Published Articles Mentioning MLAB

Title: Reliable Determination of Freeze-Concentration Using DSC
Source: Thermochimica Acta 425 (2005) 149-163
Description: differential equations in thermodynamic model
Authors: B.S. Bhatnagar, S. Cardon, M.J. Pikal, R.H. Bogner

Title: Determination of Bull Sperm Membrane Permeability to Water and
Cryoprotectants Using a Concentration-dependent Self-quenching Fluorophore
Source: Cryobiology 48 (2004) 72-80.
Description: Kadem-Katchalsky model
Authors: A. Chaveiro, J. Liu, S. Mullen, H. Woelders, J.K. Critser

Title: In vitro 13-C-NMR and Modelling Study of Metabolic Yield Response
to Ethanol Stress in a Wild-type Strain of Saccharomyces cerevisiae
Source: FEBS Letters 564 (2004) 63-68
Description: reaction kinetics for compartmental model
Authors: S. Martini, M. Ricci, C. Bonechi, L. Trabalzini, A. Santucci, C. Rossi

Title: The Time-dependent Distribution of Phophorylated Intermediates in
Native Sarcoplasmic Reticulum Ca-2+ ATPase from Skeletal Muscle is not
Compatible with a Linear Kinetic Model
Source: Biochem 43 (2004) 4400-4416
Description: fit of sum of 3-exponetial functions
Authors: J.E. Mahaney, D.D. Thomas, J.P. Froehlich

Title: Pharmacokinetics of O6-benzyulguanine in Pediatric Patients with
Central Nervous System Tumors
Source: Clin. Canc. Res. 10 (2004) 5072-5075
Description: 2 compartmental model, area under curve calculations
Authors: K. Neville, S. Blaney, M. Bernstein, P. Thompson, D. Adams,
A. Aleksic, S. Berg

Title: Inhibition Effects of Ethanol on the Kinetics of Glucose Metabolism
by S. cerevisiae: NMR and Modelling Study
Source: Chem. Phys. Lett. 387 (2004) 377-382
Description: compartmental differential equation model
Authors: M. Ricci, S. Martini, C. Bonechi, L. Trabalzini, A. Santucci,
C. Rossi

Title: Pharmacokinetic/Pharmacodynamic Analysis of Neutrophil Proliferation
Induced by rhG-CSF in Patients Receiving Antineoplastic Drugs
Source: J. Pharm. Soc. Japan 124 (2004) 599
Authors: M. Sugiura, Y. Ohno, Y. Yamada, H. Suzuki, T. Iga

Title: Plasma and Cerebrospinal Fluid Pharmacokinetic Study of BNP1350 in
Nonhuman Primates
Source: Canc. Chemotherapy and Pharmacology 53 (2004) 527-532
Description: biexponential compartmental model
Authors: P.A. Thompson, S.L. Berg, A. Aleksic, J.Z. Kerr, L. McGuffey,
R. Dauser, J.G. Nuchtern, F. Hauser, S.M. Blaney

Title: Solving and Fitting France's Rumen Model with MLAB
Source: Mathematical Modeling in Nutrition and the Health Sciences, ed. by
J.A. Novotny, M.H. Green, R.C. Boston, NY: Kluwers Academic, 2003,
pp. 389-400.
Description: compartmental model with complex flows
Authors: G. Knott, D. Kerner

Title: Application of the Continuous Variation Method to Cooperative Interactions: Mechanism of Fe(II)-ferrozine Chelation and Conditions Leading to Anomolous Binding Ratios
Source: Biophys. Chem. 100 (2003) 143-149.
Authors: Huang, C.Y.; Zhou, R.; Yang, D.C.H.; Boon Chock, P.

Title: The Possible Role of Glutamate Uptake in Metaphit-Induced Seizures
Source: Neurochem. Res. 28 (2003) 723-731.
Description: Michaelis-Menten kinetics
Authors: Lipovac, M.N.; Holland, T.; Poleksic, A.; Killian, C.;
Lajtha, A.

Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Temozolamide in Non-Human Primates
Source: J. Neuro-oncology 61 (2003) 203-207.
Description: two compartment model with first order elimination for plasma-concentration time data.
Authors: Patel, M.; McCully, C.; Godwin, K.; Balis, F.

Title: A Model for the Activation of Plasma Membrane Calcium Pump Isoform 4b by Calmodulin
Source: Biochem. 42 (2003) 12115-12124
Authors: Penheiter, A.R.; Bajzer, Z.; Filoteo, A.G.; Thorogate, R.; Torok, K.; Caride, A.J.

Title: General Statistics of Stochastic Process of Gene Expression in
Eukaryotic Cells
Source: Genetics 161 (2002) 1321-1332
Description: Pareto-like probability density function
Authors: V.A. Kuznetsov, G.D. Knott, R.F. Bonner

Title: Analysis of Evolving Proteomes: Predictions of the Number of
Protein Domains in Nature and the Number of Genes in Eukaryotic Organisms
Source: J. Biol. Systems 10 (2002) 381-407
Authors: V.A. Kuznetsov, V.V. Pickelov, O.V. Senko, G.D. Knott

Title: The Metal-binding Properties of DREAM (Downstream Regulatory Element Antagonist Modulator)
Source: J. Biol. Chem. 277 (2002) 10955-10966
Authors: Craig, T.A.; Benson, L.M.; Venyaminov, S.Y.; Klimtchuk, E.S.; Bajzer, Z.; Prendergast, F.G.; Naylor, S.; Kumer, R.

Title: Free Radicals and Disease
Source: Arch. Biochem. & Biophys. 397 (2002) 354-359
Description: solve odes describing rates of free radical reactions
Authors: Moskovitz, J.; Yim, M.B; Boon Chock, P.

Title: Exploring the Role of Alanine in the Structure of the Lac Repressor Tetramerization Domain, a Ferritin-like Alacoil
Source: J. Mol. Biol. 317 (2002) 601-612
Authors: Solan, A.; Ratia, K.; Fairman, R.

Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of Phenylacetate and Phenylbutyrate in the Nonhuman Primate
Source: Canc. Chem. Pharmacol. 47 (2001) 385-390
Description: six compartment model, area under curve calculations
Authors: Berg, S.; Serabe, B.; Aleksic, A.; Bomgaars, L.; McGuffey, L.; Dauser, R.; Durfee, J.; Nuchtern, J.; Blaney, S.

Title: The Plasma Membrane Calcium Pump Displays Memory of Past Calcium Spikes
Source: J. Biol. Chem. 276 (2001) 39797-39804
Authors: Caride, A.J.; Penhieter, A.R.; Filoteo, A.G.; Bajzer, Z.; Enyedi, A.; Penniston, J.T.

Title: Maximizing the Success Rate of Minimal Model Insulin Sensitivity Measurement in Humans: the Importance of Basal Glucose Levels
Source: Clinical Science 101 (2001) 1-9
Description: Bergman Minimal Model
Authors: Godsland, I.F.; Walton, C.

Title: Ionic Interactions in Molten Complex Chlorides from Vibrational Dephasing
Source: J. Chem. Phys. 114 (2001) 3683-3691
Authors: Kirillov, S.A.; Musiyenko, I.S.; Photiadis, G.M.;

Title: Modeling Tumor Regrowth and Immunotherapy
Source: Math. Comput. Mod. 33 (2001) 1275-1287
Description: solved odes for tumor cell population growth.
Authors: Kuznetsov, V.A.; Knott, G.D.

Title: Characterization of a Histidine Rich Cluster of Amino Acids in the Cytoplasmic Domain of the Na+/H+ Exchanger
Source: Biosci. Reports 20 (2000) 185
Description: Hill equation
Authors: Dibrov, Pavel; Murtazina, Rakhilya; Kinsella, James; Fliegel, Larry

Title: Resolution of two [35S] GTP-gamma-S Binding Sites and Their Response to Chronic Morphine Treatment: A Binding Surface Analysis
Source: Brain Research Bull. 51 (2000) 357
Description: 1- and 2-site binding models
Authors: Heylinger, Simone O.; Ni, Qing; Rothman, Richard B.

Title: Boson Peak in the Low Frequency Raman Spectra of Ordinary Liquids
Source: J. Mol. Struct. 526 (2000) 317-321
Description: curve fit peaks in Raman spectrum of formamide.
Authors: Kirillov, S.A.; Nielsen, O.F.

Title: Charge-Current Contribution to Low-Frequency Raman Scattering from Glass-Forming Ionic Liquids
Source: Phys. Rev. B 61 (2000) 11391-11399
Description: curve fit peaks in Raman spectra.
Authors: Kirillov, S.V.; Yannopoulos, S.N.

Title: Ultracentrifugal Analysis of Molecular Mass of Glycoproteins of Unknown or Ill-Defined Carbohydrate Consumption
Source: Meth. Enzym. 321 (2000) 136
Description: ultracentrifuge model
Authors: Lewis, Marc S.; Junghans, Richard P.

Title: Redox Control of Aryl Sulfotransferase Specificity
Source: Arch. Bioch. 382 (2000) 95
Description: ligand binding to multiple sites
Authors: Marshall, A. David; McPhie, Peter; Jakoby, William B.

Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of CI-944 (N-Acetyldinaline) in the Nonhuman Primate
Source: Clin. Canc. R. 6 (2000) 994
Description: 5-compartment model, multiexponential function fit
Authors: Riva, Luca; Blaney, Susan M.; Dauser, Robert; Nuchtern, Jed G.; Durfee, John; McGuffey, Leticia; Berg, Stacey L.

Title: Lumped Parameter Estimation for the Embryonic Chick Vascular
System-A Time Domain Approach Using MLAB
Source: Comp. Meth. Prog. Biomed. 63 (2000) 29-41
Description: Windkessel ode circuit models
Authors: Yoshigi, M.; Knott, G.D.; Keller, B.B.

Title: Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphate 1B
Source: J. Biol. Chem. 274 (1999) 34543
Description: kinetic rate constants
Authors: Barrett, William C.; DeGnore, Jon P.; Keng, Yen-Fang; Zhang, Zhong-Yin; Kim, Moon B.; Chock, P.Boon

Title: A Modellistic View of the Kinetics of Metabolic Processes: Differences in Glucose and Xylose Degradation Pathway
Source: Chem. Phys. Lett. 310 (1999) 38-42
Description: non-linear differential equation model
Authors: Bastianoni, Simone; Donati, Alessandro; Gastaldelli, Amalia; Marchettini, Nadia; Martini, Silvia; Rossi, Claudio

Title: Modeling the Complex Behavior of Microorganisms
Source: Ann. NY Acad. 879 (1999) 387
Description: three coupled non-linear differential equations
Authors: Bastianoni, S.; Martini, S.; Porcelli, M.; Rossi, C.

Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of Daunorubicin, Idarubicin, and their Metabolites in the Nonhuman Primate Model
Source: J. Ped. Hematology/Oncology 21 (1999) 26
Description: multiexponential model
Authors: Berg, Stacey L.; Reid, Joel; Godwin, Karen; Murry, Daryl J.; Poplack, David G.; Balis, Frank M.; Ames, Matthew M.

Title: Differences in Metabolism of 5-fluorouracil and 5-fluorouridine and Regulation by Glucosamine in Human Colon Cancer Multicell Tumor Spheroids
Source: NMR in Biomedicine 12 (1999) 157-167
Description: differential equation models
Authors: Chen, Tong-Bin; Bajzer, Zeljko; Macura, Slobodan; Vuk-Paulovic, Stanimir

Title: Cu(II) Inhibition of the Proton Translocation Machinery of the Influenza A Virus M2 Protein
Source: J. Biol. Chem. 274 (1999) 5474
Description: differential equations for 2-state binding of Cu+2 to M2 ion channel protein
Authors: Gandhi, Chris J.; Shuck, Kevin; Lear, James D.; Dieckmann, Gregg R.; DeGrado, William F.; Lamb, Robert A.; Pinto, Lawrence H.

Title: Modeling of P-glycoprotein-involved Epithelial Drug Transport in MDCK Cells
Source: Am. J. Physiol. 277 (1999) F84-F96
Authors: Ito, Shinya; Woodland, Cindy; Sarkadi, Balazs; Hockmann, Guido; Walker, Scott E.; Koren, Gideon

Title: Glucose and Fructose Decomposition in Subcritical and Supercritical Water-Detailed Reaction Pathway, Mechanisms, and Kinetics
Source: Ind. Eng. Res. 38 (1999) 2888-2895
Authors: Kabyemela, Bernard M.; Adschiri, Todafumi; Malaluan, Roberto M.; Arai, Kunio

Title: Fitting the Low-Frequency Raman Spectra to Boson Peak Models- Glycerol, Triacetin, and Polystyrene
Source: J. Mol. Struct. 479 (1999) 271-278
Description: fit lineshape functions to peaks in spectra.
Authors: Kirillov, S.A.; Perova, T.S.; Nielsen, O.F.; Praestgaard, E.; Rasmussen, U.; Kolomiyets, T.M.; Voyiatzis, G.A.; Anastasiadis, S.H.

Title: Spatial Correlations and Exact Solution of the Problem of the Boson Peak Profile in Amorphous Media
Source: Phys. Lett. A 262 (1999) 186-190
Description: curve fitting
Authors: Kirillov, S.A.; Voyiatzis, G.A.; Kolomiyets, T.M.; Anastasiadis, S.H.

Title: Time Correlation Functions from Band-Shape Fits without Fourier Transform
Source: Chem. Phys. Lett. 303 (1999) 37-42
Description: fit of line shape function with K1(x) Bessel function as a factor.
Authors: Kirillov, S.A.

Title: Kinetic Analysis of High Affinity Forms of Interlukin (IL)-13 Receptors: Supression of IL-13 Binding by IL-2 Receptor Gamma Chain
Source: Biophys. J. 77 (1999) 154
Authors: Kuznetsov, Vladimir; Puri, Raj K.

Title: Subcutaneous Glucose Predicts Plasma Glucose Independent of Insulin: Implications for Continuous Monitoring
Source: Am. J. Phys.-Endocr. 277 (1999) E561
Description: nonlinear least squares analysis of ODE model
Authors: Rebrin, Kerstin; Steil, Garry M.; Van Antwerp, William P.; Mastrototaro, John J.

Title: Temporal Responses of Oxidative vs. Glycolytic Skeletal Muscles to K+ Deprivation- Na+ Pumps and Cell Cations
Source: Am. J. Physiol.- Cell Phys. 276 (1999) C1411-C1419
Authors: Thompson, Curtis B.; Choi, Cheolsoo; Youn, Jang H.; McDonough, Alicia A.

Title: The Plasma Pharmacokinetics and Cerebrospinal Fluid Penetration of the Thymidylate Synthase Inhibitor Raltitrexed (Tomudex) in a Nonhuman Primate Model
Source: Canc. Chemot. 44 (1999) 439
Description: 3-compartment pharmacokinetic model, EWT
Authors: Widemann, Brigette C.; Balis, Frank M.; Godwin, Karen S.; McCully, Cindy; Adamson, Peter C.

Title: Determination of Human Platelet Membrane Permeability Coefficients Using the Kedem-Katchalsky Formalism: Estimates from Two- vs Three-Parameter Fits
Source: Cryobiol. 38 (1999) 200
Description: Kedem-Katchalsky model for cell membrane permeability.
Authors: Woods, E.J.; Liu, J.; Gilmore, J.A.; Reid, T.J.; Gao, D.Y.; Critser, J.K.

Title: Opioid Peptide Receptor Studies. 11: Involvement of Tyr148, Trp318, and His319 of the Rat mu-Opioid Receptor in Binding of mu-Selective Ligands
Source: Synapse 32 (1999) 23
Description: 1-site binding model, 2-parameter logistic model
Authors: Xu, Heng; Lu, Yi-Feng; Partilla, John S.; Zhang, Qiao-Xi; Weng, Jia-Bei; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Chen, Kai-Xian; Lui, Zhi-Qiang; Rothman, Richard B.

Title: Effect of Developmental Stage on Bovine Oocyte Plasma Membrane Water and Cryoprotectant Permeability Characteristics
Source: Mol. Reprod. 49 (1998) 408
Description: Kedem Katchalsky differential equation model of membrane
Authors: Agca, Y.; Liu, J.; Peter, A.T.; Critser, E.S.; Critser, J.K.

Title: Membrane Permeability Characteristics of Metaphase II Mouse Oocytes at Various Temperatures in the Presence of Me2SO
Source: Cryobiol. 36 (1998) 287
Description: Kedem Katchalsky differential model of membrane
Authors: Agca, Y.; Liu, J.; McGrath, J.J.; Peter, A.T.; Critser, E.S.; Critser, J.K.

Title: Phase I Trial and Pharmacokinetic Study of Pyrazoloacridine in Children and Young Adults with Refractory Cancers
Source: J. Clin. Oncol. 16 (1998) 181-186
Description: 2-compartment model, Hill constant estimate
Authors: Berg, Stacey L.; Blaney, Susan M.; Adamson, Peter C.; O'Brien, Michelle; Poplack, David G.; Arndt, Carola; Blatt, Julie; Balis, Frank M.

Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of 9-aminocamptothein (9-AC), irinotecan (CPT-11), and SN-38 in Nonhuman Primates
Source: Canc. Chemot. Pharm. 41 (1998) 464
Description: area under moment curve, rate constants
Authors: Kuttesch, Nancy; McCully, Cynthia; Cole, Diane E.; Godwin, Karen; Balis, Frank M.

Title: Prenatal Cocaine Exposure Affects Postnatal Dopaminergic Systems in Various Regions of the Rat Brain
Source: Ann. NY Acad. 844 (1998) 293-302
Description: 1,2,and 3-site binding models
Authors: Choi, Sun-Jo; Mazzio, Elizabeth; Kolta, Malak G.; Soliman, Karam F.A.

Title: Determination of Plasma Membrane Characteristics of Boar Spermatozoa and Their Relevance to Cryopreservation
Source: Biol. Reprod. 58 (1998) 28
Description: Kedem Katchalsky differential equation model of membrane
Authors: Gilmore, J.A.; Liu, J.; Peter, A.T.; Critser, J.K.

Title: Mechanism and Kinetics of Cellobiose Decomposition in Sub- and Supercritical Water
Source: Ind. Eng. Res. 37 (1998) 357-361
Description: kinetics, rate equations
Authors: Kabyemela, B.M.; Takigawa, M.; Adschiri, T.; Malaluan, R.M.; Arai, K.

Title: Opioid Peptide Receptor Studies. 7. The Methylfentanyl Cogener RTI-4614-4 and its Four Enantiomers Bind to Different Domains of the Rat mu Opioid Receptor
Source: Synapse 28 (1998) 117-124
Description: multiple site binding
Authors: Lu, Yi Feng; Xu, Heng; Liu-Chen, Lee-Yuan; Chen, Chongguang; Partilla, John S.; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Sadee, Wolfgang; Rothman, Richard B.

Title: Pharmacokinetics of the Protease Inhibitor KNI-272 in Plasma and Cerebrospinal Fluid in Human Immunodeficiency Virus-Infected Children after Intravenous and Oral Dosing
Source: Antim. Ag. Ch. 42 (1998) 1815
Description: 2-compartment model
Authors: Mueller, Brigitta U.; Anderson, Barry D.; Farley, Maureen Q.; Murphy, Robert; Zuckerman, Judy; Jarosinski, Paul; Godwin, Karen; McCully, Cindy L.; Mitsuya, Hiroaki; Pizzo, Philip A.; Balis, Frank M.

Title: Serum and Cerebrospinal Fluid Pharmacokinetics of Intravenous and Oral Lamivudine in Human Immunodeficiency Virus-Infected Children
Source: Antim. Ag. Ch. 42 (1998) 3187
Description: 2-compartment model
Authors: Mueller, Brigitta U.; Lewis, Linda L.; Yuen, Geoffrey J.; Farley, Maureen; Keller, Amy; Church, Joseph A.; Goldsmith, Jonathan C.; Venzon, David J.; Rubin, Marc; Pizzo, Philip A.; Balis, Frank

Title: Opioid Peptide Receptor Studies. 9. Identification of a Novel
Non-mu-Non-delta-like Opioid Peptide Binding Site in Rat Brain
Source: Peptides 19 (1998) 1079
Description: two-parameter logistic and 1- and 2-site binding
Authors: Ni, Qing; Xu, Heng; Partilla, John S.; Rice, Kenner C.; Matecka, Dorota; Calderone, Silvia N.; Porreca, Frank; Liu, Josephine; Schmidhammer, Helmut; Krasonig, Roland; Rothman, Richard B.

Title: Studies of the Biogenic Amine Transporters. VII. Characterization of a Novel Cocaine Binding Site Identified with [125-I]RTI-55 in Membranes Prepared from Human, Monkey, and Guinea Pig Caudate
Source: Synapse 28 (1998) 322
Description: 1- and 2-site binding models
Authors: Rothman, Richard B.; Silverhorne, Mayme L.; Glowa, John R.; Matecka, Dorota; Rice, Kenner C.; Carroll, F. Ivy; Partilla, John S.; Uhl, George R.; Vanderbergh, David J.; Dersch, Christina

Title: Beta-2 adrenergic receptors mediate cAMP, tissue-type plasminogen activator and transferin production in rat Sertoli cells
Source: Mol. C. Endoc. 142 (1998) 75
Description: Scatchard analysis programmed with MLAB by M. McNamara(Liege, Be)
Authors: Troispoux, Carine; Reiter, Eric; Combarnous, Yves; Guillon, Florian

Title: Critical Evaluation of the Combined Model Approach for Estimation of Prehapatic Insulin Secretion
Source: Am. J. Physiology-Endo. 274 (1998) E172-E183
Description: not available
Authors: Watanabe, Richard M.; Steil, Garry M.; Bergman, Richard N.

Title: Optioid Peptide Receptor Studies. 8. One of the Mouse Brain delta-NCX Binding Sites is Similar to the Cloned Mouse Opioid delta Receptor
Source: Peptides 19 (1998) 343
Description: 1- and 2-site binding models, 2 parameter logistic equation
Authors: Xu, Heng; Lu, Yi-Feng; Partilla, John S.; Pinto, Julia; Calderone, Sylvia N.; Matecka, Dorota; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Ananthan, Subramaniam; Rothman, Richard B.

Title: A Self-Replicating Peptide under Ionic Control
Source: Angew. Chemistry, Intl. Ed. 37 (1998) 478-481.
Description: values of dissociation rate constants fit from denaturation data in 2-state model for monomer-tetramer transition,
Authors: Yao, Shao; Ghosh, Indraneel

Title: Glycolysis in Bloodstream from Trypanosoma brucei can be Understood in Terms of the Glycolytic Enzymes
Source: J. Biol. Chem. 272 (1997) 3207-3215
Description: Michaelis-Menten kinetics simulations with MLAB, no cite.
Authors: Bakker, B.M.; Michels, P.A.M.; Opperdoes, F.R.; Westerhoff, H.V.

Title: Improved Estimation of Anaplerosis in Heart Using 13C NMR
Source: Am. J. Physiology-Endo 273 (1997) E1228-E1242
Description: MLAB ode script for 180 diff eqs, but did not use.
Authors: Cohen, David M.; Bergman, Richard N.

Title: Glucose Kinetics in Interstitial Fluid Can Be Predicted by Compartmental Modeling
Source: Am. J. Physiol. 272 (1997) E494-E505
Description: model concentration of tracer in time
Authors: Gastaldelli, Amalia; Schwartz, Jean-Marc; Caveggion, Elisabetta; Traber, Lillian D.; Traber, Daniel L.; Rosenblatt, Judah; Toffolo, Giana; Cobelli, Claudio; Wolfe, Robert R.

Title: Complex Kinetic Behavior in the Na, K, and Ca-ATPases
Source: Ann. NY Acad 834 (1997) 280-
Description: kinetics of catalysis
Authors: Froehlich, Jeffrey P.; Taniguchi, Kazuya; Fendler, Klaus; Mchaney, James E.; Thomas, David D.; Albers, R. Wayne

Title: Reverse-Phase High-Performance Liquid Chromatographic Determination of the New Antitumor Agent Cyclopentyl Cytosine in Biological Fluids
Source: J. Chrom. B 692 (1997) 169-179
Description: biexponential, 2 compartment open model, weighted least squares fit, area under curve-trapezoidal rule.
Authors: Hegedus, Lajos; Ford, Harry, Jr.; Hartman, Neil R.; Kelley, James A.

Title: Self-Assembly of Designed Antimicrobial Peptides in Solution and Micelles
Source: Biochem. 36 (1997) 9540-9549
Description: concentration distributions were fit to various mathematical models.
Authors: Javadpour, Maryam; Barkley, Mary D.

Title: Degradation Kinetics of Dihydroxyacetone and Glyceraldehyde in Subcritical and Supercritical Water
Source: Ind. Eng. Res. 36 (1997) 2025-2030
Description: not available
Authors: Kabymela, Bernard M.; Adschiri, Todafumi; Malaluan, Roberto; Arai, Kunio

Title: Flip-flop is Slow and Rate Limiting for the Transbilayer Transport of Long Chain AOFA
Source: Biochem. 36 (1997) 5702-5711
Description: ode rate kinetics equations, MLAB mentioned, no cite
Authors: Kleinfeld, Alan M.; Chu, P.; Storch, J.

Title: Electrostatic Effects on Ion Selectivity and Rectification in Designed Ion Channel Peptides
Source: JACS 119 (1997) 3212-3217
Description: equation fit with MLAB to ion-channel measurement data.
Authors: Lear, James D.; Schneider, J.P.; Kienker, P.K.; DeGrado, W.F.

Title: The Determination of Membrane Permeability Coefficients of Canine Pancreatic Islet Cells and Their Application to Islet Cryopreservation
Source: Cryobiology 35 (1997) 1-13
Description: gear method in MLAB for Boyle van't Hoff plots.
Authors: Liu, Jun; Zieger, Michael A.J.; Lakey, Jonathan RT; Woods, Erik J.; Critser, John K.

Title: Control of Activity through Oxidative Modification at the Conserved Residue Cys-66 of Aryl Sulfotransferase IV
Source: J. Biol. Chem. 272 (1997) 9153-9160
Description: Scatchard equation.
Authors: Marshall, A. David; Darbyshire, John F.; Hunter, Ann P.; McPhie, Peter; Jakoby, William B.

Title: Heteroaromatic Analogs of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-Phenylpropyl) Piperazines (GBR 12935 and GBR 12909) as High-Affinity Dopamine Reuptake Inhibitors
Source: J. Med. Chem. 40 (1997) 705-716
Description: PCMLAB, fit 2 parameter logistic to obtain IC50 and slope factor.
Authors: Matecka, Dorota; Lewis, David; Rothman, Richard B.; Dersch, Christina M.; Wojnicki, Francis H.E.; Glowa, John R.; DeVries, A. Courtney; Pert, Agu; Rice, Kenner C.

Title: Clinical Trials-A Methodologic Perspective
Source: book published by John Wiley & Sons, NY.
Description: uses MLAB for pharmacokinetic models and briefly discusses the software.
Authors: Piantadosi, S.

Title: A Designed Buried Salt Bridge in a Hetero-dimeric Coiled-coil
Source: JACS 119 (1997) 5742-5743
Description: no specific cite of MLAB
Authors: Schneider, J.P.; Lear, J.D.; DeGrado, W.F.

Title: Misakinolide A is a Marine Macrolide That Caps but Does Not Sever Filamentous Actin
Source: J. Biol. Chem. 272 (1997) 7841-7845
Description: estimate Kd of the interaction between misakinolide A and actin.
Authors: Terry, David R.; Spector, Ilan; Higa, Tatsuo; Bubb, Michael R.

Title: Characterization of Embryonic Aortic Impedance with Lumped
Parameter Models
Source: Am. J. Phys. 273 (1997) H19-H27
Description: Windkessel ode circuit models
Authors: Yoshigi, Masaaki; Keller, Bradley B.

Title: Modeling Interpretation of Microbe Metabolism Detected by Nuclear Magnetic Resonance
Source: Biochem. Biophys. Rpts. 227 (1996) 53-58
Description: differential equation model
Authors: Bastiononi, Simone; Donati, Alessandro; Gastaldelli, Amalia; Marchettini, Nadia; Renzoni, Debora; Rossi, Claudio

Title: Structural Characterization of the Tumor Supressor p16, an Ankyrin-Like Repeat Protein
Source: Protein Sci. 5 (1996) 1776-1784
Description: circular dichroism signal at 222nm recorded at 25 degrees C for 500 seconds. data fit applying specialized algorithm. sedimentation equilibrium equation not fit with MLAB.
Authors: Boice, Judith A.; Fairman, Robert

Title: Thermodynamic Analysis of a Designed Three-Stranded Coiled Coil
Source: Biochem. 35 (1996) 14480-14485
Description: PCMLAB, global fits of thermal unfolding data.
Authors: Boice, Judith A.; Dieckmann, Gregg R.; DeGrado, William F.; Fairman, Robert

Title: Downregulation of Mu-Opioid Binding Sites Following Chronic Administration of Neuropeptide FF (NPFF) and Morphine
Source: Peptides 17 (1996) 389-397
Description: PCMLAB, 1-site binding model
Authors: Goodman, Carl B.; Emilien, Betsey; Becketts, Karen; Cadet, Jean L.; Rothman, Richard B.

Title: The Amplitude and Time Course of the Myoplasmic Free [Ca+2] Transient in Fast-Switch Fibers of Mouse Muscle
Source: J. General Phys. 108 (1996) 455-469
Description: modeling but no mention or cite of MLAB.
Authors: Hollingsworth, S.; Zhao, Mingdi; Baylor, S.M.

Title: Differential Expression and Cell Envelope Incorporation of Small Proline-Rich Protein 1 in Different Cornified Epithelia
Source: J. Cell Sci. 109 (1996) 1381-1391
Description:
Authors: Jarnik, Michael; Kartasova, Tonja; Steinert, Peter M.; Lichti, Ulrike; Steven, Alasdair C.

Title: Biophysical Characterization of a Recombinant Soluble Interleukin 2 Receptor (Tac)
Source: J. Biol. Chem. 271 (1996) 10453-10460
Description: ultracentrifuge sedimentation experimental data fit to model.
Authors: Junghans, R.P.; Stone, A.L.; Lewis, M.S.

Title: Peroxynitrite Disables the Tyrosine Phosphorylation Regulatory Mechanism: Lymphocyte-specific Tyrosine Kinase Fails to Phosphorylate Nitrated cdc2(6-20) NH2 Peptide
Source: Proc. Natl. Acad. Sci. 93 (1996) 3377-3382
Description: PCMLAB, integrated differential equations describing reaction scheme.
Authors: Kong, Siow-Kee; Yim, Moon Bin; Stadtman, Earl R.; Chock, P. Boon

Title: Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of [1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl) Piperazines (GBR 12935 and GBR 12909)
Source: J. Med. Chem. 39 (1996) 4704-4716
Description: PCMLAB, fit 2 parameter logistic to find IC50 and slope factor.
Authors: Matecka, Dorota; Rothman, Richard B.; Redesca, Lilian; de Costa, Brian R.; Dersch, Christina M.; Partilla, John S.; Pert, Agu; Glowa, John R.; Wojnicki, Francis H.E.; Rice, Kenner C.

Title: Kinetics of Fatty Acid Interactions with Fatty Acid Binding Proteins from Adipocyte, Heart, and Intestine
Source: J. Biol. Chem. 271 (1996) 11291-11300
Description: MLAB fit of rate constants in kinetic rate odes, no cite, verified fit solution with Macsyma.
Authors: Richieri, Gary V.; Ogata, Ronald T.; Kleinfeld, Alan M.

Title: Thermodynamics and Kinetic Properties of Fatty Acid Interactions with Rat Liver Fatty Acid Binding Protein
Source: J. Biol. Chem. 271 (1996) 31068-31075
Description: MLAB fit of rate constants in kinetic rate odes, no cite.
Authors: Richieri, Gary V.; Ogata, Ronald T.; Kleinfeld, Alan M.

Title: Analysis of Mass Transport-Limited Binding Kinetics in Evanescent Wave Biosensors
Source: Analytical Biochem. 240 (1996) 262-272
Description: 2 compartment model and ode model fit with MLAB, but no MLAB cite.
Authors: Schuck, Peter; Minton, Allen P.

Title: Randomized Trial of the Cardioprotective Agent ICRF-187 in Pediatric Sarcoma Patients with Doxorubicin
Source: J. Clin. Onc. 14 (1996) 362-372
Description: plasma concentration fit to mono, biexponential models.
Authors: Wexler, Leonard H.; Andrich, Mary P.; Venzon, David; Berg, Stacey L.; Weaver-McClure, Linda; Chan, Clara C.; Dilsizian, Vasken; Avila, Nilo; Jarosinski, Paul; Balis, Frank M.; Poplack, David G.; Horowitz, Marc E.

Title: Properties of Tri- and Tetracarboxylate Ca+2 Indicators in Frog Skeletal Muscle Fibers
Source: Biophys. J. 70 (1996) 896-916
Description: MLAB for figures and data analysis, no cites
Authors: Zhao, Mingdi; Hollingsworth, S.; Baylor, S.M. 

Title: Subunit Assembly in the Tryptophan Synthase Alpha-2 Beta-2 Complex
Source: J. Biol. Chem. 270 (1995) 7944-7949
Description: MLAB fit 3 binding models, no cites
Authors: Ahmed, S.A.; McPhie, P.; Miles, E.W.

Title: The Tryptophan Synthase Alpha2 Beta2 Complex: Kinetic Studies with a Mutant Enzyme (Beta K87T) to Provide Evidence for Allosteric Activation by an Aminoacrylate Intermediate
Source: Biochem. 34 (1995) 12704-12711
Description: solving odes for reaction scheme using Adams-Gear method. Also used Enzyme Kinetics program from Trinity Software and Cricket Graph III from Computer Associates.
Authors: Banik, Utpal; Zhu, De-Min; Chock, P. Boon; Miles, Edith Wilson

Title: Effect of R-Verapamil on the Pharmacokinetics of Paclitaxel in Women with Breast Cancer
Source: J. Clin. Oncol. 13 (1995) 2039-2042
Description: 2 compartment open model, fit ordinary differential rate equations, determined half lives and rate constants, computed area under curve.
Authors: Berg, Stacey L.; Tolcher, Anthony; O'Shaughnessy, Joyce A.; Denicoff, Andrea M.; Noone, Marianne; Ognibene, Frederick P.; Cowan, Kenneth H.

Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of O6-Benzyl-Guanine and Time Course of Peripheral Blood Mononuclear Cell O6-Methylguanine-DNA Methyltransferase Inhibition in the Nonhuman Primate
Source: Cancer Res. 55 (1995) 4606-4610
Description: compartmental model, first order kinetics
Authors: Berg, Stacey L.; Gerson, Stanton L.; Godwin, Karen; Cole, Diane E.; Liu, Lili; Balis, Frank M.

Title: Structure of the Carboxy-Terminal Region of Thyroid Hormone Nuclear Receptors and Its Possible Role in Hormone- Dependent Intermolecular Interactions
Source: Biochem. 34 (1995) 10591-10599
Description: ligand binding, no mention of MLAB or cites.
Authors: Bhat, M.K.; McPhie, P.; Ting, Y-T; Zhu, X-G; Chang, S-Y

Title: Intrathecal Administration of Topotecan in Nonhuman Primates
Source: Cancer Chemot. 36 (1995) 121-124
Description: half lives of the lactone and total drug estimated by nonlinear least squares analysis.
Authors: Blaney, Susan M.; Cole, Dianne E.; Godwin, Karen; Sung, Cynthia; Poplack, David G.; Balis, Frank M.

Title: Pharmacokinetics of Lamivudine and BCH-189 in Plasma and Cerebrospinal Fluid of Nonhuman Primates
Source: Antim. Ag. Ch. 39 (1995) 2779-2782
Description: plasma concentration time data fit to differential equation model.
Authors: Blaney, Susan M.; Daniel, Michael J.; Harker, Andrew J.; Godwin, Karen; Balis, Frank M.

Title: Enantiomers of Diastereomeric cis-N-[1-(2-Hydroxy- 2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanimides: Synthesis, X-ray Analysis, and Biological Activities
Source: J. Med. Chem. 38 (1995) 1547-1557
Description: 2 parameter logistic, IC50, Hill slope, no mention of MLAB or cites
Authors: Brine, George A.; Stark, Peter A., Liu, Young; Carroll, F. Ivy; Singh, P.; Xu, Heng; Rothman, Richard B.

Title: Kinetic Model for the Inhibition of Actin Polymerization by Actobindin
Source: Biochem. 34 (1995) 3921-3926
Description: differential equations for kinetic rate equations, fit constants.
Authors: Bubb, Michael R.; Korn, Edward D.

Title: Opioid Peptide Receptor Studies. 1. Identification of a Novel Delta-Opioid Receptor Binding Site in Rat Brain Membranes
Source: Peptides 16 (1995) 191-198
Description: one site binding model.
Authors: Cha, Xian Yuan; Xu, Heng; Rice, Kenner C.; Porreca, Frank; Lai, Josephine; Aranthan, Subramaniam; Rothman, Richard B.

Title: Estimation of TCA Cycle Flux, Aminotransferase Flux, and Anaplerosis in Heart: Validation With Syntactic Model
Source: Am. J. Physiol. 268 (1995) E397-E409
Description: fit sum of exponentials to graphs of enrichment of C-2 and C04 vs. time.
Authors: Cohen, David M.; Bergman, Richard N.

Title: Cell Surface Binding of TIMP-2 and pro-MMP-2/TIMP-2 Complex
Source: FEBS Lett. 364 (1995) 28-32
Description: analysis of binding data.
Authors: Emmert-Buck, Michael R.; Emonard, Herve P.; Corcoran, Marta L.; Krutzsch, Henry C.; Foidart, Jean-Michel; Statler-Stevenson, William G.

Title: Characterization of a New Four-Chain Coiled Coil: Influence of Chain Length on Stability
Source: Protein Sci. 4 (1995) 1457-1469
Description: PCMLAB, peptide concentration dependent data and GuCl denatured data fit to sum of first and fourth powers of concentration of monomer.
Authors: Fairman, Robert; Chao, Hann-Guang; Mueller, Luciano; Lavoie, Thomas B.; Shen, Liyang; Novotny, Jiri; Matsueda, Gary R.

Title: Pharmacokinetics of Dideoxypurine Necleoside Analogs in Plasma and Cerebrospinal Fluid of Rhesus Monkeys
Source: Antim. Ag. Ch. 39 (1995) 1259-1268
Description: comparmental models for CSF and plasma concentration in time, area under curve, Mann-Whitney test.
Authors: Hawkins, Mary E.; Mitsuya, Hiroaki; McCully, Cynthia M.; Godwin, Karen S.; Murakami, Kunichika; Poplack, David G.; Balis, Frank M.

Title: Somatogenic and Lactogenic Activity of the Recombinant 22 kDa Isoform of Human Placental Growth Hormone
Source: Grow Reg. 5 (1995) 60-65
Description: scatchard analysis.
Authors: Igout, A.; Frankenne, F.; L'Hermite-Baleriaux, M.; Martin, A.; Hennen, G.

Title: Conformational Transitions of the Sarcoplasmic Reticulum Ca-ATPase Studied by Time-Resolved EPR and Quenched-Flow Kinetics
Source: Biochem. 34 (1995) 4864-4879
Description: pre-steady state behavior of phosphorylation reaction modeled using mono- and bi-exponential functions.
Authors: Mahaney, James E.; Froehlich, Jeffrey P.; Thomas, David D.

Title: Opioid Peptide Receptor Studies. 2. [3-H]SNC-121, A Novel, Selective, and High Affinity Ligand for Opioid Delta Receptors
Source: Analgesia 1 (1995) 185-193
Description: not found in print or on web.
Authors: Ni, Q.; Xu, H.; Partilla, J.S.; Calderon, S.N.; Porreca, F.; Rice, K.C.; Bertha, C.M.; McNutt, R.W.; Ananthan, S.; Rothman, R.B.

Title: Opioid Peptide Receptor Studies. 3. Interaction of Opioid Peptides and Other Drugs With Four Subtypes of the Kappa-2 Receptor in Guinea Pig Brain
Source: Peptides 16 (1995) 1083-1095
Description: PCMLAB, binding surfaces fit to various models.
Authors: Ni, Qing; Xu, Heng; Partilla, John S.; de Costa, Brian; Rice, Kenner C.; Kayakiri, Hiroshi; Rothman, Richard B.

Title: An Implicitly Defined Parametric Model for Censored Survival Data and Covariates
Source: Biometrics 51 (1995) 249-258
Description: analytic derivatives, root finding, and graphics
Authors: Piantadosi, Steven; Crowley, John

Title: Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin
Source: Diabetes 44 (1995) 1038-1045
Description: paired t-tests and regression lines were calculated with PCMLAB.
Authors: Rebrin, Kerstin; Steil, Garry M.; Getty, Lisa; Bergman, Richard N.

Title: Expression and Functionality of Luteinizing Hormone/Chronic Gonadotropin Receptor in the Rat Prostate
Source: Endocrin. 136 (1995) 917-923
Description: 2 Scatchard models: single site of high affinity and low capacity, single site with additional nonsaturable component
Authors: Reiter, Eric; McNamara, Michael; Closset, Jean; Hennen, Georges

Title: Ligand Selectivity of Cloned Human and Rat Opioid Mu Receptors
Source: Synapse 21 (1995) 60-64
Description: PCMLAB, 1-site binding model, 2-parameter logistic
Authors: Rothman, Richard B.; Xu, Heng; Wang, Jia Bei; Partilla, John S.; Kayakiri, Hiroshi; Rice, Kenner C.; Uhl, George R.

Title: Studies of the Biogenic Amine Transporters: VI. Characterization of a Novel Cocaine Binding Site, Identified with [125-I] RTI-55, in Membranes Prepared from Whole Rat Brain Minus Caudate
Source: J. Pharm. Exp. 274 (1995) 385-395
Description: PCMLAB, binding surface analysis
Authors: Rothman, Richard B.; Silverthorn, Mayme L.; Baumann, Michael H.; Goodman, Carl B.; Cadet, Jean L.; Matecka, Dorota; Rice, Kenner C.; Carroll, F. Ivy; Wang, Jia-Bei; Uhl, George R.; Partilla, John S.; Dersch, Christina M.

Title: Monovalent Cations Partially Repair a Conformational Defect in a Mutant Tryptophan Synthase Alpha-2 Beta-2 Complex (Beta-E109A)
Source: J. Biol. Chem. 270 (1995) 17333-17338
Description: fit noncooperative binding rate constants with MLAB, no cites.
Authors: Ruvirov, Sergei B.; Ahmed, S. Ashraf; McPhie, Peter; Miles, Edith Wilson

Title: Studies of the Biogenic Amine Transporters. V. Demonstration of Two Binding Sites for the Cocaine Analog [125-I] RTI-55 Associated with the 5-HT Transporter in Rat Brain Membranes
Source: J. Pharm. Exp. 273 (1995) 213-222
Description: PCMLAB, binding model.
Authors: Silverthorn, Mayme L.; Dersch, Christina M.; Baumann, Michael H.; Cadet, Jean L.; Partilla, John S.; Rice, Kenner C.; Carroll, F. Ivy; Becketts, Karen M.; Brockington, Alicia; Rothman, Richard B.

Title: G-Beta-[125-I]-3,14-Dihydroxy-17-Methyl-4,5-Alpha- Epoxymorphinean ([125-I] IOXY-AGD): A Potent and Selective Radioligand for Opioid Mu Receptors
Source: Synapse 19 (1995) 105-111
Description: one and two component models, dissociation data, PCMLAB.
Authors: Xu, Heng; Goodman, Carl B.; Partilla, John S.; Ni, Qi; Kayakiri, Hiroshi; Rice, Kenner C.; Rothman, Richard B. 

Title: Oxidation of Hemoglobin and the Enhancement Produced by Nitroblue Tetrazolium
Source: J. Biol. Chem. 269 (1994) 24845-24853
Description: kinetic data fit to ode model.
Authors: Abugo, Omoefe O.; Rifkind, Joseph M.

Title: Studies of the Biogenic Amine Transporters. III. Demonstration of Two Binding Sites for [3H] GBR12935 and [3H] BTCP in Rat Caudate Membranes
Source: J. Pharm. Exp. 268 (1994) 1462-1475
Description: PCMLAB, multiple site binding analysis.
Authors: Akunne, Hyacinth C.; Dersch, Christine M.; Cadet, Jean L.; Baumann, Michael H.; Char, George U.; Partilla, John S.; de Costa, Brian; Rice, Kenner C.; Carroll, F. Ivy; Rothman, Richard B.

Title: An Electrophilic Affinity Ligand Based on (+)-MK801 Distinguishes PCP Site 1 from PCP Site 2
Source: Neurochem. R. 19 (1994) 385-389
Description: [3H]TCP binding surfaces fit.
Authors: Akunne, Hyacinth C.; Monn, J.A.; Thurkauf, Andrew; Jacobson, Arthur E.; Rice, Kenner C.; Linders, Joannes T.M.; Jiang, Q.; Porreca, F.; Rothman, Richard B.

Title: Synthesis and Solvolysis of Acridine 1,2- and 3,4-Oxides: Crystal Structure and Solvolysis of Acridine 1,2-Oxide
Source: J. Org. Chem. 59 (1994) 984-990
Description: rate constants determined by reciprocal plots or curve-fitting.
Authors: Boyd, Derek R.; Davies, R. Jeremy H.; Hamilton, Lynne; McCullough, John J.; Malone, John F.; Porter, H. Patricia; Smith, Allison; Carl, John M.; Sayer, Jane M.; Jerina, Donald M.

Title: Phase I and Pharmacokinetic Study of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Given in Combination With Fluorouracil Plus Calcium Leucovorin in Metastatic Gastrointestinal Adenocarcinoma
Source: J. Clin. Oncol. 12 (1994) 560-568
Description: Kaplan-Meier survival curves, plasma concentration curves fit to monoexponential function.
Authors: Grem, J.L.; McAtee, N.; Murphy, R.F.; Hamilton, J.M.; Balis, F.; Steinberg, S.; Arbuck, S.G.; Setser, A.; Jordan, E.; Chen, A.; Kobler, D.R.; Kotite, B.; Allegra, C.J.

Title: Characterization of the Tryptophan Fluorescence and Hydrodynamic Properties of Rat DNA Polymerase Beta
Source: J. Mol. Biol. 244 (1994) 224-235
Description: PCMLAB, ultracentrifuge sedimentation data analysis
Authors: Kim, Soon-Jong; Lewis, Marc S.; Knutson, Jay R.; Porter, Denise K.; Kumar, Amalendra; Wilson, Samuel H.

Title: Studies of the Biogenic Amine Transporters. IV. Demonstration of a Multiplicity of Binding Sites in Rat Caudate Membranes for the Cocaine Analog [125-I] RTI-55
Source: J. Pharm. Exp. 270 (1994) 296-309
Description: 1-site and 2-site binding models.
Authors: Rothman, Richard B.; Cadet, Jean L.; Akunne, Hyacinth C.; Silverthorn, Mayme L.; Baumann, Michael H.; Carroll, F. Ivy; Rice, Kenner C.; de Costa, Brian R.; Partilla, John S.; Wang, Jia-Bei; Uhl, George; Glowa, John R.; Dersch, Christine M.

Title: Protein Composition of Cornified Cell Envelopes of Epidermal Keratinocytes
Source: J. Cell Sci. 107 (1994) 693-700
Description: amino acid compositions fit to data with constraints.
Authors: Steven, Alasdair C.; Steinert, Peter M.

Title: Endurance Training Fails to Inhibit Skeletal Muscle Glucose Uptake During Exercise
Source: J. Appl. Physiol. 76 (1994) 1876-1881
Description: Plasma 2-[3-H]DG data fitted to a double exponential equation with subsequent determination of y-intercept and integral.
Authors: Sumida, Ken D.; Donovan, Casey M.

Title: Transport Properties of Vertebrate Blood-Nerve Barrier: Comparison with Blood-Brain Barrier
Source: Prog. Neurob. 43 (1994) 235-279
Description: plasma concentration as time-dependent multiexponential process.
Authors: Wadhwani, Kishena C.; Rapoport, Stanley I.

Title: Time Course of Induction of Metabolism of All-Trans-Retinoic Acid and the Up-Regulation of Cellular Retinoic Acid-Binding Protein
Source: Cancer Res. 53 (1993) 472-476
Description: Michaelis Menten model, Vmax, Km, area under curve
Authors: Adamson, Peter C.; Boylan, John F.; Balis, Frank M.; Murphy, Robert F.; Godwin, Karen A.; Gudas, Loraine J.; Poplack, David G.

Title: Effects of Chronic Stress on Anterior Pituitary and Brain Corticotropin-Releasing Factor Receptors
Source: Pharm. Bio. B. 44 (1993) 755-761
Description: estimates for dissociation constant, Kd, and maximum concentration, Bmax, of [125-I] on CRF binding sites in membrane preparations from anterior pituitary gland were determined by nonlinear curve-fitting using DEC10 MLAB.
Authors: Anderson, Sally M.; Kant, G. Jean; De Souza, Errol B.

Title: Pharmacokinetics of PEG-L-Asparaginase and Plasma and Cerebrospinal Fluid L-Asparagine Concentrations in the Rhesus Monkey
Source: Cancer Chemot. 32 (1993) 310-314
Description: Postplateau plasma PEG-asp concentration time data fit to monoexponential, area under curve via trapezoidal rule.
Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Godwin, Karen S.; Poplack, David G.

Title: Pharmacokinetics of Piroxantrone in a Phase I Trial of Piroxantrone and Granulocyte-Colony Stimulating Factor
Source: Cancer Res. 53 (1993) 2587-2590
Description: postinfusion concentration-time data fit to bi-, tri-exponential functions.
Authors: Berg, Stacey L.; Savarese, Diane M.F.; Balis, Frank M.; Denicoff, Andrea M.; Hillig, Marianne; O'Shaughnessy, Joyce A.; Poplack, David G.; Cowan, Kenneth H.

Title: Pharmacokinetics, Cerebrospinal Fluid Penetration, and Metabolism of Piroxantrone in the Rhesus Monkey
Source: Inv. New Drugs 11 (1993) 255-261
Description: post infusion concentration time data fit to multiexponential model.
Authors: Berg, Stacey L.; Balis, Frank M.; Godwin, Karen S.; Poplack, David G.

Title: Plasma and Cerebrospinal Fluid Pharmacokinetic Study of Topotecan in Nonhuman Primates
Source: Cancer Res. 53 (1993) 725-727
Description: plasma concentration vs time data from topotecan bolus experiment fit to mono-, bi-exponential equations.
Authors: Blaney, Susan M.; Cole, Diane E.; Balis, Frank M.; Godwin, Karen; Poplack, David G.

Title: Pediatric Phase I Trial and Pharmacokinetic Study of Topotecan Administered as a 24-Hour Continuous Infusion
Source: Cancer Res. 53 (1993) 1032-1036
Description: post infusion concentration time data fit to mono-, bi-exponential model.
Authors: Blaney, Susan M.; Balis, Frank M.; Cole, Diane E.; Craig, Catherine; Reid, Joel M.; Ames, Matthew M.; Krailo, Mark; Reaman, Gregory; Hammond, Denman; Poplack, David G.

Title: Quantitation of Measurement Error with Optimal Segments: Basis for Adaptive Time Course Smoothing
Source: Am. J. Physiol. 264 (1993) E902-E911
Description: simulations performed with MLAB.
Authors: Bradley, David C.; Steil, Garry M.; Bergman, Richard N.

Title: State-Dependent Radial Elasticity of Attached Cross-Bridges in Single Skinned Fibres of Rabbit Psoas Muscle--Erratum
Source: J. Physiol. 465 (1993) 749-765
Description: responses of fibres to applied radial force fit to exponential.
Authors: Brenner, Bernhard; Yu, Leepo C.

Title: Structural Changes in the Actomyosin Cross-Bridges Associated with Force Generation
Source: Proc. Natl Acad. Sci. 90 (1993) 5252-5256
Description: fit reflection peaks to Lorentzian with amplitude, width and centroid as parameters.
Authors: Brenner, B.; Yu, L.C.

Title: Cognitive and Motor Function Impairments During Continuous Opioid Analgesic Infusions
Source: Hum. Psychopharm. 8 (1993) 383-400
Description: biexponential model of plasma concentration of opioid versus time.
Authors: Coda, Barbara A.; Hill, Harlan F.; Hunt, Earl B.; Kerr, E. Beth; Jacobson, Robert C.; Chapman, C. Richard

Title: Phase I and Pharmacokinetic Trial of Liposome-Encapsulated Doxorubicin
Source: Cancer Chemot. 33 (1993) 107-112
Description: doxorubicinol area under curve determined by trapezoidal rule
Authors: Conley, Barbara A.; Egorin, Merrill J.; Whitacre, Margaret Y.; Carter, D. Canville; Zuhowski, Eleanor G.; Van Echo, David A.

Title: Multiple Oligomeric States Regulate the DNA Binding of Helix-Loop-Helix Peptides
Source: Proc. Natl. Acad. Sci. 90 (1993) 10429-10433
Description: obtained dissociation constants by curve fitting.
Authors: Fairman, Robert; Beran-Steed, Rita K.; Anthony-Cahill, Spencer J.; Lear, James D.; Stafford, Walter F., III; DeGrado, William F.; Benfield, Pamela A.; Brenner, Stephen L.

Title: Cerebrospinal Fluid Pharmacokinetics and Toxicology of Intraventricular and Intrathecal Arabinosyl-5-Azacytosine (Fazarabine, NSC 281272) in the Nonhuman Primate
Source: Inv. New Drug 11 (1993) 135-140
Description: half-life, CSF disappearance for AAC fit to multi-exponential functions.
Authors: Heideman, Richard L.; McCully, Cynthia; Balis, Frank M.; Poplack, David G.

Title: Lysine 87 in the Beta Subunit of Tryptophan Synthase That Forms an Internal Aldimine with Pyridoxal Phosphate Serves Critical Roles in Transamination, Catalysis, and Product Release
Source: J. Biol. Chem. 268 (1993) 8727-8734
Description: fluorescence spectra and fluorimeter measurements analyzed with PCMLAB.
Authors: Lu, Zichen; Nagata, Shinji; McPhie, Peter; Miles, Edith Wilson

Title: Structure of the Hormone Binding Domain of Human Beta-1 Thyroid Hormone Nuclear Receptor: Is It an Alpha/Beta Barrel?
Source: Biochem. 32 (1993) 7460-7465
Description: analysis of circular dichroism spectra in terms of secondary structure using MLAB, no cite.
Authors: McPhie, P.; Parkinson, C.; Lee, B.K.; Chang, S-Y

Title: Stereochemical Requirements for Pseudoirreversible Inhibition of Opioid Mu Receptor Binding in the 3-Methlyfentanyl Cogeners RTI-46144 and Its Enantiomers: Evidence for Different Binding Domains
Source: Synapse 15 (1993) 296-306
Description: PCMLAB used to determine Kd, Bmax.
Authors: Ni, Qi; Xu, Heng; Partilla, J.S.; Stank, P.A.; Carroll, F.I.; Brine, G.A.; Rothman, R.B.

Title: Selective Labeling of Kappa-2 Opioid Receptors in Rat Brain by [125-I] IOXY: Interaction of Opioid Peptides and Other Drugs With Multiple Kappa-2a Binding Sites
Source: Peptides 14 (1993) 1279-1293
Description: binding surfaces fit to various models, PCMLAB, IC50, slope factor, 2 parameter logistic.
Authors: Ni, Q.; Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B.

Title: Sodium Dependence of the Na+ H+ Exchange in the Pre-steady State
Source: J. Biol. Chem. 268 (1993) 3184-3193
Description: MLAB used for simulating time course of Na+ accumulation.
Authors: Otsu, Kinya; Kinsella, James L.; Heller, Phillip; Froehlich, Jeffrey P.

Title: Chronic Cannabinoid Administration Alters Cannabinoid Receptor Binding in Rat Brain: A Quantitative Autoradiographic Study
Source: Brain Res. 616 (1993) 293-302
Description: Kd-Bmax values fit in 1-site binding model using MLAB, no cites.
Authors: Oviedo, Angelica; Glowa, John; Herkenham, Miles

Title: Chronic Intracerebroventricular Infusion of the Antiopioid Peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), Downregulates Mu Opioid Binding Sites in Rat Brain
Source: Peptides 14 (1993) 1271-1277
Description: fit to one-site binding model, PCMLAB.
Authors: Rothman, Richard B.; Brady, Linda S.; Xu, Heng; Long, Joseph B.

Title: Identification of a GBR12935 Homolog, LR1111, Which is Over 4,000-Fold Selective for the Dopamine Transporter, Relative to Serotonin and Norepinephrine Transporters
Source: Synapse 14 (1993) 34-39
Description: PCMLAB, inhibition curves fit to 2 parameter logisitic.
Authors: Rothman, Richard B.; Lewis, Bruce; Dersch, Chris; Xu, Heng; Redesca, Lilian; de Costa, Brian R.; Rice, Kenner C.; Kilburn, Robert B.; Akunne, Hyacinth; Pert, Agu

Title: Redistribution of Sufentanil to Cerebrospinal Fluid and Systemic Circulation After Administration in Dogs
Source: Anesth. Anal. 76 (1993) 323-327
Description: triexponential model.
Authors: Stevens, Rom A.; Petty, Robert H.; Hill, Harlan F.; Kao, Tzu-Cheng; Schaffer, Randy; Hahn, Marc B.; Harris, Paul

Title: Differential Binding of Opioid Peptides and Other Drugs to Two Subtypes of Opioid Delta-ncx Binding Sites in Mouse Brain: Further Evidence for Delta Receptor Heterogeneity
Source: Peptides 14 (1993) 893-907
Description: single inhibition curves fit to 2-parameter logistic equation, 1 and 2 site binding models, PCMLAB.
Authors: Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B.

Title: Phenylpiperidine Opioid Antagonists That Promote Weight Loss in Rats Have High Affinity for the Kappa-2B (Enkephalin-Sensitive) Binding Site
Source: Peptides 14 (1993) 17-20
Description: 2 parameter logistic, best fit IC50 and slope factor.
Authors: Rothman, Richard B.; Xu, Heng; Char, George U.; Kim, Andrew; de Costa, Brian R.; Rice, Kenner C.; Zimmerman, Dennis M.

Title: Reduced Sample Number for Calculation of Insulin Sensitivity and Glucose Effectiveness From the Minimal Model
Source: Diabetes 42 (1993) 250-256
Description: statistics, minimal model with MLAB, no cite.
Authors: Steil, Garry M.; Volund, Aage; Kehr, Stephen E.; Bergman, Richard

Title: State-Dependent Radial Elasticity of Attached Cross-Bridges in Single Skinned Fibres of Rabbit Psoas Muscle
Source: J. Physiol. 461 (1993) 283-299
Description: responses of fibres to applied radial force fit to single exponential.
Authors: Xu, Sengen; Brenner, Bernhard; Yu, Leepo C.

Title: Dimerization and Tetramerization Properties of the C-Terminal Region of Chromogramin A: A Thermodynamic Analysis
Source: Biochem. 32 (1993) 8816-8822
Description: PCMLAB, ultracentrifuge sedimentation data analysis
Authors: Yoo, Seung Hyun; Lewis, Marc S. 

Title: Dose-Dependent Pharmacokinetics of All-Trans-Retinoic Acid
Source: JNCI 84 (1992) 1332-1335
Description: fit Michaelis Menten differential equation.
Authors: Adamson, Peter C.; Balis, Frank M.; Smith, Malcolm A.; Murphy, Robert F.; Godwin, Karen A.; Poplack, David G.

Title: [3H] Cocaine Labels a Binding Site Associated With the Serotonin Transporter in Guinea Pig Brain: Allosteric Modulation by Paroxetine
Source: Neurochem. R. 17 (1992) 1275-1283
Description: 1,2,3 site binding models, IC50, Hill coefficients
Authors: Akunne, Hyacinth C.; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B.

Title: Analytical Ultracentrifugation in Biochemistry and Polymer Science
Source: Chapter 9 of book edited by Harding, Rowe, and Horton, (1992) 138-146
Description: ultracentrifuge modeling
Authors: Attri, A.K.; Lewis, Marc S.

Title: A Kinetic Model of CD4+Lymphocytes with the Human Immunodeficiency Virus (HIV)
Source: Biosystems 26 (1992) 177-183
Description: 5 coupled ordinary differential equations describing cell populations.
Authors: Bailey, James J.; Fletcher, John E.; Chuck, Emil T.; Shrager, Richard I.

Title: Clinical Pharmacology of 2',3'-Dideoxyinosine in Human Immunodeficiency Virus-Infected Children
Source: J. Infect. Dis. 165 (1992) 99-104
Description: postinfusion ddI concentration fit to mono and biexponential curves
Authors: Balis, Frank M.; Pizzo, Philip A.; Butler, Karina M.; Hawkins, Mary E.; Brouwers, Pim; Husson, Robert N.; Jacobsen, Freda; Blaney, Susan M.; Gress, Janet; Jarosinski, Paul; Poplack, David G.

Title: Intrathecal 5-Fluorouracil in the Rhesus Monkey
Source: Cancer Chemot. 31 (1992) 127-130
Description: concentration time data fit to mono and biexponential models.
Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Parker, George A.; Murphy, Robert F.; Poplack, David G.

Title: Folding Kinetics of T4 Lysozyme and Nine Mutants at 12 Degrees C
Source: Biochem. 31 (1992) 1464-1476
Description: thermodynamic function fit to find rate constants.
Authors: Chen, Bau-Lu; Baase, Walter A.; Nicholson, Hale; Schellman, John A.

Title: Fluorescence Studies of the Secondary Structure and Orientation of a Model Ion Channel Peptide in Phospholipid Vesicles
Source: Biochem. 31 (1992) 6608-6616
Description: root and fit operators to find dissociation constants.
Authors: Chung, Laura Ann; Lear, James D.; DeGrado, William F.

Title: Biochemical Modulation of Fluorouracil with Leucovorin and Interferon: Preclinical and Clinical Investigations
Source: Semin. Oncol. 19 (1992) 36-44
Description: 5-FU plasma concentration in time fit to monoexponential, computed area under curve.
Authors: Grem, Jean L.; Chu, Edward; Boarman, Donna; Balis, Frank M.; Murphy, Robert F.; McAtee, Nanette; Allegra, Carmen J.

Title: A Study of Core Domains and the Core Domain-Domain Interaction of Cytochrome c Fragment Complex
Source: Arch. Biochem. 296 (1992) 1-16
Description:
Authors: Fisher, Alice; Taniuchi, Hiroshi

Title: Alanine-Scanning Mutagenesis of Human Prolactin: Importance of the 58-74 Region for Bioactivity
Source: Mol. Endocr. 6 (1991) 1381-1392
Description: Scatchard anaylsis of binding data with MLAB, competition curves analyzed with LIGAND.
Authors: Goffin, V.; Norman, M.; Martial, J.A.

Title: Patient-Controlled Analgesic Infusions: Alfentanil Versus Morphine
Source: Pain 49 (1992) 301-310
Description: bi, triexponential models of plasma opioid concentration vs. time.
Authors: Hill, Harlan F.; Coda, Barbara A.; Mackie, Adam M.; Iverson, Karen

Title: Interpretation of Time Constant and Electronic Length Estimates in Multicylinder or Branched Neuronal Structures
Source: J. Neurophys. 68 (1992) 1401-1420
Description: estimates of T0, T1, C0, C1 determined by variety of methods including MLAB.
Authors: Holmes, William R.; Segev, Idan; Rall, Wilfrid

Title: Cellular Processing of Growth Hormone in IM-9 Cells: Evidence for Exocytosis of Internalized Hormone
Source: Endocrin. 130 (1992) 2037-2044
Description: [125-I] hGH internalization, DEC20 MLAB.
Authors: Ilondo, Mapoko M.; Vandershueren-Lodeweyckx, Magda; Courtoy, Pierre J.; De Meyts, Pierre

Title: Clinical Pharmacokinetic Study of Tiazofurin Administered as a 1-Hour Infusion
Source: Int J. Cancer 51 (1992) 182-188
Description: plasma clearance as 2 compartment model.
Authors: Jayaram, Hiremagalur N.; Lapis, Erzsebet; Tricot, Guido; Kneebore, Patricia; Paulik, Edith; Zhen, Weining; Engeler, George P.; Hoffman, Ronald; Weber, George

Title: An Investigation of the Thermal Unfolding of Swine Pepsinogen Using Circular Dichroism
Source: Arch. Biochem. 293 (1992) 46-53
Description: SVD analysis, DEC10 MLAB.
Authors: McPhie, Peter; Shrager, Richard I.

Title: The Mass of the Sindbis Virus Neucleocapsid Suggests It Has T=4 Icosahedral Symmetry
Source: Virology 187 (1992) 329-332
Description: fit gaussian to histogram.
Authors: Paredes, Angel M.; Simon, Martha N.; Brown, Dennis T.

Title: Interaction of Opioid Peptides and Other Drugs With Multiple Kappa Receptors in Rat and Human Brain: Evidence for Species Differences
Source: Peptides 13 (1992) 977-987
Description: binding studies, F-test
Authors: Rothman, Richard B.; Bykov, Victor; Xue, B.G.; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Kleinman, Joel E.; Brady, Linda S.

Title: Probing the Opioid Receptor Complex With (+)-Trans SUPERFIT. II. Evidence that Mu Ligands Are Noncompetitive Inhibitors of the Delta-cx Opioid Peptide Binding Site
Source: Peptides 13 (1992) 1137-1143
Description: inhibition curves fit to 2 parameter logistic
Authors: Rothman, Richard B.; Mahboubi, Artin; Bykov, Victor; Kim, Chong-Ho; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.

Title: Effect of Salt on the Kinetic Parameters of Retroviral and Mammalian Aspartic Acid Proteases
Source: Bioorg. Chem. 20 (1992) 67-76
Description: inhibition constants, pseudo-first order rate constants.
Authors: Tropea, Joseph E.; Nashed, Nashaat T.; Louis, John M.; Sayer, Jane M.; Jerina, Donald M.

Title: Saturable Transport of Manganese (II) Across Blood-Nerve Barrier of Rat Peripheral Nerve
Source: Am. J. Physiol. 262 (1992) R284-R288
Description: determine saturation-kinetic parameters for Mn influx.
Authors: Wadhwani, Kishena C.; Murphy, Vincent A.; Smith, Quentin R.; Rapoport, Stanley I.

Title: Kinetic Method for Differentiating Mechanisms for Ligand Exchange Reactions: Application to Test for Substrate Channeling in Glycolysis
Source: Biochem. 31 (1992) 2123-2128
Description: numerical analysis carried out by solving the differential equations describing the mechanism being considered using the integrator in MLAB.
Authors: Wu, Xiaomao; Gutfreund, H.; Chock, P.B.

Title: Interaction of Opioid Peptides and Other Drugs With Multiple Delta-ncx Binding Sites in Rat Brain: Further Evidence for Heterogeneity
Source: Peptides 13 (1992) 1207-1213
Description: fit data to 1 and 2 site models.
Authors: Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B.

Title: Effects of pH and Ca2+ on Monomer-Dimer and Monomer-Tetramer Equilibria of Chromogranin A*
Source: J. Biol. Chem. 267 (1992) 11236-11241
Description: ultracentrifuge data analysis.
Authors: Yoo, S.H.; Lewis, Marc S.

Title: Contribution of De-Novo and Salvage Synthesis to the Uracil Nucleotide Pool in Mouse Tissues and Tumors in Vivo
Source: Eur. J. Biochem. 210 (1992) 293-296
Description: linear regression
Authors: Zaharevitz, Daniel W.; Anderson, Lawrence W.; Malinowski, Nancy M.; Hyman, Roosevelt; Strong, John M.; Cysyk, Richard L. 

Title: [3H]1-[2-(2-Thienyl)Cyclohexyl] Piperidine Labels Two High-Affinity Binding Sites in Human Cortex: Further Evidence for Phencyclidine Binding Sites Associated With the Biogenic Amine Reuptake Complex
Source: Synapse 8 (1991) 289-300
Description: 1 and 2 site binding model.
Authors: Akunne, Hyacinth C.; Reid, Audrey A.; Thurkauf, Andrew; Jacobson, Arthur E.; de Costa, Brian R.; Rice, Kenner C.; Heyes, Melvin P.; Rothman, Richard B.

Title: An in Vitro Novel Mechanism of Regulating the Activity of Pyruvate Kinase M2 by Thyroid Hormone and Fructose 1,6-Bisphosphate
Source: Biochem. 30 (1991) 7105-7111
Description: Michaelis Menten equation, DEC10 MLAB.
Authors: Ashizawa, Kiyoto; McPhie, Peter; Lin, Kwang-huei; Cheng, Sheue-yann

Title: The Formation of Actin Oligomers Studied by Analytical Ultracentrifugation
Source: J. Biol. Chem. 266 (1991) 6815-6824
Description: ultracentrifuge sedimentation velocity data analysis.
Authors: Attri, Arun K.; Lewis, Marc S.; Korn, Edward D.

Title: Protein-Protein Interactions of HIV-1 Reverse Transcriptase: Implication of Central and C-Terminal Regions in Subunit Binding
Source: Biochem. 30 (1991) 11707-11719
Description: PCMLAB, ultracentrifuge data analysis.
Authors: Becerra, S. Patricia; Kumar, Amalendra; Lewis, Marc S.; Widem, Steven G.; Abbotts, John; Karawya, Essam M.; Hughes, Stephen H.; Shiloach, Joseph; Wilson, Samuel H.

Title: Pharmacokinetics of Pyrazoloacridine in the Rhesus Monkey
Source: Cancer Res. 51 (1991) 5467-5470
Description: post infusion concentration-time data fit to bi- and tri-exponential functions.
Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Godwin, Karen S.; Poplack, David G.

Title: Characterization of Radial Force and Radial Stiffness in Ca2+ Activated Skinned Fibres of the Rabbit Psoas Muscle
Source: J. Physiol. 441 (1991) 703-718
Description: cross-bridge theory of muscle contraction, response of single fibres to applied radial force by dextran T500 fit to function of two exponentials plus a constant.
Authors: Brenner, Bernhard; Yu, Leepo C.

Title: The Interaction of Monomeric Actin with Two Binding Sites on Acanthamoeba Actobindin
Source: J. Biol. Chem. 266 (1991) 3820-3826
Description: sedimentation equilibrium determination of the Mr of labeled and unlabeled actobinbin.
Authors: Bubb, Michael R.; Lewis, Marc S.; Korn, Edward D.

Title: Eukaryotic Initiation Factor 5A: The Molecular Form of the Hypusine-Containing Protein from Human Erythrocytes
Source: Bioch. Biophys. A 1076 (1991) 448-451
Description: elution profiles of eIF-5A recorded at 280nm, values of Kd as functions of MW of standards fit to logistic.
Authors: Chung, Soo Il; Park, Myung Hee; Folk, J.E.; Lewis, Marc S.

Title: Effects of Bovine, Human, and Rat Growth Hormones on Immature Hypophysectomized Rat Testis
Source: Growth Reg. 1 (1991) 29-37
Description: analysis of binding data using PDP20 MLAB.
Authors: Closset, J.; Dumbrowicz, D.; Vandenbroek, M.; Hennen, G.

Title: Compartmental Analysis of Steady-State Taurocholate Transport Kinetics by Isolated Rat Hepatocytes
Source: Hepatology 13 (1991) 1203-1214
Description: differential equations for compartmental model.
Authors: Coche, Thierry; Deroubaix, Xavier; Depiereux, Eric; Feytmans, Ernest

Title: Analysis of the Dynamics of Relaxation Type Oscillation in Glycolysis of Yeast Extracts
Source: Biophys. J. 60 (1991) 369-379
Description: linear algebraic systems of equations for concentrations of substances in chemical system, MLAB PDP10.
Authors: Das, Joachim; Busse, Heinrich-Gustav

Title: Saturation of Hepatic Transport of Taurocholate in Rats in Vivo
Source: Am. J. Physiol. 260 (1991) G189-G196
Description: compartmental model, Michaelis Menten parameters, DEC20 MLAB
Authors: Deroubaix, Xavier; Coche, Thierry; Depiereux, Eric; Feytmans, Ernest

Title: 2-Amino-3-(Methylamino)-Propanoic Acid (BroAA) Pharmacokinetics and Blood-Brain Barrier Permeability in the Rat
Source: J. Pharm. Exp. 258 (1991) 27-35
Description: plasma concentration fit to 3 component exponential equation using DEC10 MLAB.
Authors: Duncan, Mark W.; Villacreses, Nelly E.; Pearson, Philip G.; Wyatt, Lance; Rapoport, Stanley I.; Kopin, Irwin J.; Markey, Sanford P.; Smith, Quentin R.

Title: Roles of Metal Ions in the Maintenance of the Tertiary and Quaternary Structure of Arginase from Saccharomyces cerevisiae
Source: J. Biol. Chem. 266 (1991) 21474-21481
Description: equilibrium sedimentation studies, ultracentrifuge data.
Authors: Green, Susan M.; Ginsburg, Ann; Lewis, Marc S.; Hensley, Preston

Title: A Pilot Study of Interferon Alpha-2a in Combination with Fluorouracil Plus High-Dose Leucovorin in Metastatic Gastrointestinal Carcinoma
Source: J. Clin. Onc. 9 (1991) 1811-1820
Description: plasma concentration time data fit to monoexponential decay function.
Authors: Grem, Jean L.; McAtee, Nanette; Murphy, Robert F.; Balis, Frank M.; Steinberg, Seth M.; Hamilton, J. Michael; Sorensen, J. Mel; Santor, Oliver; Kramer, Barnett S.; Goldstein, Lori J.; Gay, Laura M.; Caubo, Kathleen M.; Goldspiel, Barry; Allegra, Carmen J.

Title: Multiple-Dose Evaluation of Intravenous Hydromorphone Pharmacokinetics in Normal Human Subjects
Source: Anesth. Analg. 72 (1991) 330-336
Description: triexponential model, area under curve
Authors: Hill, Harlan F.; Coda, Barbara A.; Tanaka, Akira; Shaffer, Randy

Title: Comparison of the Effects of Hypertonic Sucrose and Intracellular Potassium Depletion on Growth Hormone Receptor Binding Kinetics and Down-Regulation in IM-9 Cells: Evidence for a Sequential Block of Receptor-Mediated Endocytosis
Source: Endocrin. 128 (1991) 1597-1602
Description: dissociation kinetics modeled using biexponential model, DEC20 MLAB.
Authors: Ilondo, M. Mapoko; Smal, Jean; De Meyts, Pierre; Courtoy, Pierre J.

Title: Effect of Single Amino Acid Substitutions at Positions 49 and 60 on the Thermal Unfolding of the Tryptophan Synthase Alpha Subunit from Salmonella typhimurium
Source: Arch. Bioch. 284 (1991) 174-180
Description: ellipticities of native and denatured proteins fit using DEC10 MLAB.
Authors: Kanzaki, Hiroshi; McPhie, Peter; Miles, Edith Wilson

Title: Site-Directed Mutagenesis of the Beta Subunit of Tryptophan Synthase from Salmonella typhimurium
Source: J. Biol. Chem. 266 (1991) 7618-7625
Description: fluorescence intensity data were collected on a solution of the apoE350Q Alpha-2, Beta-2 complex in the presence of pyridoxal phosphate concentration ranging from .05 to 2.2 microM, dissociation constants determined.
Authors: Kayastha, Arvind M.; Sawa, Yoshiro; Nagata, Shinji; Miles, Edith Wilson

Title: Concentration-Related Effects of Morphine on Cognition and Motor Control in Human Subjects
Source: Neuropsych. 5 (1991) 157-166
Description: biexponential model of plasma concentration-time.
Authors: Kerr, Beth; Hill, Harlan; Coda, Barbara; Celogero, Mark; Chapman, C. Richard; Hunt, Earl; Buffington, Veronica; Mackie, Adam

Title: A Bivariate Version of Andrews Plots
Source: IEEE Biomed. 38 (1991) 1271-1274
Description: 3d graphics
Authors: Koziol, James A.; Hacke, W.

Title: Image Averaging of Flexible Fibrous Macromolecules: The Clathrin Triskelion Has an Elastic Proximal Segment
Source: J. Struct. Bio. 107 (1991) 6-14
Description: fit line shape to sum of 3 Gaussians.
Authors: Kocsis, Eva; Trus, Benes L.; Steer, Clifford J.; Bisher, Margaret E.; Steven, Alasdair C.

Title: Compartmental Analysis of 45-Ca 2+ Efflux in Perfused Rat Liver: Effects of Hormonal Stimulation
Source: Cell Calcium 12 (1991) 743-753
Description: exponetial function fit with MLAB and SAAM/CONSAM.
Authors: Lapointe, D.S.; Olson, M.S.

Title: An Essential Role of Domain D in the Hormone-Binding Activity of Human Beta-1 Thyroid Hormone Nuclear Receptor
Source: Mol. Endocr. 5 (1991) 485-492
Description: affinity constants for binding of T3 to intact and truncated h-TR-Beta-1.
Authors: Lin, Kwang-Huei; Parkinson, Clifford; McPhie, Peter; Cheng, Sheue-yann

Title: Changes in pH Associated with Clotting of Fibrinogen. Kinetic Studies of the pH Shift and Correlation of the pH Change with the Release of Fibrinopeptides and the Ensuing Polymerization
Source: Biochem. 30 (1991) 4753-4762
Description: mathematical analysis of the pH shift recordings, fibrinopeptide release, and optical density increase curves was performed by curve fitting with MLAB.
Authors: Mihalyi, Elemer; Tercero, Juan Carlos; Diaz-Maurino, Teresa

Title: Saturable Transport of Manganese (II) Across the Rat Blood-Brain Barrier
Source: J. Neurochem. 57 (1991) 948-954
Description: values of Vmax, Km, and Kns nonlinear least squares curve fit.
Authors: Murphy, Vincent A.; Wadhwani, Kishena C.; Smith, Quentin R.; Rapoport, Stanley I.

Title: Saturable Transport of Ca Into CSF in Chronic Hypo- and Hypercalcemia
Source: J. Neurosci. R. 30 (1991) 421-426
Description: data fit to Michaelis Menten equation.
Authors: Murphy, V.A.; Smith, Q.R.; Rapoport, S.I.

Title: Phase I/Pharmacokinetic Reevaluation of ThioTEPA
Source: Cancer Res. 51 (1991) 3171-3176
Description: plasma concentration-time, area under curve, linear, exponential and Hill parameters.
Authors: O'Dwyer, Peter J.; LaCreta, Frank; Engstrom, Paul F.; Peter, Ruth; Tartaglia, Laura; Cole, Diane; Litwin, Samuel; DeVito, Joseph; Poplack, David; DeLap, Robert J.; Comis, Robert L.

Title: Labeling by [3H] 1,3-Di(2-tolyl)guanidine of Two High Affinity Binding Sites in Guinea Pig Brain: Evidence for Allosteric Regulation by Calcium Channel Antagonists and Pseudoallosteric Modulation by Sigma Ligands
Source: Molec. Pharm. 39 (1991) 222-232
Description: F-test, 1,2, and 3-site binding model.
Authors: Rothman, Richard B.; Reid, Audrey; Mahboubi, Artin; Kim, Chong-Ho; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.

Title: Upregulation of the Opioid Receptor Complex by the Chronic Administration of Morphine: A Biochemical Marker Related to the Development of Tolerance and Dependence
Source: Peptides 12 (1991) 151-160
Description: 2 component dissociation model
Authors: Rothman, Richard B.; Long, Joseph B.; Bykov, Victor; Xu, Heng; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W.

Title: Probing the Opioid Receptor Complex With (+)-Trans-Superfit. I. Evidence That [D-Pen2,D-Pen5] Enkephalin Interacts with High Affinity at the Delta-cx Binding Site
Source: Peptides 12 (1991) 359-364
Description: surfaces fit to one site binding model
Authors: Rothman, Richard B.; Mahboubi, Artin; Bykov, Victor; Kim, Chong-Ho; Jacobson, Arthur E.; Rice, Kenner C.

Title: Interaction of Beta-Funal Trexamine With [3H] CycloFOXY Binding in Rat Brain: Further Evidence that Beta-FNA Alkylates the Opioid Receptor Complex
Source: Synapse 8 (1991) 86-99
Description: binding surfaces were fit to appropriate equations using MLAB.
Authors: Rothman, Richard B.; Bykov, Victor; Mahboubi, Artin; Long, Joseph B.; Jiang, Qi; Porreca, Frank; de Costa, Brian R.; Jacobson, Arthur E.

Title: RTI-4614-4: An Analog of (+)-Cis-3-Methylfentanyl with a 27,000-Fold Binding Selectivity for Mu Versus Delta Opioid Binding Sites
Source: Life Sci. 48 (1991) PL111-PL116
Description: 2 parameter logistic, IC50, slope factor, ligand binding analysis.
Authors: Rothman, Richard B.; Xu, Heng; Seggel, Mark; Jacobson, Arthur E.; Rice, Kenner C.; Brine, George A.; Carroll, F. Ivy

Title: GBR12909 Antagonizes the Ability of Cocaine to Elevate Extracellular Levels of Dopamine
Source: Pharm. Bioch. B. 40 (1991) 387-397
Description: 1,2,3-site binding models
Authors: Rothman, Richard; Mele, Andrea; Reid, Audrey R.; Akunne, Hyacinth; Greig, Nigel; Thurkauf, Andrew; de Costa, Brian R.; Rice, Kenner C.; Pert, Agu

Title: Evidence for Entry of Plasma Insulin into Cerebrospinal Fluid through an Intermediate Compartment in Dogs
Source: J. Clin. Inv. 88 (1991) 1272-1281
Description: 3 compartment model, DEC10 MLAB.
Authors: Schwartz, Michael W.; Bergman, Richard N.; Kahn, Steven E.; Taborsky, Gerald J., Jr.; Fisher, Lloyd D.; Sipols, Alfred J.; Woods, Stephen C.; Steil, Gary M.; Porte, Daniel, Jr.

Title: Analysis of One-Dimensional Gels and Two-Dimensional Serwer-type Gels on the Basis of the Extended Ogston Model Using Personal Computers
Source: Electrophoresis 12 (1991) 28-39
Description: Ferguson plots
Authors: Tietz, Dietmar

Title: Procedures and Computer Program for Deriving the Ferguson Plot from Gel Electrophoresis in a Single Pore Gradient Gel: Application to Agarose Gel and a Polystyrene Particle
Source: Electrophoresis 12 (1991) 710-721
Description: GRADFIT for Macintosh
Authors: Tietz, Dietmar; Gombocz, Erich; Chrambach, Andreas

Title: A Phase I Bioavailability and Pharmacokinetic Study of Hexamethylene Bisacetamide (NSC 95580) Administered via Nasogastric Tube
Source: Cancer Res. 51 (1991) 1803-1810
Description: Area under curve calculated using trapezoidal rule, plasma concnetration fit to monoexponetial.
Authors: Ward, Frank T.; Kelley, James A.; Roth, Jeri S.; Lombardo, Frederic A.; Weiss, Raymond B.; Leyland-Jones, Brian; Chun, Hoo G.

Title: Preliminary Ligand Binding Data for Subtypes of the Delta Opioid Receptor in Rat Brain Membranes
Source: Life Sci. 49 (1991) PL141-PL146
Description: 2 parameter logistic equation, IC50, slope, 1 and 2 site binding, PCMLAB.
Authors: Xu, Heng; Ni, Qing; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B.

Title: Cyclopentenyl Cytosine: Interspecies Predictions Based on Rodent Plasma and Urine Kinetics
Source: Inv. New Drugs 9 (1991) 9-17
Description: DEC10/20 MLAB, statistical fitting, simulation using differential equations, graphical output
Authors: Zaharko, Daniel S.; Keller, James A.; Tomaszewski, Joseph E.; Hegedus, Lajos; Hartman, Neil R. 

Title: Regulation of Thyroid Hormone Binding to its Cytosolic Binding Protein by L-Alpha-Alanine
Source: Biochem. Biophys. Res. 167 (1990) 587-592
Description: affinity constants obtained with DEC10 MLAB.
Authors: Ashizawa, Kiyoto; Kato, Hirokazu; McPhie, Peter; Cheng, Sheue-yann

Title: Oxalyl Hydroxamates as Reaction-Intermediate Analogues for Ketol-Acid Reductoisomerase
Source: Biochem. 29 (1990) 2824-2830
Description: exponential model, Michaelis constants
Authors: Aulabaugh, Ann; Schloss, John V.

Title: Placental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women
Source: J. Clin. End. 71 (1990) 725-731
Description: significant GH peaks were identified with Pulsar program in connection with MLAB on DEC20.
Authors: Beckers, Albert; Stevenaert, Achille; Foidart, Jean-Michel; Hennen, Georges; Frankenne, Francis

Title: Cyclical Cushing's Disease and Its Successful Control Under Sodium Valproate
Source: J. Endocr. Inv. 13 (1990) 923-929
Description: Pulsar program and MLAB on DEC20 used to detect cortisol peaks.
Authors: Beckers, A.; Stevenaert, A.; Pirens, G.; Flandroy, P.; Sulon, J.; Hennen, G.

Title: Pharmacokinetics and Metabolism of Cyclopentenyl Cytosine in Nonhuman Primates
Source: Cancer Res. 50 (1990) 7915-7919
Description: plasma disappearance of CPE-C following iv bolus dose, fit to biexponential function.
Authors: Blaney, Susan M.; Balis, Frank M.; Hegedus, Lajos; Heideman, Richard L.; McCully, Cynthia; Murphy, Robert F.; Kelley, James A.; Poplack, David G.

Title: High Performance Liquid Chromotographic Method for Analysis of 2',3'-Dideoxyinosine in Human Body Fluids
Source: J. Chrom. 526 (1990) 69-75
Description: using reciprocally weighted linear regression analysis, the peak height ratios of ddI to internal standard vs. concentration gave a correlation coefficient of .998.
Authors: Carpen, Mary E.; Poplack, David G.; Pizzo, Philip A.; Balis, Frank M.

Title: Muscarinic Receptors and Second-Messenger Responses of Neurons in Primary Culture
Source: Brain Res. 511 (1990) 234-240
Description: data from receptor binding studies analyzed according to equations describing competitive interactions at one or more sites.
Authors: Ellis, John; Huyler, Joanne H.; Kemp, Dorothy E.; Weiss, Samuel

Title: High-Performance Liquid Chromotographic Method for the Analysis of 2',3'-Dideoxycytidine in Human Plasma
Source: J. Chrom. 532 (1990) 442-444
Description: linear regression of peak height ratios of internal standard versus concentration of ddc gave correlation coefficient of .97.
Authors: Hawkins, Mary E.; Poplack, David G.; Pizzo, Philip A.; Balis, Frank M.

Title: Steady-State Infusions of Opioids in Human Volunteers. I. Pharmacokinetic Tailoring
Source: Pain 43 (1990) 57-67
Description: concentration-time data fit to biexponential model.
Authors: Hill, H.F.; Saeger, L.; Bjurstrom, R.; Donaldson, G.; Chapman, C.R.; Jacobson, R.

Title: Effect of Urine pH on the Stability of Doxorubicin and Its Recovery from Bladder Instillations
Source: Br. J. Urol. 65 (1990) 478-482
Description: urinary concentration data fit to biexponential equation.
Authors: Ilett, K.F.; Ong, R.T.T.; Batty, K.T.; Taylor, J.D.

Title: Characterization of Putative Cytoskeletal Proteins from a Trypanosomatid and Their Comparative Binding to Microtubules and Soluble Tubulin
Source: J. Biol. Chem. 265 (1990) 20959-20965
Description: dissociation constant and maximum number of sites fit as parameters.
Authors: Kambadur, Ravi; Lewis, Marc; Chang, Sulie; Flavin, Martin

Title: Effects of 2-Deoxyglucose on Drug Sensitive and Drug Resistant Human Breast Cancer Cells: Toxicity and Magnetic Resonance Spectroscopy Studies of Metabolism
Source: Cancer Res. 50 (1990) 544-551
Description: DEC10 MLAB.
Authors: Kaplan, Ofer; Navon, Gil; Lyon, Robbe C.; Faustino, Patrick J.; Straba, Eric J.; Cohen, Jack S.

Title: Characterisation of Putrescine Uptake by Cultured Adult Mouse Hepatocytes
Source: Bioch. Biophys. A. 1051 (1990) 32-59
Description: Kinetics parameters +/- standard error for putrescine uptake assuming Michaelis Menten kinetics determines with MLAB.
Authors: Martin, Roger L.; Ilett, Kenneth F.; Minchin, Rodney F.

Title: Dideoxycytidine Alone and in an Alternating Schedule with Zidovudine in Children with Symptomatic Human Immunodeficiency Virus Infection
Source: J. Pediatrics 117 (1990) 799-808
Description: postinfusion data from iv dose fit to monoexponential equation, compute area under curve.
Authors: Pizzo, Philip A.; Butler, Karina; Balis, Frank; Brouwers, Emile; Hawkins, Mary; Eddy, Janie; Einloth, Michele; Falloon, Judy; Husson, Robert; Jarosinski, Paul; Meer, Jacob; Moss, Howard; Poplack, David G.; Santacroce, Sheila; Weiner, Lori; Wolters, Pam

Title: Specificity of Phencyclidine-Like Drugs and Benzomorphan Opiates for Two High Affinity Phencyclidine Binding Sites in Guinea Pig Brain
Source: Neuropharm. 29 (1990) 811-817
Description: Kd and Bmax estimated.
Authors: Reid, A.A.; Mattison, M.V.; de Costa, B.R.; Thurkauf, A.; Jacobson, A.E.; Monn, J.A.; Rice, K.C.; Rothman, R.B.

Title: Pseudoallosteric Modulation by (+)-MK801 of NMDA-Coupled Phencyclidine Binding Sites
Source: Life Sci. 46 (1990) PL77-PL82
Description: dissociation curves fit to 1-,2-component dissociation models as mono- and bi-exponential functions.
Authors: Reid, Audrey A.; Monn, James A.; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B.

Title: The Binding of Palaritoyl-CoA to Bovine Serum Albumin
Source: Bioch. Biophys. A 1044 (1990) 361-367
Description: data obtained from fluorescence enhancement studies were fitted to mathematical models using DEC10 MLAB.
Authors: Richards, Ernest W.; Hamm, Michael W.; Fletcher, John E.; Otto, David A.

Title: A Critical Reappraisal of the Bleeding Time
Source: Sem. Thromb. 16 (1990) 1-144
Description: linear least squares analysis.
Authors: Rodgers, R.P. Channing; Levin, Jack

Title: Interaction of Endogenous Opioid Peptides and Other Drugs with Four Kappa Opioid Binding Sites in Guinea Pig Brain
Source: Peptides 11 (1990) 311-331
Description: each surface fit to 2-site binding model.
Authors: Rothman, Richard B.; Bykov, Victor; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Brady, Linda S.

Title: Pretreatment of Rats with the Irreversible Mu-Receptor Antagonist, Beta-FNA, Fails to Prevent Naltrexone-Induced Upregulation of Mu-Opioid Receptors
Source: Neuropharm. 29 (1990) 805-810
Description: one site binding model.
Authors: Rothman, R.B.; Long, J.B.; Bykov, V.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W.

Title: Mechanism of Sulfonylurea Herbicide Resistance in the Broadleaf Weed, Kochia scoparia
Source: Plant Physiol. 93 (1990) 55-61
Description: determine Michaelis constants.
Authors: Saari, Leonard L.; Cotterman, Josephine C.; Primiani, Michael M.

Title: Comparative Solvolytic Reactivity of Bay-Region Diol Epoxides Derived from Dibenz-[a,j]-Anthracene and Dibenzacridines
Source: JACS 112 (1990) 1177-1185
Description: rate law, fit rate constants to measured kinetic data.
Authors: Sayer, J.M.; Lehr, R.E.; Kumar, S.; Yagi, H.; Yeh, H.J.C.; Holder, G.M.; Duke, C.C.; Silverton, J.V.; Gibson, C.; Jerina, D.M.

Title: Inhibition of N6-[3H] Cyclohexyladenosine Binding by Carbamazepine
Source: Epilepsia 31 (1990) 503-512
Description: single and dual state receptor models fitted to data.
Authors: Weir, Roger L.; Anderson, Sally M.; Daly, John W.

Title: Cleavage of Spermidine as the First Step in Deoxyhypusine Synthesis
Source: J. Biol. Chem. 265 (1990) 4793-4799
Description: For kinetic studies, the concentration of substrates and enzyme fraction were varied and assays were conducted for 60 minutes, data fitted to Michaelis Menten equation with PDP10 MLAB.
Authors: Wolff, Edith C.; Park, Myung Hee; Folk, J.E.

Title: Rapid Increase of Cellular UDP-Glucuromide After Mitogen Stimulation of Quiescent 3T3 Mouse Fibroblasts
Source: Biochem. Int. 20 (1990) 1067-1076
Description: least squares curve fitting.
Authors: Zaharevitz, Daniel W.; Chisena, Christine A.; Cysyk, Richard L.

Title: Kinetics of Arginine-Vasopressin Uptake at the Blood-Brain Barrier
Source: Biochem. Biophys. A. 1025 (1990) 191-198
Description: best fit values for Vmax, Km, Kd, Michaelis parameters.
Authors: Zlokovic, Berislav V.; Hyman, Shigeyo; McComb, J. Gordon; Lipovac, Milo N.; Tang, Gordon; Dauson, Hugh 

Title: Extraction Kinetics of Zinc from Aqueous Perchlorate Solution by D2EHPA Dissolved in Isopar-H
Source: Hydrometallurgy 21 (1989) 385-399
Description: evaluated rate constants and order of reactions by curve-fitting.
Authors: Aparacio, J.; Muhammed, M.

Title: The Pharmacokinetics of Zidovudine Administered by Continuous Infusion in Children
Source: Ann. Int. Med. 110 (1989) 279-285
Description: Zidovudine disappearance following bolus adminstration fit to biexponential function.
Authors: Balis, Frank M.; Pizzo, Philip A.; Murphy, Robert F.; Eddy, Janie; Jarosinski, Paul F.; Falloon, Judith; Broder, Samuel; Poplack, David G.

Title: Pharmacokinetics of Zidovudine Administered Intravenously and Orally in Children with Human Immunodeficiency Virus Infection
Source: J. Pediatrics 114 (1989) 880-884
Description: post infusion data fit to biexponential function.
Authors: Balis, Frank M.; Pizzo, Philip A.; Eddy, Janie; Wilfert, Cathy; McKinney, Ross; Scott, Gwendolyn; Murphy, Robert F.; Jarosinski, Paul F.

Title: Apparent Down-Regulation of Rat Brain Mu- and Kappa-Opioid Binding Sites Labelled with [3H]-Cyclo-FOXY Following Chronic Administration of the Potent 5-Hydroxytryptamine Reuptake Blocker, Clomipramine
Source: J. Pharm. 41 (1989) 865-867
Description: binding surfaces fit to binding equations
Authors: Benkelfat, Chawlei; Aulakh, Charanjit S.; Bykov, Victor; Rice, Kenner C.; de Costa, Brian R.; Rothman, Richard B.

Title: 31-P NMR Studies of the Kinetics of Bisalkylation by Isophosphoramide Mustard: Comparisons With Phosphoramide Mustard
Source: J. Med. Chem. 32 (1989) 1768-1773
Description: 31-P NMR data fit to solution of system of 3, first order differential equations.
Authors: Boal, Jila H.; Williamson, Margaret; Boyd, Victoria L.; Ludeman, Susan M.; Egan, William

Title: Beta-1 and Beta-2 Adrenergic Receptor Subpopulations in Nonfailing and Failing Human Ventricular Myocardium: Coupling of Both Receptor Subtypes to Muscle Contraction and Selective Beta-1 Receptor Down-Regulation in Heart Failure
Source: Circ. Res. 59 (1989) 297-309
Description: ICYP bound vs log(ligand conc) curve fit
Authors: Bristow, Michael R.; Ginsburg, Robert; Umans, Victor; Fowler, Michael; Minobe, Wayne; Rasmussen, Randy; Zera, Pauline; Menlove, Ronald; Shah, Pir; Jamieson, Stuart; Stinson, Edward B.

Title: Biopotency of Highly Purified Porcine FSH and Human LH on Gonadal Function
Source: J. Endocrin. 120 (1989) 89-96
Description: Scatchard analysis was performed on data from binding inhibition experiments. PDP20 MLAB.
Authors: Closset, J.; Hennen, G.

Title: Compartmental Modeling of the Hepatic Transport of Taurocholate in the Rat in Vivo
Source: Am. J. Physiol. 257 (1989) G210-G220
Description: compartmental models, DEC20 MLAB
Authors: Deroubaix, Xavier; Coche, Thierry; Depiereux, Eric; Feytmans, Ernest

Title: A Limited Sampling Stategy for Cyclophosphamide Pharmacokinetics
Source: Cancer Res. 49 (1989) 3129-3133
Description: computer modeling of the decline in plasma conc of cyclophosphamide.
Authors: Egorin, Merrill J.; Forest, Alan; Belani, Chandra P.; Ratain, Mark J.; Abrams, Jeffrey S.; Van Echo, David A.

Title: Kinetics of the Copper- and Iron-Catalyzed Oxidation of Cysteine by Dioxygen
Source: Acta Chem. Scand. 43 (1989) 177-187
Description: parameters k0 and K were estimated by minimizing sum of squares, Michaelis Menten, Lineweaver Burk
Authors: Ehrenberg, L.; Harms-Ringdahl, M.; Fedorcsak, I.; Granath, F.

Title: Intermediate Oxygen Exchange Catalyzed by the Actin-Activated Skeletal Myosin Adenosine Triphosphatase
Source: Biochem. 28 (1989) 7741-7747
Description: The oxygen isotopic composition was used to calculate a partition coefficient and a theoretical distribution assuming a single path using algorithms written in MLAB.
Authors: Evans, John A.; Eisenberg, Evan

Title: Hydrochloric Acid Transport Through a Trilaurylamine-Supported Liquid Membrane from Aqueous Lithium Chloride Media
Source: J. Membrane Sci. 44 (1989) 213-232
Description: obtained accurate estimate of parameters in flux equations using MLAB.
Authors: Fernandez, L.A.; Elizaldi, M.P.; Aparacio, J.L.

Title: Phase I and Pharmacokinetic Evaluation of Thiotepa in the Cerebrospinal Fluid and Plasma of Pediatric Patients: Evidence for Dose-Dependent Plasma Clearance of Thiotepa
Source: Cancer Res. 49 (1989) 736-741
Description: thiotepa plasma disappearance fit to biexponential model.
Authors: Heideman, Richard L.; Cole, Diane E.; Balis, Frank; Sato, Judy; Reaman, Gregory H.; Packer, Roger J.; Singher, Lawrence J.; Ettinger, Lawrence J.; Gillespie, Andrea; Sam, Joseph; Poplack, David G.

Title: Reverse Phase HPLC Determination and Murine Pharmacokinetics of Arabinosyl-5-Azacytosine
Source: J. Liq. Chrom. 12 (1989) 1613-1633
Description: Initial pharmacokinetic parameters for ara-AC in mice were estimated from plasma conc. vs time curve, then fit to triexponential function representing 3 compartment open model.
Authors: Heideman, Richard L.; Roth, Jeri S.; Ford, Harry, Jr.; Kinnard, Richard D.; Litterst, Charles L.; Kelley, James A.

Title: Diurnal Variation in the Concentrations of Catecholamines and Indolearines in the Median Eminence and in the Intermediate and Posterior Lobes of the Pituitary Gland of the Male Rat
Source: Brain Res. 503 (1989) 246-252
Description: fit concentrations to sums of trignometric functions with variable amplitude and phase and DC offset
Authors: Koulu, Markku; Bjelogrlic, Nina; Agren, Hans; Saavedra, Juan M.; Potter, William Z.; Linnoila, Markku

Title: Stepwise Mechanism of HIV Reverse Transcriptase: Primer Function of Phosphorothioate Oligodeoxynucleotide
Source: Biochem. 28 (1989) 1340-1346
Description: fit kinetic constants to polymerization reaction rate laws.
Authors: Majumdar, Chirabrata; Stein, Cy A.; Cohen, Jack S.; Broder, Samuel; Wilson, Samuel H.

Title: Absence of Monocyte Procoagulant Activity During the Immune Response to Influenza Virus
Source: J. Clin. Micr. 27 (1989) 615-621
Description: linear regression experimental clotting times converted to units of PCA activity.
Authors: Mathies, Margaret; Hogg, Nancy

Title: Nucleocapsid Mass and Capsomer Protein Stoichiometry in Equine Herpes Virus 1: Scanning Transmission Electron Microscopic Study
Source: J. Virology 63 (1989) 3777-3783
Description: histograms were drawn and statistical analysis of data with DEC10 MLAB.
Authors: Newcomb, William W.; Brown, Jay C.; Booy, Frank P.; Steven, Alasdair C.

Title: Sieving of Ionic Constituents Across Moving Boundaries in Gel Electrophoresis
Source: Electrophoresis 10 (1989) 254-259
Description: evaluating Ferguson plot (mobility vs. gel concentration) of HEM-chloride-bicinate moving boundary. includes do-file.
Authors: Orban, Laszlo; Fawcett, John S.; Tietz, Dietmar; Chrambach, Andreas

Title: Transient State Kinetic Evidence for an Oligomer in the Mechanism of Na+ H+ Exchange
Source: Proc. Natl. Acad. Sci. 86 (1989) 4818-4822
Description: computer simulations of time-dependent Na+ accumulation, bimolecular reactions simulated with pseudo-first order approximation.
Authors: Otsu, Kinya; Kinsella, James; Sacktor, Bertam; Froehlich, Jeffrey P.

Title: Mechanistic Studies on Phenylalanine Hydroxylase from Chromobacterium violaceum. Evidence for the Formation of an Enzyme-Oxygen Complex
Source: Biochem. 28 (1989) 2124-2130
Description: Michaelis constants, kinetic constants for each of the sustrates were determined by computer fit of data to overall steady state equation.
Authors: Pember, Stephen O.; Johnson, Kenneth A.; Villafranca, Joseph J.; Benkovic, Stephen J.

Title: An Analysis of the Relationship Between the Cellular Distribution and the Rate of Turnover for the Separate Classes of Unoccupied, Noncovalently Occupied, and Covalently Occupied Insulin Receptor
Source: J. Biol. Chem. 264 (1989) 12673-12679
Description: apparent first order rate constants for various receptor processes.
Authors: Reed, Dana Kim; Newton, Cathy; Fraga, Mark; Glastad, Karl; Bagheri, Ali; Harris, Sonja; Reed, Brent C.

Title: The Psychotomimetic Drug Phencyclidine Labels Two High Affinity Binding Sites in Guinea Pig Brain: Evidence for N-Methyl-D-Aspartate-Coupled and Dopamine Reuptake Carrier-Associated Phencylclidine Binding Sites
Source: Mol. Pharm. 36 (1989) 887-896
Description: 2 site binding model, estimate Bmax, Kd values
Authors: Rothman, Richard B.; Reid, Audrey A.; Monn, James A.; Jacobson, Arthur E.; Rice, Kenner C.

Title: Pharmacological Activities of Optically Pure Enantiomers of the Kappa Opioidagonist, U50,488, and its Cis Diastereomer: Evidence for Three Kappa Receptor Subtypes
Source: Eur. J. Pharm. 167 (1989) 345-353
Description: one or two-site binding model
Authors: Rothman, Richard B.; France, Charles P.; Bykov, Victor; de Costa, Brian R.; Jacobson, Arthur E.; Woods, James H.; Rice, Kenner C.

Title: Chronic Adminstration of Morphine and Natrexone Up-Regulate Mu-Opioid Binding Sites Labeled by [3-H][D-Ala-2,MePhe-4,Gly-ol-5] Enkephalin: Further Evidence for Two Mu-Binding Sites
Source: Eur. J. Pharm. 160 (1989) 71-82
Description: best fit estimates of Bmax and Kd
Authors: Rothman, Richard B.; Bykov, Victor; Long, Joseph B.; Brady, Linda S.; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W.

Title: A Study of the Interaction of the Alkylating Agent, NIH10236, with Opioid Receptors in Vitro and in Vivo
Source: Neuropharm. 28 (1989) 1349-1356
Description: IC50 and slope factors fit displacement curve to 2-parameter logistic.
Authors: Rothman, R.B.; Long, J.B.; Holaday, J.W.; Bykov, V.; de Costa, B. R.; Kim, C.-H.; Jacobson, A.E.; Rice, K.C.

Title: Pulmonary Alveolar Macrophages Express a Polyamine Transport System
Source: J. Cell Physiol. 139 (1989) 624-631
Description: Henri-Michaelis-Menten equation, Boxenbaum, all data fitted with MLAB.
Authors: Saunders, Nicholas A.; Ilett, Kenneth F.; Minchin, Rodney F.

Title: Localization of Spermidine Uptake in Rabbit Lung Slices
Source: Am. J. Physiol. 257 (1989) C579-C587
Description: Henri-Michaelis-Menten equations fitted using MLAB
Authors: Saunders, Nicholas; McGeachie, John K.; Ilett, Kenneth F.; Minchin, Rodney F.

Title: Pharmacokinetics of Ritabulin
Source: Antimicr. Ag. and Chem. 33 (1989) 1237-1241
Description: Prophet-parameter estimates of half-life, oral bioavailability, area under curve
Authors: Skinner, Michael H.; Hsieh, Mark; Torseth, John; Pauloin, Danielle; Bhatiz, Gulshan; Harkonen, Scott; Merigan, Thomas C.; Blaschke, Terrence F.

Title: Computer Assisted Evaluation of Polydisperse Two-Dimensional Gel Patterns of Polysaccharide-Protein Conjugate Preparations with Regard to Size and Net Charge
Source: Electrophoresis 10 (1989) 667-680
Description: computed particle and gel fiber specific parameters from positions of standards and unknowns on 2D gel. includes do-file.
Authors: Tietz, Dietmar; Chrambach, Andreas

Title: Phase I Clinical and Pharmacokinetic Study of Thiotepa Administered Intraperitoneally in Patients with Advanced Malignancies
Source: J. Clin. Onc. 7 (1989) 132-139
Description: loss of thiotepa from peritoneal cavity fit to biexponential model.
Authors: Wadler, Scott; Egorin, Merrill J.; Zuhowski, Eleanor G.; Tortorello, Laura; Salva, Kathryn; Runowicz, Carolyn D.; Wiernik, Peter H.

Title: Catalytic Mechanism and Interactions of NAD+ with Glyceraldehyde-3-Phosphate Dehydrogenase: Correlation of EPR Data and Enzymatic Studies
Source: Bioch. Biophy. A. 997 (1989) 65-77
Description: Adair equation, binding constants
Authors: Wilder, Robert T.; Venkataramu, S.D.; Dalton, Larry R.; Birktoff, Jens J.; Trommer, Wofgang E.; Park, Jane H.

Title: Structures of Actomyosin Crossbridges in Relaxed and Rigor Muscle Fibers
Source: Biophys. J. 55 (1989) 441-453
Description: integrated intensities of each reflection were subsequently obtained by fitting to Lorentzian line shape function.
Authors: Yu, Leepo C.; Brenner, Bernhard

Title: Kinetic Analysis of Leucine-Enkephalin Cellular Uptake at the Luminal Side of the Blood-Brain Barrier of an in Situ Perfused Guinea-Pig Brain
Source: J. Neurochem. 53 (1989) 1333-1340
Description: best fit for Vmax, Km, and Kd were obtained for leu-enkephalin by fitting to brain vascular perfusion data.
Authors: Zlokovic, Berislav V.; Maokic, Jasmina B.; Djuricic, Bogdan; Pavson, Hugh 

Title: Chronic Stress Increases the Binding of the A1 Adenosine Receptor Agonist, [3-H] Cyclohexyladenosine, to Rat Hypothalamus
Source: Pharm. Biochem. Behav. 30 (1988) 169-175
Description: saturation curves fit to single and dual site receptor models.
Authors: Anderson, S.M.; Leu, J.R.; Kant, G.J.

Title: Kinetics of Activation of the Respiratory Burst Oxidase in a Fully Soluble System from Human Neutrophils
Source: J. Biol. Chem. 263 (1988) 1713-1718
Description: nonlinear regression
Authors: Babior, Bernard M.; Kuves, Rahul; Curnutte, John T.

Title: Pharmacokinetics of Subcutaneous Methotrexate
Source: J. Clin. Onc. 6 (1988) 1882-1886
Description: biexponential model, bioavailability, area under curve.
Authors: Balis, Frank M.; Miro, Joseph, Jr.; Reaman, Gregory H.; Evans, William E.; McCully, Cynthia; Doherty, Karen M.; Murphy, Robert F.; Jeffries, Susan; Poplack, David G.

Title: Determination of the Partition Coefficients, Acid Dissociation Constants, and Intrinsic Solubility of Carbenoxolone
Source: J. Pharm. Sci. 77 (1988) 548-552
Description: solubility vs. pH data fit to model, Henderson-Hasselbach equation.
Authors: Blanchard, James; Boyle, Jay O.; Van Wagenen, Stan

Title: Physiological Regulation of Neurohypophyseal Kappa Opiate Receptors
Source: Brain Res. 443 (1988) 398-402
Description: fit data to one-site competitive binding model.
Authors: Brady, Linda S.; Rothman, Richard B.; Herkenham, Miles

Title: Chronic Administration of Morphine and Naltrexone Up-Regulate [3-H] [D-Ala2-D-Leu5] Enkephalin Binding Sites by Different Mechanisms
Source: Neuropharm. 27 (1988) 965-974
Description: binding surfaces fit to 1 site binding model to find Bmax and Kd.
Authors: Danks, Janine A.; Tortella, F.C.; Long, J.B.; Bykov, V.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W.; Rothman, R.B.

Title: Measurement of Local Mr 97,000 and 250,000 Protein Antigen Concentration in Sections of Human Melanoma Tumor Using in Vitro Quantitative Autoradiography
Source: Cancer Res. 48 (1988) 5475-5481
Description: results of staturation study, Bmax and Kd
Authors: Del Vecchio, Silvana; Reynolds, James C.; Blasberg, Ronald G.; Neumann, Ronald D.; Cartasquillo, Jorge A.; Hellstrom, Ingegard; Larson, Steven M.

Title: Phase I Clinical and Pharmacokinetic Trial of Oral Menogaril Administered on Three Consecutive Days
Source: Eur. J. Cancer 24 (1988) 1019-1026
Description: weighted least squares fit of plasma concentration curves to biexponential model.
Authors: Dodion, P.; de Valeriola, D.; Crespeigne, N.; Peeters, B.; Wery, F.; Van Berchem, C.; Piccart, M.; Tueni, E.; Gopggi, J.; Kenis, Y.

Title: Method for Comparing Selectivities of Unlabelled Subpopulation Selective Ligands: Application to Muscarinic Receptors
Source: J. Receptor Res. 8 (1988) 885-900
Description: 2 site binding of 2 competitors, simulations on DEC20 MLAB
Authors: Ellis, John

Title: The Physiology of Growth Hormones (GHs) in Pregnant Women and Partial Characterization of the Placental GH Variant
Source: J. Clin. End. 66 (1988) 1171-1180
Description: affinity constants determined from Scatchard plots analysis, DEC20 MLAB
Authors: Frankenne, F.; Closset, J.; Gomez, F.; Scippo, M.L.; Smal, J.; Hennen, G.

Title: Effect of pH on the Myocardial Uptake and Pharmacodynamics of Propafenone in the Isolated Rabbit Heart
Source: J. Cardiovasc. Pharm. 12 (1988) 526-534
Description: exponential model, time-integral.
Authors: Gillis, Anne M.; Kates, Robert E.

Title: Comparative Brain and Plasma Pharmacokinetics and Anticancer Activities of Chlorambucil and Melphalan in the Rat
Source: Cancer Chemot. 21 (1988) 1-8
Description: single n biexponential equation, melphalan and chlorambucil concentration-time data
Authors: Greig, Nigel H.; Sweeney, Daniel J.; Rapoport, Stanley I.

Title: Delivery of Human Interferon-Alpha to Brain by Transient Osmotic Blood-Brain Barrier Modification in the Rat
Source: J. Pharm. Exp. 245 (1988) 581
Description: exponential decay curve fit of brain concnetration data
Authors: Greig, Nigel H.; Fredericks, Wendy R.; Halloway, Harold W.; Soncrant, Timothy T.; Rapoport, Stanley I.

Title: Linear Ferguson Plots of Polystyrene Sulfate Size Standards for the Quantitative Agarose Gel Electrophoresis of Subcellular Particles
Source: Electrophoresis 9 (1988) 243-255
Description: Ferguson plots, do-file, DEC10 MLAB
Authors: Hahn, Elisabeth; Wurts, Linda; Tietz, Dietmar; Chrambach, Andreas

Title: A Pediatric Phase I and Pharmacokinetic Study of Spirohydantoin Mustard
Source: Cancer Res. 48 (1988) 2292-2295
Description: SHM plasma conc. fit to biexponential model
Authors: Heideman, Richard L.; Kelley, James A.; Packer, Roger J.; Reaman, Gregory H.; Roth, Jeri S.; Balis, Frank; Ettinger, Lawrence J.; Doherty, Karen M.; Jeffries, Susan L.; Poplack, David G.

Title: Preclinical Pharmacology of Arabinosyl-5-Azacytidine in Nonhuman Primates
Source: Cancer Res. 48 (1988) 4294-4298
Description: plasma concentration time data fit to multi-exponential functions.
Authors: Heideman, Richard L.; Balis, Frank M.; McCully, Cynthia; Poplack, David G.

Title: Neuroplasticity and the Progression of Alzhiemer's Disease
Source: Int. J. Neurosci. 41 (1988) 1-14
Description: density of neuritic placques in its cortical projection area as a function of per cent loss of cells in a subpopulation of cholinergic forebrain
Authors: Horwitz, Barry

Title: In Vitro-in Vivo Correlation Exemplified by Sustained Release Formulations of Suprofen
Source: Arzneim.-Forsch. 38 (1988) 305-308
Description: dissolution data as function of percentage dissolved fit to Weibull distribution.
Authors: Huguenin, P.N.; Zulliger, H.W.; Niederer, R.

Title: Scale Effects in Ballistic Wounding
Source: J. Trauma 28 (1988) S29-S32
Description: standard statistical methods were used, and computations of linear regression, mean, and standard error of the mean with MLAB.
Authors: Janzon, Bo; Schantz, Birger; Seeman, Torsten

Title: Kinetics of Histone Gene Expression during Early Development of Xenopus laevis
Source: J. Theor. Biol. 135 (1988) 139-167
Description: used integrate statement to find RNA concs. as a function of time.
Authors: Koster, Johanna; Destree, Olivier H.J.; Westerhoff, Hans V.

Title: Measurement of Branched-Chain Alpha-Keto Acid Dehydrogenase Flux Rates in Perfused Heart and Liver
Source: Methods Enzym. 166 (1988) 484-497
Description: fit sum of exponentials using SAAM, MLAB, curve peeling of the data, half-life of 14-CO2 washout from liver.
Authors: Lapointe, David S.; Hildebrandt, Ellen; Buxton, Dennis B.; Patel, Tarun B.; Waymack, Parvan P.; Olson, Merle S.

Title: Phase I and Pharmacokinetic Trial of Carboplatin in Refractory Adult Leukemia
Source: JNCI 80 (1988) 131-135
Description: computer modeling of decline in plasma concentration of unfilterable and total platinum accumulate as sum of two exponentials.
Authors: Lee, Edward J.; Egorin, Merrill J.; Van Echo, David A.; Cohen, Adam E.; Tait, Nancy; Schiffer, Charles A.

Title: Alterations in Plasma Pharmacokinetics of Cisplatin in Tumor Bearing Rats
Source: Cancer Chemot. 22 (1988) 1-4
Description: plasma decay of radioactivity over 96 hour time course fit to 3 compartment model.
Authors: Litterst, Charles L.; Magin, Richard

Title: Decreased Serum Insulin-Like Growth Factor I Response to Growth Hormone in Hypophysectomized Rats Fed a Low Protein Diet: Evidence for a Postreceptor Defect
Source: Acta Endocrin. 117 (1988) 320-326
Description: binding inhibition experiments expressed as bound vs free hormone concentration, analysis of curves with MLAB.
Authors: Maes, M.; Amand, Y.; Underwood, L.E.; Maiter, D.; Ketelslegers, J.-M.

Title: Studies on the Mechanism of Human Immunodeficiency Virus Reverse Transcriptase
Source: J. Biol. Chem. 263 (1988) 15657-15665
Description: Michaelis Menten constants.
Authors: Majumdar, Chirabrata; Abbotts, John; Broder, Samuel; Wilson, Samuel H.

Title: Coloration of Silver-Stained Protein Bands in Polyacrylamide Gels is Caused by Light Scattering from Silver Grains of Characteristic Sizes
Source: Proc. Natl. Acad. Sci. 85 (1988) 453-457
Description: statistical analysis using DEC10 MLAB.
Authors: Merril, Carl R.; Bisher, Magaret E.; Harrington, Michael; Steven, Alasdair C.

Title: Clotting of Bovine Fibrinogen: Kinetic Analysis of the Release of Fibrinopeptides by Thrombin and of the Calcium Uptake Upon Clotting at High Fibrinogen Concentrations
Source: Biochem. 27 (1988) 976-982
Description: 3 data sets were analyzed by nonlinear least squares curve fitting, 1,2, and 3 exponential models.
Authors: Mihalyi, Elemer

Title: Evidence that Glutamic Acid 49 of Tryptophan Synthase Alpha Subunit is a Catalytic Residue
Source: J. Biol. Chem. 263 (1988) 8611-8614
Description: circular dichroism data at 285nm, 289nm collected. To determine maximum changes in ellipticity at each wavelength, results fitted to quadratic root formula.
Authors: Miles, Edith Wilson; McPhie, Peter; Yutani, Katsuhide

Title: Nonrandom Turnover of Actin and Tubulin in Cultured Rabbit Cardiac Fibroblasts
Source: Am. J. Physiol. 255 (1988) C202-C213
Description: precursor-product turnover model fit and total protein accumulation curve = a*(1-exp(-b*x))-c*(1-exp(-d*x))+k
Authors: Mostow, William R.; Ferguson, Allan G.; Lesch, Michael; Decker, Robert S.; Samarel, Allen M.

Title: Local Cerebral Glucose Utilization in Controlled Graded Levels of Hyperglycemia in the Conscious Rat
Source: J. Cereb. Bl. Fl. 8 (1988) 346-356
Description: least squares fit of integrated plasma concentration in time.
Authors: Orzi, F.; Lucignani, G.; Dow-Edwards, D.; Namba, H.; Nehlig, A.; Patlak, C.S.; Pettigrew, K.; Schrier, F.; Sokoloff, L.

Title: Note on Ethene and Other Low-Molecular Weight Hydrocarbons in Environmental Tobacco Smoke
Source: Act. Chem. B 42 (1988) 690-696
Description: fit ordinary differential equation for concentration of hydrocarbon in air.
Authors: Persson, Karl-Axel; Berg, Sven; Tornqvist, Margareta; Scalia-Tomba, Gian-Paolo; Ehrenberg, Lars

Title: Therapeutic and Pharmacological Studies of Tetrachloro (d,l-trans) 1,2-Diaminocyclohexane Platinum (IV) (Tetraplatin), a New Platinum Analogue
Source: Cancer Res. 48 (1988) 1745-1752
Description: plasma levels fit to biexponential model with constraints
Authors: Rahman, Aquilur; Roh, Jae Kyung; Wolpert-De Filippes, Mary K.; Goldin, Abraham; Venditti, John M.; Woolley, Paul V.

Title: A Compartmental Analysis of Solute Transfer and Exchange Across Blood-Nerve Barrier
Source: Am. J. Physiol. 255 (1988) R317-R325
Description: DEC10 computer employing MLAB was used for curve fitting of models of nerve plasma exchange and calculating plasma concentration time integrals.
Authors: Rechthand, Emanuel; Smith, Quentin R.; Rapoport, Stanley I.

Title: Induction of Sulfamethazine Acetylation by Hydrocortisone in the Rabbit
Source: Drug Metab. 16 (1988) 110-115
Description: Michaelis Menten equation fitted to data using MLAB, Km and Vmax estimated
Authors: Reeves, Philip T.; Minchin, Rodney F.; Ilett, Kenneth F.

Title: Beta-FNA Binds Irreversibly to the Opiate Receptor Complex: In Vivo and In Vitro Evidence
Source: J. Pharm. Exp. 247 (1988) 405
Description: weighted least squares curve fitting of 1 or 2 site competitive binding models
Authors: Rothman, Richard B.; Long, Joseph B.; Bykov, Victor; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W.

Title: Interaction of Enantiomeric Pairs of Opiates with Phencyclidine Binding Sites in Rat Brain: Identification of (+) Pentazocine as a Ligand Potentially Suitable for Imaging Sigma Binding Sites Using Positron Emission Tomography
Source: Neuropeptides 12 (1988) 1-5
Description: binding surfaces were fit to a one-site model.
Authors: Rothman, Richard B.; Bykov, Victor; Hauck-Newman, Amy; Jacobson, A.E.; Rice, Kenner C.

Title: LY164929-A Highly Selective Ligand for the Lower Affinity [3H]D-Ala2-D-Leu-5-Enkephalin Binding Site
Source: Neuropeptides 11 (1988) 13
Description: ligand binding models
Authors: Rothman, Richard B.; Bykov, Victor; Ofri, Danielle; Rice, Kenner C.

Title: Tritiated-6-Beta-Fluoro-6-Desoxy-Oxymorphone ([3H]FOXY)- A New Ligand and Photoaffinity Probe for the MU Opioid Receptors
Source: Neuropeptides 11 (1988) 1
Description: ligand binding models
Authors: Rothman, Richard B.; Bykov, Victor; Rice, Kenner C.; Jacobson, Arthur E.; Kooper, Grace N.; Bowen, Wayne D.

Title: Kinetics and Mechanism of Solvolysis of Precocene I 3,4-Oxide: Change in Rate-Determining Step and Trapping of an Intermediate in an Epoxide Solvolysis Reaction
Source: JACS 110 (1988) 5068-5074
Description: analysis of the data by double-reciprocal plots or MLAB gave values of rate constant.
Authors: Sayer, J.M.; Grossman, S.J.; Adusei-Poku, K.S.; Jerina, D.M.

Title: Binding of Diptheria Toxin to CHO-K1 and Vero Cells is Dependent on Cell Density
Source: J. Cell Physiol. 135 (1988) 407-415
Description: binding of 125-I-labelled DTX to low density vero cells curves drawn and analyzed by nonlinear curve fit.
Authors: Schaefer, Erik M.; Moehring, Joan M.; Moehring, Thomas J.

Title: Comparative Affinities of the Epimeric Reaction-Intermediate Analogs 2- and 4- Carboxy-D-Arabinitol 1,5-Bisphosphate for Spinach Ribulose 1,5-Bisphosphate Carboxylase
Source: J. Biol. Chem. 263 (1988) 4145-4150
Description: fit several models comprised of exponentials.
Authors: Schloss, John V.

Title: A Convenient Spectroscopic Method for the Estimation of Hemoglobin Concentrations in Cell-Free Solutions
Source: J. Biochem. Biophys. Meth. 17 (1988) 25-34
Description: the pK' calculated for a variety of wavelengths is 7.99 +/- .08 using curve-fitting algorithm in MLAB.
Authors: Snell, S.M.; Marini, M.A.

Title: Membrane Contents of Distinct Subpopulations of Coated Vesicles Determined by Scanning Transmission Electron Microscopy
Source: Bioch. Biophys. A. 938 (1988) 167-180
Description: histograms and statistical procedures.
Authors: Steer, Clifford J.; Bisher, Margaret E.; Trus, Benes L.; Hainfeld, James F.; Wall, Joseph S.; Steven, Alasdair C.

Title: Differential Stereoselectivity on Metabolism of Triphenylene by Cytochromes P-450 in Liver Microsomes from 3-Methylcholantrene- and Phenobarbital-Treated Rats
Source: J. Biol. Chem. 263 (1988) 98-105
Description: time courses of mole fraction of oxide formed, described by first order differential rate equations.
Authors: Thakker, Dhiren R.; Boehlert, Charles; Mirsadeghi, Seid; Levin, Wayne; Ryan, Deni E.; Thomas, Paul E.; Yagi, Haruhiko; Pannell, Lewis K.; Sayer, Jane M.; Jerina, Donald M.

Title: Phase I and Clinical Pharmacology Study of Intravenous Flavone Acetic Acid (NSC 347512)
Source: Cancer Res. 48 (1988) 5878-5882
Description: mono or biexponential model of postinfusion plasma concentration.
Authors: Weiss, Raymond B.; Greene, Raymond F.; Knight, Robert D.; Collins, Jerry M.; Pelosi, John J.; Sulkes, Aaron; Curt, Gregory A.

Title: The in Vivo Ageing of Red Cell Enzymes: Direct Evidence of Biphasic Decay from Polycythaemic Rabbits with Reticulocytosis
Source: Br. J. Hae. 69 (1988) 67-70
Description: sums of one and two exponential terms fitted to Hx, G6PD, and p5'N activity data using MLAB, F statistics
Authors: Zimran, Ari; Torem, Shlomo; Beutler, Ernest 

Title: Evaluation of Models for Analysis of Radioligand Binding Data
Source: Mol. Pharm. 31 (1987) 103-111
Description: ternary complex model, two-independent-receptor model, DEC10 MLAB
Authors: Abramson, Stewart N.; McGonigle, Paul; Molinoff, Perry B.

Title: Glutamine and Glutamate: Automated Quantification and Isotopic Enrichments by Gas Chromotography/Mass Spectrometry
Source: Anal. Bioch. 163 (1987) 358-368
Description: linear regression analysis
Authors: Anderson, Lawrence W.; Zaharevitz, Daniel W.; Strong, John M.

Title: Effects of Stress on [3-H] Cyclohexyladenosine Binding to Rat Brain Membranes
Source: Pharm. Bio. and Behav. 26 (1987) 829-833
Description: single and dual site (or state) receptor models were fitted to data by using a computer assisted nonlinear least squares curve fitting technique.
Authors: Anderson, S.M.; Leu, J.R.; Kant, G.J.

Title: Intrathecal Administration of 4-Hydroperoxycyclophosphamide in Rhesus Monkeys
Source: Cancer Res. 47 (1987) 5932-5934
Description: CSF disappearance curves following iv 4-HC administration were fit to monoexponential curve.
Authors: Arndt, Carola A.S.; Colvin, O. Michael; Balis, Frank M.; Lester, Cynthia M.; Johnson, Gloria; Poplack, David G.

Title: Affinity and Stability Modifications of Immobilized Alcohol Dehydrogenase through Multipoint Copolymerization
Source: Bioch. Biophys. A. 915 (1987) 393-398
Description: Michaelis parameters, DEC20 MLAB
Authors: Bille, Vincent; Plainchamp, Dominique; Remacle, Jose

Title: Modelling of a Double-Layered PTFE-Bonded Oxygen Electrode
Source: Electroch. Acta 32 (1987) 115-119
Description: Kinetic equation for a flooded catalyst aggregate.
Authors: Bjornbom, Pehr

Title: Purification and Properties of Two Phospholipid Transfer Proteins from Yeast
Source: Biochem. Cell Biol. 65 (1987) 195-202
Description: Transfer activities were determined by measurement of the fractional transfer (in triplicate) at a number of time points (usually 3 or 4) and calculating the true initial velocity by curve fitting.
Authors: Bozzato, Richard P.; Tinker, David O.

Title: Catalytic Properties of the Yeast Phospholipid Transfer Protein
Source: Biochem. Cell Biol. 65 (1987) 203-210
Description: reaction time points were fitted to f*(1-exp(-k*t)).
Authors: Bozzato, Richard P.; Woolley, Drew; Tinker, David O.

Title: Effect of Allyl Alcohol-induced Sublethal Hepatic Damage Upon Doxorubicin Metabolism and Toxicity in the Rabbit
Source: Cancer Res. 47 (1987) 3259-3265
Description: Doxorubicin plasma conc. fit to biexponential model, calculated area under curve.
Authors: Brenner, Dean E.; Anthony, Lowell B.; Halter, Susan; Harris, N. Lindsay; Collins, Jerry C.; Hande, Kenneth R.

Title: Beryllium (II) Hydrolysis in 3.0 mol/dm^3 Perchlorate
Source: J. Chem. Soc. Dalton (1987) 2431-2437
Description: graphical interpretation made with MLAB.
Authors: Bruno, Jordi

Title: Studies of Metal Carbonate Equilibria. Part 15. The Beryllium (II)-Water-Carbon Dioxide (g) System in Acidic 3.0 mol/dm^3 Perchlorate Media
Source: J. Chem. Soc. Dalton (1987) 2439-2444
Description: fit rate constants.
Authors: Bruno, Jordi; Grenthe, Ingmar; Sandstrom, Magnus; Ferri, Diego

Title: Studies of Metal Carbonate Equilibria. Part 16. The Beryllium (II) Water-Carbon Dioxide (g) System in Neutral-to-Alkaline 3.0 mol/dm^3 Perchlorate Media at 25 degrees C
Source: J. Chem. Soc. Dalton (1987) 2445-2449
Description: used MLAB to calculate unknown solubility constants by least squares fit.
Authors: Bruno, Jordi; Grenthe, Ingmar; Munoz, Maria

Title: Impaired Gastric Emptying in Diabetic Patients with Cardiac Autonomic Neuropathy
Source: Diabetes Care 10 (1987) 448-452
Description: initial radioactivity in stomach at time t fit to 2^(-t/thalf)^beta.
Authors: Buysschaert, Martin; Moulant, Michel; Urbain, Jean Luc; Pauwels, Steny; de Roy, Luc; Ketelslegers, Jean Marie; Lambert, Andre E.

Title: Rat Brain PCP Receptors: Alterations in Binding Parameters Following Chronic Administration of Opiate Agonists and Antagonists
Source: Neruopeptides 10 (1987) 201-205
Description: displacement curves analyzed with MLAB.
Authors: Byrd, James C.; Bykov, Victor; Rothman, Richard B.

Title: Identification and Characterization of a Monoclonal Antibody Recognizing a Galactose-Binding Domain of the Toxin Ricin
Source: J. Immunology 138 (1987) 3339-3344
Description: analytical ultracentrifuge scans obtained after equation was attained.
Authors: Colombatti, Marco; Johnson, Virginia G.; Skopicki, Hal A.; Fendley, Brian; Lewis, Marc S.; Youle, Richard J.

Title: Sensitivity of Normal Human Bone Marrow Myeloid Progenitor Cells to Anthracycline, Cisplatin, Anthracene, and Flavone Acetic Acid Derivatives, and Its Relevance for the Prediction of Human Plasma Concentrations of Anticancer Drugs
Source: Eur. J. Cancer 23 (1987) 1901-1908
Description: semi-logarithmic linear regression
Authors: Dodion, P.; Bron, D.; Mattelaer, M.A.; Loos, M.; Delforge, A.; Rozencweig, M.; Stryckmans, P.; Kenis, Y.

Title: Clinical and Pharmacokinetic Phase I Trial with the Diethyl-Amino Ester of Flavone Acetic Acid (LM985, NSC293015)
Source: Eur. J. Cancer 23 (1987) 837-842
Description: single exponential fit by weighted least squares.
Authors: Dodion, Pierre F.; Abrams, Jeffrey; Gerard, Beatrice; Crespeigne, Nadine; Peeters, Bernadette; Van Berchem, Christine; Kenis, Yvon

Title: Phase I Study and Pharmacokinetics of Menogaril (NSC 269148) in Patients with Hepatic Dysfunction
Source: Cancer Res. 47 (1987) 6104-6110
Description: plasma conc. of menogaril, Hill equation, Nelder-Mead.
Authors: Egorin, Merrill J.; Conley, Barbara A.; Forest, Alan; Zuhowski, Eleanor G.; Sinibaldi, Vickie; Van Echo, David A.

Title: Phase I Clinical and Pharmacokinetic Study of Hexamethylene Bisacetamide (NSC 95580) Administered as Five-Day Continuous Infusion
Source: Cancer Res. 47 (1987) 617-623
Description: plasma conc. of HMBA decline modeled with MLAB, Nelder-Mead with ADAPT.
Authors: Egorin, Merrill J.; Sigman, Lawrence M.; Van Echo, David A.; Forest, Alan; Whitacre, Margaret Y.; Aisner, Joseph

Title: The Role of Feed Metal Concentration in the Coupled Transport of Zinc through a Bis-(2-Ethylhexyl) Phosphoric Acid Solid Supported Liquid Membrane from Aqueous Perchlorate Media
Source: Sep. Science and Tech. 22 (1987) 1577-1595
Description: fit model flux equations to whole set of experimental data
Authors: Fernandez, L.; Aparacio, J.; Muhammed, M.

Title: Cerebrospinal Fluid and Plasma Pharmacokinetics of Morphine Infusions in Pediatric Cancer Patients and Rhesus Monkeys
Source: Pain 30 (1987) 339-348
Description: triexponential equation, area under curve
Authors: Greene, Raymond F.; Miser, Angela W.; Lester, Cindy M.; Balis, Frank M.; Poplack, David G.

Title: Facilitated Transport of Melphelan at the Rat Blood-Brain Barrier by the Large Neutral Amino Acid Carrier System
Source: Cancer Res. 47 (1987) 1571-1576
Description: melphelan concentration-time data fit to biexponential, determined plasma half-life, Michaelis Menten kinetics, DEC10 MLAB.
Authors: Greig, Nigel H.; Momma, Seiji; Sweeney, Daniel J.; Smith, Quentin R.; Rapoport, Stanley I.

Title: Melphelan Concentration Dependent Plasma Protein Binding in Healthy Humans and Rats
Source: Eur. J. Clin. Pharm. 32 (1987) 179-185
Description: Scatchard plots
Authors: Greig, N.H.; Sweeney, D.J.; Rapoport, S.I.

Title: Defects in Insulin Binding and Autophophorylation of Erythrocyte Insulin Receptors in Patients with Syndromes of Severe Insulin Resistance and Their Parents
Source: J. Clin. End. 64 (1987) 549-556
Description: logistic equation for total insulin conc. versus 125-I insulin bound/free.
Authors: Grigorescu, F.; Herzberg, U.; King, G.; Meistas, M.; Elders, J.; Frazer, T.; Kahn, C.R.

Title: Photoinactivation of the Mu Opioid Receptor Using a Novel Synthetic Morphiceptin Analog
Source: Eur. J. Pharm. 139 (1987) 273-279
Description: [3-H] Naloxone binding data fit to simple equation for single binding site.
Authors: Herblin, W.F.; Kauer, J.C.; Tam, S.W.

Title: Intercorrelations of Regional Cerebral Glucose Metabolic Rates in Alzheimer's Disease
Source: Brian Res. 407 (1987) 294-306
Description: correlation matrix plots.
Authors: Horwitz, B.; Grady, C.L.; Schlageter, N.L.; Duara, R.; Rapoport, S.I.

Title: Calmodulin Binding By Calcineurin
Source: J. Biol. Chem. 262 (1987) 15062-15070
Description: curve fitting and graphics with DEC10 MLAB, equilibrium binding data fit to Hill equation.
Authors: Hubbard, Michael J.; Klee, Claude B.

Title: Intramolecular Flip Between Two Alternative Forms of Complex Formed from a Heme Fragment and Apoprotein of Horse Cytochrome c
Source: J. Biol. Chem. 262 (1987) 13440-13448
Description: fit parameters in integrated form of van't Hoff equation.
Authors: Juillerat, Marcel A.; Taniuchi, Hiroshi

Title: Human Epidermal Keratinocytes Retain Radiation Resistance Following in Vitro Immortalization and Malignant Transformation
Source: Radiation Res. 111 (1987) 565-571
Description: survival curve s = (1-(1-exp(-d/d0))^n).
Authors: Kasid, Usha N.; Dritschilo, Anatoly; Rhim, Johng S.

Title: The Disposition and Metabolism of 2',3'-Dideoxycytidine, an in Vitro Inhibitor of Human T-Lymphotrophic Virus Type III Infectivity, in Mice and Monkeys
Source: Drug Metab. 15 (1987) 595
Description: biexponential model for plasma concentration.
Authors: Kelley, James A.; Litterst, Charles L.; Roth, Jeri S.; Vistica, David T.; Poplack, David G.; Cooney, David A.; Nadkarni, Mohan; Balis, Frank M.; Broder, Samuel; Johns, David G.

Title: Effects of Heparin on Insulin Binding and Biological Activity
Source: Diabetes 36 (1987) 163-168
Description: Scatchard plots
Authors: Kriauciunas, Kristina M.; Grigorescu, Florin; Kahn, C. Ronald

Title: Fetal Toxicity of Cadmium Chloride: The Pharmacokinetics in the Pregnant Wistar Rat
Source: Teratology 36 (1987) 163-170
Description: biexponential model of blood concentration data
Authors: Levin, Arthur A.; Kilpper, Robert W.; Miller, Richard K.

Title: A QSAR Study of the Acute Toxicity of Some Industrial Organic Chemicals to Goldfish. Narcosis, Electrophile, and Proelectrophile Mechanisms
Source: Xenobiotica 17 (1987) 1011-1025
Description: quantitative structure-activity relationships, log P parameter
Authors: Lipnick, R.L.; Watson, K.R.; Strausz, A.K.

Title: An Open-Loop Computer-Based Drug Infusion System
Source: IEEE Biomed. 34 (1987) 642-649
Description: biexponential model of plasma concentration.
Authors: Martin, Roy W.; Hill, Harlan F.; Yee, Hsiao Ching; Saeger, Louis C.; Walter, M. Hildegard; Chapman, C. Richard

Title: Competition Between Two Enzymes for Substrate Removal in Liver: Modulating Effects Due to Substrate Recruitment of Hepatocyte Activity
Source: J. Pharm. Bioph. 15 (1987) 473
Description: fit Km and Vmax in Michaelis Menten equation for 3 models.
Authors: Morris, Marilyn E.; Pang, K. Sandy

Title: D-Myo-Inositol (1,4)-Bisphosphate 1-Phosphatase. Partial Purification from Rat Liver and Characterization
Source: Biochem. Biophys. Res. 146 (1987) 1018-1026
Description: linear regression
Authors: Moyer, James D.; Peizes, Ofer; Dean, Nicholas M.; Malinowski, Nancy

Title: Effects of Insulin on Hexose Transport Across Blood-Brain Barrier in Normoglycemia
Source: Am. J. Physiol. 252 (1987) E299
Description: ci(t) = k1*exp(-k2*t)*integral(x,0,t,cp(t)*exp(k2*t)).
Authors: Namba, Hiroki; Lucignanni, Giovanni; Nehlig, Astrid; Patlak, Clifford; Pettigrew, Karen; Kennedy, Charles; Sokoloff, Louis

Title: Peripheral Nerve as an Osmometer: Role of Endoneurial Capillaries in Frog Sciatic Nerve
Source: Am. J. Physiol. 252 (1987) C335-C341
Description: fit initial rate of change of nerve diameter as quadratic function of time.
Authors: Odman, Suarte; Levitan, Herbert; Robinson, Peter J.; Michel, Mary Ellen; Ask, Per; Rapoport, Stanley I.

Title: Generalizing Growth Functions Assuming Parameter Heterogeneity
Source: Growth 51 (1987) 50-63
Description: fitting data
Authors: Piantadosi, Steven

Title: A Method for Predicting Accrual, Cost, and Paper Flow in Clinical Trials
Source: Contr. Clin. Tr. 8 (1987) 202-215
Description: the numerical tasks involved in this procedure are greatly simplified by using MLAB.
Authors: Piantadosi, Steven; Patterson, Blossom

Title: Preclinical Antitumor Activity and Pharmacological Properties of Deoxyspergualin
Source: Cancer Res. 47 (1987) 685-689
Description: plasma data fitted to bi-exponential model.
Authors: Plowman, Jacqueline; Harrison, Steadman D., Jr.; Trader, Mary W.; Griswold, Daniel P., Jr.; Chadwick, Marjory; McComish, Madeline F.; Silveira, Denise M.; Zaharko, Daniel

Title: Transfer of Nonelectrolytes from Blood into Peripheral Nerve Endoneurium
Source: Am. J. Physiol. 252 (1987) H1175-H1182
Description: plasma concentration-time integral calculated with DEC10 MLAB from arterial plasma samples.
Authors: Rechthand, Emanuel; Smith, Quentin R.; Rapoport, Stanley I.

Title: Altered Blood-Nerve Barrier Permeability to Small Molecules in Experimental Diabetes Mellitus
Source: J. Neuropath. and Exp. Neurol. 46 (1987) 302-314
Description: integrated plasma concentrations from t=0 to T calculated for each animal from arterial plasma samples on DEC10 employing MLAB.
Authors: Rechthand, Emanuel; Smith, Quentin R.; Latker, Carole H.; Rapoport, Stanley I.

Title: A Postmortem Study of the Effect of Chronic Opiate Abuse on Psychotomimetic Binding Sites of Human Frontal Cortex
Source: Neuropeptides 10 (1987) 261-264
Description: Binding parameters Kd and Bmax were determined by fitting each surface to a one site binding model.
Authors: Rothman, Richard B.; Bykov, Victor; Cadet, Jean L.; Kleinman, Joel E.

Title: Autoradiographic Evidence for Two Classes of Mu Opioid Binding Sites in Rat Brain Using [125-I] FK33824
Source: Peptides 8 (1987) 1015-1021
Description: data were fit to two-site binding model.
Authors: Rothman, Richard B.; Jacobson, Arthur E.; Rice, Kenner C.; Herkenham, Miles

Title: In Vitro Chemosensitivity Testing of Flavone Acetic Acid (LM975; NSC347512) and Its Diethylaminethyl Ester Derivative (LM985; NSC293015)
Source: Eur. J. Canc. C. 23 (1987) 1135
Description: semilogarithmic linear regression.
Authors: Schroyens, Wilfried A.; Dodion, Pierre F.; Sanders, Charlotte; Loos, Micheline; Dethier, Nathalie E.; Delforge, Alain R.; Stryckmans, Pierre A.; Kenis, Yvon

Title: Pulmonary Vascular Responses Induced by the Pyrrolizidine Alkaloid, Monocrotaline in Rats
Source: Toxicon 25 (1987) 995-1002
Description: nonlinear regression of dose-response curve
Authors: Shubat, P.J.; Banner, W., Jr.; Huxtable, R.J.

Title: Kinetics of Neutral Amino Acid Transport Across the Blood-Brain Barrier
Source: J. Neurochem. 49 (1987) 1651-1658
Description: Vmax, Km, Kd were obtained by fitting Michaelis Menten to perfusion data
Authors: Smith, Quentin R.; Momma, Seiji; Aoyagi, Masaki; Rapoport, Stanley I.

Title: Correlations Between Cyclic AMP Binding and Chemoreception in Paramecium
Source: Bioch. Biophys. A. 928 (1987) 171-178
Description: CPM versium -log(cAMP molarity) binding curve
Authors: Smith, Robert; Preston, Robin R.; Schulz, Stephanie; Gagnon, Michael L.; Van Houlten, Judith

Title: Sexual Differences in the Excretion of Organic and Inorganic Mercury by Methyl Mercury-Treated Rats
Source: Env. Res. 43 (1987) 203-216
Description: percent injected dose fit to linear combination of two exponentials.
Authors: Thomas, David J.; Fisher, Henry L.; Sumler, Martha R.; Mushak, Paul; Hall, Larry L.

Title: Characterization of Subcellular Particles by Size, Charge, and Apparent Compressibility on the Basis of Mobility in Agarose Gel Electrophoresis: Procedures of Computer Simulation
Source: Electrophoresis 8 (1987) 271-285
Description: fit nonlinear Ferguson p