data from the iv bolus experiments were fitted to both bi- and tri-exponential functions



Authors: Bille, Vincent; Remacle, Jose
Title: Simple-Kinetic Descriptions of Alcohol Dehydrogenase After Immobilization on Tresyl-Chloride-Activated Agarose
Source: Eur. J. Biochem. 160 (1986) 343-348
Description: Michaelis Menten equation



Authors: Brenner, Dean E.; Collins, Jerry C.; Hande, Kenneth R.
Title: The Effects of Cimetidine Upon the Plasma Pharmacokinetics of Doxorubicin in Rats
Source: Cancer Chemot. 18 (1986) 219-222
Description: 2 compartment, bi-exponential model



Authors: Bron, Dominique; Dodion, Pierre; Rozencweig, Marcel; Delforge, Alain; Mattelaer, Marie-Anne; Kenis, Yvon; Stryckmans, Pierre
Title: Quantitation of Differential Sensitivity of Normal Marrow Myeloid Progenitor Cells to Anthracene Derivatives
Source: Inv. New Drugs 4 (1986) 11-16
Description: Student's t, semilogarithmic linear regression, colony formation versus drug concentration.



Authors: Chang, Seung K.; Chung, Soo Il
Title: Cellular Transglutaminase
Source: J. Biol. Chem. 261 (1986) 8112-8121
Description: all curve fitting of Michaelis constants from kinetic data, DEC10 MLAB



Authors: Cohen, Brian E.; Egorin, Merrill J.; Kohlhepp, Elizabeth A.; Aisner, Joseph; Gutierrez, Peter L.
Title: Human Plasma Pharmacokinetics and Urinary Excretion of Thiotepa and its Metabolites
Source: Cancer Trt. Rep. 70 (1986) 859-864
Description: computer modeling of the decline in plasma concentration of thiotepa, area under curve, 2 compartment model



Authors: Collins, Jerry M.; Klecker, Raymond W.; Yarchoan, Robert; Lowe, H. Clifford; Fauci, Anthony S.; Redfield, Robert R.; Broder, Samuel; Myers, Charles E.
Title: Clinical Pharmacokinetics of Suramin in Patients with HTLV-III/LAV Infection
Source: J. Clin. Pharm. 26 (1986) 22-26
Description: simulation of data based on 2 compartment model, disappearance curves



Authors: Dodion, P.; Sessa, C.; Joss, R.; Crespeigne, N.; Willems, Y.; Kitt, M.; Abrams, J.; Finet, C.; Brewer, J.E.; Adams, W.J.; Earhart, R.H.; Rozencweig, M.; Kenis, Y.; Cavalli, F.
Title: Phase I Study of Intravenous Menogaril Administered Intermittently
Source: J. Clin. Onc.
Description: 4 (1986) 767-774



Authors: Egorin, Merrill J.; Van Echo, David A.; Whitacre, Margaret Y.; Forrest, Alan; Sigman, Lawrence M.; Engisch, Kathrin L.; Aisner, Joseph
Title: Human Pharmacokinetics, Excretion, and Metabolism of the Anthracycline Antibiotic Menogaril (7-OMEN, NSC269148) and Their Correlation with Clinical Toxicities
Source: Cancer Res. 46 (1986) 1513-1520
Description: 7-OMEN plasma concentration decline modeled with MLAB and ADAPT



Authors: Fernandez, L.; Aparacio, J.; Muhammed, M.
Title: Coupled Zinc Transport Through a Bis(2-Ethylhexyl)-Phosphoric Acid Solid-Supported Liquid Membrane from Aqueous Perchlorate Media
Source: J. Membrane Sci. 27 (1986) 77-91
Description: unknown parameters were calculated by fitting experimental data to model function, permeability equations.



Authors: Gillis, Anne M.; Kates, Robert E.
Title: Influence of Protein Binding on the Myocardial Uptake and Pharmacodynamics of Propafenone
Source: J. Card. Pharm. 8 (1986) 1163-1167
Description: efferent perfusate propafenone concentration-time data fit to c = c0*(1-exp(-k*t)).



Authors: Gillis, Anne M.; Kates, Robert E.
Title: Myocardial Uptake Kinetics and Pharmacodynamics of Propafenone in the Isolated Perfused Rabbit Heart
Source: J. Pharm. Exp. 237 (1986) 708
Description: efferent perfusate concentration fit to c = c0*(1-exp(-k*t)).



Authors: Graber, Stephen G.; Woodworth, Robert C.
Title: Myoglobin Expression in L6 Muscle Cell
Source: J. Biol. Chem. 261 (1986) 9150-9154
Description: A standard curve is generated for each assay using a weighted regression routine in MLAB.



Authors: Grigorescu, Florin; Flier, Jeffrey S.; Kahn, C. Ronald
Title: Characterization of Binding and Phosphorylation Defects of Erythrocyte Insulin Receptors in the Type A Syndrome of Insulin Resistance
Source: Diabetes 35 (1986) 127-138
Description: Stoichiometric binding parameters were determined by a statistical curve fitting procedure in MLAB.



Authors: Herblin, W.F.
Title: Characterization of Benzodiazepine Binding Sites After Shortwave Photo-Affinity Labeling with Flunitrazepam
Source: Life Sci. 38 (1986) 507
Description: binding parameters derived by fitting to two-site logistic equation



Authors: Horwitz, Barry; Duara, Ranjan; Rapoport, Stanley I.
Title: Age Differences in Intercorrelations Between Regional Cerebral Metabolic Rates for Glucose
Source: Ann. Neurol. 19 (1986) 60-67
Description: displays of correlation matrices were obtained using MLAB on DEC10.



Authors: Huang, M.-T.; Wood, A.W.; Chang, R.L.; Yagi, H.; Sayer, J.M.; Jerina, D.M.; Conney, A.H.
Title: Inhibitory Effect of 3-Hydroxybenzo(Alpha)Pyrene on the Mutagenicity and Tumorgenicity of (+-)-7-Beta,8-Alpha-Dihydroxy-9-Alpha, 10-Alpha-Epoxy-7,8,9,10-Tetrahydrobenzo(Alpha)Pyrene
Source: Cancer Res. 46 (1986) 558-566
Description: odes for second order rate equations



Authors: Ilondo, M. Mapoko; Courtoy, Pierre J.; Geiger, Dominique; Carpentier, Jean-Louis; Rousseau, Guy G.; De Meyts, Pierre
Title: Intracellular Potassium Depletion in IM-9 Lymphocytes Suppresses the Slowly Dissociating Component of Human Growth Hormone Binding and the Down-Regulation of its Receptors But Does Not Affect Insulin Receptors
Source: Proc. Natl. Acad. Sci. 83 (1986) 6460-6464
Description: association kinetics in K+ depleted cells



Authors: Jacques, B.; Depiereux, E.; Feytmans, E.
Title: Effects of a sewage plant treatment on physico-chemical quality and community structure of the polluted river Haute-Semois
Source: Acta Oecologia Applicata 7 (1986) 261-279.
Description: dendrograms and cluster analysis



Authors: Juillerat, Marcel A.; Taniuchi, Hiroshi
Title: A Study on the Role of Evolutionary Invariant Leucine 32 of Cytochrome c
Source: J. Biol. Chem. 261 (1986) 2697-2711
Description: equilibrium data curve fitted to van't Hoff plots, DEC10 MLAB



Authors: Kapetavnovic, Izet M.; Yonekawa, Wayne D.; Kupferberg, Harvey J.; Cos, Lynn; Rollins, Douglas E.; Tolman, Keith G.
Title: Single and Multiple Dose Kinetics of a New Antiepileptic Drug, Org 6370, and Its Desmethyl Metabolite, Org 6363
Source: Ther. Drug Mon. 8 (1986) 140-144
Description: compartmental model



Authors: Kelley, James A.; Driscoll, John S.; McCormack, John J.; Roth, Jeri S.; Marquez, Victor E.
Title: Furanose-Pyranose Isomerization of Reduced Pyrimidine and Cyclic Urea Ribosides
Source: J. Med. Chem. 29 (1986) 2351-2358
Description: the change of absolute peak height kinetically analyzed with MLAB.



Authors: Kelley, Susan L.; Peters, William P.; Anderson, Janet; Furlong, Eileen A.; Frei, Emil, III; Henner, William D.
Title: Pharmacokinetics of Dibromodulcitol in Humans: A Phase I Study
Source: J. Clin. Onc. 4 (1986) 753-761
Description: regression analysis using MLAB, STAT80, DASH



Authors: Kinsella, James L.; Cujdik, Timothy; Sacktor, Bertram
Title: Kinetic Studies on the Stimulation of Na+-H+ Exchange Activity in Renal Brush Border Membranes Isolated from Thyroid Hormone-Treated Rats
Source: J. Membrane Biol. 91 (1986) 183-191
Description: kinetic constants determined with MLAB



Authors: Koziol, James A.
Title: An Introduction to Multivariate Growth Curve Analysis
Source: Growth 50 (1986) 259-272
Description: Potthoff-Roy multivariate growth curve model



Authors: Kreis, Willi; Budman, Daniel R.; Schulman, Philip; Freeman, Jean; Greist, Anne; Nelson, Robert L.; Marks, Mary; Kevill, Lydia
Title: Clinical Pharmacology of Vinzolidine
Source: Cancer Chemot. 16 (1986) 70-74
Description: weighted least squares regression of triexponential model



Authors: Krumins, S.A.; Lutz, R.A.; Costa, T.; Rodbard, D.
Title: Interaction of Dimeric and Monomeric Enkephalins with NG108-15 Hybrid Cells: A Kinetic Analysis
Source: Neurochem. Res. 11 (1986) 839-850
Description: ligand binding analysis with MLAB and LIGAND



Authors: Lagast, H.; Dodion, P.; Klastersky, J.
Title: Comparison of Pharmacokinetics and Bactericidal Activity of Teicoplanin and Vancomycin
Source: J. Antimic. Chemot. 18 (1986) 513-520
Description: Plasma conc fit to 2,3 compartment models, Student's t and Wilcoxon tests



Authors: Lee, Edward J.; Van Echo, David A.; Egorin, Merrill J.; Nayar, Balchandran; Shulman, Philip; Schiffer, Charles A.
Title: Diaziquone Given as a Continuous Infusion is an Active Agent for Relapsed Adult Acute Nonlymphocytic Leukemia
Source: Blood 67 (1986) 182-187
Description: diaziquone conc in plasma-time



Authors: Lewis, Marc S.; Youle, Richard J.
Title: Ricin Subunit Association
Source: J. Biol. Chem. 261 (1986) 11571-11577
Description: DEC10 MLAB, ultracentrifuge data analysis



Authors: Lynch, Christopher J.; Sobo, Gwenn E.; Exton, John H.
Title: An Endogenous Ca2+-Sensitive Proteinase Converts the Hepatic Alpha-1-Adrenergic Receptor to Guanine Nucleotide-Insensitive Forms
Source: Biochim. Biophys. A. 885 (1986) 110-120
Description: [3-H] Prazosin binding to plasma membranes was performed and data were analyzed using MLAB.



Authors: Maes, M.; Underwood, L.E.; Ketelslegers, J.-M.
Title: Low Serum Somatomedin-C in Insulin-Dependent Diabetes: Evidence for a Postreceptor Mechanism
Source: Endocrin. 118 (1986) 377-382
Description: The number and affinity of the specific binding sites were determined from the saturation curves by nonlinear curve fitting.



Authors: Marini, M.A.; Evans, W.J.; Berger, R.L.
Title: The Determination of Binding Constants with a Differential Thermal and Potiometric Titration Apparatus. II. EDTA, EGTA, and Calcium
Source: J. Biochem. Biophys. Meth. 12 (1986) 135-146
Description: ionization constants and heats of ionization derived by simulataneous fit of potentiometric and titration curves.



Authors: Martin, C.J.; Evans, W.J.
Title: Phytic Acid-Zinc Ion Interactions: A Calorimetric and Titrimetric Study
Source: J. Inorg. Biochem. 26 (1986) 169-183
Description: all calculations, including corrections for non-zero baseline, curve-fitting procedures, and solutions to diff. eqs. for heat-loss corrections done with MLAB.



Authors: McGonigle, Paul A.; Neve, Kim A.; Molinoff, Perry B.
Title: A Quantitative Method of Analyzing the Interaction of Slightly Selective Radioligands with Multiple Receptor Subtypes
Source: Mol. Pharm. 30 (1986) 329-337
Description: Scatchard analysis, 2 site model



Authors: Mossman, K.L.
Title: Gustatory Tissue Injury in Man-Radiation Dose Response Relationships and Mechanisms of Taste Loss
Source: Br. J. Cancer 53 (1986) 9
Description: logistic model



Authors: Nashed, Nashaat T.; Michaud, Dennis P.; Levin, Wayne; Jerina, Donald M.
Title: 7-Dehydrocholesterol 5,6 Beta-Oxide as a Mechanism-Based Inhibitor of Microsomal Cholesterol Oxide Hydrolase
Source: J. Biol. Chem. 261 (1986) 2510-2513
Description: kinetics, time vs conc., fit rate constants



Authors: Neve, Kim A.; McGonigle, P.; Molinoff, Perry B.
Title: Quantitative Analysis of the Selectivity of Radioligands for Subtypes of Beta Adrenergic Receptors
Source: J. Pharm. Exp. Ther. 238 (1986) 46
Description: dose response curves, Scatchard analysis



Authors: Pang, K. Sandy; Terrell, Julia A.; Nelson, Sidney D.; Feuer, Kathleen F.; Clements, Mary-Jean; Endrenyi, Laszlo
Title: An Enzyme-Distributed System for Lidocaine Metabolism in the Perfused Rat Liver Preparation
Source: J. Pharm. Biopharm. 14 (1986) 107
Description: computer for simulations for distribution of metabolic activities for metabolism of lidocaine and metabolites.



Authors: Pang, K. Sandy; Yuen, Vincent; Fayz, Shirin; Te Koppele, Johan M.; Mulder, Gerard J.
Title: Absorption and Metabolism of Acetominophen by the in Situ Perfused Rat Small Intestine Preparation
Source: Drug Metab. 14 (1986) 102-111
Description: weighted least squares fit rate constants for absorption of intestinal preparations



Authors: Perez, Pilar; Hoffman, Robert W.; Titus, Julie A.; Segal, David M.
Title: Specific Targeting of Human Peripheral Blood T Cells By Heteroaggregates Containing Anti-T3 Crosslinked to Anti-Target Cell Antibodies
Source: J. Exp. Med. 163 (1986) 166-178
Description: In some experiments, curves of percent lysis versus effector target were analyzed by fitting them to a hyperbolic function.



Authors: Phillips, Robert S.; Cohen, Louis A.
Title: Intramolecular General Acid and General Base Catalyses in the Hydrolysis of 2-Halotryptophans and Their Analogues
Source: JACS 108 (1986) 2023-2030
Description: log of rate constant versus pH fit to rate equations



Authors: Poerio, Elia; Parr, Gary R.; Taniuchi, Hiroshi
Title: A Study of Roles of Evolutionary Invariant Proline 30 and Glycine 34 of Cytochrome C
Source: J. Biol. Chem. 261 (1986) 10976-10989
Description: MLAB DEC10, curve fitting.



Authors: Prasad, Kondury; Lippoldt, Roland E.; Edelhoch, Harold
Title: An Intermediate Polymer in the Assembly of Clathrin Baskets
Source: Biochem. 25 (1986) 5214-5219
Description: ultracentrifuge, digitize scans, convert (x,y) coordinates to concentration form of optical density at 280nm as function of radial position.



Authors: Rabiet, Marie Josephe; Blashill, Alisan; Furie, Bruce; Furie, Barbara C.
Title: Prothrombin Fragment 1.2.3, a Major Product of Prothrombin Activation in Human Plasma
Source: J. Biol. Chem. 261 (1986) 13210-13215
Description: the radioactivity profiles from gels were calculated, normalized, and visualized with MLAB.



Authors: Rahman, Aquilur; Carmichael, Don; Harris, Mary; Roh, Jae Kyung
Title: Comparative Pharmacokinetics of Free Doxorubicin and Doxorubicin Entrapped in Cardiolipin Liposomes
Source: Cancer Res. 46 (1986) 2295-2299
Description: 2 and 3 compartment model plasma level decrease in tissue levels following administration.



Authors: Robinson, P.J.; Rapoport, S.I.
Title: Kinetics of Protein Binding Determine Rates of Uptake of Drugs by Brain
Source: Am. J. Physiol. 251 (1986) R1212-1220
Description: Michaelis Menten and other models.



Authors: Rothman, Richard B.; Cadet, Jean Lud
Title: Chronic Iminodipropionitrile (IDPN) Causes no Changes in the Rat Brain Phencyclidine (PCP) Receptor
Source: Neuropeptides 7 (1986) 259-263



Authors: Roy, S.; Weinstein, S.; Borah, B.; Nickol, J.; Appella, E.; Sussman, J.L.; Miller, M.; Shindo, H.; Cohen, J.S.
Title: Mechanism of Oligonucleotide Loop Formation in Solution
Source: Biochem. 25 (1986) 7417-7423


23-30. ACS Symposium Series, volume 313 (1986).
Authors: Russell, C.H.
Title: Advances in Scientific Software Packages
Source: Computer Applications in the Polymer Lab, Chapter 4, pages



Authors: Shenvi, Ashok B.
Title: Alpha-Aminoboronic Acid Derivatives: Effective Inhibitors of Aminopeptidases
Source: Biochem. 25 (1986) 1286-1291
Description: kinetic data fitted to reciprocal Michaelis Menten equation



Authors: Shrager, Richard I.; Hendler, Richard W.
Title: Processing and Analysis of Potentiometric Data
Source: Biophys. J. 49 (1986) 687-691
Description: Sum of Nernstians, SVD method.



Authors: Smith, Quentin R.; Rapoport, Stanley I.
Title: Cerebrovascular Permeability Coefficients to Sodium, Potassium, and Chloride
Source: J. Neurochem. 46 (1986) 1732-1742
Description: time course of plasma concentration as sum of exponentials.



Authors: Smith, Quentin R.; Takasato, Yoshio
Title: Kinetics of Amino Acid Transport at the Blood-Brain Barrier Studied Using an in Situ Brain Perfusion Technique
Source: Ann. NY Acad. Sci. 481 (1986) 186-201
Description: Best fit values for Vmax, Km, and Kd can be obtained by fitting equation 6 to saline perfusion data with weighted nonlinear least squares.



Authors: Stevenaert, A.; Beckers, A.; Vandalem, J.L.; Hennen, G.
Title: Early Normalization of Luteinizing Hormone Pulsatility after Successful Transphenoid Surgery in Women with Microprolactinomas
Source: J. Clin. End. 62 (1986) 1044-1047
Description: Significant LH peaks were identified with the Pulsar program in connection with MLAB on DEC20.



Authors: Suarez-Isla, Benjamin A.; Orozco, Carlos; Heller, Phillip F.; Froehlich, Jeffrey P.
Title: Single Calcium Channels in Native Sarcoplasmic Reticulum Membranes from Skeletal Muscle
Source: Proc. Natl. Acad. Sci. 83 (1986) 7741-7745
Description: data fitted to a hyperbola.



Authors: Tabata, Hitoshi; Holloway, Harold; Fredericks, Wendy R.; French, A. Wayne; Rapoport, Stanley I.
Title: Regional Cerebral Blood Flow in Awake Beagles of Different Ages
Source: Brain 109 (1986) 771-784
Description: bi-exponential plus constant model of plasma concentration in time.



Authors: Takei, Hidemori; Fredericks, Wendy R.; Rapoport, Stanley I.
Title: The Lumped Constant in the Deoxyglucose Procedure Declines with Age in Fischer-344 Rats
Source: J. Neurochem. 46 (1986) 931-938
Description: fit exponential model to glucose and [14-C]DG concentrations in time.



Authors: Tchekmedyian, N. Simon; Egorin, Merrill J.; Cohen, Brian E.; Kaplan, Richard S.; Poplin, Elizabeth; Aisner, Joseph
Title: Phase I Clinical and Pharmacokinetic Study of Cyclophosphamide Administered by Five-Day Continuous Intravenous Infusion
Source: Cancer Chemot. 18 (1986) 33-38
Description: computer modeling of the decline in plasma concentration of cyclophosphamide by weighted least squares.



Authors: Tejani-Butt, S.M.; Brunswick, D.J.
Title: Synthesis and Beta-andrenergic Receptor Blocking Potency of 1-(substituted amino)-3-(4-indolyloxy) propan-2-ols
Source: J. Med. Chem. 29 (1986) 1524-1527



Authors: Thomas, David J.; Fisher, Henry L.; Sumler, Martha R.; Marcus, Allan H.; Mushak, Paul; Hall, Larry L.
Title: Sexual Differences in the Distribution and Retention of Organic and Inorganic Mercury in Methyl Mercury-Treated Rats
Source: Env. Res. 41 (1986) 219-234
Description: Fit retention as a linear combination of exponentials.



Authors: Thraves, Peter J.; Mossman, Kenneth L.; Brennan, Terrance; Dritschilo, Anatoly
Title: Differential Radiosensitization of Human Tumor Cells by 3-Aminobenzamide and Benzamide Inhibitors of Poly (ADP-Ribosylation)
Source: Int. J. Radiat. Biol. 50 (1986) 961-972
Description: survival curves from colony count data.



Authors: Valcour, Andre A.; Woodworth, Robert C.
Title: Internal Proton Magnetic Resonance Probes for pH Titration Proteins
Source: J. Mag. Res. 66 (1986) 536-541
Description: fit chemical shift as function of minimum shift, maximum shift, proton concentration, and association rate constant



Authors: Vandalem, J.L.; McNamara, M.; Petit, R.; Hennen, G.
Title: Developmental Changes in Gonadotrophins and Testicular Gonadotrophin Receptors in the Pig, From Neonatal to Adult Life
Source: J. Endocr. 111 (1986) 301-308
Description: Scatchard analysis, parallel line assay, and analysis of variance.



Authors: Van Dyk, D.E.; Schloss, J.V.
Title: Deuterium Isotope Effects in the Carboxylase Reaction of Ribulose-1,5-bisphosphate Carboxylase/Oxygenase
Source: Biochem. 25 (1986) 5146-5156



Authors: Villeneuve, Jean-Pierre; Verbeeck, Roger K.; Wilkinson, Grant R.; Branch, Robert A.
Title: Furosemide Kinetics and Dynamics in Patients with Cirrhosis
Source: Clin. Pharm. 40 (1986) 14
Description: Renal clearance, urinary excretion best fit parameters.



Authors: Wahlund, L.-O.; Saaf, J.; Eneroth-Grimfors, E.; Nilsson, B.A.; Bevegard, S.
Title: Reduced Platelet MAO Activity During Pregnancy
Source: Acta Physiol. Scand. 126 (1986) 135-138
Description: Lineweaver-Burk plots, kinetic constants, DEC10 MLAB.



Authors: Westerhoff, Hans V.; Tsong, Tian Yow; Chock, P.B.; Chen, Yi-der; Astumian, R.D.
Title: How Enzymes Can Capture and Transmit Free Energy From an Oscillating Electric Field
Source: Proc. Natl. Acad. Sci. 83 (1986) 4734-4738
Description: solved 2 diff. eqs.



Authors: Yeh, Herman J.C.; Balari, Suresh K.; Yagi, Haruhiko; Greene, Ruth M.E.; Sharma, Narain D.; Boyd, Derek R.; Jerina, Donald M.
Title: Use of Chiral Lanthanide Shift Reagents in the Determination of Enantiomer Composition and Absolute Configuration of Epoxides and Arene Oxides
Source: J. Org. Chem. 51 (1986) 5439-5443
Description: values of limiting chemical shift and rate constant were determined by fitting data observed as function of added shift reagent.



Authors: Zaharko, Daniel S.; Griesheber, Charles K.; Plowman, Jacqueline; Cradock, James C.
Title: Therapeutic and Pharmacokinetic Relationships of Flavone Acetic Acid: An Agent with Activity Against Solid Tumors
Source: Cancer Trt. Rep. 70 (1986) 1415-1421
Description: fit plasma concentration in time to biexponential model.


1987


Title: Evaluation of Models for Analysis of Radioligand Binding Data
Source: Mol. Pharm. 31 (1987) 103-111
Description: ternary complex model, two-independent-receptor model, DEC10 MLAB
Authors: Abramson, Stewart N.; McGonigle, Paul; Molinoff, Perry B.
Title: Annotated List of Laboratory Experiments Available
Source: J. Chem. Ed 64 (1987) 439



Authors: Anderson, Lawrence W.; Zaharevitz, Daniel W.; Strong, John M.
Title: Glutamine and Glutamate: Automated Quantification and Isotopic Enrichments by Gas Chromotography/Mass Spectrometry
Source: Anal. Bioch. 163 (1987) 358-368
Description: linear regression analysis



Authors: Anderson, S.M.; Leu, J.R.; Kant, G.J.
Title: Effects of Stress on [3-H] Cyclohexyladenosine Binding to Rat Brain Membranes
Source: Pharm. Bio. and Behav. 26 (1987) 829-833
Description: single and dual site (or state) receptor models were fitted to data by using a computer assisted nonlinear least squares curve fitting technique.



Authors: Arndt, Carola A.S.; Colvin, O. Michael; Balis, Frank M.; Lester, Cynthia M.; Johnson, Gloria; Poplack, David G.
Title: Intrathecal Administration of 4-Hydroperoxycyclophosphamide in Rhesus Monkeys
Source: Cancer Res. 47 (1987) 5932-5934
Description: CSF disappearance curves following iv 4-HC administration were fit to monoexponential curve.



Authors: Bille, Vincent; Plainchamp, Dominique; Remacle, Jose
Title: Affinity and Stability Modifications of Immobilized Alcohol Dehydrogenase through Multipoint Copolymerization
Source: Bioch. Biophys. A. 915 (1987) 393-398
Description: Michaelis parameters, DEC20 MLAB



Authors: Bjornbom, Pehr
Title: Modelling of a Double-Layered PTFE-Bonded Oxygen Electrode
Source: Electroch. Acta 32 (1987) 115-119
Description: Kinetic equation for a flooded catalyst aggregate.



Authors: Bozzato, Richard P.; Tinker, David O.
Title: Purification and Properties of Two Phospholipid Transfer Proteins from Yeast
Source: Biochem. Cell Biol. 65 (1987) 195-202
Description: Transfer activities were determined by measurement of the fractional transfer (in triplicate) at a number of time points (usually 3 or 4) and calculating the true initial velocity by curve fitting.



Authors: Bozzato, Richard P.; Woolley, Drew; Tinker, David O.
Title: Catalytic Properties of the Yeast Phospholipid Transfer Protein
Source: Biochem. Cell Biol. 65 (1987) 203-210
Description: reaction time points were fitted to f*(1-exp(-k*t)).



Authors: Brenner, Dean E.; Anthony, Lowell B.; Halter, Susan; Harris, N. Lindsay; Collins, Jerry C.; Hande, Kenneth R.
Title: Effect of Allyl Alcohol-induced Sublethal Hepatic Damage Upon Doxorubicin Metabolism and Toxicity in the Rabbit
Source: Cancer Res. 47 (1987) 3259-3265
Description: Doxorubicin plasma conc. fit to biexponential model, calculated area under curve.



Authors: Bruno, Jordi
Title: Beryllium (II) Hydrolysis in 3.0 mol/dm^3 Perchlorate
Source: J. Chem. Soc. Dalton (1987) 2431-2437
Description: graphical interpretation made with MLAB.



Authors: Bruno, Jordi; Grenthe, Ingmar; Munoz, Maria
Title: Studies of Metal Carbonate Equilibria. Part 16. The Beryllium (II) Water-Carbon Dioxide (g) System in Neutral-to-Alkaline 3.0 mol/dm^3 Perchlorate Media at 25 degrees C
Source: J. Chem. Soc. Dalton (1987) 2445-2449
Description: used MLAB to calculate unknown solubility constants by least squares fit.



Authors: Bruno, Jordi; Grenthe, Ingmar; Sandstrom, Magnus; Ferri, Diego
Title: Studies of Metal Carbonate Equilibria. Part 15. The Beryllium (II)-Water-Carbon Dioxide (g) System in Acidic 3.0 mol/dm^3 Perchlorate Media
Source: J. Chem. Soc. Dalton (1987) 2439-2444
Description: fit rate constants.



Authors: Buysschaert, Martin; Moulant, Michel; Urbain, Jean Luc; Pauwels, Steny; de Roy, Luc; Ketelslegers, Jean Marie; Lambert, Andre E.
Title: Impaired Gastric Emptying in Diabetic Patients with Cardiac Autonomic Neuropathy
Source: Diabetes Care 10 (1987) 448-452
Description: initial radioactivity in stomach at time t fit to 2^(-t/thalf)^beta.



Authors: Byrd, James C.; Bykov, Victor; Rothman, Richard B.
Title: Rat Brain PCP Receptors: Alterations in Binding Parameters Following Chronic Administration of Opiate Agonists and Antagonists
Source: Neruopeptides 10 (1987) 201-205
Description: displacement curves analyzed with MLAB.



Authors: Colombatti, Marco; Johnson, Virginia G.; Skopicki, Hal A.; Fendley, Brian; Lewis, Marc S.; Youle, Richard J.
Title: Identification and Characterization of a Monoclonal Antibody Recognizing a Galactose-Binding Domain of the Toxin Ricin
Source: J. Immunology 138 (1987) 3339-3344
Description: analytical ultracentrifuge scans obtained after equation was attained.



Authors: Dodion, Pierre F.; Abrams, Jeffrey; Gerard, Beatrice; Crespeigne, Nadine; Peeters, Bernadette; Van Berchem, Christine; Kenis, Yvon
Title: Clinical and Pharmacokinetic Phase I Trial with the Diethyl-Amino Ester of Flavone Acetic Acid (LM985, NSC293015)
Source: Eur. J. Cancer 23 (1987) 837-842
Description: single exponential fit by weighted least squares.



Authors: Dodion, P.; Bron, D.; Mattelaer, M.A.; Loos, M.; Delforge, A.; Rozencweig, M.; Stryckmans, P.; Kenis, Y.
Title: Sensitivity of Normal Human Bone Marrow Myeloid Progenitor Cells to Anthracycline, Cisplatin, Anthracene, and Flavone Acetic Acid Derivatives, and Its Relevance for the Prediction of Human Plasma Concentrations of Anticancer Drugs
Source: Eur. J. Cancer 23 (1987) 1901-1908
Description: semi-logarithmic linear regression



Authors: Egorin, Merrill J.; Conley, Barbara A.; Forest, Alan; Zuhowski, Eleanor G.; Sinibaldi, Vickie; Van Echo, David A.
Title: Phase I Study and Pharmacokinetics of Menogaril (NSC 269148) in Patients with Hepatic Dysfunction
Source: Cancer Res. 47 (1987) 6104-6110
Description: plasma conc. of menogaril, Hill equation, Nelder-Mead.



Authors: Egorin, Merrill J.; Sigman, Lawrence M.; Van Echo, David A.; Forest, Alan; Whitacre, Margaret Y.; Aisner, Joseph
Title: Phase I Clinical and Pharmacokinetic Study of Hexamethylene Bisacetamide (NSC 95580) Administered as Five-Day Continuous Infusion
Source: Cancer Res. 47 (1987) 617-623
Description: plasma conc. of HMBA decline modeled with MLAB, Nelder-Mead with ADAPT.



Authors: Fernandez, L.; Aparacio, J.; Muhammed, M.
Title: The Role of Feed Metal Concentration in the Coupled Transport of Zinc through a Bis-(2-Ethylhexyl) Phosphoric Acid Solid Supported Liquid Membrane from Aqueous Perchlorate Media
Source: Sep. Science and Tech. 22 (1987) 1577-1595
Description: fit model flux equations to whole set of experimental data



Authors: Greene, Raymond F.; Miser, Angela W.; Lester, Cindy M.; Balis, Frank M.; Poplack, David G.
Title: Cerebrospinal Fluid and Plasma Pharmacokinetics of Morphine Infusions in Pediatric Cancer Patients and Rhesus Monkeys
Source: Pain 30 (1987) 339-348
Description: triexponential equation, area under curve



Authors: Greig, Nigel H.; Momma, Seiji; Sweeney, Daniel J.; Smith, Quentin R.; Rapoport, Stanley I.
Title: Facilitated Transport of Melphelan at the Rat Blood-Brain Barrier by the Large Neutral Amino Acid Carrier System
Source: Cancer Res. 47 (1987) 1571-1576
Description: melphelan concentration-time data fit to biexponential, determined plasma half-life, Michaelis Menten kinetics, DEC10 MLAB.



Authors: Greig, N.H.; Sweeney, D.J.; Rapoport, S.I.
Title: Melphelan Concentration Dependent Plasma Protein Binding in Healthy Humans and Rats
Source: Eur. J. Clin. Pharm. 32 (1987) 179-185
Description: Scatchard plots



Authors: Grigorescu, F.; Herzberg, U.; King, G.; Meistas, M.; Elders, J.; Frazer, T.; Kahn, C.R.
Title: Defects in Insulin Binding and Autophophorylation of Erythrocyte Insulin Receptors in Patients with Syndromes of Severe Insulin Resistance and Their Parents
Source: J. Clin. End. 64 (1987) 549-556
Description: logistic equation for total insulin conc. versus 125-I insulin bound/free.



Authors: Herblin, W.F.; Kauer, J.C.; Tam, S.W.
Title: Photoinactivation of the Mu Opioid Receptor Using a Novel Synthetic Morphiceptin Analog
Source: Eur. J. Pharm. 139 (1987) 273-279
Description: [3-H] Naloxone binding data fit to simple equation for single binding site.



Authors: Ho, S.P.; DeGrado, W.F.
Title: Design of a 4-helix bundle protein: Synthesis of Peptides which Self-Associate into a Helical Protein
Source: JACS 109 (1987) 6751-6758



Authors: Horwitz, B.; Grady, C.L.; Schlageter, N.L.; Duara, R.; Rapoport, S.I.
Title: Intercorrelations of Regional Cerebral Glucose Metabolic Rates in Alzheimer's Disease
Source: Brian Res. 407 (1987) 294-306
Description: correlation matrix plots.



Authors: Hubbard, Michael J.; Klee, Claude B.
Title: Calmodulin Binding By Calcineurin
Source: J. Biol. Chem. 262 (1987) 15062-15070
Description: curve fitting and graphics with DEC10 MLAB, equilibrium binding data fit to Hill equation.



Authors: Jimenez, B.D.; Cirmo, C.P.; McCarthy, J.F.
Title: Effects of Feeding and Temperature on Uptake, Elimination, and Metabolism of benzo(alpha)pyrene in the bluegill sunfish (Lepomis macrochirus)
Source: Aquat. Tox. 10 (1987) 41-57
Description: two compartment model, fish and water; curve fit decrease in radioactivity with time to polynomial



Authors: Juillerat, Marcel A.; Taniuchi, Hiroshi
Title: Intramolecular Flip Between Two Alternative Forms of Complex Formed from a Heme Fragment and Apoprotein of Horse Cytochrome c
Source: J. Biol. Chem. 262 (1987) 13440-13448
Description: fit parameters in integrated form of van't Hoff equation.



Authors: Kasid, Usha N.; Dritschilo, Anatoly; Rhim, Johng S.
Title: Human Epidermal Keratinocytes Retain Radiation Resistance Following in Vitro Immortalization and Malignant Transformation
Source: Radiation Res. 111 (1987) 565-571
Description: survival curve s = (1-(1-exp(-d/d0))^n).



Authors: Kelley, James A.; Litterst, Charles L.; Roth, Jeri S.; Vistica, David T.; Poplack, David G.; Cooney, David A.; Nadkarni, Mohan; Balis, Frank M.; Broder, Samuel; Johns, David G.
Title: The Disposition and Metabolism of 2',3'-Dideoxycytidine, an in Vitro Inhibitor of Human T-Lymphotrophic Virus Type III Infectivity, in Mice and Monkeys
Source: Drug Metab. 15 (1987) 595
Description: biexponential model for plasma concentration.



Authors: Kriauciunas, Kristina M.; Grigorescu, Florin; Kahn, C. Ronald
Title: Effects of Heparin on Insulin Binding and Biological Activity
Source: Diabetes 36 (1987) 163-168
Description: Scatchard plots



Authors: Levin, Arthur A.; Kilpper, Robert W.; Miller, Richard K.
Title: Fetal Toxicity of Cadmium Chloride: The Pharmacokinetics in the Pregnant Wistar Rat
Source: Teratology 36 (1987) 163-170
Description: biexponential model of blood concentration data



Authors: Lipnick, R.L.; Watson, K.R.; Strausz, A.K.
Title: A QSAR Study of the Acute Toxicity of Some Industrial Organic Chemicals to Goldfish. Narcosis, Electrophile, and Proelectrophile Mechanisms
Source: Xenobiotica 17 (1987) 1011-1025
Description: quantitative structure-activity relationships, log P parameter



Authors: Martin, Roy W.; Hill, Harlan F.; Yee, Hsiao Ching; Saeger, Louis C.; Walter, M. Hildegard; Chapman, C. Richard
Title: An Open-Loop Computer-Based Drug Infusion System
Source: IEEE Biomed. 34 (1987) 642-649
Description: biexponential model of plasma concentration.



Authors: Morris, Marilyn E.; Pang, K. Sandy
Title: Competition Between Two Enzymes for Substrate Removal in Liver: Modulating Effects Due to Substrate Recruitment of Hepatocyte Activity
Source: J. Pharm. Bioph. 15 (1987) 473
Description: fit Km and Vmax in Michaelis Menten equation for 3 models.



Authors: Moyer, James D.; Peizes, Ofer; Dean, Nicholas M.; Malinowski, Nancy
Title: D-Myo-Inositol (1,4)-Bisphosphate 1-Phosphatase. Partial Purification from Rat Liver and Characterization
Source: Biochem. Biophys. Res. 146 (1987) 1018-1026
Description: linear regression



Authors: Namba, Hiroki; Lucignanni, Giovanni; Nehlig, Astrid; Patlak, Clifford; Pettigrew, Karen; Kennedy, Charles; Sokoloff, Louis
Title: Effects of Insulin on Hexose Transport Across Blood-Brain Barrier in Normoglycemia
Source: Am. J. Physiol. 252 (1987) E299
Description: ci(t) = k1*exp(-k2*t)*integral(x,0,t,cp(t)*exp(k2*t)).



Authors: Odman, Suarte; Levitan, Herbert; Robinson, Peter J.; Michel, Mary Ellen; Ask, Per; Rapoport, Stanley I.
Title: Peripheral Nerve as an Osmometer: Role of Endoneurial Capillaries in Frog Sciatic Nerve
Source: Am. J. Physiol. 252 (1987) C335-C341
Description: fit initial rate of change of nerve diameter as quadratic function of time.



Authors: Piantadosi, Steven
Title: Generalizing Growth Functions Assuming Parameter Heterogeneity
Source: Growth 51 (1987) 50-63
Description: fitting data



Authors: Piantadosi, Steven; Patterson, Blossom
Title: A Method for Predicting Accrual, Cost, and Paper Flow in Clinical Trials
Source: Contr. Clin. Tr. 8 (1987) 202-215
Description: the numerical tasks involved in this procedure are greatly simplified by using MLAB.



Authors: Plowman, Jacqueline; Harrison, Steadman D., Jr.; Trader, Mary W.; Griswold, Daniel P., Jr.; Chadwick, Marjory; McComish, Madeline F.; Silveira, Denise M.; Zaharko, Daniel
Title: Preclinical Antitumor Activity and Pharmacological Properties of Deoxyspergualin
Source: Cancer Res. 47 (1987) 685-689
Description: plasma data fitted to bi-exponential model.



Authors: Rechthand, Emanuel; Smith, Quentin R.; Latker, Carole H.; Rapoport, Stanley I.
Title: Altered Blood-Nerve Barrier Permeability to Small Molecules in Experimental Diabetes Mellitus
Source: J. Neuropath. and Exp. Neurol. 46 (1987) 302-314
Description: integrated plasma concentrations from t=0 to T calculated for each animal from arterial plasma samples on DEC10 employing MLAB.



Authors: Rechthand, Emanuel; Smith, Quentin R.; Rapoport, Stanley I.
Title: Transfer of Nonelectrolytes from Blood into Peripheral Nerve Endoneurium
Source: Am. J. Physiol. 252 (1987) H1175-H1182
Description: plasma concentration-time integral calculated with DEC10 MLAB from arterial plasma samples.



Authors: Rothman, Richard B.; Bykov, Victor; Cadet, Jean L.; Kleinman, Joel E.
Title: A Postmortem Study of the Effect of Chronic Opiate Abuse on Psychotomimetic Binding Sites of Human Frontal Cortex
Source: Neuropeptides 10 (1987) 261-264
Description: Binding parameters Kd and Bmax were determined by fitting each surface to a one site binding model.



Authors: Rothman, Richard B.; Jacobson, Arthur E.; Rice, Kenner C.; Herkenham, Miles
Title: Autoradiographic Evidence for Two Classes of Mu Opioid Binding Sites in Rat Brain Using [125-I] FK33824
Source: Peptides 8 (1987) 1015-1021
Description: data were fit to two-site binding model.



Authors: Schroyens, Wilfried A.; Dodion, Pierre F.; Sanders, Charlotte; Loos, Micheline; Dethier, Nathalie E.; Delforge, Alain R.; Stryckmans, Pierre A.; Kenis, Yvon
Title: In Vitro Chemosensitivity Testing of Flavone Acetic Acid (LM975; NSC347512) and Its Diethylaminethyl Ester Derivative (LM985; NSC293015)
Source: Eur. J. Canc. C. 23 (1987) 1135
Description: semilogarithmic linear regression.



Authors: Shubat, P.J.; Banner, W., Jr.; Huxtable, R.J.
Title: Pulmonary Vascular Responses Induced by the Pyrrolizidine Alkaloid, Monocrotaline in Rats
Source: Toxicon 25 (1987) 995-1002
Description: nonlinear regression of dose-response curve



Authors: Smith, Quentin R.; Momma, Seiji; Aoyagi, Masaki; Rapoport, Stanley I.
Title: Kinetics of Neutral Amino Acid Transport Across the Blood-Brain Barrier
Source: J. Neurochem. 49 (1987) 1651-1658
Description: Vmax, Km, Kd were obtained by fitting Michaelis Menten to perfusion data



Authors: Smith, Robert; Preston, Robin R.; Schulz, Stephanie; Gagnon, Michael L.; Van Houlten, Judith
Title: Correlations Between Cyclic AMP Binding and Chemoreception in Paramecium
Source: Bioch. Biophys. A. 928 (1987) 171-178
Description: CPM versium -log(cAMP molarity) binding curve



Authors: Thomas, David J.; Fisher, Henry L.; Sumler, Martha R.; Mushak, Paul; Hall, Larry L.
Title: Sexual Differences in the Excretion of Organic and Inorganic Mercury by Methyl Mercury-Treated Rats
Source: Env. Res. 43 (1987) 203-216
Description: percent injected dose fit to linear combination of two exponentials.



Authors: Tietz, Dietmar; Gombocz, Erich; Chrambach, Andreas
Title: Characterization of Subcellular Particles by Size, Charge, and Apparent Compressibility on the Basis of Mobility in Agarose Gel Electrophoresis: Procedures of Computer Simulation
Source: Electrophoresis 8 (1987) 271-285
Description: fit nonlinear Ferguson plots.



Authors: Tobacman, L.S.
Title: Activation of Actin-Cardiac Myosin Subfragment 1 Magnesium- ATPase rate by Calcium Shows Cooperativity Intrinsic to the Thin Filament
Source: Biochem. 26 (1987) 492-497



Authors: Valcour, A.A.; Woodworth, R.C.
Title: Proton Nuclear Magnetic Resonance Spectroscopy of Human Transferrin N-Terminal Half-Molecule: Titration and Hydrogen-Deuterium Exchange
Source: Biochem. 26 (1987) 3120-3125
Description: Deuterium ion concentration, proton ion concentration, versus chemical shift fit to expression involving Hill coefficient.



Authors: Weber, Annemarie; Northrop, Jennifer; Bishop, Marilyn F.; Ferrone, Frank A.; Mooscher, Mark S.
Title: Nucleation of Actin Polymerization by Villin and Elongation at Subcritical Monomer Concentration
Source: Biochem. 26 (1987) 2528-2536
Description: used Marquardt routine from Bevington instead of MLAB



Authors: Weber, E.J.; Wolfe, N.L.
Title: Kinetic Studies of the Reduction of Aromatic Azo Compounds in Anaerobic Sediment/Water Systems
Source: Env. Tox. Chem. 6 (1987) 911-919
Description: pseudo first order rate law change in concentration vs. time



Authors: Wroblewska, B.; Kumami, K.; Cvejic, V.; Mrsulja, B.B.; Spatz, M.
Title: Cerebrocortical Modulation of S2-Receptors and Turnover Rate of 5-Hydroxytryptamine in Ischemia
Source: Neurochem. Res. 12 (1987) 21-25
Description: wherever biphasic shape of the curves suggested more than 1 binding site fit multiple site binding model, Scatchard analysis


1988

Authors: Anderson, S.M.; Leu, J.R.; Kant, G.J.
Title: Chronic Stress Increases the Binding of the A1 Adenosine Receptor Agonist, [3-H] Cyclohexyladenosine, to Rat Hypothalamus
Source: Pharm. Biochem. Behav. 30 (1988) 169-175
Description: saturation curves fit to single and dual site receptor models.



Authors: Babior, Bernard M.; Kuves, Rahul; Curnutte, John T.
Title: Kinetics of Activation of the Respiratory Burst Oxidase in a Fully Soluble System from Human Neutrophils
Source: J. Biol. Chem. 263 (1988) 1713-1718
Description: nonlinear regression



Authors: Balis, Frank M.; Miro, Joseph, Jr.; Reaman, Gregory H.; Evans, William E.; McCully, Cynthia; Doherty, Karen M.; Murphy, Robert F.; Jeffries, Susan; Poplack, David G.
Title: Pharmacokinetics of Subcutaneous Methotrexate
Source: J. Clin. Onc. 6 (1988) 1882-1886
Description: biexponential model, bioavailability, area under curve.



Authors: Blanchard, James; Boyle, Jay O.; Van Wagenen, Stan
Title: Determination of the Partition Coefficients, Acid Dissociation Constants, and Intrinsic Solubility of Carbenoxolone
Source: J. Pharm. Sci. 77 (1988) 548-552
Description: solubility vs. pH data fit to model, Henderson-Hasselbach equation.



Authors: Brady, Linda S.; Rothman, Richard B.; Herkenham, Miles
Title: Physiological Regulation of Neurohypophyseal Kappa Opiate Receptors
Source: Brain Res. 443 (1988) 398-402
Description: fit data to one-site competitive binding model.



Authors: Danks, Janine A.; Tortella, F.C.; Long, J.B.; Bykov, V.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W.; Rothman, R.B.
Title: Chronic Administration of Morphine and Naltrexone Up-Regulate [3-H] [D-Ala2-D-Leu5] Enkephalin Binding Sites by Different Mechanisms
Source: Neuropharm. 27 (1988) 965-974
Description: binding surfaces fit to 1 site binding model to find Bmax and Kd.



Authors: Del Vecchio, Silvana; Reynolds, James C.; Blasberg, Ronald G.; Neumann, Ronald D.; Cartasquillo, Jorge A.; Hellstrom, Ingegard; Larson, Steven M.
Title: Measurement of Local Mr 97,000 and 250,000 Protein Antigen Concentration in Sections of Human Melanoma Tumor Using in Vitro Quantitative Autoradiography
Source: Cancer Res. 48 (1988) 5475-5481
Description: results of staturation study, Bmax and Kd



Authors: Dodion, P.; de Valeriola, D.; Crespeigne, N.; Peeters, B.; Wery, F.; Van Berchem, C.; Piccart, M.; Tueni, E.; Gopggi, J.; Kenis, Y.
Title: Phase I Clinical and Pharmacokinetic Trial of Oral Menogaril Administered on Three Consecutive Days
Source: Eur. J. Cancer 24 (1988) 1019-1026
Description: weighted least squares fit of plasma concentration curves to biexponential model.



Authors: Ellis, John
Title: Method for Comparing Selectivities of Unlabelled Subpopulation Selective Ligands: Application to Muscarinic Receptors
Source: J. Receptor Res. 8 (1988) 885-900
Description: 2 site binding of 2 competitors, simulations on DEC20 MLAB



Authors: Frankenne, F.; Closset, J.; Gomez, F.; Scippo, M.L.; Smal, J.; Hennen, G.
Title: The Physiology of Growth Hormones (GHs) in Pregnant Women and Partial Characterization of the Placental GH Variant
Source: J. Clin. End. 66 (1988) 1171-1180
Description: affinity constants determined from Scatchard plots analysis, DEC20 MLAB



Authors: Gillis, Anne M.; Kates, Robert E.
Title: Effect of pH on the Myocardial Uptake and Pharmacodynamics of Propafenone in the Isolated Rabbit Heart
Source: J. Cardiovasc. Pharm. 12 (1988) 526-534
Description: exponential model, time-integral.



Authors: Greig, Nigel H.; Fredericks, Wendy R.; Halloway, Harold W.; Soncrant, Timothy T.; Rapoport, Stanley I.
Title: Delivery of Human Interferon-Alpha to Brain by Transient Osmotic Blood-Brain Barrier Modification in the Rat
Source: J. Pharm. Exp. 245 (1988) 581
Description: exponential decay curve fit of brain concnetration data



Authors: Greig, Nigel H.; Sweeney, Daniel J.; Rapoport, Stanley I.
Title: Comparative Brain and Plasma Pharmacokinetics and Anticancer Activities of Chlorambucil and Melphalan in the Rat
Source: Cancer Chemot. 21 (1988) 1-8
Description: single n biexponential equation, melphalan and chlorambucil concentration-time data



Authors: Hahn, Elisabeth; Wurts, Linda; Tietz, Dietmar; Chrambach, Andreas
Title: Linear Ferguson Plots of Polystyrene Sulfate Size Standards for the Quantitative Agarose Gel Electrophoresis of Subcellular Particles
Source: Electrophoresis 9 (1988) 243-255
Description: Ferguson plots, do-file, DEC10 MLAB



Authors: Heideman, Richard L.; Balis, Frank M.; McCully, Cynthia; Poplack, David G.
Title: Preclinical Pharmacology of Arabinosyl-5-Azacytidine in Nonhuman Primates
Source: Cancer Res. 48 (1988) 4294-4298
Description: plasma concentration time data fit to multi-exponential functions.



Authors: Heideman, Richard L.; Kelley, James A.; Packer, Roger J.; Reaman, Gregory H.; Roth, Jeri S.; Balis, Frank; Ettinger, Lawrence J.; Doherty, Karen M.; Jeffries, Susan L.; Poplack, David G.
Title: A Pediatric Phase I and Pharmacokinetic Study of Spirohydantoin Mustard
Source: Cancer Res. 48 (1988) 2292-2295
Description: SHM plasma conc. fit to biexponential model



Authors: Horwitz, Barry
Title: Neuroplasticity and the Progression of Alzhiemer's Disease
Source: Int. J. Neurosci. 41 (1988) 1-14
Description: density of neuritic placques in its cortical projection area as a function of per cent loss of cells in a subpopulation of cholinergic forebrain



Authors: Huguenin, P.N.; Zulliger, H.W.; Niederer, R.
Title: In Vitro-in Vivo Correlation Exemplified by Sustained Release Formulations of Suprofen
Source: Arzneim.-Forsch. 38 (1988) 305-308
Description: dissolution data as function of percentage dissolved fit to Weibull distribution.



Authors: Indalicato, J.M.; Parsini, C.E.
Title: The Acylating Potential of gamma-lactam Antibacterials: Base Hydrolysis of Bicyclic Pyrazolidinones
Source: J. Med. Chem. 31 (1988) 1227-1230



Authors: Janzon, Bo; Schantz, Birger; Seeman, Torsten
Title: Scale Effects in Ballistic Wounding
Source: J. Trauma 28 (1988) S29-S32
Description: standard statistical methods were used, and computations of linear regression, mean, and standard error of the mean with MLAB.



Authors: Koster, Johanna; Destree, Olivier H.J.; Westerhoff, Hans V.
Title: Kinetics of Histone Gene Expression during Early Development of Xenopus laevis
Source: J. Theor. Biol. 135 (1988) 139-167
Description: used integrate statement to find RNA concs. as a function of time.



Authors: Lapointe, David S.; Hildebrandt, Ellen; Buxton, Dennis B.; Patel, Tarun B.; Waymack, Parvan P.; Olson, Merle S.
Title: Measurement of Branched-Chain Alpha-Keto Acid Dehydrogenase Flux Rates in Perfused Heart and Liver
Source: Methods Enzym. 166 (1988) 484-497
Description: fit sum of exponentials using SAAM, MLAB, curve peeling of the data, half-life of 14-CO2 washout from liver.



Authors: Lee, Edward J.; Egorin, Merrill J.; Van Echo, David A.; Cohen, Adam E.; Tait, Nancy; Schiffer, Charles A.
Title: Phase I and Pharmacokinetic Trial of Carboplatin in Refractory Adult Leukemia
Source: JNCI 80 (1988) 131-135
Description: computer modeling of decline in plasma concentration of unfilterable and total platinum accumulate as sum of two exponentials.



Authors: Litterst, Charles L.; Magin, Richard
Title: Alterations in Plasma Pharmacokinetics of Cisplatin in Tumor Bearing Rats
Source: Cancer Chemot. 22 (1988) 1-4
Description: plasma decay of radioactivity over 96 hour time course fit to 3 compartment model.



Authors: Maes, M.; Amand, Y.; Underwood, L.E.; Maiter, D.; Ketelslegers, J.-M.
Title: Decreased Serum Insulin-Like Growth Factor I Response to Growth Hormone in Hypophysectomized Rats Fed a Low Protein Diet: Evidence for a Postreceptor Defect
Source: Acta Endocrin. 117 (1988) 320-326
Description: binding inhibition experiments expressed as bound vs free hormone concentration, analysis of curves with MLAB.



Authors: Majumdar, Chirabrata; Abbotts, John; Broder, Samuel; Wilson, Samuel H.
Title: Studies on the Mechanism of Human Immunodeficiency Virus Reverse Transcriptase
Source: J. Biol. Chem. 263 (1988) 15657-15665
Description: Michaelis Menten constants.



Authors: Merril, Carl R.; Bisher, Magaret E.; Harrington, Michael; Steven, Alasdair C.
Title: Coloration of Silver-Stained Protein Bands in Polyacrylamide Gels is Caused by Light Scattering from Silver Grains of Characteristic Sizes
Source: Proc. Natl. Acad. Sci. 85 (1988) 453-457
Description: statistical analysis using DEC10 MLAB.



Authors: Mihalyi, Elemer
Title: Clotting of Bovine Fibrinogen: Kinetic Analysis of the Release of Fibrinopeptides by Thrombin and of the Calcium Uptake Upon Clotting at High Fibrinogen Concentrations
Source: Biochem. 27 (1988) 976-982
Description: 3 data sets were analyzed by nonlinear least squares curve fitting, 1,2, and 3 exponential models.



Authors: Miles, Edith Wilson; McPhie, Peter; Yutani, Katsuhide
Title: Evidence that Glutamic Acid 49 of Tryptophan Synthase Alpha Subunit is a Catalytic Residue
Source: J. Biol. Chem. 263 (1988) 8611-8614
Description: circular dichroism data at 285nm, 289nm collected. To determine maximum changes in ellipticity at each wavelength, results fitted to quadratic root formula.



Authors: Mostow, William R.; Ferguson, Allan G.; Lesch, Michael; Decker, Robert S.; Samarel, Allen M.
Title: Nonrandom Turnover of Actin and Tubulin in Cultured Rabbit Cardiac Fibroblasts
Source: Am. J. Physiol. 255 (1988) C202-C213
Description: precursor-product turnover model fit and total protein accumulation curve = a*(1-exp(-b*x))-c*(1-exp(-d*x))+k



Authors: Orzi, F.; Lucignani, G.; Dow-Edwards, D.; Namba, H.; Nehlig, A.; Patlak, C.S.; Pettigrew, K.; Schrier, F.; Sokoloff, L.
Title: Local Cerebral Glucose Utilization in Controlled Graded Levels of Hyperglycemia in the Conscious Rat
Source: J. Cereb. Bl. Fl. 8 (1988) 346-356
Description: least squares fit of integrated plasma concentration in time.



Authors: Persson, Karl-Axel; Berg, Sven; Tornqvist, Margareta; Scalia-Tomba, Gian-Paolo; Ehrenberg, Lars
Title: Note on Ethene and Other Low-Molecular Weight Hydrocarbons in Environmental Tobacco Smoke
Source: Act. Chem. B 42 (1988) 690-696
Description: fit ordinary differential equation for concentration of hydrocarbon in air.



Authors: Rahman, Aquilur; Roh, Jae Kyung; Wolpert-De Filippes, Mary K.; Goldin, Abraham; Venditti, John M.; Woolley, Paul V.
Title: Therapeutic and Pharmacological Studies of Tetrachloro (d,l-trans) 1,2-Diaminocyclohexane Platinum (IV) (Tetraplatin), a New Platinum Analogue
Source: Cancer Res. 48 (1988) 1745-1752
Description: plasma levels fit to biexponential model with constraints



Authors: Rechthand, Emanuel; Smith, Quentin R.; Rapoport, Stanley I.
Title: A Compartmental Analysis of Solute Transfer and Exchange Across Blood-Nerve Barrier
Source: Am. J. Physiol. 255 (1988) R317-R325
Description: DEC10 computer employing MLAB was used for curve fitting of models of nerve plasma exchange and calculating plasma concentration time integrals.



Authors: Reeves, Philip T.; Minchin, Rodney F.; Ilett, Kenneth F.
Title: Induction of Sulfamethazine Acetylation by Hydrocortisone in the Rabbit
Source: Drug Metab. 16 (1988) 110-115
Description: Michaelis Menten equation fitted to data using MLAB, Km and Vmax estimated



Authors: Rothman, Richard B.; Bykov, Victor; Hauck-Newman, Amy; Jacobson, A.E.; Rice, Kenner C.
Title: Interaction of Enantiomeric Pairs of Opiates with Phencyclidine Binding Sites in Rat Brain: Identification of (+) Pentazocine as a Ligand Potentially Suitable for Imaging Sigma Binding Sites Using Positron Emission Tomography
Source: Neuropeptides 12 (1988) 1-5
Description: binding surfaces were fit to a one-site model.



Authors: Rothman, Richard B.; Bykov, Victor; Ofri, Danielle; Rice, Kenner C.
Title: LY164929-A Highly Selective Ligand for the Lower Affinity [3H]D-Ala2-D-Leu-5-Enkephalin Binding Site
Source: Neuropeptides 11 (1988) 13
Description: ligand binding models



Authors: Rothman, Richard B.; Bykov, Victor; Rice, Kenner C.; Jacobson, Arthur E.; Kooper, Grace N.; Bowen, Wayne D.
Title: Tritiated-6-Beta-Fluoro-6-Desoxy-Oxymorphone ([3H]FOXY)- A New Ligand and Photoaffinity Probe for the MU Opioid Receptors
Source: Neuropeptides 11 (1988) 1
Description: ligand binding models



Authors: Rothman, Richard B.; Long, Joseph B.; Bykov, Victor; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W.
Title: Beta-FNA Binds Irreversibly to the Opiate Receptor Complex: In Vivo and In Vitro Evidence
Source: J. Pharm. Exp. 247 (1988) 405
Description: weighted least squares curve fitting of 1 or 2 site competitive binding models



Authors: Sayer, J.M.; Grossman, S.J.; Adusei-Poku, K.S.; Jerina, D.M.
Title: Kinetics and Mechanism of Solvolysis of Precocene I 3,4-Oxide: Change in Rate-Determining Step and Trapping of an Intermediate in an Epoxide Solvolysis Reaction
Source: JACS 110 (1988) 5068-5074
Description: analysis of the data by double-reciprocal plots or MLAB gave values of rate constant.



Authors: Schaefer, Erik M.; Moehring, Joan M.; Moehring, Thomas J.
Title: Binding of Diptheria Toxin to CHO-K1 and Vero Cells is Dependent on Cell Density
Source: J. Cell Physiol. 135 (1988) 407-415
Description: binding of 125-I-labelled DTX to low density vero cells curves drawn and analyzed by nonlinear curve fit.



Authors: Schloss, John V.
Title: Comparative Affinities of the Epimeric Reaction-Intermediate Analogs 2- and 4- Carboxy-D-Arabinitol 1,5-Bisphosphate for Spinach Ribulose 1,5-Bisphosphate Carboxylase
Source: J. Biol. Chem. 263 (1988) 4145-4150
Description: fit several models comprised of exponentials.



Authors: Snell, S.M.; Marini, M.A.
Title: A Convenient Spectroscopic Method for the Estimation of Hemoglobin Concentrations in Cell-Free Solutions
Source: J. Biochem. Biophys. Meth. 17 (1988) 25-34
Description: the pK' calculated for a variety of wavelengths is 7.99 +/- .08 using curve-fitting algorithm in MLAB.



Authors: Steer, Clifford J.; Bisher, Margaret E.; Trus, Benes L.; Hainfeld, James F.; Wall, Joseph S.; Steven, Alasdair C.
Title: Membrane Contents of Distinct Subpopulations of Coated Vesicles Determined by Scanning Transmission Electron Microscopy
Source: Bioch. Biophys. A. 938 (1988) 167-180
Description: histograms and statistical procedures.



Authors: Thakker, Dhiren R.; Boehlert, Charles; Mirsadeghi, Seid; Levin, Wayne; Ryan, Deni E.; Thomas, Paul E.; Yagi, Haruhiko; Pannell, Lewis K.; Sayer, Jane M.; Jerina, Donald M.
Title: Differential Stereoselectivity on Metabolism of Triphenylene by Cytochromes P-450 in Liver Microsomes from 3-Methylcholantrene- and Phenobarbital-Treated Rats
Source: J. Biol. Chem. 263 (1988) 98-105
Description: time courses of mole fraction of oxide formed, described by first order differential rate equations.



Authors: Weiss, Raymond B.; Greene, Raymond F.; Knight, Robert D.; Collins, Jerry M.; Pelosi, John J.; Sulkes, Aaron; Curt, Gregory A.
Title: Phase I and Clinical Pharmacology Study of Intravenous Flavone Acetic Acid (NSC 347512)
Source: Cancer Res. 48 (1988) 5878-5882
Description: mono or biexponential model of postinfusion plasma concentration.



Authors: Zimran, Ari; Torem, Shlomo; Beutler, Ernest
Title: The in Vivo Ageing of Red Cell Enzymes: Direct Evidence of Biphasic Decay from Polycythaemic Rabbits with Reticulocytosis
Source: Br. J. Hae. 69 (1988) 67-70
Description: sums of one and two exponential terms fitted to Hx, G6PD, and p5'N activity data using MLAB, F statistics


1989

Authors: Aparacio, J.; Muhammed, M.
Title: Extraction Kinetics of Zinc from Aqueous Perchlorate Solution by D2EHPA Dissolved in Isopar-H
Source: Hydrometallurgy 21 (1989) 385-399
Description: evaluated rate constants and order of reactions by curve-fitting.



Authors: Balis, Frank M.; Pizzo, Philip A.; Eddy, Janie; Wilfert, Cathy; McKinney, Ross; Scott, Gwendolyn; Murphy, Robert F.; Jarosinski, Paul F.
Title: Pharmacokinetics of Zidovudine Administered Intravenously and Orally in Children with Human Immunodeficiency Virus Infection
Source: J. Pediatrics 114 (1989) 880-884
Description: post infusion data fit to biexponential function.



Authors: Balis, Frank M.; Pizzo, Philip A.; Murphy, Robert F.; Eddy, Janie; Jarosinski, Paul F.; Falloon, Judith; Broder, Samuel; Poplack, David G.
Title: The Pharmacokinetics of Zidovudine Administered by Continuous Infusion in Children
Source: Ann. Int. Med. 110 (1989) 279-285
Description: Zidovudine disappearance following bolus adminstration fit to biexponential function.



Authors: Benkelfat, Chawlei; Aulakh, Charanjit S.; Bykov, Victor; Rice, Kenner C.; de Costa, Brian R.; Rothman, Richard B.
Title: Apparent Down-Regulation of Rat Brain Mu- and Kappa-Opioid Binding Sites Labelled with [3H]-Cyclo-FOXY Following Chronic Administration of the Potent 5-Hydroxytryptamine Reuptake Blocker, Clomipramine
Source: J. Pharm. 41 (1989) 865-867
Description: binding surfaces fit to binding equations



Authors: Boal, Jila H.; Williamson, Margaret; Boyd, Victoria L.; Ludeman, Susan M.; Egan, William
Title: 31-P NMR Studies of the Kinetics of Bisalkylation by Isophosphoramide Mustard: Comparisons With Phosphoramide Mustard
Source: J. Med. Chem. 32 (1989) 1768-1773
Description: 31-P NMR data fit to solution of system of 3, first order differential equations.



Authors: Bristow, Michael R.; Ginsburg, Robert; Umans, Victor; Fowler, Michael; Minobe, Wayne; Rasmussen, Randy; Zera, Pauline; Menlove, Ronald; Shah, Pir; Jamieson, Stuart; Stinson, Edward B.
Title: Beta-1 and Beta-2 Adrenergic Receptor Subpopulations in Nonfailing and Failing Human Ventricular Myocardium: Coupling of Both Receptor Subtypes to Muscle Contraction and Selective Beta-1 Receptor Down-Regulation in Heart Failure
Source: Circ. Res. 59 (1989) 297-309
Description: ICYP bound vs log(ligand conc) curve fit



Authors: Closset, J.; Hennen, G.
Title: Biopotency of Highly Purified Porcine FSH and Human LH on Gonadal Function
Source: J. Endocrin. 120 (1989) 89-96
Description: Scatchard analysis was performed on data from binding inhibition experiments. PDP20 MLAB.



Authors: Deroubaix, Xavier; Coche, Thierry; Depiereux, Eric; Feytmans, Ernest
Title: Compartmental Modeling of the Hepatic Transport of Taurocholate in the Rat in Vivo
Source: Am. J. Physiol. 257 (1989) G210-G220
Description: compartmental models, DEC20 MLAB



Authors: Egorin, Merrill J.; Forest, Alan; Belani, Chandra P.; Ratain, Mark J.; Abrams, Jeffrey S.; Van Echo, David A.
Title: A Limited Sampling Stategy for Cyclophosphamide Pharmacokinetics
Source: Cancer Res. 49 (1989) 3129-3133
Description: computer modeling of the decline in plasma conc of cyclophosphamide.



Authors: Ehrenberg, L.; Harms-Ringdahl, M.; Fedorcsak, I.; Granath, F.
Title: Kinetics of the Copper- and Iron-Catalyzed Oxidation of Cysteine by Dioxygen
Source: Acta Chem. Scand. 43 (1989) 177-187
Description: parameters k0 and K were estimated by minimizing sum of squares, Michaelis Menten, Lineweaver Burk



Authors: Evans, John A.; Eisenberg, Evan
Title: Intermediate Oxygen Exchange Catalyzed by the Actin-Activated Skeletal Myosin Adenosine Triphosphatase
Source: Biochem. 28 (1989) 7741-7747
Description: The oxygen isotopic composition was used to calculate a partition coefficient and a theoretical distribution assuming a single path using algorithms written in MLAB.



Authors: Fernandez, L.A.; Elizaldi, M.P.; Aparacio, J.L.
Title: Hydrochloric Acid Transport Through a Trilaurylamine-Supported Liquid Membrane from Aqueous Lithium Chloride Media
Source: J. Membrane Sci. 44 (1989) 213-232
Description: obtained accurate estimate of parameters in flux equations using MLAB.



Authors: Heideman, Richard L.; Cole, Diane E.; Balis, Frank; Sato, Judy; Reaman, Gregory H.; Packer, Roger J.; Singher, Lawrence J.; Ettinger, Lawrence J.; Gillespie, Andrea; Sam, Joseph; Poplack, David G.
Title: Phase I and Pharmacokinetic Evaluation of Thiotepa in the Cerebrospinal Fluid and Plasma of Pediatric Patients: Evidence for Dose-Dependent Plasma Clearance of Thiotepa
Source: Cancer Res. 49 (1989) 736-741
Description: thiotepa plasma disappearance fit to biexponential model.



Authors: Heideman, Richard L.; Roth, Jeri S.; Ford, Harry, Jr.; Kinnard, Richard D.; Litterst, Charles L.; Kelley, James A.
Title: Reverse Phase HPLC Determination and Murine Pharmacokinetics of Arabinosyl-5-Azacytosine
Source: J. Liq. Chrom. 12 (1989) 1613-1633
Description: Initial pharmacokinetic parameters for ara-AC in mice were estimated from plasma conc. vs time curve, then fit to triexponential function representing 3 compartment open model.



Authors: Jaroszewski, J.W.; Ettlinger, M.G.
Title: Medium Effects on Formation of Cyclic Enolates from (2E,4Z)-3-formyl-2,4-hexadienedioates, a Novel Ring-Chain Equilibrium: Importance of hydrogen bonding, solvent dipolarity/ polarizability and ion-pairing effects. Stereoisomerism of 3-formyl-2,3-hexadienedioates
Source: J. Org. Chem. 54 (1989) 1506-1518



Authors: Koulu, Markku; Bjelogrlic, Nina; Agren, Hans; Saavedra, Juan M.; Potter, William Z.; Linnoila, Markku
Title: Diurnal Variation in the Concentrations of Catecholamines and Indolearines in the Median Eminence and in the Intermediate and Posterior Lobes of the Pituitary Gland of the Male Rat
Source: Brain Res. 503 (1989) 246-252
Description: fit concentrations to sums of trignometric functions with variable amplitude and phase and DC offset



Authors: Majumdar, Chirabrata; Stein, Cy A.; Cohen, Jack S.; Broder, Samuel; Wilson, Samuel H.
Title: Stepwise Mechanism of HIV Reverse Transcriptase: Primer Function of Phosphorothioate Oligodeoxynucleotide
Source: Biochem. 28 (1989) 1340-1346
Description: fit kinetic constants to polymerization reaction rate laws.



Authors: Mathies, Margaret; Hogg, Nancy
Title: Absence of Monocyte Procoagulant Activity During the Immune Response to Influenza Virus
Source: J. Clin. Micr. 27 (1989) 615-621
Description: linear regression experimental clotting times converted to units of PCA activity.



Authors: Newcomb, William W.; Brown, Jay C.; Booy, Frank P.; Steven, Alasdair C.
Title: Nucleocapsid Mass and Capsomer Protein Stoichiometry in Equine Herpes Virus 1: Scanning Transmission Electron Microscopic Study
Source: J. Virology 63 (1989) 3777-3783
Description: histograms were drawn and statistical analysis of data with DEC10 MLAB.



Authors: Orban, Laszlo; Fawcett, John S.; Tietz, Dietmar; Chrambach, Andreas
Title: Sieving of Ionic Constituents Across Moving Boundaries in Gel Electrophoresis
Source: Electrophoresis 10 (1989) 254-259
Description: evaluating Ferguson plot (mobility vs. gel concentration) of HEM-chloride-bicinate moving boundary. includes do-file.



Authors: Otsu, Kinya; Kinsella, James; Sacktor, Bertam; Froehlich, Jeffrey P.
Title: Transient State Kinetic Evidence for an Oligomer in the Mechanism of Na+ H+ Exchange
Source: Proc. Natl. Acad. Sci. 86 (1989) 4818-4822
Description: computer simulations of time-dependent Na+ accumulation, bimolecular reactions simulated with pseudo-first order approximation.



Authors: Pember, Stephen O.; Johnson, Kenneth A.; Villafranca, Joseph J.; Benkovic, Stephen J.
Title: Mechanistic Studies on Phenylalanine Hydroxylase from Chromobacterium violaceum. Evidence for the Formation of an Enzyme-Oxygen Complex
Source: Biochem. 28 (1989) 2124-2130
Description: Michaelis constants, kinetic constants for each of the sustrates were determined by computer fit of data to overall steady state equation.



Authors: Reed, Dana Kim; Newton, Cathy; Fraga, Mark; Glastad, Karl; Bagheri, Ali; Harris, Sonja; Reed, Brent C.
Title: An Analysis of the Relationship Between the Cellular Distribution and the Rate of Turnover for the Separate Classes of Unoccupied, Noncovalently Occupied, and Covalently Occupied Insulin Receptor
Source: J. Biol. Chem. 264 (1989) 12673-12679
Description: apparent first order rate constants for various receptor processes.



Authors: Rothman, Richard B.; Bykov, Victor; Long, Joseph B.; Brady, Linda S.; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W.
Title: Chronic Adminstration of Morphine and Natrexone Up-Regulate Mu-Opioid Binding Sites Labeled by [3-H][D-Ala-2,MePhe-4,Gly-ol-5] Enkephalin: Further Evidence for Two Mu-Binding Sites
Source: Eur. J. Pharm. 160 (1989) 71-82
Description: best fit estimates of Bmax and Kd



Authors: Rothman, Richard B.; France, Charles P.; Bykov, Victor; de Costa, Brian R.; Jacobson, Arthur E.; Woods, James H.; Rice, Kenner C.
Title: Pharmacological Activities of Optically Pure Enantiomers of the Kappa Opioidagonist, U50,488, and its Cis Diastereomer: Evidence for Three Kappa Receptor Subtypes
Source: Eur. J. Pharm. 167 (1989) 345-353
Description: one or two-site binding model



Authors: Rothman, R.B.; Long, J.B.; Holaday, J.W.; Bykov, V.; de Costa, B. R.; Kim, C.-H.; Jacobson, A.E.; Rice, K.C.
Title: A Study of the Interaction of the Alkylating Agent, NIH10236, with Opioid Receptors in Vitro and in Vivo
Source: Neuropharm. 28 (1989) 1349-1356
Description: IC50 and slope factors fit displacement curve to 2-parameter logistic.



Authors: Rothman, Richard B.; Reid, Audrey A.; Monn, James A.; Jacobson, Arthur E.; Rice, Kenner C.
Title: The Psychotomimetic Drug Phencyclidine Labels Two High Affinity Binding Sites in Guinea Pig Brain: Evidence for N-Methyl-D-Aspartate-Coupled and Dopamine Reuptake Carrier-Associated Phencylclidine Binding Sites
Source: Mol. Pharm. 36 (1989) 887-896
Description: 2 site binding model, estimate Bmax, Kd values



Authors: Saunders, Nicholas A.; Ilett, Kenneth F.; Minchin, Rodney F.
Title: Pulmonary Alveolar Macrophages Express a Polyamine Transport System
Source: J. Cell Physiol. 139 (1989) 624-631
Description: Henri-Michaelis-Menten equation, Boxenbaum, all data fitted with MLAB.



Authors: Saunders, Nicholas; McGeachie, John K.; Ilett, Kenneth F.; Minchin, Rodney F.
Title: Localization of Spermidine Uptake in Rabbit Lung Slices
Source: Am. J. Physiol. 257 (1989) C579-C587
Description: Henri-Michaelis-Menten equations fitted using MLAB



Authors: Skinner, Michael H.; Hsieh, Mark; Torseth, John; Pauloin, Danielle; Bhatiz, Gulshan; Harkonen, Scott; Merigan, Thomas C.; Blaschke, Terrence F.
Title: Pharmacokinetics of Ritabulin
Source: Antimicr. Ag. and Chem. 33 (1989) 1237-1241
Description: Prophet-parameter estimates of half-life, oral bioavailability, area under curve



Authors: Tietz, Dietmar; Chrambach, Andreas
Title: Computer Assisted Evaluation of Polydisperse Two-Dimensional Gel Patterns of Polysaccharide-Protein Conjugate Preparations with Regard to Size and Net Charge
Source: Electrophoresis 10 (1989) 667-680
Description: computed particle and gel fiber specific parameters from positions of standards and unknowns on 2D gel. includes do-file.



Authors: Wadler, Scott; Egorin, Merrill J.; Zuhowski, Eleanor G.; Tortorello, Laura; Salva, Kathryn; Runowicz, Carolyn D.; Wiernik, Peter H.
Title: Phase I Clinical and Pharmacokinetic Study of Thiotepa Administered Intraperitoneally in Patients with Advanced Malignancies
Source: J. Clin. Onc. 7 (1989) 132-139
Description: loss of thiotepa from peritoneal cavity fit to biexponential model.



Authors: Wilder, Robert T.; Venkataramu, S.D.; Dalton, Larry R.; Birktoff, Jens J.; Trommer, Wofgang E.; Park, Jane H.
Title: Catalytic Mechanism and Interactions of NAD+ with Glyceraldehyde-3-Phosphate Dehydrogenase: Correlation of EPR Data and Enzymatic Studies
Source: Bioch. Biophy. A. 997 (1989) 65-77
Description: Adair equation, binding constants



Authors: Yu, Leepo C.; Brenner, Bernhard
Title: Structures of Actomyosin Crossbridges in Relaxed and Rigor Muscle Fibers
Source: Biophys. J. 55 (1989) 441-453
Description: integrated intensities of each reflection were subsequently obtained by fitting to Lorentzian line shape function.



Authors: Zlokovic, Berislav V.; Maokic, Jasmina B.; Djuricic, Bogdan; Pavson, Hugh
Title: Kinetic Analysis of Leucine-Enkephalin Cellular Uptake at the Luminal Side of the Blood-Brain Barrier of an in Situ Perfused Guinea-Pig Brain
Source: J. Neurochem. 53 (1989) 1333-1340
Description: best fit for Vmax, Km, and Kd were obtained for leu-enkephalin by fitting to brain vascular perfusion data.


1990

Authors: Ashizawa, Kiyoto; Kato, Hirokazu; McPhie, Peter; Cheng, Sheue-yann
Title: Regulation of Thyroid Hormone Binding to its Cytosolic Binding Protein by L-Alpha-Alanine
Source: Biochem. Biophys. Res. 167 (1990) 587-592
Description: affinity constants obtained with DEC10 MLAB.



Authors: Aulabaugh, Ann; Schloss, John V.
Title: Oxalyl Hydroxamates as Reaction-Intermediate Analogues for Ketol-Acid Reductoisomerase
Source: Biochem. 29 (1990) 2824-2830
Description: exponential model, Michaelis constants



Authors: Beckers, Albert; Stevenaert, Achille; Foidart, Jean-Michel; Hennen, Georges; Frankenne, Francis
Title: Placental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women
Source: J. Clin. End. 71 (1990) 725-731
Description: significant GH peaks were identified with Pulsar program in connection with MLAB on DEC20.



Authors: Beckers, A.; Stevenaert, A.; Pirens, G.; Flandroy, P.; Sulon, J.; Hennen, G.
Title: Cyclical Cushing's Disease and Its Successful Control Under Sodium Valproate
Source: J. Endocr. Inv. 13 (1990) 923-929
Description: Pulsar program and MLAB on DEC20 used to detect cortisol peaks.



Authors: Blaney, Susan M.; Balis, Frank M.; Hegedus, Lajos; Heideman, Richard L.; McCully, Cynthia; Murphy, Robert F.; Kelley, James A.; Poplack, David G.
Title: Pharmacokinetics and Metabolism of Cyclopentenyl Cytosine in Nonhuman Primates
Source: Cancer Res. 50 (1990) 7915-7919
Description: plasma disappearance of CPE-C following iv bolus dose, fit to biexponential function.



Authors: Blaszczak, L.C.; Brown, R.F.; Cook, G.K.; Hornback, W.J.; Indelicato, J.M.; Jordan, C.L.; Katner, A.S.; Kinnick, M.D.; McDonald, J.H.
Title: Comparative Reactivity of 1-carba-1-dethiacephelosporins with Cephalosporins
Source: J. Med. Chem. 33 (1990) 1656-1662



Authors: Carpen, Mary E.; Poplack, David G.; Pizzo, Philip A.; Balis, Frank M.
Title: High Performance Liquid Chromotographic Method for Analysis of 2',3'-Dideoxyinosine in Human Body Fluids
Source: J. Chrom. 526 (1990) 69-75
Description: using reciprocally weighted linear regression analysis, the peak height ratios of ddI to internal standard vs. concentration gave a correlation coefficient of .998.



Authors: Ellis, John; Huyler, Joanne H.; Kemp, Dorothy E.; Weiss, Samuel
Title: Muscarinic Receptors and Second-Messenger Responses of Neurons in Primary Culture
Source: Brain Res. 511 (1990) 234-240
Description: data from receptor binding studies analyzed according to equations describing competitive interactions at one or more sites.



Authors: Hawkins, Mary E.; Poplack, David G.; Pizzo, Philip A.; Balis, Frank M.
Title: High-Performance Liquid Chromotographic Method for the Analysis of 2',3'-Dideoxycytidine in Human Plasma
Source: J. Chrom. 532 (1990) 442-444
Description: linear regression of peak height ratios of internal standard versus concentration of ddc gave correlation coefficient of .97.



Authors: Hill, H.F.; Saeger, L.; Bjurstrom, R.; Donaldson, G.; Chapman, C.R.; Jacobson, R.
Title: Steady-State Infusions of Opioids in Human Volunteers. I. Pharmacokinetic Tailoring
Source: Pain 43 (1990) 57-67
Description: concentration-time data fit to biexponential model.



Authors: Ilett, K.F.; Ong, R.T.T.; Batty, K.T.; Taylor, J.D.
Title: Effect of Urine pH on the Stability of Doxorubicin and Its Recovery from Bladder Instillations
Source: Br. J. Urol. 65 (1990) 478-482
Description: urinary concentration data fit to biexponential equation.



Authors: Kambadur, Ravi; Lewis, Marc; Chang, Sulie; Flavin, Martin
Title: Characterization of Putative Cytoskeletal Proteins from a Trypanosomatid and Their Comparative Binding to Microtubules and Soluble Tubulin
Source: J. Biol. Chem. 265 (1990) 20959-20965
Description: dissociation constant and maximum number of sites fit as parameters.



Authors: Kaplan, Ofer; Navon, Gil; Lyon, Robbe C.; Faustino, Patrick J.; Straba, Eric J.; Cohen, Jack S.
Title: Effects of 2-Deoxyglucose on Drug Sensitive and Drug Resistant Human Breast Cancer Cells: Toxicity and Magnetic Resonance Spectroscopy Studies of Metabolism
Source: Cancer Res. 50 (1990) 544-551
Description: DEC10 MLAB.



Authors: Marquez, V.E.; Tseng, C.K.H.; Mitsutya, H.; Aoki, S.; Kelley, J.A.; Ford, H.; Roth, J.S.; Broder, S.; Johns, D.G.; Driscoll, J.S.
Title: Acid-Stable 2' Fluoro Purine Dideoxynucleosides as Active Agents Against HIV
Source: J. Med. Chem. 33 (1990) 978-985



Authors: Martin, Roger L.; Ilett, Kenneth F.; Minchin, Rodney F.
Title: Characterisation of Putrescine Uptake by Cultured Adult Mouse Hepatocytes
Source: Bioch. Biophys. A. 1051 (1990) 32-59
Description: Kinetics parameters +/- standard error for putrescine uptake assuming Michaelis Menten kinetics determines with MLAB.



Authors: Metwally, M.E.; Wolfe, N.L.
Title: Hydrolysis of Chlorostilbene Oxide II. Modeling of Hydrolysis in Aquifer Samples and in Sediment/Water Systems
Source: Env. Tos. Chem. 9 (1990) 963-973
Description: pseudo first order fit of expoxide accumulation in ground water versus time.



Authors: Pizzo, Philip A.; Butler, Karina; Balis, Frank; Brouwers, Emile; Hawkins, Mary; Eddy, Janie; Einloth, Michele; Falloon, Judy; Husson, Robert; Jarosinski, Paul; Meer, Jacob; Moss, Howard; Poplack, David G.; Santacroce, Sheila; Weiner, Lori; Wolters, Pam
Title: Dideoxycytidine Alone and in an Alternating Schedule with Zidovudine in Children with Symptomatic Human Immunodeficiency Virus Infection
Source: J. Pediatrics 117 (1990) 799-808
Description: postinfusion data from iv dose fit to monoexponential equation, compute area under curve.



Authors: Reid, A.A.; Mattison, M.V.; de Costa, B.R.; Thurkauf, A.; Jacobson, A.E.; Monn, J.A.; Rice, K.C.; Rothman, R.B.
Title: Specificity of Phencyclidine-Like Drugs and Benzomorphan Opiates for Two High Affinity Phencyclidine Binding Sites in Guinea Pig Brain
Source: Neuropharm. 29 (1990) 811-817
Description: Kd and Bmax estimated.



Authors: Reid, Audrey A.; Monn, James A.; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B.
Title: Pseudoallosteric Modulation by (+)-MK801 of NMDA-Coupled Phencyclidine Binding Sites
Source: Life Sci. 46 (1990) PL77-PL82
Description: dissociation curves fit to 1-,2-component dissociation models as mono- and bi-exponential functions.



Authors: Richards, Ernest W.; Hamm, Michael W.; Fletcher, John E.; Otto, David A.
Title: The Binding of Palaritoyl-CoA to Bovine Serum Albumin
Source: Bioch. Biophys. A 1044 (1990) 361-367
Description: data obtained from fluorescence enhancement studies were fitted to mathematical models using DEC10 MLAB.



Authors: Rodgers, R.P. Channing; Levin, Jack
Title: A Critical Reappraisal of the Bleeding Time
Source: Sem. Thromb. 16 (1990) 1-144
Description: linear least squares analysis.



Authors: Rothman, Richard B.; Bykov, Victor; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Brady, Linda S.
Title: Interaction of Endogenous Opioid Peptides and Other Drugs with Four Kappa Opioid Binding Sites in Guinea Pig Brain
Source: Peptides 11 (1990) 311-331
Description: each surface fit to 2-site binding model.



Authors: Rothman, R.B.; Long, J.B.; Bykov, V.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W.
Title: Pretreatment of Rats with the Irreversible Mu-Receptor Antagonist, Beta-FNA, Fails to Prevent Naltrexone-Induced Upregulation of Mu-Opioid Receptors
Source: Neuropharm. 29 (1990) 805-810
Description: one site binding model.



Authors: Saari, Leonard L.; Cotterman, Josephine C.; Primiani, Michael M.
Title: Mechanism of Sulfonylurea Herbicide Resistance in the Broadleaf Weed, Kochia scoparia
Source: Plant Physiol. 93 (1990) 55-61
Description: determine Michaelis constants.



Authors: Sayer, J.M.; Lehr, R.E.; Kumar, S.; Yagi, H.; Yeh, H.J.C.; Holder, G.M.; Duke, C.C.; Silverton, J.V.; Gibson, C.; Jerina, D.M.
Title: Comparative Solvolytic Reactivity of Bay-Region Diol Epoxides Derived from Dibenz-[a,j]-Anthracene and Dibenzacridines
Source: JACS 112 (1990) 1177-1185
Description: rate law, fit rate constants to measured kinetic data.



Authors: Weir, Roger L.; Anderson, Sally M.; Daly, John W.
Title: Inhibition of N6-[3H] Cyclohexyladenosine Binding by Carbamazepine
Source: Epilepsia 31 (1990) 503-512
Description: single and dual state receptor models fitted to data.



Authors: Wolff, Edith C.; Park, Myung Hee; Folk, J.E.
Title: Cleavage of Spermidine as the First Step in Deoxyhypusine Synthesis
Source: J. Biol. Chem. 265 (1990) 4793-4799
Description: For kinetic studies, the concentration of substrates and enzyme fraction were varied and assays were conducted for 60 minutes, data fitted to Michaelis Menten equation with PDP10 MLAB.



Authors: Zaharevitz, Daniel W.; Chisena, Christine A.; Cysyk, Richard L.
Title: Rapid Increase of Cellular UDP-Glucuromide After Mitogen Stimulation of Quiescent 3T3 Mouse Fibroblasts
Source: Biochem. Int. 20 (1990) 1067-1076
Description: least squares curve fitting.



Authors: Zlokovic, Berislav V.; Hyman, Shigeyo; McComb, J. Gordon; Lipovac, Milo N.; Tang, Gordon; Dauson, Hugh
Title: Kinetics of Arginine-Vasopressin Uptake at the Blood-Brain Barrier
Source: Biochem. Biophys. A. 1025 (1990) 191-198
Description: best fit values for Vmax, Km, Kd, Michaelis parameters.


1991

Authors: Akunne, Hyacinth C.; Reid, Audrey A.; Thurkauf, Andrew; Jacobson, Arthur E.; de Costa, Brian R.; Rice, Kenner C.; Heyes, Melvin P.; Rothman, Richard B.
Title: [3H]1-[2-(2-Thienyl)Cyclohexyl] Piperidine Labels Two High-Affinity Binding Sites in Human Cortex: Further Evidence for Phencyclidine Binding Sites Associated With the Biogenic Amine Reuptake Complex
Source: Synapse 8 (1991) 289-300
Description: 1 and 2 site binding model.



Authors: Ashizawa, Kiyoto; McPhie, Peter; Lin, Kwang-huei; Cheng, Sheue-yann
Title: An in Vitro Novel Mechanism of Regulating the Activity of Pyruvate Kinase M2 by Thyroid Hormone and Fructose 1,6-Bisphosphate
Source: Biochem. 30 (1991) 7105-7111
Description: Michaelis Menten equation, DEC10 MLAB.



Authors: Attri, Arun K.; Lewis, Marc S.; Korn, Edward D.
Title: The Formation of Actin Oligomers Studied by Analytical Ultracentrifugation
Source: J. Biol. Chem. 266 (1991) 6815-6824
Description: ultracentrifuge sedimentation velocity data analysis.



Authors: Becerra, S. Patricia; Kumar, Amalendra; Lewis, Marc S.; Widem, Steven G.; Abbotts, John; Karawya, Essam M.; Hughes, Stephen H.; Shiloach, Joseph; Wilson, Samuel H.
Title: Protein-Protein Interactions of HIV-1 Reverse Transcriptase: Implication of Central and C-Terminal Regions in Subunit Binding
Source: Biochem. 30 (1991) 11707-11719
Description: PCMLAB, ultracentrifuge data analysis.



Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Godwin, Karen S.; Poplack, David G.
Title: Pharmacokinetics of Pyrazoloacridine in the Rhesus Monkey
Source: Cancer Res. 51 (1991) 5467-5470
Description: post infusion concentration-time data fit to bi- and tri-exponential functions.



Authors: Brenner, Bernhard; Yu, Leepo C.
Title: Characterization of Radial Force and Radial Stiffness in Ca2+ Activated Skinned Fibres of the Rabbit Psoas Muscle
Source: J. Physiol. 441 (1991) 703-718
Description: cross-bridge theory of muscle contraction, response of single fibres to applied radial force by dextran T500 fit to function of two exponentials plus a constant.



Authors: Bubb, Michael R.; Lewis, Marc S.; Korn, Edward D.
Title: The Interaction of Monomeric Actin with Two Binding Sites on Acanthamoeba Actobindin
Source: J. Biol. Chem. 266 (1991) 3820-3826
Description: sedimentation equilibrium determination of the Mr of labeled and unlabeled actobinbin.



Authors: Chung, Soo Il; Park, Myung Hee; Folk, J.E.; Lewis, Marc S.
Title: Eukaryotic Initiation Factor 5A: The Molecular Form of the Hypusine-Containing Protein from Human Erythrocytes
Source: Bioch. Biophys. A 1076 (1991) 448-451
Description: elution profiles of eIF-5A recorded at 280nm, values of Kd as functions of MW of standards fit to logistic.



Authors: Climent, I.; Sjoeberg, B.M.; Huang, C.Y.
Title: Carboxyl-terminal Peptides as Probes for Escherichia coli Ribonucleotide Reductase Subunit Interaction: Kinetic Analysis of Inhibition Studies
Source: Biochem. 30 (1991) 5146-5171



Authors: Closset, J.; Dumbrowicz, D.; Vandenbroek, M.; Hennen, G.
Title: Effects of Bovine, Human, and Rat Growth Hormones on Immature Hypophysectomized Rat Testis
Source: Growth Reg. 1 (1991) 29-37
Description: analysis of binding data using PDP20 MLAB.



Authors: Coche, Thierry; Deroubaix, Xavier; Depiereux, Eric; Feytmans, Ernest
Title: Compartmental Analysis of Steady-State Taurocholate Transport Kinetics by Isolated Rat Hepatocytes
Source: Hepatology 13 (1991) 1203-1214
Description: differential equations for compartmental model.



Authors: Das, Joachim; Busse, Heinrich-Gustav
Title: Analysis of the Dynamics of Relaxation Type Oscillation in Glycolysis of Yeast Extracts
Source: Biophys. J. 60 (1991) 369-379
Description: linear algebraic systems of equations for concentrations of substances in chemical system, MLAB PDP10.



Authors: Deroubaix, Xavier; Coche, Thierry; Depiereux, Eric; Feytmans, Ernest
Title: Saturation of Hepatic Transport of Taurocholate in Rats in Vivo
Source: Am. J. Physiol. 260 (1991) G189-G196
Description: compartmental model, Michaelis Menten parameters, DEC20 MLAB



Authors: Duncan, Mark W.; Villacreses, Nelly E.; Pearson, Philip G.; Wyatt, Lance; Rapoport, Stanley I.; Kopin, Irwin J.; Markey, Sanford P.; Smith, Quentin R.
Title: 2-Amino-3-(Methylamino)-Propanoic Acid (BroAA) Pharmacokinetics and Blood-Brain Barrier Permeability in the Rat
Source: J. Pharm. Exp. 258 (1991) 27-35
Description: plasma concentration fit to 3 component exponential equation using DEC10 MLAB.



Authors: Goffin, V.; Norman, M.; Martial, J.A.
Title: Alanine-Scanning Mutagenesis of Human Prolactin: Importance of the 58-74 Region for Bioactivity
Source: Mol. Endocr. 6 (1991) 1381-1392
Description: Scatchard anaylsis of binding data with MLAB, competition curves analyzed with LIGAND.



Authors: Green, Susan M.; Ginsburg, Ann; Lewis, Marc S.; Hensley, Preston
Title: Roles of Metal Ions in the Maintenance of the Tertiary and Quaternary Structure of Arginase from Saccharomyces cerevisiae
Source: J. Biol. Chem. 266 (1991) 21474-21481
Description: equilibrium sedimentation studies, ultracentrifuge data.



Authors: Grem, Jean L.; McAtee, Nanette; Murphy, Robert F.; Balis, Frank M.; Steinberg, Seth M.; Hamilton, J. Michael; Sorensen, J. Mel; Santor, Oliver; Kramer, Barnett S.; Goldstein, Lori J.; Gay, Laura M.; Caubo, Kathleen M.; Goldspiel, Barry; Allegra, Carmen J.
Title: A Pilot Study of Interferon Alpha-2a in Combination with Fluorouracil Plus High-Dose Leucovorin in Metastatic Gastrointestinal Carcinoma
Source: J. Clin. Onc. 9 (1991) 1811-1820
Description: plasma concentration time data fit to monoexponential decay function.



Authors: Hill, Harlan F.; Coda, Barbara A.; Tanaka, Akira; Shaffer, Randy
Title: Multiple-Dose Evaluation of Intravenous Hydromorphone Pharmacokinetics in Normal Human Subjects
Source: Anesth. Analg. 72 (1991) 330-336
Description: triexponential model, area under curve



Authors: Ilondo, M. Mapoko; Smal, Jean; De Meyts, Pierre; Courtoy, Pierre J.
Title: Comparison of the Effects of Hypertonic Sucrose and Intracellular Potassium Depletion on Growth Hormone Receptor Binding Kinetics and Down-Regulation in IM-9 Cells: Evidence for a Sequential Block of Receptor-Mediated Endocytosis
Source: Endocrin. 128 (1991) 1597-1602
Description: dissociation kinetics modeled using biexponential model, DEC20 MLAB.



Authors: Kanzaki, Hiroshi; McPhie, Peter; Miles, Edith Wilson
Title: Effect of Single Amino Acid Substitutions at Positions 49 and 60 on the Thermal Unfolding of the Tryptophan Synthase Alpha Subunit from Salmonella typhimurium
Source: Arch. Bioch. 284 (1991) 174-180
Description: ellipticities of native and denatured proteins fit using DEC10 MLAB.



Authors: Kayastha, Arvind M.; Sawa, Yoshiro; Nagata, Shinji; Miles, Edith Wilson
Title: Site-Directed Mutagenesis of the Beta Subunit of Tryptophan Synthase from Salmonella typhimurium
Source: J. Biol. Chem. 266 (1991) 7618-7625
Description: fluorescence intensity data were collected on a solution of the apoE350Q Alpha-2, Beta-2 complex in the presence of pyridoxal phosphate concentration ranging from .05 to 2.2 microM, dissociation constants determined.



Authors: Kerr, Beth; Hill, Harlan; Coda, Barbara; Celogero, Mark; Chapman, C. Richard; Hunt, Earl; Buffington, Veronica; Mackie, Adam
Title: Concentration-Related Effects of Morphine on Cognition and Motor Control in Human Subjects
Source: Neuropsych. 5 (1991) 157-166
Description: biexponential model of plasma concentration-time.



Authors: Kocsis, Eva; Trus, Benes L.; Steer, Clifford J.; Bisher, Margaret E.; Steven, Alasdair C.
Title: Image Averaging of Flexible Fibrous Macromolecules: The Clathrin Triskelion Has an Elastic Proximal Segment
Source: J. Struct. Bio. 107 (1991) 6-14
Description: fit line shape to sum of 3 Gaussians.



Authors: Koziol, James A.; Hacke, W.
Title: A Bivariate Version of Andrews Plots
Source: IEEE Biomed. 38 (1991) 1271-1274
Description: 3d graphics



Authors: Lapointe, D.S.; Olson, M.S.
Title: Compartmental Analysis of 45-Ca 2+ Efflux in Perfused Rat Liver: Effects of Hormonal Stimulation
Source: Cell Calcium 12 (1991) 743-753
Description: exponetial function fit with MLAB and SAAM/CONSAM.



Authors: Lin, Kwang-Huei; Parkinson, Clifford; McPhie, Peter; Cheng, Sheue-yann
Title: An Essential Role of Domain D in the Hormone-Binding Activity of Human Beta-1 Thyroid Hormone Nuclear Receptor
Source: Mol. Endocr. 5 (1991) 485-492
Description: affinity constants for binding of T3 to intact and truncated h-TR-Beta-1.



Authors: Mihalyi, Elemer; Tercero, Juan Carlos; Diaz-Maurino, Teresa
Title: Changes in pH Associated with Clotting of Fibrinogen. Kinetic Studies of the pH Shift and Correlation of the pH Change with the Release of Fibrinopeptides and the Ensuing Polymerization
Source: Biochem. 30 (1991) 4753-4762
Description: mathematical analysis of the pH shift recordings, fibrinopeptide release, and optical density increase curves was performed by curve fitting with MLAB.



Authors: Murphy, V.A.; Smith, Q.R.; Rapoport, S.I.
Title: Saturable Transport of Ca Into CSF in Chronic Hypo- and Hypercalcemia
Source: J. Neurosci. R. 30 (1991) 421-426
Description: data fit to Michaelis Menten equation.



Authors: Murphy, Vincent A.; Wadhwani, Kishena C.; Smith, Quentin R.; Rapoport, Stanley I.
Title: Saturable Transport of Manganese (II) Across the Rat Blood-Brain Barrier
Source: J. Neurochem. 57 (1991) 948-954
Description: values of Vmax, Km, and Kns nonlinear least squares curve fit.



Authors: O'Dwyer, Peter J.; LaCreta, Frank; Engstrom, Paul F.; Peter, Ruth; Tartaglia, Laura; Cole, Diane; Litwin, Samuel; DeVito, Joseph; Poplack, David; DeLap, Robert J.; Comis, Robert L.
Title: Phase I/Pharmacokinetic Reevaluation of ThioTEPA
Source: Cancer Res. 51 (1991) 3171-3176
Description: plasma concentration-time, area under curve, linear, exponential and Hill parameters.



Authors: Rafalski, M.; Ortiz, A.; Rockwell, A.; van Ginkel, L.C.; Lear, J.D.; DeGrado, W.F.; Wilscut, J.
Title: Membrane Fusion Activity of the Influenza Virus hemagglutinin: Interaction of HA2 N-Terminal Peptides with Phospholipid Vesicles
Source: Biochem. 30 (1991) 10211-10220



Authors: Ross, P.D.; Howard, F.B.; Lewis, M.S.
Title: Thermodynamics of Antiparallel Hairpinn-Double Helix Equilibria in DNA Oligonucleotides from Equilibrium Centrifugation
Source: Biochem. 30 (1991) 6269-6275



Authors: Rothman, Richard B.; Bykov, Victor; Mahboubi, Artin; Long, Joseph B.; Jiang, Qi; Porreca, Frank; de Costa, Brian R.; Jacobson, Arthur E.
Title: Interaction of Beta-Funal Trexamine With [3H] CycloFOXY Binding in Rat Brain: Further Evidence that Beta-FNA Alkylates the Opioid Receptor Complex
Source: Synapse 8 (1991) 86-99
Description: binding surfaces were fit to appropriate equations using MLAB.



Authors: Rothman, Richard B.; Long, Joseph B.; Bykov, Victor; Xu, Heng; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W.
Title: Upregulation of the Opioid Receptor Complex by the Chronic Administration of Morphine: A Biochemical Marker Related to the Development of Tolerance and Dependence
Source: Peptides 12 (1991) 151-160
Description: 2 component dissociation model



Authors: Rothman, Richard B.; Mahboubi, Artin; Bykov, Victor; Kim, Chong-Ho; Jacobson, Arthur E.; Rice, Kenner C.
Title: Probing the Opioid Receptor Complex With (+)-Trans-Superfit. I. Evidence That [D-Pen2,D-Pen5] Enkephalin Interacts with High Affinity at the Delta-cx Binding Site
Source: Peptides 12 (1991) 359-364
Description: surfaces fit to one site binding model



Authors: Rothman, Richard; Mele, Andrea; Reid, Audrey R.; Akunne, Hyacinth; Greig, Nigel; Thurkauf, Andrew; de Costa, Brian R.; Rice, Kenner C.; Pert, Agu
Title: GBR12909 Antagonizes the Ability of Cocaine to Elevate Extracellular Levels of Dopamine
Source: Pharm. Bioch. B. 40 (1991) 387-397
Description: 1,2,3-site binding models



Authors: Rothman, Richard B.; Reid, Audrey; Mahboubi, Artin; Kim, Chong-Ho; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.
Title: Labeling by [3H] 1,3-Di(2-tolyl)guanidine of Two High Affinity Binding Sites in Guinea Pig Brain: Evidence for Allosteric Regulation by Calcium Channel Antagonists and Pseudoallosteric Modulation by Sigma Ligands
Source: Molec. Pharm. 39 (1991) 222-232
Description: F-test, 1,2, and 3-site binding model.



Authors: Rothman, Richard B.; Xu, Heng; Seggel, Mark; Jacobson, Arthur E.; Rice, Kenner C.; Brine, George A.; Carroll, F. Ivy
Title: RTI-4614-4: An Analog of (+)-Cis-3-Methylfentanyl with a 27,000-Fold Binding Selectivity for Mu Versus Delta Opioid Binding Sites
Source: Life Sci. 48 (1991) PL111-PL116
Description: 2 parameter logistic, IC50, slope factor, ligand binding analysis.



Authors: Sackett, D.L.; Lippoldt, R.E.
Title: Thermodynamics of Reversible Monomer-Dimer Association of Tubulin
Source: Biochem. 30 (1991) 3511-3517



Authors: Schwartz, Michael W.; Bergman, Richard N.; Kahn, Steven E.; Taborsky, Gerald J., Jr.; Fisher, Lloyd D.; Sipols, Alfred J.; Woods, Stephen C.; Steil, Gary M.; Porte, Daniel, Jr.
Title: Evidence for Entry of Plasma Insulin into Cerebrospinal Fluid through an Intermediate Compartment in Dogs
Source: J. Clin. Inv. 88 (1991) 1272-1281
Description: 3 compartment model, DEC10 MLAB.



Authors: Tietz, Dietmar
Title: Analysis of One-Dimensional Gels and Two-Dimensional Serwer-type Gels on the Basis of the Extended Ogston Model Using Personal Computers
Source: Electrophoresis 12 (1991) 28-39
Description: Ferguson plots



Authors: Tietz, Dietmar; Gombocz, Erich; Chrambach, Andreas
Title: Procedures and Computer Program for Deriving the Ferguson Plot from Gel Electrophoresis in a Single Pore Gradient Gel: Application to Agarose Gel and a Polystyrene Particle
Source: Electrophoresis 12 (1991) 710-721
Description: GRADFIT for Macintosh



Authors: Ward, Frank T.; Kelley, James A.; Roth, Jeri S.; Lombardo, Frederic A.; Weiss, Raymond B.; Leyland-Jones, Brian; Chun, Hoo G.
Title: A Phase I Bioavailability and Pharmacokinetic Study of Hexamethylene Bisacetamide (NSC 95580) Administered via Nasogastric Tube
Source: Cancer Res. 51 (1991) 1803-1810
Description: Area under curve calculated using trapezoidal rule, plasma concnetration fit to monoexponetial.



Authors: Xu, Heng; Ni, Qing; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B.
Title: Preliminary Ligand Binding Data for Subtypes of the Delta Opioid Receptor in Rat Brain Membranes
Source: Life Sci. 49 (1991) PL141-PL146
Description: 2 parameter logistic equation, IC50, slope, 1 and 2 site binding, PCMLAB.



Authors: Zaharko, Daniel S.; Keller, James A.; Tomaszewski, Joseph E.; Hegedus, Lajos; Hartman, Neil R.
Title: Cyclopentenyl Cytosine: Interspecies Predictions Based on Rodent Plasma and Urine Kinetics
Source: Inv. New Drugs 9 (1991) 9-17
Description: DEC10/20 MLAB, statistical fitting, simulation using differential equations, graphical output


1992

Authors: Adamson, Peter C.; Balis, Frank M.; Smith, Malcolm A.; Murphy, Robert F.; Godwin, Karen A.; Poplack, David G.
Title: Dose-Dependent Pharmacokinetics of All-Trans-Retinoic Acid
Source: JNCI 84 (1992) 1332-1335
Description: fit Michaelis Menten differential equation.



Authors: Akunne, Hyacinth C.; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B.
Title: [3H] Cocaine Labels a Binding Site Associated With the Serotonin Transporter in Guinea Pig Brain: Allosteric Modulation by Paroxetine
Source: Neurochem. R. 17 (1992) 1275-1283
Description: 1,2,3 site binding models, IC50, Hill coefficients


(1992) 138-146
Description: ultracentrifuge modeling
Authors: Attri, A.K.; Lewis, Marc S.
Title: Analytical Ultracentrifugation in Biochemistry and Polymer Science
Source: Chapter 9 of book edited by Harding, Rowe, and Horton,



Authors: Bailey, James J.; Fletcher, John E.; Chuck, Emil T.; Shrager, Richard I.
Title: A Kinetic Model of CD4+Lymphocytes with the Human Immunodeficiency Virus (HIV)
Source: Biosystems 26 (1992) 177-183
Description: 5 coupled ordinary differential equations describing cell populations.



Authors: Balis, Frank M.; Pizzo, Philip A.; Butler, Karina M.; Hawkins, Mary E.; Brouwers, Pim; Husson, Robert N.; Jacobsen, Freda; Blaney, Susan M.; Gress, Janet; Jarosinski, Paul; Poplack, David G.
Title: Clinical Pharmacology of 2',3'-Dideoxyinosine in Human Immunodeficiency Virus-Infected Children
Source: J. Infect. Dis. 165 (1992) 99-104
Description: postinfusion ddI concentration fit to mono and biexponential curves



Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Parker, George A.; Murphy, Robert F.; Poplack, David G.
Title: Intrathecal 5-Fluorouracil in the Rhesus Monkey
Source: Cancer Chemot. 31 (1992) 127-130
Description: concentration time data fit to mono and biexponential models.



Authors: Chen, Bau-Lu; Baase, Walter A.; Nicholson, Hale; Schellman, John A.
Title: Folding Kinetics of T4 Lysozyme and Nine Mutants at 12 Degrees C
Source: Biochem. 31 (1992) 1464-1476
Description: thermodynamic function fit to find rate constants.



Authors: Chung, Laura Ann; Lear, James D.; DeGrado, William F.
Title: Fluorescence Studies of the Secondary Structure and Orientation of a Model Ion Channel Peptide in Phospholipid Vesicles
Source: Biochem. 31 (1992) 6608-6616
Description: root and fit operators to find dissociation constants.



Authors: Fisher, Alice; Taniuchi, Hiroshi
Title: A Study of Core Domains and the Core Domain-Domain Interaction of Cytochrome c Fragment Complex
Source: Arch. Biochem. 296 (1992) 1-16



Authors: Grem, Jean L.; Chu, Edward; Boarman, Donna; Balis, Frank M.; Murphy, Robert F.; McAtee, Nanette; Allegra, Carmen J.
Title: Biochemical Modulation of Fluorouracil with Leucovorin and Interferon: Preclinical and Clinical Investigations
Source: Semin. Oncol. 19 (1992) 36-44
Description: 5-FU plasma concentration in time fit to monoexponential, computed area under curve.



Authors: Hill, Harlan F.; Coda, Barbara A.; Mackie, Adam M.; Iverson, Karen
Title: Patient-Controlled Analgesic Infusions: Alfentanil Versus Morphine
Source: Pain 49 (1992) 301-310
Description: bi, triexponential models of plasma opioid concentration vs. time.



Authors: Holmes, William R.; Segev, Idan; Rall, Wilfrid
Title: Interpretation of Time Constant and Electronic Length Estimates in Multicylinder or Branched Neuronal Structures
Source: J. Neurophys. 68 (1992) 1401-1420
Description: estimates of T0, T1, C0, C1 determined by variety of methods including MLAB.



Authors: Ilondo, Mapoko M.; Vandershueren-Lodeweyckx, Magda; Courtoy, Pierre J.; De Meyts, Pierre
Title: Cellular Processing of Growth Hormone in IM-9 Cells: Evidence for Exocytosis of Internalized Hormone
Source: Endocrin. 130 (1992) 2037-2044
Description: [125-I] hGH internalization, DEC20 MLAB.



Authors: Jayaram, Hiremagalur N.; Lapis, Erzsebet; Tricot, Guido; Kneebore, Patricia; Paulik, Edith; Zhen, Weining; Engeler, George P.; Hoffman, Ronald; Weber, George
Title: Clinical Pharmacokinetic Study of Tiazofurin Administered as a 1-Hour Infusion
Source: Int J. Cancer 51 (1992) 182-188
Description: plasma clearance as 2 compartment model.



Authors: McPhie, Peter; Shrager, Richard I.
Title: An Investigation of the Thermal Unfolding of Swine Pepsinogen Using Circular Dichroism
Source: Arch. Biochem. 293 (1992) 46-53
Description: SVD analysis, DEC10 MLAB.



Authors: Paredes, Angel M.; Simon, Martha N.; Brown, Dennis T.
Title: The Mass of the Sindbis Virus Neucleocapsid Suggests It Has T=4 Icosahedral Symmetry
Source: Virology 187 (1992) 329-332
Description: fit gaussian to histogram.



Authors: Rothman, Richard B.; Bykov, Victor; Xue, B.G.; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Kleinman, Joel E.; Brady, Linda S.
Title: Interaction of Opioid Peptides and Other Drugs With Multiple Kappa Receptors in Rat and Human Brain: Evidence for Species Differences
Source: Peptides 13 (1992) 977-987
Description: binding studies, F-test



Authors: Rothman, Richard B.; Mahboubi, Artin; Bykov, Victor; Kim, Chong-Ho; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.
Title: Probing the Opioid Receptor Complex With (+)-Trans SUPERFIT. II. Evidence that Mu Ligands Are Noncompetitive Inhibitors of the Delta-cx Opioid Peptide Binding Site
Source: Peptides 13 (1992) 1137-1143
Description: inhibition curves fit to 2 parameter logistic



Authors: Tropea, Joseph E.; Nashed, Nashaat T.; Louis, John M.; Sayer, Jane M.; Jerina, Donald M.
Title: Effect of Salt on the Kinetic Parameters of Retroviral and Mammalian Aspartic Acid Proteases
Source: Bioorg. Chem. 20 (1992) 67-76
Description: inhibition constants, pseudo-first order rate constants.



Authors: Wadhwani, Kishena C.; Murphy, Vincent A.; Smith, Quentin R.; Rapoport, Stanley I.
Title: Saturable Transport of Manganese (II) Across Blood-Nerve Barrier of Rat Peripheral Nerve
Source: Am. J. Physiol. 262 (1992) R284-R288
Description: determine saturation-kinetic parameters for Mn influx.



Authors: Wu, Xiaomao; Gutfreund, H.; Chock, P.B.
Title: Kinetic Method for Differentiating Mechanisms for Ligand Exchange Reactions: Application to Test for Substrate Channeling in Glycolysis
Source: Biochem. 31 (1992) 2123-2128
Description: numerical analysis carried out by solving the differential equations describing the mechanism being considered using the integrator in MLAB.



Authors: Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B.
Title: Interaction of Opioid Peptides and Other Drugs With Multiple Delta-ncx Binding Sites in Rat Brain: Further Evidence for Heterogeneity
Source: Peptides 13 (1992) 1207-1213
Description: fit data to 1 and 2 site models.



Authors: Yoo, S.H.; Lewis, Marc S.
Title: Effects of pH and Ca2+ on Monomer-Dimer and Monomer-Tetramer Equilibria of Chromogranin A*
Source: J. Biol. Chem. 267 (1992) 11236-11241
Description: ultracentrifuge data analysis.



Authors: Zaharevitz, Daniel W.; Anderson, Lawrence W.; Malinowski, Nancy M.; Hyman, Roosevelt; Strong, John M.; Cysyk, Richard L.
Title: Contribution of De-Novo and Salvage Synthesis to the Uracil Nucleotide Pool in Mouse Tissues and Tumors in Vivo
Source: Eur. J. Biochem. 210 (1992) 293-296
Description: linear regression


1993

Authors: Adamson, Peter C.; Boylan, John F.; Balis, Frank M.; Murphy, Robert F.; Godwin, Karen A.; Gudas, Loraine J.; Poplack, David G.
Title: Time Course of Induction of Metabolism of All-Trans-Retinoic Acid and the Up-Regulation of Cellular Retinoic Acid-Binding Protein
Source: Cancer Res. 53 (1993) 472-476
Description: Michaelis Menten model, Vmax, Km, area under curve



Authors: Anderson, Sally M.; Kant, G. Jean; De Souza, Errol B.
Title: Effects of Chronic Stress on Anterior Pituitary and Brain Corticotropin-Releasing Factor Receptors
Source: Pharm. Bio. B. 44 (1993) 755-761
Description: estimates for dissociation constant, Kd, and maximum concentration, Bmax, of [125-I] on CRF binding sites in membrane preparations from anterior pituitary gland were determined by nonlinear curve-fitting using DEC10 MLAB.



Authors: Berg, Stacey L.; Balis, Frank M.; Godwin, Karen S.; Poplack, David G.
Title: Pharmacokinetics, Cerebrospinal Fluid Penetration, and Metabolism of Piroxantrone in the Rhesus Monkey
Source: Inv. New Drugs 11 (1993) 255-261
Description: post infusion concentration time data fit to multiexponential model.



Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Godwin, Karen S.; Poplack, David G.
Title: Pharmacokinetics of PEG-L-Asparaginase and Plasma and Cerebrospinal Fluid L-Asparagine Concentrations in the Rhesus Monkey
Source: Cancer Chemot. 32 (1993) 310-314
Description: Postplateau plasma PEG-asp concentration time data fit to monoexponential, area under curve via trapezoidal rule.



Authors: Berg, Stacey L.; Savarese, Diane M.F.; Balis, Frank M.; Denicoff, Andrea M.; Hillig, Marianne; O'Shaughnessy, Joyce A.; Poplack, David G.; Cowan, Kenneth H.
Title: Pharmacokinetics of Piroxantrone in a Phase I Trial of Piroxantrone and Granulocyte-Colony Stimulating Factor
Source: Cancer Res. 53 (1993) 2587-2590
Description: postinfusion concentration-time data fit to bi-, tri-exponential functions.



Authors: Blaney, Susan M.; Balis, Frank M.; Cole, Diane E.; Craig, Catherine; Reid, Joel M.; Ames, Matthew M.; Krailo, Mark; Reaman, Gregory; Hammond, Denman; Poplack, David G.
Title: Pediatric Phase I Trial and Pharmacokinetic Study of Topotecan Administered as a 24-Hour Continuous Infusion
Source: Cancer Res. 53 (1993) 1032-1036
Description: post infusion concentration time data fit to mono-, bi-exponential model.



Authors: Blaney, Susan M.; Cole, Diane E.; Balis, Frank M.; Godwin, Karen; Poplack, David G.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetic Study of Topotecan in Nonhuman Primates
Source: Cancer Res. 53 (1993) 725-727
Description: plasma concentration vs time data from topotecan bolus experiment fit to mono-, bi-exponential equations.



Authors: Bradley, David C.; Steil, Garry M.; Bergman, Richard N.
Title: Quantitation of Measurement Error with Optimal Segments: Basis for Adaptive Time Course Smoothing
Source: Am. J. Physiol. 264 (1993) E902-E911
Description: simulations performed with MLAB.



Authors: Brenner, Bernhard; Yu, Leepo C.
Title: State-Dependent Radial Elasticity of Attached Cross-Bridges in Single Skinned Fibres of Rabbit Psoas Muscle--Erratum
Source: J. Physiol. 465 (1993) 749-765
Description: responses of fibres to applied radial force fit to exponential.



Authors: Brenner, B.; Yu, L.C.
Title: Structural Changes in the Actomyosin Cross-Bridges Associated with Force Generation
Source: Proc. Natl Acad. Sci. 90 (1993) 5252-5256
Description: fit reflection peaks to Lorentzian with amplitude, width and centroid as parameters.



Authors: Coda, Barbara A.; Hill, Harlan F.; Hunt, Earl B.; Kerr, E. Beth; Jacobson, Robert C.; Chapman, C. Richard
Title: Cognitive and Motor Function Impairments During Continuous Opioid Analgesic Infusions
Source: Hum. Psychopharm. 8 (1993) 383-400
Description: biexponential model of plasma concentration of opioid versus time.



Authors: Conley, Barbara A.; Egorin, Merrill J.; Whitacre, Margaret Y.; Carter, D. Canville; Zuhowski, Eleanor G.; Van Echo, David A.
Title: Phase I and Pharmacokinetic Trial of Liposome-Encapsulated Doxorubicin
Source: Cancer Chemot. 33 (1993) 107-112
Description: doxorubicinol area under curve determined by trapezoidal rule



Authors: Fairman, Robert; Beran-Steed, Rita K.; Anthony-Cahill, Spencer J.; Lear, James D.; Stafford, Walter F., III; DeGrado, William F.; Benfield, Pamela A.; Brenner, Stephen L.
Title: Multiple Oligomeric States Regulate the DNA Binding of Helix-Loop-Helix Peptides
Source: Proc. Natl. Acad. Sci. 90 (1993) 10429-10433
Description: obtained dissociation constants by curve fitting.



Authors: Heideman, Richard L.; McCully, Cynthia; Balis, Frank M.; Poplack, David G.
Title: Cerebrospinal Fluid Pharmacokinetics and Toxicology of Intraventricular and Intrathecal Arabinosyl-5-Azacytosine (Fazarabine, NSC 281272) in the Nonhuman Primate
Source: Inv. New Drug 11 (1993) 135-140
Description: half-life, CSF disappearance for AAC fit to multi-exponential functions.



Authors: Lu, Zichen; Nagata, Shinji; McPhie, Peter; Miles, Edith Wilson
Title: Lysine 87 in the Beta Subunit of Tryptophan Synthase That Forms an Internal Aldimine with Pyridoxal Phosphate Serves Critical Roles in Transamination, Catalysis, and Product Release
Source: J. Biol. Chem. 268 (1993) 8727-8734
Description: fluorescence spectra and fluorimeter measurements analyzed with PCMLAB.



Authors: McPhie, P.; Parkinson, C.; Lee, B.K.; Chang, S-Y
Title: Structure of the Hormone Binding Domain of Human Beta-1 Thyroid Hormone Nuclear Receptor: Is It an Alpha/Beta Barrel?
Source: Biochem. 32 (1993) 7460-7465
Description: analysis of circular dichroism spectra in terms of secondary structure using MLAB.



Authors: Ni, Q.; Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B.
Title: Selective Labeling of Kappa-2 Opioid Receptors in Rat Brain by [125-I] IOXY: Interaction of Opioid Peptides and Other Drugs With Multiple Kappa-2a Binding Sites
Source: Peptides 14 (1993) 1279-1293
Description: binding surfaces fit to various models, PCMLAB, IC50, slope factor, 2 parameter logistic.



Authors: Ni, Qi; Xu, Heng; Partilla, J.S.; Stank, P.A.; Carroll, F.I.; Brine, G.A.; Rothman, R.B.
Title: Stereochemical Requirements for Pseudoirreversible Inhibition of Opioid Mu Receptor Binding in the 3-Methlyfentanyl Cogeners RTI-46144 and Its Enantiomers: Evidence for Different Binding Domains
Source: Synapse 15 (1993) 296-306
Description: PCMLAB used to determine Kd, Bmax.



Authors: Otsu, Kinya; Kinsella, James L.; Heller, Phillip; Froehlich, Jeffrey P.
Title: Sodium Dependence of the Na+ H+ Exchange in the Pre-steady State
Source: J. Biol. Chem. 268 (1993) 3184-3193
Description: MLAB used for simulating time course of Na+ accumulation.



Authors: Oviedo, Angelica; Glowa, John; Herkenham, Miles
Title: Chronic Cannabinoid Administration Alters Cannabinoid Receptor Binding in Rat Brain: A Quantitative Autoradiographic Study
Source: Brain Res. 616 (1993) 293-302
Description: Kd-Bmax values fit in 1-site binding model using MLAB.



Authors: Rothman, Richard B.; Brady, Linda S.; Xu, Heng; Long, Joseph B.
Title: Chronic Intracerebroventricular Infusion of the Antiopioid Peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), Downregulates Mu Opioid Binding Sites in Rat Brain
Source: Peptides 14 (1993) 1271-1277
Description: fit to one-site binding model, PCMLAB.



Authors: Rothman, Richard B.; Lewis, Bruce; Dersch, Chris; Xu, Heng; Redesca, Lilian; de Costa, Brian R.; Rice, Kenner C.; Kilburn, Robert B.; Akunne, Hyacinth; Pert, Agu
Title: Identification of a GBR12935 Homolog, LR1111, Which is Over 4,000-Fold Selective for the Dopamine Transporter, Relative to Serotonin and Norepinephrine Transporters
Source: Synapse 14 (1993) 34-39
Description: PCMLAB, inhibition curves fit to 2 parameter logisitic.



Authors: Rothman, Richard B.; Xu, Heng; Char, George U.; Kim, Andrew; de Costa, Brian R.; Rice, Kenner C.; Zimmerman, Dennis M.
Title: Phenylpiperidine Opioid Antagonists That Promote Weight Loss in Rats Have High Affinity for the Kappa-2B (Enkephalin-Sensitive) Binding Site
Source: Peptides 14 (1993) 17-20
Description: 2 parameter logistic, best fit IC50 and slope factor.



Authors: Steil, Garry M.; Volund, Aage; Kehr, Stephen E.; Bergman, Richard
Title: Reduced Sample Number for Calculation of Insulin Sensitivity and Glucose Effectiveness From the Minimal Model
Source: Diabetes 42 (1993) 250-256
Description: statistics, minimal model with MLAB.



Authors: Stevens, Rom A.; Petty, Robert H.; Hill, Harlan F.; Kao, Tzu-Cheng; Schaffer, Randy; Hahn, Marc B.; Harris, Paul
Title: Redistribution of Sufentanil to Cerebrospinal Fluid and Systemic Circulation After Administration in Dogs
Source: Anesth. Anal. 76 (1993) 323-327
Description: triexponential model.



Authors: Vas Gomes, A.; de Waal, A.; Berden, J.A.; Westerhoff, H.V.
Title: Electric Potentiation, Cooperativity, and Synergism of Magainin Peptides in Protein-Free Liposomes
Source: Biochem. 32 (1993) 5365-5372



Authors: Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B.
Title: Differential Binding of Opioid Peptides and Other Drugs to Two Subtypes of Opioid Delta-ncx Binding Sites in Mouse Brain: Further Evidence for Delta Receptor Heterogeneity
Source: Peptides 14 (1993) 893-907
Description: single inhibition curves fit to 2-parameter logistic equation, 1 and 2 site binding models, PCMLAB.



Authors: Xu, Sengen; Brenner, Bernhard; Yu, Leepo C.
Title: State-Dependent Radial Elasticity of Attached Cross-Bridges in Single Skinned Fibres of Rabbit Psoas Muscle
Source: J. Physiol. 461 (1993) 283-299
Description: responses of fibres to applied radial force fit to single exponential.



Authors: Yoo, Seung Hyun; Lewis, Marc S.
Title: Dimerization and Tetramerization Properties of the C-Terminal Region of Chromogramin A: A Thermodynamic Analysis
Source: Biochem. 32 (1993) 8816-8822
Description: PCMLAB, ultracentrifuge sedimentation data analysis


1994

Authors: Abugo, Omoefe O.; Rifkind, Joseph M.
Title: Oxidation of Hemoglobin and the Enhancement Produced by Nitroblue Tetrazolium
Source: J. Biol. Chem. 269 (1994) 24845-24853
Description: kinetic data fit to ode model.



Authors: Akunne, Hyacinth C.; Dersch, Christine M.; Cadet, Jean L.; Baumann, Michael H.; Char, George U.; Partilla, John S.; de Costa, Brian; Rice, Kenner C.; Carroll, F. Ivy; Rothman, Richard B.
Title: Studies of the Biogenic Amine Transporters. III. Demonstration of Two Binding Sites for [3H] GBR12935 and [3H] BTCP in Rat Caudate Membranes
Source: J. Pharm. Exp. 268 (1994) 1462-1475
Description: PCMLAB, multiple site binding analysis.



Authors: Akunne, Hyacinth C.; Monn, J.A.; Thurkauf, Andrew; Jacobson, Arthur E.; Rice, Kenner C.; Linders, Joannes T.M.; Jiang, Q.; Porreca, F.; Rothman, Richard B.
Title: An Electrophilic Affinity Ligand Based on (+)-MK801 Distinguishes PCP Site 1 from PCP Site 2
Source: Neurochem. R. 19 (1994) 385-389
Description: [3H]TCP binding surfaces fit.



Authors: Bertha, C.M.; Mattson, M.V.; Flippen-Anderson, J.L.; Rothman, R.B.; Xu, H.; Cha X.Y.; Becketts, K.; Rice, K.C.
Title: A Marked Change of Receptor Affinity of the 2-Methyl-5- (3-hydroxyphenyl) morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Elucidation of a New Class of Sigma Receptor Ligands
Source: J. Mod. Chem. 37 (1994) 3163-3170



Authors: Boyd, Derek R.; Davies, R. Jeremy H.; Hamilton, Lynne; McCullough, John J.; Malone, John F.; Porter, H. Patricia; Smith, Allison; Carl, John M.; Sayer, Jane M.; Jerina, Donald M.
Title: Synthesis and Solvolysis of Acridine 1,2- and 3,4-Oxides: Crystal Structure and Solvolysis of Acridine 1,2-Oxide
Source: J. Org. Chem. 59 (1994) 984-990
Description: rate constants determined by reciprocal plots or curve-fitting.



Authors: Grem, J.L.; McAtee, N.; Murphy, R.F.; Hamilton, J.M.; Balis, F.; Steinberg, S.; Arbuck, S.G.; Setser, A.; Jordan, E.; Chen, A.; Kobler, D.R.; Kotite, B.; Allegra, C.J.
Title: Phase I and Pharmacokinetic Study of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Given in Combination With Fluorouracil Plus Calcium Leucovorin in Metastatic Gastrointestinal Adenocarcinoma
Source: J. Clin. Oncol. 12 (1994) 560-568
Description: Kaplan-Meier survival curves, plasma concentration curves fit to monoexponential function.



Authors: Kim, Soon-Jong; Lewis, Marc S.; Knutson, Jay R.; Porter, Denise K.; Kumar, Amalendra; Wilson, Samuel H.
Title: Characterization of the Tryptophan Fluorescence and Hydrodynamic Properties of Rat DNA Polymerase Beta
Source: J. Mol. Biol. 244 (1994) 224-235
Description: PCMLAB, ultracentrifuge sedimentation data analysis



Authors: Rothman, Richard B.; Cadet, Jean L.; Akunne, Hyacinth C.; Silverthorn, Mayme L.; Baumann, Michael H.; Carroll, F. Ivy; Rice, Kenner C.; de Costa, Brian R.; Partilla, John S.; Wang, Jia-Bei; Uhl, George; Glowa, John R.; Dersch, Christine M.
Title: Studies of the Biogenic Amine Transporters. IV. Demonstration of a Multiplicity of Binding Sites in Rat Caudate Membranes for the Cocaine Analog [125-I] RTI-55
Source: J. Pharm. Exp. 270 (1994) 296-309
Description: 1-site and 2-site binding models.



Authors: Steven, Alasdair C.; Steinert, Peter M.
Title: Protein Composition of Cornified Cell Envelopes of Epidermal Keratinocytes
Source: J. Cell Sci. 107 (1994) 693-700
Description: amino acid compositions fit to data with constraints.



Authors: Sumida, Ken D.; Donovan, Casey M.
Title: Endurance Training Fails to Inhibit Skeletal Muscle Glucose Uptake During Exercise
Source: J. Appl. Physiol. 76 (1994) 1876-1881
Description: Plasma 2-[3-H]DG data fitted to a double exponential equation with subsequent determination of y-intercept and integral.



Authors: Wadhwani, Kishena C.; Rapoport, Stanley I.
Title: Transport Properties of Vertebrate Blood-Nerve Barrier: Comparison with Blood-Brain Barrier
Source: Prog. Neurob. 43 (1994) 235-279
Description: plasma concentration as time-dependent multiexponential process.


1995

Authors: Ahmed, S.A.; McPhie, P.; Miles, E.W.
Title: Subunit Assembly in the Tryptophan Synthase Alpha-2 Beta-2 Complex
Source: J. Biol. Chem. 270 (1995) 7944-7949
Description: MLAB fit 3 binding models.



Authors: Banik, Utpal; Zhu, De-Min; Chock, P. Boon; Miles, Edith Wilson
Title: The Tryptophan Synthase Alpha2 Beta2 Complex: Kinetic Studies with a Mutant Enzyme (Beta K87T) to Provide Evidence for Allosteric Activation by an Aminoacrylate Intermediate
Source: Biochem. 34 (1995) 12704-12711
Description: solving odes for reaction scheme using Adams-Gear method. Also used Enzyme Kinetics program from Trinity Software and Cricket Graph III from Computer Associates.



Authors: Berg, Stacey L.; Gerson, Stanton L.; Godwin, Karen; Cole, Diane E.; Liu, Lili; Balis, Frank M.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of O6-Benzyl-Guanine and Time Course of Peripheral Blood Mononuclear Cell O6-Methylguanine-DNA Methyltransferase Inhibition in the Nonhuman Primate
Source: Cancer Res. 55 (1995) 4606-4610
Description: compartmental model, first order kinetics



Authors: Berg, Stacey L.; Tolcher, Anthony; O'Shaughnessy, Joyce A.; Denicoff, Andrea M.; Noone, Marianne; Ognibene, Frederick P.; Cowan, Kenneth H.
Title: Effect of R-Verapamil on the Pharmacokinetics of Paclitaxel in Women with Breast Cancer
Source: J. Clin. Oncol. 13 (1995) 2039-2042
Description: 2 compartment open model, fit ordinary differential rate equations, determined half lives and rate constants, computed area under curve.



Authors: Bertha, C.M.; Flippen-Anderson, J.L.; Rothman, R.B.; Porreca, F.; Davis, P.; Xu, H.; Becketts, K.; Cha, X.Y.; Rice, K.C.
Title: Probes for Narcotic Receptor-Mediated Phenomena. 20. Alteration of Opioid Receptor Subtype Selectivity of the 5-(3-Hydroxyphenyl) Morphans by Application of the Message-Address Concept: Preparation of Delta-Opioid Receptor Ligands
Source: J. Med. Chem. 38 (1995) 1523-1537



Authors: Bertha, C.M.; Vilner, B.J.; Mattson, M.V.; Bowen, W.D.; Becketts, K.; Xu, H.; Rothman, R.B.; Flippen-Anderson, J.L.; Rice, K.C.
Title: (E)-8-Benzylidene Derivatives of 2-Methyl-5-(3-hydroxyphenyl) morphans: Highly Selective Ligands for the Sigma-2 Receptor Subtype
Source: J. Med. Chem. 38 (1995) 4776-4785



Authors: Bhat, M.K.; McPhie, P.; Ting, Y-T; Zhu, X-G; Chang, S-Y
Title: Structure of the Carboxy-Terminal Region of Thyroid Hormone Nuclear Receptors and Its Possible Role in Hormone- Dependent Intermolecular Interactions
Source: Biochem. 34 (1995) 10591-10599
Description: ligand binding.



Authors: Bishop, P.; Ghosh, I.; Jones, C.; Chmielewski, J.
Title: Basic-Helix-Loop-Helix Region o Tal: Evaluation of Structure and DNA Affinity
Source: JACS 117 (1995) 8283-8284



Authors: Blaney, Susan M.; Cole, Dianne E.; Godwin, Karen; Sung, Cynthia; Poplack, David G.; Balis, Frank M.
Title: Intrathecal Administration of Topotecan in Nonhuman Primates
Source: Cancer Chemot. 36 (1995) 121-124
Description: half lives of the lactone and total drug estimated by nonlinear least squares analysis.



Authors: Blaney, Susan M.; Daniel, Michael J.; Harker, Andrew J.; Godwin, Karen; Balis, Frank M.
Title: Pharmacokinetics of Lamivudine and BCH-189 in Plasma and Cerebrospinal Fluid of Nonhuman Primates
Source: Antim. Ag. Ch. 39 (1995) 2779-2782
Description: plasma concentration time data fit to differential equation model.



Authors: Brine, George A.; Stark, Peter A., Liu, Young; Carroll, F. Ivy; Singh, P.; Xu, Heng; Rothman, Richard B.
Title: Enantiomers of Diastereomeric cis-N-[1-(2-Hydroxy- 2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanimides: Synthesis, X-ray Analysis, and Biological Activities
Source: J. Med. Chem. 38 (1995) 1547-1557
Description: 2 parameter logistic, IC50, Hill slope



Authors: Bubb, Michael R.; Korn, Edward D.
Title: Kinetic Model for the Inhibition of Actin Polymerization by Actobindin
Source: Biochem. 34 (1995) 3921-3926
Description: differential equations for kinetic rate equations, fit constants.



Authors: Bucher, W.E.; Currao, A.; Nesper, R.; Ruegger, H.; Venanzi, L.M.; Younger, E.
Title: K2-K3 Isomerism in Rhodium (l) Tris (pyrazolyl) borate Complexes of the Type Tp3R,4R,5RRh(LL) (LL-2CO,COD, and NBD) and Their Dynamic Behavior in Solution. X-Ray Crystal Structure of TpMeRh (NBD)
Source: Inorg. Chem. 34 (1995) 66-74



Authors: Cha, Xian Yuan; Xu, Heng; Rice, Kenner C.; Porreca, Frank; Lai, Josephine; Aranthan, Subramaniam; Rothman, Richard B.
Title: Opioid Peptide Receptor Studies. 1. Identification of a Novel Delta-Opioid Receptor Binding Site in Rat Brain Membranes
Source: Peptides 16 (1995) 191-198
Description: one site binding model.



Authors: Cohen, David M.; Bergman, Richard N.
Title: Estimation of TCA Cycle Flux, Aminotransferase Flux, and Anaplerosis in Heart: Validation With Syntactic Model
Source: Am. J. Physiol. 268 (1995) E397-E409
Description: fit sum of exponentials to graphs of enrichment of C-2 and C04 vs. time.



Authors: Emmert-Buck, Michael R.; Emonard, Herve P.; Corcoran, Marta L.; Krutzsch, Henry C.; Foidart, Jean-Michel; Statler-Stevenson, William G.
Title: Cell Surface Binding of TIMP-2 and pro-MMP-2/TIMP-2 Complex
Source: FEBS Lett. 364 (1995) 28-32
Description: analysis of binding data.



Authors: Fairman, Robert; Chao, Hann-Guang; Mueller, Luciano; Lavoie, Thomas B.; Shen, Liyang; Novotny, Jiri; Matsueda, Gary R.
Title: Characterization of a New Four-Chain Coiled Coil: Influence of Chain Length on Stability
Source: Protein Sci. 4 (1995) 1457-1469
Description: PCMLAB, peptide concentration dependent data and GuCl denatured data fit to sum of first and fourth powers of concentration of monomer.



Authors: Hawkins, Mary E.; Mitsuya, Hiroaki; McCully, Cynthia M.; Godwin, Karen S.; Murakami, Kunichika; Poplack, David G.; Balis, Frank M.
Title: Pharmacokinetics of Dideoxypurine Necleoside Analogs in Plasma and Cerebrospinal Fluid of Rhesus Monkeys
Source: Antim. Ag. Ch. 39 (1995) 1259-1268
Description: comparmental models for CSF and plasma concentration in time, area under curve, Mann-Whitney test.



Authors: Igout, A.; Frankenne, F.; L'Hermite-Baleriaux, M.; Martin, A.; Hennen, G.
Title: Somatogenic and Lactogenic Activity of the Recombinant 22 kDa Isoform of Human Placental Growth Hormone
Source: Grow Reg. 5 (1995) 60-65
Description: scatchard analysis.



Authors: Koga, M.; Wilk, A.; Moore, M.F.; Seremin, C.L.; Zhou, L.; Beaucage, S.L.
Title: Synthesis and Physicochemical Properties of Alternating alpha beta-oligodeoxyribonucleotides with Alternating (3->3) and (5->5) Internucleotidic Phosphodiester Linkages
Source: J. Org. Chem. 60 (1995) 1520-1530



Authors: Liu, F.W.M.; Freedman, M.V.; Chalovich, J.M.
Title: Characterization of Calponin Binding to Actin
Source: Biochem. 34 (1995) 11864-11871



Authors: Mahaney, James E.; Froehlich, Jeffrey P.; Thomas, David D.
Title: Conformational Transitions of the Sarcoplasmic Reticulum Ca-ATPase Studied by Time-Resolved EPR and Quenched-Flow Kinetics
Source: Biochem. 34 (1995) 4864-4879
Description: pre-steady state behavior of phosphorylation reaction modeled using mono- and bi-exponential functions.



Authors: Ni, Q.; Xu, H.; Partilla, J.S.; Calderon, S.N.; Porreca, F.; Rice, K.C.; Bertha, C.M.; McNutt, R.W.; Ananthan, S.; Rothman, R.B.
Title: Opioid Peptide Receptor Studies. 2. [3-H]SNC-121, A Novel, Selective, and High Affinity Ligand for Opioid Delta Receptors
Source: Analgesia 1 (1995) 185-193
Description: not found in print or on web.



Authors: Ni, Qing; Xu, Heng; Partilla, John S.; de Costa, Brian; Rice, Kenner C.; Kayakiri, Hiroshi; Rothman, Richard B.
Title: Opioid Peptide Receptor Studies. 3. Interaction of Opioid Peptides and Other Drugs With Four Subtypes of the Kappa-2 Receptor in Guinea Pig Brain
Source: Peptides 16 (1995) 1083-1095
Description: PCMLAB, binding surfaces fit to various models.



Authors: Piantadosi, Steven; Crowley, John
Title: An Implicitly Defined Parametric Model for Censored Survival Data and Covariates
Source: Biometrics 51 (1995) 249-258
Description: analytic derivatives, root finding, and graphics



Authors: Rebrin, Kerstin; Steil, Garry M.; Getty, Lisa; Bergman, Richard N.
Title: Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin
Source: Diabetes 44 (1995) 1038-1045
Description: paired t-tests and regression lines were calculated with PCMLAB.



Authors: Reiter, Eric; McNamara, Michael; Closset, Jean; Hennen, Georges
Title: Expression and Functionality of Luteinizing Hormone/Chronic Gonadotropin Receptor in the Rat Prostate
Source: Endocrin. 136 (1995) 917-923
Description: 2 Scatchard models: single site of high affinity and low capacity, single site with additional nonsaturable component



Authors: Rothman, Richard B.; Silverthorn, Mayme L.; Baumann, Michael H.; Goodman, Carl B.; Cadet, Jean L.; Matecka, Dorota; Rice, Kenner C.; Carroll, F. Ivy; Wang, Jia-Bei; Uhl, George R.; Partilla, John S.; Dersch, Christina M.
Title: Studies of the Biogenic Amine Transporters: VI. Characterization of a Novel Cocaine Binding Site, Identified with [125-I] RTI-55, in Membranes Prepared from Whole Rat Brain Minus Caudate
Source: J. Pharm. Exp. 274 (1995) 385-395
Description: PCMLAB, binding surface analysis



Authors: Rothman, Richard B.; Xu, Heng; Wang, Jia Bei; Partilla, John S.; Kayakiri, Hiroshi; Rice, Kenner C.; Uhl, George R.
Title: Ligand Selectivity of Cloned Human and Rat Opioid Mu Receptors
Source: Synapse 21 (1995) 60-64
Description: PCMLAB, 1-site binding model, 2-parameter logistic



Authors: Ruvirov, Sergei B.; Ahmed, S. Ashraf; McPhie, Peter; Miles, Edith Wilson
Title: Monovalent Cations Partially Repair a Conformational Defect in a Mutant Tryptophan Synthase Alpha-2 Beta-2 Complex (Beta-E109A)
Source: J. Biol. Chem. 270 (1995) 17333-17338
Description: fit noncooperative binding rate constants with MLAB.



Authors: Silverthorn, Mayme L.; Dersch, Christina M.; Baumann, Michael H.; Cadet, Jean L.; Partilla, John S.; Rice, Kenner C.; Carroll, F. Ivy; Becketts, Karen M.; Brockington, Alicia; Rothman, Richard B.
Title: Studies of the Biogenic Amine Transporters. V. Demonstration of Two Binding Sites for the Cocaine Analog [125-I] RTI-55 Associated with the 5-HT Transporter in Rat Brain Membranes
Source: J. Pharm. Exp. 273 (1995) 213-222
Description: PCMLAB, binding model.



Authors: Xu, Heng; Goodman, Carl B.; Partilla, John S.; Ni, Qi; Kayakiri, Hiroshi; Rice, Kenner C.; Rothman, Richard B.
Title: G-Beta-[125-I]-3,14-Dihydroxy-17-Methyl-4,5-Alpha- Epoxymorphinean ([125-I] IOXY-AGD): A Potent and Selective Radioligand for Opioid Mu Receptors
Source: Synapse 19 (1995) 105-111
Description: one and two component models, dissociation data, PCMLAB.



Authors: Young, Sidney
Title: Review of MLAB: A Mathematical Modelling Laboratory
Source: J. Chem. Inf. Comput. Sci. 35 (1995) 781-782


1996

Authors: Ahmed, S.A.; McPhie, P.; Miles, E.W.
Title: A Thermally Induced Reversible Conformational Transition of the Tryptophan Synthase Beta-2 Subunit Probe by the Spectroscopic Properties of Pyridoxal Phosphate and by Enzymatic Activity
Source: J. Biol. Chem. 271 (1996) 8612-8617
Description: MLAB fit parameters in Arrhenius equation.



Authors: Bastiononi, Simone; Donati, Alessandro; Gastaldelli, Amalia; Marchettini, Nadia; Renzoni, Debora; Rossi, Claudio
Title: Modeling Interpretation of Microbe Metabolism Detected by Nuclear Magnetic Resonance
Source: Biochem. Biophys. Rpts. 227 (1996) 53-58
Description: differential equation model



Authors: Bastiononi, Simone; Gastaldelli, Amalia; Bonechi, Claudia; Mocenni, Chiarra; Rossi, Claudio
Title: Kinetic Analysis and Comparison of Models of Xylose Metabolism by Klebsiella planticola
Source: Biochem. Biophys. Res. Comm. 227 (1996) 41-46
Description: Michaelis-Menten and ode kinetics models.



Authors: Bertha, C.M.; Ellis, M.; Flippen-Anderson, J.L.; Porreca, F.; Rothman, R.B.; Davis, P.; Xu, H.; Becketts, K.; Rice, K.C.
Title: Probes for Narcotic Receptor-Mediated Phenomena. 21. Novel Derivatives of 3-(1,2,3,4,5,11-Hexahydro-3-methyl-2, 6-methano-6J-azocino[4,5-b] indol-6-yl)-phenols with Improved Delta-Opioid Receptor Selectivity
Source: J. Med. Chem. 39 (1996) 2081-2086



Authors: Boice, Judith A.; Dieckmann, Gregg R.; DeGrado, William F.; Fairman, Robert
Title: Thermodynamic Analysis of a Designed Three-Stranded Coiled Coil
Source: Biochem. 35 (1996) 14480-14485
Description: PCMLAB, global fits of thermal unfolding data.



Authors: Boice, Judith A.; Fairman, Robert
Title: Structural Characterization of the Tumor Supressor p16, an Ankyrin-Like Repeat Protein
Source: Protein Sci. 5 (1996) 1776-1784
Description: circular dichroism signal at 222nm recorded at 25 degrees C for 500 seconds. data fit applying specialized algorithm. sedimentation equilibrium equation not fit with MLAB.



Authors: Goodman, Carl B.; Emilien, Betsey; Becketts, Karen; Cadet, Jean L.; Rothman, Richard B.
Title: Downregulation of Mu-Opioid Binding Sites Following Chronic Administration of Neuropeptide FF (NPFF) and Morphine
Source: Peptides 17 (1996) 389-397
Description: PCMLAB, 1-site binding model



Authors: Hollingsworth, S.; Zhao, Mingdi; Baylor, S.M.
Title: The Amplitude and Time Course of the Myoplasmic Free [Ca+2] Transient in Fast-Switch Fibers of Mouse Muscle
Source: J. General Phys. 108 (1996) 455-469



Authors: Jarnik, Michal; Kartasova, Tonja; Steinert, Peter M.; Lichti, Ulrike; Steven, Alasdair C.
Title: Differential Expression and Cell Envelope Incorporation of Small Proline-Rich Protein 1 in Different Cornified Epithelia
Source: J. Cell Sci. 109 (1996) 1381-1391



Authors: Jin, H.; Emanuele, J.J.; Fairman, R.; Roberson, J.G.; Hail, M.E.; Ho, H.T.; Falk, P.J.; Villafranca, J.J.
Title: Structural Studies of Escherichia coli UDP-N-Acetylmuramate: L-Alanine Ligase
Source: Biochem. 35 (1996) 1423-1431



Authors: Junghans, R.P.; Stone, A.L.; Lewis, M.S.
Title: Biophysical Characterization of a Recombinant Soluble Interleukin 2 Receptor (Tac)
Source: J. Biol. Chem. 271 (1996) 10453-10460
Description: ultracentrifuge sedimentation experimental data fit to model.



Authors: Kong, Siow-Kee; Yim, Moon Bin; Stadtman, Earl R.; Chock, P. Boon
Title: Peroxynitrite Disables the Tyrosine Phosphorylation Regulatory Mechanism: Lymphocyte-specific Tyrosine Kinase Fails to Phosphorylate Nitrated cdc2(6-20) NH2 Peptide
Source: Proc. Natl. Acad. Sci. 93 (1996) 3377-3382
Description: PCMLAB, integrated differential equations describing reaction scheme.



Authors: Matecka, Dorota; Rothman, Richard B.; Redesca, Lilian; de Costa, Brian R.; Dersch, Christina M.; Partilla, John S.; Pert, Agu; Glowa, John R.; Wojnicki, Francis H.E.; Rice, Kenner C.
Title: Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of [1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl) Piperazines (GBR 12935 and GBR 12909)
Source: J. Med. Chem. 39 (1996) 4704-4716
Description: PCMLAB, fit 2 parameter logistic to find IC50 and slope factor.



Authors: Richieri, Gary V.; Ogata, Ronald T.; Kleinfeld, Alan M.
Title: Kinetics of Fatty Acid Interactions with Fatty Acid Binding Proteins from Adipocyte, Heart, and Intestine
Source: J. Biol. Chem. 271 (1996) 11291-11300
Description: MLAB fit of rate constants in kinetic rate odes, verified fit solution with Macsyma.



Authors: Richieri, Gary V.; Ogata, Ronald T.; Kleinfeld, Alan M.
Title: Thermodynamics and Kinetic Properties of Fatty Acid Interactions with Rat Liver Fatty Acid Binding Protein
Source: J. Biol. Chem. 271 (1996) 31068-31075
Description: MLAB fit of rate constants in kinetic rate odes.



Authors: Schuck, Peter; Minton, Allen P.
Title: Analysis of Mass Transport-Limited Binding Kinetics in Evanescent Wave Biosensors
Source: Analytical Biochem. 240 (1996) 262-272
Description: 2 compartment model and ode model fit with MLAB.



Authors: Wexler, Leonard H.; Andrich, Mary P.; Venzon, David; Berg, Stacey L.; Weaver-McClure, Linda; Chan, Clara C.; Dilsizian, Vasken; Avila, Nilo; Jarosinski, Paul; Balis, Frank M.; Poplack, David G.; Horowitz, Marc E.
Title: Randomized Trial of the Cardioprotective Agent ICRF-187 in Pediatric Sarcoma Patients with Doxorubicin
Source: J. Clin. Onc. 14 (1996) 362-372
Description: plasma concentration fit to mono, biexponential models.



Authors: Zhao, Mingdi; Hollingsworth, S.; Baylor, S.M.
Title: Properties of Tri- and Tetracarboxylate Ca+2 Indicators in Frog Skeletal Muscle Fibers
Source: Biophys. J. 70 (1996) 896-916
Description: MLAB for figures and data analysis.


1997

Authors: Bakker, B.M.; Michels, P.A.M.; Opperdoes, F.R.; Westerhoff, H.V.
Title: Glycolysis in Bloodstream from Trypanosoma brucei can be Understood in Terms of the Glycolytic Enzymes
Source: J. Biol. Chem. 272 (1997) 3207-3215
Description: Michaelis-Menten kinetics simulations with MLAB.



Authors: Bhat, M.K.; McPhie, P.; Chang, S
Title: Critical Role of Glutamine 252 in the Hormone-Dependent Transcriptional Activity of the Thyroid Hormone Beta-1 Nuclear Receptor
Source: Biochem. 36 (1997) 4233-4239



Authors: Calderone, S.N.; Rice, K.C.; Rothman, R.B.; Porreca, F.; Flippen-Anderson, J.L.; Kayakiri, H.; Xu, H.; Becketts, K.; Smith, L.E.; Bilsky, E.J.; Davis, P.; Horvath, R.
Title: Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Receptor Binding, and Bioassay of the Highly Selective Delta-Agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl- 2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamid (SNC 80) and Related Novel Nonpeptide Delta-Opioid Receptor Ligands
Source: J. Med. Chem. 40 (1997) 695-704



Authors: Cohen, David M.; Bergman, Richard N.
Title: Improved Estimation of Anaplerosis in Heart Using 13C NMR
Source: Am. J. Physiology-Endo 273 (1997) E1228-E1242
Description: MLAB ode script for 180 diff eqs, but did not use.



Authors: Froehlich, Jeffrey P.; Taniguchi, Kazuya; Fendler, Klaus; Mchaney, James E.; Thomas, David D.; Albers, R. Wayne
Title: Complex Kinetic Behavior in the Na, K, and Ca-ATPases
Source: Ann. NY Acad 834 (1997) 280-296
Description: kinetics of catalysis



Authors: Gastaldelli, Amalia; Schwartz, Jean-Marc; Caveggion, Elisabetta; Traber, Lillian D.; Traber, Daniel L.; Rosenblatt, Judah; Toffolo, Giana; Cobelli, Claudio; Wolfe, Robert R.
Title: Glucose Kinetics in Interstitial Fluid Can Be Predicted by Compartmental Modeling
Source: Am. J. Physiol. 272 (1997) E494-E505
Description: model concentration of tracer in time



Authors: Hegedus, Lajos; Ford, Harry, Jr.; Hartman, Neil R.; Kelley, James A.
Title: Reverse-Phase High-Performance Liquid Chromatographic Determination of the New Antitumor Agent Cyclopentyl Cytosine in Biological Fluids
Source: J. Chrom. B 692 (1997) 169-179
Description: biexponential, 2 compartment open model, weighted least squares fit, area under curve-trapezoidal rule.



Authors: Ibarra-Molero, S.; Sanchez-Ruiz, J.M.
Title: Are There Equilibrium Intermediate States in the Urea-Induced Unfolding of Hen Egg-White Lysozyme
Source: Biochem. 36 (1997) 9616-9624



Authors: Javadpour, Maryam; Barkley, Mary D.
Title: Self-Assembly of Designed Antimicrobial Peptides in Solution and Micelles
Source: Biochem. 36 (1997) 9540-9549
Description: concentration distributions were fit to various mathematical models.



Authors: Kabymela, Bernard M.; Adschiri, Todafumi; Malaluan, Roberto; Arai, Kunio
Title: Degradation Kinetics of Dihydroxyacetone and Glyceraldehyde in Subcritical and Supercritical Water
Source: Ind. Eng. Res. 36 (1997) 2025-2030



Authors: Katsura, Y.; Zhang, X.; Homma, K.; Rice, K.C.; Calderon, S.N.; Rothman, R.B.; Yamamura, H.Z.; Davis, P.; Flippen-Anderson, J.L.; Xu, H.; Becketts, K.; Foltz, E.J.; Porreca, F.
Title: Probes for Narcotic Receptor-Mediated Phenomena. 25. Synthesis and Evaluation of N-Alkyl-Substituted (alpha-Piperazinylbenzyl) benzamides as Novel, Highly Selective Delta-Opioid Receptor Agonists
Source: J. Med. Chem. 40 (1997) 2936-2947



Authors: Kleinfeld, A.M.; Chu, P.; Romero, C.
Title: Transport of Long-Chain Native Fatty Acids across Lipid Bilayer Membranes Indicates that Transbilayer Flip-flop is Rate Limiting
Source: Biochem. 36 (1997) 14146-14158



Authors: Kleinfeld, A.M.; Chu, P.; Storch, J.
Title: Flip-flop is Slow and Rate Limiting for the Movement of Long Chain Anthroyloxy Fatty Acids across Lipid Vesicles
Source: Biochem. 36 (1997) 5702-5711



Authors: Lear, James D.; Schneider, J.P.; Kienker, P.K.; DeGrado, W.F.
Title: Electrostatic Effects on Ion Selectivity and Rectification in Designed Ion Channel Peptides
Source: JACS 119 (1997) 3212-3217
Description: equation fit with MLAB to ion-channel measurement data.



Authors: Lee, S.P.; Xiao, J.; Knudson, J.R.; Lewis, M.S.; Han, M.K.
Title: Zn 2+ Promotes the Self-Association of Human Immunodeficiency Virus Type-1 Integrase in Vitro
Source: Biochem. 36 (1997) 173-180



Authors: Liu, Jun; Zieger, Michael A.J.; Lakey, Jonathan RT; Woods, Erik J.; Critser, John K.
Title: The Determination of Membrane Permeability Coefficients of Canine Pancreatic Islet Cells and Their Application to Islet Cryopreservation
Source: Cryobiology 35 (1997) 1-13
Description: gear method in MLAB for Boyle van't Hoff plots.



Authors: Marshall, A. David; Darbyshire, John F.; Hunter, Ann P.; McPhie, Peter; Jakoby, William B.
Title: Control of Activity through Oxidative Modification at the Conserved Residue Cys-66 of Aryl Sulfotransferase IV
Source: J. Biol. Chem. 272 (1997) 9153-9160
Description: Scatchard equation.



Authors: Matecka, Dorota; Lewis, David; Rothman, Richard B.; Dersch, Christina M.; Wojnicki, Francis H.E.; Glowa, John R.; DeVries, A. Courtney; Pert, Agu; Rice, Kenner C.
Title: Heteroaromatic Analogs of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-Phenylpropyl) Piperazines (GBR 12935 and GBR 12909) as High-Affinity Dopamine Reuptake Inhibitors
Source: J. Med. Chem. 40 (1997) 705-716
Description: PCMLAB, fit 2 parameter logistic to obtain IC50 and slope factor.



Authors: Paalman, S.P.; Sung, C.; Clarke, N.D.
Title: Specificity of DNA Repair Methyltransferases Determined by Competitive Inactivation with Oligonucleotide Substrates: Evidence that Escherichia coli Ada Repairs O-6-Methylguanine and O-4-Methyl thymine with Similar Efficiency
Source: Biochem. 36 (1997) 11118-1124



Authors: Piantadosi, S.
Title: Clinical Trials-A Methodologic Perspective
Source: book published by John Wiley & Sons, NY.
Description: uses MLAB for pharmacokinetic models and briefly discusses the software.



Authors: Sakaguchi, K.; Sakamoto, H.; Lewis, M.S.; Anderson, C.W.; Erickson, J.W.; Appella, E.; Xie, D.
Title: Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Supressor Protein p53
Source: Biochem. 36 (1997) 10117-10124



Authors: Schneider, J.P.; Lear, J.D.; DeGrado, W.F.
Title: A Designed Buried Salt Bridge in a Hetero-dimeric Coiled-coil
Source: JACS 119 (1997) 5742-5743



Authors: Terry, David R.; Spector, Ilan; Higa, Tatsuo; Bubb, Michael R.
Title: Misakinolide A is a Marine Macrolide That Caps but Does Not Sever Filamentous Actin
Source: J. Biol. Chem. 272 (1997) 7841-7845
Description: estimate Kd of the interaction between misakinolide A and actin.



Authors: Yoshigi, Masaaki; Keller, Bradley B.
Title: Characterization of Embryonic Aortic Impedance with Lumped Parameter Models
Source: Am. J. Phys. 273 (1997) H19-H27
Description: Windkessel ode circuit models


1998

Authors: Agca, Y.; Liu, J.; McGrath, J.J.; Peter, A.T.; Critser, E.S.; Critser, J.K.
Title: Membrane Permeability Characteristics of Metaphase II Mouse Oocytes at Various Temperatures in the Presence of Me2SO
Source: Cryobiol. 36 (1998) 287-300
Description: Kedem Katchalsky differential model of membrane



Authors: Agca, Y.; Liu, J.; Peter, A.T.; Critser, E.S.; Critser, J.K.
Title: Effect of Developmental Stage on Bovine Oocyte Plasma Membrane Water and Cryoprotectant Permeability Characteristics
Source: Mol. Reprod. 49 (1998) 408-415
Description: Kedem Katchalsky differential equation model of membrane



Authors: Ananthan, S.; Johnson, C.A.; Carter, R.L.; Clayton, S.D.; Rice, K.C.; Xu, H.; Davis, P.; Porreca, F.; Rothman, R.B.
Title: Synthesis, Opioid Receptor Binding, and Bioassay of Naltrindole Analogues Substituted in the Indolic Benzene Moiety
Source: J. Med. Chem. 41 (1998) 2872-2881



Authors: Balagopalnkrishna, C.; Abugo, O.O.; Horsky, J.; Manoharan, P.T.; Nagababu, E.; Rifkin, J.M.
Title: Superoxide Produced in the Heme Pocket of the Beta-Chain of Hemoglobin Reacts with the Beta-93 Cystein to Produce a Thiyl Radical
Source: Biochem. 37 (1998) 13194-13202



Authors: Berg, Stacey L.; Blaney, Susan M.; Adamson, Peter C.; O'Brien, Michelle; Poplack, David G.; Arndt, Carola; Blatt, Julie; Balis, Frank M.
Title: Phase I Trial and Pharmacokinetic Study of Pyrazoloacridine in Children and Young Adults with Refractory Cancers
Source: J. Clin. Oncol. 16 (1998) 181-186
Description: 2-compartment model, Hill constant estimate



Authors: Blaney, S.M.; Takimoto, C.; Murry, D.J.; Kuttesch, Nancy; McCully, Cynthia; Cole, Diane E.; Godwin, Karen; Balis, Frank M.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in Nonhuman Primates
Source: Canc. Chemot. Pharm. 41 (1998) 464-468
Description: area under moment curve, rate constants



Authors: Choi, Sun-Jo; Mazzio, Elizabeth; Kolta, Malak G.; Soliman, Karam F.A.
Title: Prenatal Cocaine Exposure Affects Postnatal Dopaminergic Systems in Various Regions of the Rat Brain
Source: Ann. NY Acad. 844 (1998) 293-302
Description: 1,2,and 3-site binding models



Authors: Gilmore, J.A.; Liu, J.; Peter, A.T.; Critser, J.K.
Title: Determination of Plasma Membrane Characteristics of Boar Spermatozoa and Their Relevance to Cryopreservation
Source: Biol. Reprod. 58 (1998) 28-36
Description: Kedem Katchalsky differential equation model of membrane



Authors: Grandori, R.; Khalifah, P.; Boice, J.A.; Fairman, R.; Giovanelli, K.; Carey, J.
Title: Biochemical Characterization of WrbA, Founding Member of a new Family of Multimeric Flavodoxin-like Proteins
Source: J. Biol. Chem. 273 (1998) 20960-20966



Authors: Kabyemela, B.M.; Takigawa, M.; Adschiri, T.; Malaluan, R.M.; Arai, K.
Title: Mechanism and Kinetics of Cellobiose Decomposition in Sub- and Supercritical Water
Source: Ind. Eng. Res. 37 (1998) 357-361
Description: kinetics, rate equations



Authors: Kleinfeld, A.M.; Storms, S.; Watts, M.
Title: Transport of Long-Chain Native Fatty Acids across Human Erythrocyte Ghost Membranes
Source: Biochem. 37 (1998) 8011-8019



Authors: Lu, Yi Feng; Xu, Heng; Liu-Chen, Lee-Yuan; Chen, Chongguang; Partilla, John S.; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Sadee, Wolfgang; Rothman, Richard B.
Title: Opioid Peptide Receptor Studies. 7. The Methylfentanyl Cogener RTI-4614-4 and its Four Enantiomers Bind to Different Domains of the Rat mu Opioid Receptor
Source: Synapse 28 (1998) 117-124
Description: multiple site binding



Authors: Mueller, Brigitta U.; Anderson, Barry D.; Farley, Maureen Q.; Murphy, Robert; Zuckerman, Judy; Jarosinski, Paul; Godwin, Karen; McCully, Cindy L.; Mitsuya, Hiroaki; Pizzo, Philip A.; Balis, Frank M.
Title: Pharmacokinetics of the Protease Inhibitor KNI-272 in Plasma and Cerebrospinal Fluid in Human Immunodeficiency Virus-Infected Children after Intravenous and Oral Dosing
Source: Antim. Ag. Ch. 42 (1998) 1815-1818
Description: 2-compartment model



Authors: Mueller, Brigitta U.; Lewis, Linda L.; Yuen, Geoffrey J.; Farley, Maureen; Keller, Amy; Church, Joseph A.; Goldsmith, Jonathan C.; Venzon, David J.; Rubin, Marc; Pizzo, Philip A.; Balis, Frank
Title: Serum and Cerebrospinal Fluid Pharmacokinetics of Intravenous and Oral Lamivudine in Human Immunodeficiency Virus-Infected Children
Source: Antim. Ag. Ch. 42 (1998) 3187-3192
Description: 2-compartment model



Authors: Ni, Qing; Xu, Heng; Partilla, John S.; Rice, Kenner C.; Matecka, Dorota; Calderone, Silvia N.; Porreca, Frank; Liu, Josephine; Schmidhammer, Helmut; Krasonig, Roland; Rothman, Richard B.
Title: Opioid Peptide Receptor Studies. 9. Identification of a Novel Non-mu-Non-delta-like Opioid Peptide Binding Site in Rat Brain
Source: Peptides 19 (1998) 1079-1090
Description: two-parameter logistic and 1- and 2-site binding



Authors: Rossi, C.; Porcelli, M.; Mocenni, C.; Marchetti, N.; Loiselle, S.; Bastianoni, S.
Title: A Modelling Approach for the analysis of xylose-ethanol bioconversion
Source: Ecological Modeling 113 (1998) 157-162
Description: Michaelis-Menten, exponential, Odum models



Authors: Rothman, Richard B.; Silverhorne, Mayme L.; Glowa, John R.; Matecka, Dorota; Rice, Kenner C.; Carroll, F. Ivy; Partilla, John S.; Uhl, George R.; Vanderbergh, David J.; Dersch, Christina
Title: Studies of the Biogenic Amine Transporters. VII. Characterization of a Novel Cocaine Binding Site Identified with [125-I]RTI-55 in Membranes Prepared from Human, Monkey, and Guinea Pig Caudate
Source: Synapse 28 (1998) 322-338
Description: 1- and 2-site binding models



Authors: Sorgen, P.L.; Bubb, M.R.; McCormick, K.A.; Edison, A.S.; Cain, B.D.
Title: Formation of the b Subunit Dimer is Necessary for Interaction with F1-ATPase
Source: Biochem. 37 (1998) 923-932
Description: Ultra analytical centrifugation to determine oligomer subunit mass.



Authors: Stone, A.L.; Melton, D.J.; Lewis, M.S.
Title: Structure-function Relations of Heparin-Mimetic Sulfated Xylan Oligosacchirides: Inhibition of Human Immunodeficiency Virus-1 Infectivity in vitro
Source: Glycoconjugate Jrnl. 15 (1998) 697-712
Description: Sedimentation data analysis from ultracentrifuge.



Authors: Thomas, J.B.; Fall, M.J.; Cooper, J.B.; Rothman, R.B.; Mascarella, S.W.; Xu, H.; Partilla, J.S.; Dersch, C.M.; McCullogh, K.B.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I.
Title: Identification of an Opioid Kappa Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl) piperidine
Source: J. Med. Chem. 41 (1998) 5188-5197



Authors: Thomas, J.B.; Mascarella, S.W.; Rothman, R.B.; Partilla, J.S.; Xu, H.; McCullough, K.B.; Dersch, C.M.; Cantrell, B.E.;Zimmerman, D.M.; Carroll, F.I.
Title: Investigation of the N-Substituent Conformation Governing Potency and Mu-Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl- 4-(3-hydroxyphenyl)-piperidine Opioid Antagonists
Source: J. Med. Chem. 41 (1998) 1980-1990



Authors: Thomas, J.B.; Zheng, X.; Mascarella, S.W.; Rothman, R.B.; Dersch, C.M.; Partilla, J.S.; Flippen-Anderson, J.L.; George, C.F.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I.
Title: N-Substituted 9 Beta-Methyl-5-(3-hydroxyphenyl) Morphans Are Opioid Receptor Pure Antagonists
Source: J. Med. Chem. 41 (1998) 4143-4149



Authors: Torrents, A.; Anderson, B.G.; Hapeman, C.J.
Title: Kinetics of Bromacil Ozonolysis
Source: J. Agric. Food Chem. 46 (1998) 1630-1636



Authors: Troispoux, Carine; Reiter, Eric; Combarnous, Yves; Guillon, Florian
Title: Beta-2 adrenergic receptors mediate cAMP, tissue-type plasminogen activator and transferin production in rat Sertoli cells
Source: Mol. C. Endoc. 142 (1998) 75-86
Description: Scatchard analysis programmed with MLAB by M. McNamara (Liege, Be)



Authors: Watanabe, Richard M.; Steil, Garry M.; Bergman, Richard N.
Title: Critical Evaluation of the Combined Model Approach for Estimation of Prehapatic Insulin Secretion
Source: Am. J. Physiology-Endo. 274 (1998) E172-E183



Authors: Xu, Heng; Lu, Yi-Feng; Partilla, John S.; Pinto, Julia; Calderone, Sylvia N.; Matecka, Dorota; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Ananthan, Subramaniam; Rothman, Richard B.
Title: Optioid Peptide Receptor Studies. 8. One of the Mouse Brain delta-NCX Binding Sites is Similar to the Cloned Mouse Opioid delta Receptor
Source: Peptides 19 (1998) 343-350
Description: 1- and 2-site binding models, 2 parameter logistic equation



Authors: Yao, Shao; Ghosh, Indraneel
Title: A Self-Replicating Peptide under Ionic Control
Source: Angew. Chemistry, Intl. Ed. 37 (1998) 478-481.
Description: values of dissociation rate constants fit from denaturation data in 2-state model for monomer-tetramer transition,


1999

Authors: Agca, Y.; Liu, J.; Critser, E.S.; McGrath, J.J.; Critser, J.K.
Title: Temperature-Dependent Osmotic Behavior of Germinal Vesicle and Metaphase II Stage Bovine Oocytes in the Presence of Me2SO in Relationship to Cryobiology
Source: Mol. Reprod. 53 (1999) 59-67
Description: Kedem Katchalsky model of membrane permeability coefficient



Authors: Ananthan, S.; Kezar, H.S.; Carter, R.L.; Saini, S.K.; Rice, K.C.; Wells, J.L.; Davis, P.; Xu, H.; Dersch, C.M.; Bilsky, E.J.; Porreca, F.; Rothman, R.B.
Title: Synthesis, Opioid Receptor Binding, and Biological Activities of Naltrexone-Derived Pyrido- and Pyrinidomorphinans
Source: J. Med. Chem. 42 (1999) 3527-3538



Authors: Barrett, William C.; DeGnore, Jon P.; Keng, Yen-Fang; Zhang, Zhong-Yin; Kim, Moon B.; Chock, P.Boon
Title: Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphate 1B
Source: J. Biol. Chem. 274 (1999) 34543-34546
Description: kinetic rate constants



Authors: Barrett, W.C.; DeGnore, J.P.; Konig, S.; Fales, H.M.; Keng, Y.F.; Zhang, Z.Y.; Yim, M.B.; Chock, P.B.
Title: Regulation of PTPIB via Glutathionylation of the Active Site Cysteine 215
Source: Biochem. 38 (1999) 6699-6705



Authors: Bastianoni, Simone; Donati, Alessandro; Gastaldelli, Amalia; Marchettini, Nadia; Martini, Silvia; Rossi, Claudio
Title: A Modellistic View of the Kinetics of Metabolic Processes: Differences in Glucose and Xylose Degradation Pathway
Source: Chem. Phys. Lett. 310 (1999) 38-42
Description: non-linear differential equation model



Authors: Bastianoni, S.; Martini, S.; Porcelli, M.; Rossi, C.
Title: Modeling the Complex Behavior of Microorganisms
Source: Ann. NY Acad. 879 (1999) 387-391
Description: three coupled non-linear differential equations



Authors: Berg, Stacey L.; Reid, Joel; Godwin, Karen; Murry, Daryl J.; Poplack, David G.; Balis, Frank M.; Ames, Matthew M.
Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of Daunorubicin, Idarubicin, and their Metabolites in the Nonhuman Primate Model
Source: J. Ped. Hematology/Oncology 21 (1999) 26-30
Description: multiexponential model



Authors: Chen, Tong-Bin; Bajzer, Zeljko; Macura, Slobodan; Vuk-Paulovic, Stanimir
Title: Differences in Metabolism of 5-fluorouracil and 5-fluorouridine and Regulation by Glucosamine in Human Colon Cancer Multicell Tumor Spheroids
Source: NMR in Biomedicine 12 (1999) 157-167
Description: differential equation models



Authors: Clarke, R.J.; Lupfert, C.
Title: Influence of Anions and Cations on the Dipole Potential of Phosphatidylcholine Vesicles: A Basis for the Hofmeister Effect
Source: Biophys.J. 76 (1999) 2614-2624.



Authors: Coop, A.; Rothman, R.B.; Dersch, C.; Partilla, J.; Porreca, F.; Davis, P.; Jacobson, A.E.; Rice, K.C.
Title: Delta Opioid Affinity and Selectivity of 4-Hydroxy-3- methoxindolomorphion Analogues Related to Naltrindole
Source: J. Med. Chem. 42 (1999) 1673-1679



Authors: Fan, Y.X.; McPhie, P.; Miles, E.W.
Title: Guanidine Hydrochloride Exerts Dual Effects on the Tryptophan Synthesis alpha-2-beta-2 Complex as a Cation Activation and as a Modulator of the Active Site Conformation
Source: Biochem. 38 (1999) 7881-7890



Authors: Gandhi, Chris J.; Shuck, Kevin; Lear, James D.; Dieckmann, Gregg R.; DeGrado, William F.; Lamb, Robert A.; Pinto, Lawrence H.
Title: Cu(II) Inhibition of the Proton Translocation Machinery of the Influenza A Virus M2 Protein
Source: J. Biol. Chem. 274 (1999) 5474-5482
Description: differential equations for 2-state binding of Cu+2 to M2 ion channel protein



Authors: Ibarra-Molero, B.; Loladze, V.V.; Makatadze, G.I.; Sanchez-Ruiz, J.M.
Title: Thermal versus Guanidine-Induced Unfolding of Ubiquitin. An Analysis in Terms of the Contribution from Charge-Charge Interactions to Protein Stability
Source: Biochem. 38 (1999) 8138-8149



Authors: Ito, Shinya; Woodland, Cindy; Sarkadi, Balazs; Hockmann, Guido; Walker, Scott E.; Koren, Gideon
Title: Modeling of P-glycoprotein-involved Epithelial Drug Transport in MDCK Cells
Source: Am. J. Physiol. 277 (1999) F84-F96



Authors: Kabyemela, Bernard M.; Adschiri, Todafumi; Malaluan, Roberto M.; Arai, Kunio
Title: Glucose and Fructose Decomposition in Subcritical and Supercritical Water-Detailed Reaction Pathway, Mechanisms, and Kinetics
Source: Ind. Eng. Res. 38 (1999) 2888-2895



Authors: Kirillov, S.A.
Title: Time Correlation Functions from Band-Shape Fits without Fourier Transform
Source: Chem. Phys. Lett. 303 (1999) 37-42
Description: fit of line shape function with K1(x) Bessel function as a factor.



Authors: Kirillov, S.A.; Perova, T.S.; Nielsen, O.F.; Praestgaard, E.; Rasmussen, U.; Kolomiyets, T.M.; Voyiatzis, G.A.; Anastasiadis, S.H.
Title: Fitting the Low-Frequency Raman Spectra to Boson Peak Models- Glycerol, Triacetin, and Polystyrene
Source: J. Mol. Struct. 479 (1999) 271-278
Description: fit lineshape functions to peaks in spectra.



Authors: Kirillov, S.A.; Voyiatzis, G.A.; Kolomiyets, T.M.; Anastasiadis, S.H.
Title: Spatial Correlations and Exact Solution of the Problem of the Boson Peak Profile in Amorphous Media
Source: Phys. Lett. A 262 (1999) 186-190
Description: curve fitting.



Authors: Kuznetsov, Vladimir; Puri, Raj K.
Title: Kinetic Analysis of High Affinity Forms of Interlukin (IL)-13 Receptors: Supression of IL-13 Binding by IL-2 Receptor Gamma Chain
Source: Biophys. J. 77 (1999) 154-172
Description:



Authors: Leinweber, B.; Tang, J.X.; Stafford, W.F.; Chalovich, J.M.
Title: Calponin Interaction with alpha-Actinin-Actin: Evidence for a Structural Role for Calponin
Source: Biophys.J. 77 (1999) 3208-3217.



Authors: Rebrin, Kerstin; Steil, Garry M.; Van Antwerp, William P.; Mastrototaro, John J.
Title: Subcutaneous Glucose Predicts Plasma Glucose Independent of Insulin: Implications for Continuous Monitoring
Source: Am. J. Phys.-Endocr. 277 (1999) E561-E571
Description: nonlinear least squares analysis of differential equation model



Authors: Thompson, Curtis B.; Choi, Cheolsoo; Youn, Jang H.; McDonough, Alicia A.
Title: Temporal Responses of Oxidative vs. Glycolytic Skeletal Muscles to K+ Deprivation- Na+ Pumps and Cell Cations
Source: Am. J. Physiol.- Cell Phys. 276 (1999) C1411-C1419



Authors: Widemann, Brigette C.; Balis, Frank M.; Godwin, Karen S.; McCully, Cindy; Adamson, Peter C.
Title: The Plasma Pharmacokinetics and Cerebrospinal Fluid Penetration of the Thymidylate Synthase Inhibitor Raltitrexed (Tomudex) in a Nonhuman Primate Model
Source: Canc. Chemot. 44 (1999) 439-443
Description: 3-compartment pharmacokinetic model, EWT



Authors: Woods, E.J.; Liu, J.; Gilmore, J.A.; Reid, T.J.; Gao, D.Y.; Critser, J.K.
Title: Determination of Human Platelet Membrane Permeability Coefficients Using the Kedem-Katchalsky Formalism: Estimates from Two- vs Three-Parameter Fits
Source: Cryobiol. 38 (1999) 200-208
Description: Kedem-Katchalsky model for cell membrane permeability.



Authors: Xu, Heng; Lu, Yi-Feng; Partilla, John S.; Zhang, Qiao-Xi; Weng, Jia-Bei; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Chen, Kai-Xian; Lui, Zhi-Qiang; Rothman, Richard B.
Title: Opioid Peptide Receptor Studies. 11: Involvement of Tyr148, Trp318, and His319 of the Rat mu-Opioid Receptor in Binding of mu-Selective Ligands
Source: Synapse 32 (1999) 23-28
Description: 1-site binding model, 2-parameter logistic model



Authors: Xu, S.; Gu, J.; Rhodes, T.; Belknap, G.; Rosenbaum, G.O.; White, H.; Yu, L.C.
Title: The M-ADP-Pi State is Required for Helical Order in the Thick Filaments of Skeletal Muscle
Source: Biophys.J. 77 (1999) 2665-2676.



Authors: Zhang, X.; Rice, K.C.; Calderon, S.N.; Kayakiri, H.; Smith, L.; Coop, A.; Jacobson, A.E.; Rothman, R.B.; Davis, P.; Dersch, C.M.; Porreca, F.
Title: Probes for Narcotic Receptor Mediated Phenomena. 26. Synthesis and Biological Evaluation of Diarylmethylpiperazines and Diarylmethylpiperidines as Novel, Nonpeptidic Delta-Opioid Receptor Ligands
Source: J. Med. Chem. 42 (1999) 5455-5463


2000

Authors: Dibrov, Pavel; Murtazina, Rakhilya; Kinsella, James; Fliegel, Larry
Title: Characterization of a Histidine Rich Cluster of Amino Acids in the Cytoplasmic Domain of the Na+/H+ Exchanger
Source: Biosci. Reports 20 (2000) 185-197
Description: Hill equation



Authors: Fan, Y.X.; McPhie, P.; Miles, E.W.
Title: Regulation of Tryptophan Synthesis by Temperature, Monovalent Cations, and an Allosteric Ligand. Evidence from Arrhenius Plots, Absorption Spectra, and Primary Kinetic Isotope Effects
Source: Biochem. 39 (2000) 4692-4703



Authors: Geibel, S.; Barth, A.; Amslinger, S.; Jung, A.H.; Burzik, C.; Clarke, R.J.; Givens, R.S.; Fendler, K.
Title: P3-[2-(4-hydroxyphenyl)-2-oxo] ethyl ATP for the Rapid Activiation of the Na+, K+-ATPase
Source: Biophys. J. 79 (2000) 1346-1357.



Authors: Heylinger, Simone O.; Ni, Qing; Rothman, Richard B.
Title: Resolution of two [35-S] GTP-gamma-S Binding Sites and Their Response to Chronic Morphine Treatment: A Binding Surface Analysis
Source: Brain Research Bull. 51 (2000) 357-362
Description: 1- and 2-site binding models



Authors: Huang, K.P.; Huang, F.L.; Li, J.; Schuck, P.; McPhie, P.
Title: Calcium-Sensitive Interaction Between Calmodulin and Modified Forms of Rat Brain Neurogranin/RC3
Source: Biochem. 39 (2000) 7291-7299



Authors: Jhee, K.H.; McPhie, P.; Miles, E.W.
Title: Domain Architecture of the Heme-Independent Yeast Cystathionine Beta-Synthase Provides Insights into Mechanisms of Catalysis and Regulation
Source: Biochem. 39 (2000) 10548-10556



Authors: Kim, J.; Gavrilova, O.; Chen, Y.; Reitman, M.; Shulman, G.
Title: Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice
Source: J.Biol.Chem. 275 (2000) 8456-8460.



Authors: Kinsella, T.; Schupp, J.; Davis, T.; Berry, S.; Hwang, H.; Warren, K.; Balis, F.; Barnett, J.; Sands, H.
Title: Preclinical Study of the Systemic Toxicity and Pharmacokinetics of 5-Iodo-2-deoxypyrimidinone-2'-deoxyribose as a Radiosensitizing Prodrug in Two, Non-Rodent Animal Species: Implications for Phase I Study Design
Source: Clin.Canc.Res. 6 (2000) 3670-3679.



Authors: Kirillov, S.A.; Nielsen, O.F.
Title: Boson Peak in the Low Frequency Raman Spectra of Ordinary Liquids
Source: J. Mol. Struct. 526 (2000) 317-321
Description: curve fit peaks in Raman spectrum of formamide..



Authors: Kirillov, S.V.; Yannopoulos, S.N.
Title: Charge-Current Contribution to Low-Frequency Raman Scattering from Glass-Forming Ionic Liquids
Source: Phys. Rev. B 61 (2000) 11391-11399
Description: curve fit peaks in Raman spectra.



Authors: Lewis, Marc S.; Junghans, Richard P.
Title: Ultracentrifugal Analysis of Molecular Mass of Glycoproteins of Unknown or Ill-Defined Carbohydrate Consumption
Source: Meth. Enzym. 321 (2000) 136-149
Description: ultracentrifuge model



Authors: Marshall, A. David; McPhie, Peter; Jakoby, William B.
Title: Redox Control of Aryl Sulfotransferase Specificity
Source: Arch. Bioch. 382 (2000) 95-104
Description: ligand binding to multiple sites



Authors: Riva, Luca; Blaney, Susan M.; Dauser, Robert; Nuchtern, Jed G.; Durfee, John; McGuffey, Leticia; Berg, Stacey L.
Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of CI-944 (N-Acetyldinaline) in the Nonhuman Primate
Source: Clin. Canc. Res. 6 (2000) 994-997
Description: 5-compartment model, multiexponential function fit



Authors: Salom, D.; Hill, B.R.; Lear, J.D.; DeGrado, W.F.
Title: pH-Dependent Tetramerization and Amentadine Binding of the Transmembrane Helix of M2 from the Influenza A Virus
Source: Biochem. 39 (2000) 14160-14170



Authors: Slack, J; Schooley, K.; Bonnert, T.; Mitcham, J.; Qwarnstrom, E.; Sims, J.; Dower, S.
Title: Identification of Two Major Sites in the Type 1 Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways
Source: J.Biol.Chem. 275 (2000) 4670-4678.



Authors: Stern, M.D.
Title: The Model of Snyder et.al. Does Not Simulate Graded Ca2+ Release from the Cardiac Sarcoplasmic Reticulum in Intact Cells
Source: Biophys.J. 79 (2000) 3353-3354.



Authors: Yoshigi, M.; Knott, G.D.; Keller, B.B.
Title: Lumped Paramter Estimation for the Embryonic Chick Vascular System-A Time Domain Approach Using MLAB
Source: Comp. Meth. Prog. Biomed. 63 (2000) 29-41
Description: Windkessel ode circuit models


2001

Authors: Beall, B.; Chalovich, J.M.
Title: Fesselin, a Synaptopodin-like Protein, Stimulates Actin Nucleation and Polymerization
Source: Biochem. 40 (2001) 14252-14259



Authors: Berg, S.; Serabe, B.; Aleksic, A.; Bomgaars, L.; McGuffey, L.; Dauser, R.; Durfee, J.; Nuchtern, J.; Blaney, S.
Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of Phenylacetate and Phenylbutyrate in the Nonhuman Primate
Source: Canc. Chem. Pharmacol. 47 (2001) 385-390
Description: six compartment model, area under curve calculations



Authors: Caride, A.J.; Penhieter, A.R.; Filoteo, A.G.; Bajzer, Z.; Enyedi, A.; Penniston, J.T.
Title: The Plasma Membrane Calcium Pump Displays Memory of Past Calcium Spikes
Source: J. Biol. Chem. 276 (2001) 39797-39804



Authors: Godsland, I.F.; Walton, C.
Title: Maximizing the Success Rate of Minimal Model Insulin Sensitivity Measurement in Humans: the Importance of Basal Glucose Levels
Source: Clinical Science 101 (2001) 1-9
Description: Bergman Minimal Model



Authors: Hebert, A.M.; Strohmaier, J.; Whitman, M.C.; Chen, T.; Gubina, E.; Hill, D.W.; Lewis, M.S.; Kozlowski, S.
Title: Kinetics and Thermodynamics of Beta-2-Microglobulin Binding to the Alpha-3 Domain of Major Histocompatibility Complex Class 1 Heavy Chain
Source: Biochem. 40 (2001) 5233-5242



Authors: Kirillov, S.A.; Musiyenko, I.S.; Photiadis, G.M.; Pavlatou, E.A.
Title: Ionic Interactions in Molten Complex Chlorides from Vibrational Dephasing
Source: J. Chem. Phys. 114 (2001) 3683-3691
Description: fit of Kubo equation.



Authors: Kuznetsov, V.A.; Knott, G.D.
Title: Modeling Tumor Regrowth and Immunotherapy
Source: Math. Comput. Mod. 33 (2001) 1275-1287
Description: solved odes for tumor cell population growth.



Authors: Lee, S.P.; Fuior, E.; Lewis, M.S.; Han, M.K.
Title: Analytical Ultracentrifugation Studies of Translin: Analysis of Protein-DNA Interactions Using a Single-Stranded Fluorogenic Oligonucleotide
Source: Biochem. 40 (2001) 14081-14088



Authors: Tang, Y.; Ghirlanda, G.; Vaidehi, N.; Kua, J.; Mainz, D.T.; Goddard, W.A.; DeGrado, W.F.; Tirrell, D.A.
Title: Stabilization of Coiled-Coil Peptide Domains by Introduction of Trifluoroleucine
Source: Biochem. 40 (2001) 2790-2796



Authors: Thomas, J.B.; Herault, X.M.; Rothman, R.B.; Atkinson, R.N.; Burgess, J.P.; Mascarella, S.W.; Dersch, C.M.; Xu, H.; Flippen-Anderson, J.L.; George, C.F.; Carroll, F.I.
Title: Factors Influencing Agonist Potency and Selectivity for the Opioid Delta Receptor Are Revealed in Structure-Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N- diethylbenzamides
Source: J. Med. Chem. 44 (2001) 972-987


2002

Authors: Craig, T.A.; Benson, L.M.; Venyaminov, S.Y.; Klimtchuk, E.S.; Bajzer, Z.; Prendergast, F.G.; Naylor, S.; Kumer, R.
Title: The Metal-binding Properties of DREAM (Downstream Regulatory Element Antagonist Modulator)
Source: J. Biol. Chem. 277 (2002) 10955-10966



Authors: Kuznetsov, V.A.; Knott, G.D.; Bonner, R.F.
Title: General Statistics of Stochastic Process of Gene Expression in Eukaryotic Cells
Source: Genetics 161 (2002) 1321-1332
Description: fit of Pareto-like probability function

Title: Analysis of the Evolving Proteomes: Predictions of the Number of Protein Domains in Nature and the Number of Genes in Eukaryotic Organisms
J. Biol. Sys. 10 (2002) 381-407
Authors: Kuznetsov, V.A.; Pickatov, V.V.; Senko, O.V.; Knott, G.D.



Authors: Moskovitz, J.; Yim, M.B; Boon Chock, P.
Title: Free Radicals and Disease
Source: Arch. Biochem. & Biophys. 397 (2002) 354-359
Description: solve odes describing rates of free radical reactions



Authors: Resetar, A.M.; Stephens, J.M.; Chalovich, J.M.
Title: Troponin-Tropomyosin: An Allosteric Switch or a Steric Blocker?
Source: Biophys.J. 83 (2002) 1039-1049.
Description: Hill equation parameter estimation.



Authors: Schuck, P.; Perugini, M.A.; Gonzales, N.R.; Howlett, G.J.; Schubert, D.
Title: Size-Distribution Analysis of Proteins by Analytical Ultracentrifugation: Strategies and Application to Model Systems
Source: Biophys.J. 83 (2002) 1096-1111.



Authors: Solan, A.; Ratia, K.; Fairman, R.
Title: Exploring the Role of Alanine in the Structure of the Lac Repressor Tetramerization Domain, a Ferritin-like Alacoil
Source: J. Mol. Biol. 317 (2002) 601-612



Authors: Thorolfsson, M.; Ibarra-Molero, B.; Fojan, P.; Petersen, S.B.; Sanchez-Ruiz, J.M.; Martinez, A.
Title: L-Phenylalanine Binding and Domain Organization in Human Phenylalanine Hydroxylase: A Differential Scanning Calorimetry Study
Source: Biochem. 41 (2002) 7573-7585


2003

Authors: Blaney, S.; Heideman, R.; Berg, S.; Adamson, P.; Gillespie, A.; Geyer, J.; Packer, R.; Matthay, K.; Jackle, K.; Cole, D.; Kuttesch, N.; Poplack, D.; Balis, F.
Title: Phase I Clinical Trial of Intrathecal Topotecam in Patients with Neoplastic Meningitis.
Source: J. Clin. Oncol. 21 (2003) 143-147
Description: compartmental model



Authors: Henderson, T.J.; Venable, R.M.; Egan, W.
Title: Conformational Flexibility of the Group B Meningococcal Polysaccharide in Solution
Source: JACS 125 (2003) 2930-2939



Authors: Huang, C.Y.; Zhou, R.; Yang, D.C.H.; Boon Chock, P.
Title: Application of the Continuous Variation Method to Cooperative Interactions: Mechanism of Fe(II)-ferrozine Chelation and Conditions Leading to Anomolous Binding Ratios
Source: Biophys. Chem. 100 (2003) 143-149.


ed. by J.A.Novotny, M.H. Green, R.C. Boston; NY: Kluwers Academic, 2003.
Description: multicompartmental ode model
Authors: Knott, G.; Kerner, D.
Title: Solving and Fitting France's Rumen Model with MLAB
Source: Mathematical Modeling in Nutrition and the Health Sciences,



Authors: Lipovac, M.N.; Holland, T.; Poleksic, A.; Killian, C.; Lajtha, A.
Title: The Possible Role of Glutamate Uptake in Metaphit-Induced Seizures
Source: Neurochem. Res. 28 (2003) 723-731.
Description: Michaelis-Menten kinetics



Authors: Patel, M.; McCully, C.; Godwin, K.; Balis, F.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Temozolamide in Non-Human Primates
Source: J. Neuro-oncology 61 (2003) 203-207.
Description: two compartment model with first order elimination for plasma-concentration time data.



Authors: Penheiter, A.R.; Bajzer, Z.; Filoteo, A.G.; Thorogate, R.; Torok, K.; Caride, A.J.
Title: A Model for the Activation of Plasma Membrane Calcium Pump Isoform 4b by Calmodulin
Source: Biochem. 42 (2003) 12115-12124



Authors: Thomas, J.B.; Atkinson, R.N.; Vinson, N.A.; Catanzaro, J.L.; Perrella, C.L.; Fix, S.E.; Mascarella, S.W.; Rothman, R.B.; Xu, H.; Dersch, C.M.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I.
Title: Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4- (3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4- tetrahydro-3-isoquinoline carboxamide as a Novel Potent and Selective Opioid Kappa Receptor Antagonist
Source: J. Med. Chem. 46 (2003) 3127-3137



Authors: Yang, L.; Ross, K.; Qwarnstrom, E.
Title: RelA Control of I-kappa-beta-alpha Phosphorylation: A Positive Feedback Loop for High Afinity NF-kappa-beta Complexes
Source: J. Biol. Chem. 278 (2003) 30881-30888.


2004

Authors: Anathan, S.; Khare, N.K.; Saini, S.K.; Seitz, L.E.; Bartlett, J.L.; Davis, P.; Dersch, C.M.; Porreca, F.; Rothman, R.B.; Bilsky, E.J.
Title: Identification of Opioid Ligands Possessing Mixed Mu-Agonist/ Delta-Antagonist Activity among Pyridomorphinans Derived from Naloxone, Oxymorphone, and Hydropmorphone
Source: J. Med. Chem. 47 (2004) 1400-1412



Authors: Chaveiro, A.; Liu, J.; Mullen, J.; Woelders, H.; Critser, J.
Title: Determination of Bull Sperm Membrane Permeability to Water and Cryoprotectants using a Concentration-dependent Self-Quenching Fluorophore
Source: Cryobiology 48 (2004) 72-80
Description: Kedem Kachalsky model



Authors: Crupp, D.; Kampf, J.P.; Kleinfeld, A.M.
Title: Fatty Acid-Albumin Complexes and the Determination of the Transport of Long Chain Free Fatty Acids across Membranes
Source: Biochem. 43 (2004) 4473-4481



Authors: Gafurov, B; Chen, Y.D.; Chalovich, J.M.
Title: Ca+2 and Ionic Strength Dependencies of S1-ADP Binding to Actin-Tropomyosin-Tropomin: Regulatory Implications
Source: Biophys.J. 87 (2004) 1825-1835.
Description: Hill equation parameter estimation



Authors: Gafurov, B.; Frederickson, S.; Cai, A.; Brenner, B.; Chase, P.B.; Chalovich, J.M.
Title: The Delta-14 Mutation of Human Cardiac Troponin T Enhances ATPase Activity and Alters the Cooperative Binding of S1-ADP to Regulated Actin
Source: Biochem. 43 (2004) 15276-15285



Authors: Kampf, J; Kleinfeld, A
Title: Fatty Acid Transport in Adipocytes Monitored by Imaging Intracellular Free Fatty Acid Levels
Source: J.Biol.Chem. 279 (2004) 35775-35780.



Authors: Mahaney, J.; Thomas, D.; Froehlich, J.
Title: The Time-dependent Distribution of Phosphorylated Intermediates in Native Sarcoplasmic Reticulum Ca 2+ ATPase from Skeletal Muscle is not Compatible with a Linear Kinetic Model
Source: Biochem 43 (2004) 4400-4416
Description: chemical kinetics model



Authors: Martini, S.; Ricci, M.; Bonechi, C.; Trabalzine, L.; Santucci, A.; Rossi, C.
Title: In vitro 13-C-NMR and Modelling Study of Metabolic Yield Response to Ethanol Stress in a Wild-type Strain of Saccharomyces cerevisiae.
Source: FEBS Letters 564 (2004) 63-68
Description: multicompartmental ode model



Authors: Neville, K.; Blaney, S.; Bernstein, M.; Thompson, P.; Adams, D.; Aleksic, A.; Berg, S.
Title: Pharmacokinetics of O6-benzylguanine in Pediatric Patients with Central Nervous System Tumors
Source: Clin. Canc. Res. 10 (2004) 5072-5075
Description: 2 compartment, ode model



Authors: Perez-Jimenez, R.; Godoy-Ruiz, R.; Ibarra-Molero, B.; Sanchez-Ruiz, J.M.
Title: The Efficiency of Different Salts to Screen Charge Interactions in Proteins: A Hofmeister Effect?
Source: Biophys.J. 86 (2004) 2414-2429



Authors: Ricci, M.; Martini, S.; Bonechi, C.; Trabalzini, L.; Santucci, A.; Rossi, C.
Title: Inhibition Effects of Ethanol on the Kinetics of Glucose Metabolism by S. cerevisiae: NMR and Modelling Study
Source: Chem. Phys. Lett. 387 (2004) 377-382
Description: compartmental model, ode reaction kinetics



Authors: Roehl, M.H.A.; Wang, J.Y.; Wagner, G.
Title: Discovery of Small-Molecule Inhibitors of the NFAT-Calcineurin Interaction by Competitive High-Throughput Fluorescence Polarization Screening
Source: Biochem. 43 (2004) 16067-16075



Authors: Sugiura, M.; Ohno, Y.; Yamada, Y.; Suzuki, H.; Iya, T.
Title: Pharmacokinetic/Pharacodynamic Analysis of Neutrophil Proliferation Induced by rh h-CSF in Patients Receiving Antineoplastic Drugs
Source: J. Pharm. Soc. Japan 124 (2004) 599
Description: compartmental model



Authors: Thompson, P.; Berg, S.; Aleksic, A.; Kerr, J.; McGuffey, L.; Dauser, R.; Nuchtern, J.; Hauser, F.; Blaney, S.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetic Study of BNP1350 in non-human primates
Source: Canc. Chem. Pharm. 53 (2004) 527-532
Description: bi-exponential model


2005

Authors: Agca, Y.; Liu, J.; Mullen, S.; Johnson-Ward; Gould, K.; Chen, A.; Critser, J.
Title: Chimpanzee (Pantroglodytes) Spermatazoa Osmotic Tolerance and Cryoprotectant Pemeability Characteristics
Source: J. Androl. 26 (2005) 470-477
Description: Kadem-Kachalsky model



Authors: Agca, Y; Mullen, S.; Liu, J.; Johnson-Ward, J; Gould, K; Chen, A.; Critser, J.
Title: Osmotic tolerance and membrane permeability characteristics of rhesus monkey (Macaca mulatta) spermatazoa
Source: J.Cryobiology 51 (2005) 1-14.
Description: Kadem-Kachalsky model



Authors: Bhatnagar, B.; Cardon, S.; Pikal, M.
Title: Reliable Determination of Freeze-Concentration using DSC
Source: Thermochimica Acta 425 (2005) 149-163



Authors: Blaney, S.M.; Balis, F.; Berg, S.; Arndt, C.A.S.; Heideman, R.; Geyer, J.R.; Packer, R.; Adamson, P.C.; Jaeckle, K; Klenke, R.; Aikin, A.; Murphy, R.; McCully, C.; Poplack, D.G.
Title: Intrathecal Mafosfamide: A Preclinical Pharmacology and Phase I trial
Source: J. Clin. Oncol. 23 (2005) 1555-1563.
Description: compartmental model



Authors: Handa, V.; Yeh, H.; McPhie, P.; Usdin, K.
Title: The AUUCU Repeats Responsible for Spinocerebellar Ataxia Type10 Form Unusual RNA Hairpins
Source: J.Biol.Chem. 280 (2005) 29340-29345



Authors: Jacobs, S.; Fox, E.; Dennie, C.; Morgan, L.; McCully, C.; Balis, F.
Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Oxaliplatin, Cisplatin, and Carboplatin in Nonhuman Primates
Source: Clin.Canc.Res. 11 (2005) 1669-1674



Authors: Mahaney, J.E.; Albers, R.W.; Waggoner, J; Kutch, A.; Froehlich, J.P
Title: Intermolecular Conformational Coupling and Free Energy Exchange Enhance the Catalytic Efficiency of Cardiac Muscle SERCA2a following relief of Phosphorylation Inhibiter
Source: Biochem. 44 (2005) 7713-7724.



Authors: Roy, S.; Dimitriadis, E.K.; Kar, S.; Geanacopoulos, M.; Lewis, M.S.; Adhya, S.
Title: Gal Repressor-Operator-HU Ternary Complex: Pathway of Repressosome Formation
Source: Biochem. 44 (2005) 5373-5380


2006

Authors: Higashimoto, Y.; Asanomi, Y.; Takadusagu, S.; Lewis, M.S.; Uosaki, K.; Durell, S.R.; Anderson, C.W.; Appella, E.; Sakaguchi, K.
Title: Unfolding, Aggregation, and Amyloid Formation by the Tetramerization Domain from Mutant p53 Associated with Lung Cancer
Source: Biochem. 45 (2006) 1608-1619



Authors: Huber, A.H.; Kampf, J.P.; Kwon, T.; Zhu, B.; Kleinfeld, A.M.
Title: Fatty Acid-Specific Fluorescent Probes and Their Use in Resolving Mixtures of Unbound Free Fatty Acids in Equilibrium with Albumin
Source: Biochem. 45 (2006) 14263-14274



Authors: Kampf, J; Cupp, D; Kleinfeld, A
Title: Different Mechanisms of Free Fatty Acid Flip-Flop and Dissociation Revealed by Temperature and Molecular Species Dependence of Transport across Lipid Vessicles
Source: J.Biol.Chem. 281 (2006) 21566-21574



Authors: Kovaric, B.C.; Kokona, B.; Schwab, A.D.; Twomey, M.A.; dePaula, J.C.; Fairman, R.
Title: Self-Assembly of Peptide Porphyrin Complexes: Toward the Development of Smart Biomaterials
Source: JACS 128 (2006) 4166-4167



Authors: Martini, S.; Ricci, M.; Bartolini, F.; Bonechi, C.; Braconi, D.; Millucci, L.; Santucci, A.; Rossi, C.
Title: Metabolic response to exogenous ethanol in yeast: An in vivo NMR and mathematical modeling approach.
Source: Biophysical Chemistry 120 (2006) 135-142.
Description: Compartmental differential equation model



Authors: Widemann, B.C.; Salzer, WL; Arceci, RJ; Blaney, SM; Fox, E; End, D; Gillespie, A; Whitcomb, P; Palumbo, JS; Pitney, A; Jayaprakash, N; Zannikos, P; Balis, F.M.
Title: Phase I Trial and Pharmacokinetic Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas
Source: J.Clin.Onc. 24 (2006) 507-516


2007

Authors: Caride, AJ; Filoteo, AG; Penniston, JT; Strehler, EE
Title: The Plasma Membrane Ca2+ Pump Isoform 4a Differs from Isoform 4b in the Mechanism of Calmodulin Binding and Activation Kinetics: IMPLICATIONS FOR Ca2+ SIGNALING
Source: J. Biol. Chem 282 (2007) 25640-25648.
Description: Compartmental model



Authors: Hickel,R.C.; Lee, Y.S.; Bilsky, E.; Giuvelis, D.; Deschamps, J.R.; Parrish, D.A.; Piceto, M.D.; May, E.L.; Harris, L.S.; Coop, A.; Dersch, C.M.; Partilla, J.S.; Rothman, R.B.; Cheng, K.; Jacobson, A.E.; Rice, K.C.
Title: Probes for Narcotic Receptor Mediated Phenomena. 34. Synthesis and Structure Activity Relationships of a Potent Mu-Agonist Delta-Antagonist and an Exceedingly Potent Antinociceptive in the Enantiomeric C9-Substituted 5-(3-Hydroxyphenyl)-N-Phenylethythymorphan Series
Source: J. Med. Chem. 50 (2007) 3765-3776



Authors: Jung, WS; Hong, CK; Lee, S; Kim, CS; Kim,SJ; Kim, SI; Rhee S
Title: Structural and Functional Insights into Intramolecular Fructosyl Transfer by Inulin Fructotransferase
Source: J. Biol. Chem. 282 (2007) 25640-25648.
Description: trimeric model


2008

Authors: Gao, Y.; Kuwabara, H.; Spivak, C.E.; Xiao, Y.; Keller, K.; Ravert, H.; Kumar, A.; Alexander, M.; Hilton, J.; Wong, D.F.; Dannals, R.F.; Horth, A.G.
Title: Discovery of (-)-7-Methyl-z-exo-[3'-(6-[18-F] fluoropyridin-2-yl)-5'-pyridinyl]-7 azabicyclo [2.2.1]heptene, a Radiolabelled Antagonist for Cerebral Nicotinic Acetylcholine Receptor (alpha-4 beta-2-nAchR) with Optimal Positron Emission Topography Imaging Properties
Source: J. Med. Chem. 51 (2008) 4751-4764



Authors: Froehlich, JP; Mahaney, JE; Keceli, G; Pavlos, CM; Goldstein, R; Redwood, AJ; Sumbilla, C; Lee, DI; Tocchetti, CG; Kass, DA; Paolocci, N; Toscano, JP.
Title: Phospholamban Thiols Play a Central Role in Activation of the Cardiac Muscle Sarcoplasmic Reticulum Calcium Pump by Nitroxyl
Source: Biochem. 47 (2008) 13150-13152



Authors: Jiang, B.; Xiao, N.; Liu, H.; Zhou, Z.; Mao, X.; Liu, M.
Title: Optimized Quatitative DEPT and Quantitative POMMIE Experiments for 13-C NMR
Source: Anal Chem 80 (2008) 8293-8298
Description: NMR spin coupling coefficients



Authors: Mahaney, J.E.; Thomas, D.T.; Farrance, I.K.; Froehlich, J.P.
Title: Intermolecular Interactons in the Mechanism of Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ ATPase (SERCA1): Evidence for a Tripromoter
Source: Biochem. 47 (2008) 13711-13712


2009

Authors: Carley, A.N.; Kleinfeld, A.M.
Title: Flip-Flop Is the Rate-Limiting Step for Transport of Free Fatty Acids across Lipid Vesicle Membranes
Source: Biochem. 48 (2009) 10437-10445