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Published Articles Using MLAB
This file contains a list of published articles reporting work involving the use of MLAB. Note, you can search this list by keyword, author, etc., by using your browser's "find function"; generally the "find function" is found in your browser's "Edit" menu. For most articles, a link is provided to an abstract or to the full text on the journal's website.
Authors: Chhabra, K.H.; Adams, J.M.; Fagel, B.; Lam, D.D.; Rubinstein, M.; Low, M.J. Title: Hypothalmic POMC deficiency improves glucose tolerance despite insulin resistance by increasing glycosuria Source: Diabetes 65 (2016) 660-672
Authors: Gurung, R.; Yadav, R.; Brungardt, J.G.; Orlova, A.; Egelman, E.H.; Beck, M.R. Title: Actin polymerization is stimulated by actin cross-linking protein palladin Source: Biochem. J. 473 (2016) 383-396
Authors: Herrero, P.; Delaunay, B.; Jaulin, L.; Georgiou, P.; Oliver, N.; Toumazou, C. Title: Robust set-membership parameter estimation of glucose minimal model Source: Intl. J. of Adaptive Control and Sig. Processing 30 (2016) 173-185
Authors: Hoffman, A.F.; Spivak, C.E.; Lupica, C.R. Title: Enhanced dopamine release by dopamine transport inhibitors described by a restricted diffusion model and fast-scan cyclic voltammetry Source: ACS Chem. Neurosci. 7 (2016)
Authors: Shu, Z.; Hughes, J.M.; Fang, C.; Huang, J.; Fu, B.; Zhao, G.; Fialkow, M.; Lentz, G.; Hladik, F.; Gao, D. Title: A study of the osmotic characteristics, water permeability, and cryoprotectant permeability of human vaginal immune cells Source: Cryobiology 72 (2016) 93-99
Authors: An, D.R.; Kim, H.S.; Kim, J.; Im, H.N.; Yoon, H.J.; Jang, J.Y.; Hesek, D.; Lee, M.; Mobashery, S.; Kim, S-J; Lee, B.I.; Suh, S.W. Title: Structure of Csd3 from Heliobacter pylori, a Cell Shape-Determining Metallopeptidase Source: Biological Crystallography 71 (2015) 675-686
Authors: Fox, E.; Widemann, B.C.; Pastakia, D.; Chen, C.C.; Yang, S.X.; Cole, D.; Balis, F.M. Title: Pharmacokinetic and pharmacodynamic study of tariquidar (XR9576), a P-glycoprotein inhibitor, in combination with doxorubicin, vinorelbine, or docetaxel in children and adolescents with refractory solid tumors Source: Canc. Chemother. Pharmacol. 76 (2015) 1273-1283
Authors: Iyer, M.R.; Rothman, R.B.; Dersch, C.M.; Jacobson, A.E.; Rice, K.C. Title: Probes for Narcotic Receptor Mediated Phenomena. 49. N-Substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro [2,3-c] pyridin-6-ols Source: Eur. J. Med. Chem. 92 (2015) 531-539
Authors: Lamazares, E.; Clemente, I.; Bueno, M.; Velazquez-Campoy, A.; Sancho, J. Title:Rational Stabilization of Complex Proteins: A Divide and Combine Approach Source: Sci. Reports 5 (2015) 9129
Authors: Little, W.; Robblee, J.P.; Dahlberg, C.L.; Kokona, B.; Fairman, R. Title: Effect of helix length on stability of the Lac repressor antiparallel coiled coil Source: Biopolymers: Peptide Science 104 (2015) 395-404
Authors: Nakamura, H.; Yokoyama, H.; Takayanagi, R.; Yoshimoto, K.; Nakahima, A.; Okuyama, K.; Iwase, O; Yamada, Y. Title: Theoretical evaluation of antiemetic effects of 5-HT3 receptor antagonists for prevention of vomiting induced by cisplatin Source: Eur. J. of Drug Metab. and Pharmacokin. 40 (2015) 39-44
Authors: Park, S.H.; Kim, H.S.; Park, M.S.; Moon, S.; Song, M.K.; Park, H.S.; Hahn, H.; Kim, S.J.; Bae, E.; Kim, H-J; Han, B.W. Title: Structure and Stability of the Dimeric Triosephosphate Isomerase from the Thermophilic Archaeon Thermoplasma acidophilum Source: PLoS One 10 (2015) e0145331
Authors: Rothman, R.B.; Ananthan, S.; Partilla, J.S.; Sanai, S.K.; Moukha-Chafiq, O.; Pathak, V.; Baumann, M.H. Title: Studies of the Biogenic Amine Transporters. 15. Identification of Novel Allosteric Dopamine Transporter Ligands with Nanomolar Potency Source: J. Pharm. Exp. Ther. 353 (2015) 529-538
Authors: Baumann, M.H.; Bulling, S.; Benaderet, T.S.; Saha, K.; Ayestas, M.A.; Partilla, J.S.; Ali, S.F.; Stockner, T.; Rothman, R.B.; Sandtner, W.; Sitte, H.S. Title: Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced serotonin transporter substrates Source: Neuropsychopharm. 39 (2014) 1355-1365
Authors: Chiu, S.; Williams, P.T.; Dawson, T.; Bergman, R.N.; Stefanovski, D.; Watkins, S.M.; Krauss, R.M. Title: Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults Source: J. Nutrition 144 (2014) 1753-1759
Authors: Desai, A.V.; Fox, E.; Smith, L.M.; Lim, A.P.; Maris, J.M.; Balis, F.M. Title: Pharmacokinetics of the Chimeric anti-G D2 Antibody, ch14.18, in Children with High-Risk Neuroblastoma Source:Canc. Chem. Pharmacol. 74 (2014) 1047-1055
Authors: Do, H.; Kim, S-J; Kim, H.J.; Lee, J.H. Title: Structure-based characterization and antifreeze properties of a hyperactive ice-binding protein from the Antarctic bacterium Flavobacterium frigoris PS1 Source: Acta Crystal. D 70 (2014) 1061-1073
Authors: Martinez-Olivan, J.; Arias-Moreno, X.; Velazquez-Campoy, A.; Millet, O.; Sancho, J. Title: LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat Source: FEBS J. 281 (2014) 1534-1546
Authors: Nelson, F.E.; Hollingsworth, S.; Rome, L.C.; Baylor, S.M. Title: Intracellular calcium movements during relaxation and recovery of superfast muscle fibers of the toadfish swimbladder Source: J. Gen. Physiol. 143 (2014) 605-620
Authors: Tokuoka, K.; Takayanagi, R.; Suzuki, Y.; Watanabe, M.; Kitagawa, Y.; Yamada, Y. Title: Theory-based analysis of clinical efficacy of triptans using receptor occupancy Source: J. of Headache and Pain 15 (2014) 85
Authors: Cozzi, N.V.; Brandt, S.D.; Daley, P.F.; Partilla, J.S.; Rothman, R.B.; Tulzer, A.; Sitte, H.H.; Baumann, M.H. Title: Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs Source: Eur. J. Pharm. 699 (2013) 180-187
Authors: Hollingsworth, S.; Baylor, S.M. Title: Comparison of myoplasmic calcium movements during excitation-contraction coupling in frog twitch and mouse fast-twitch muscle fibers Source: J. Gen. Physiol. 141 (2013) 567-583
Authors: Hosono, M.; Yokoyama, H.; Takayanagi, R.; Yamada, Y. Title: Interactions between new quinolone antibacterials and diagnostic drug containing manganese Source: Eur. J. Drug 38 (2013) 255-259
Authors: Nagai, M.; Ohtani, H.; Satoh, H.; Matsuoka, S.; Hori, S.; Fujii, T.; Taketani, Y.; Sawada, Y. Title: Characterization of transplacental transfer of Paroxetine in perfused human placenta: Development of a pharmacokinetic model to evaluate tapered dosing Source: Drug Metab. Dispos. 41 (2013) 2124-2132
Authors: Sancho, J. Title: The stability of 2-state, 3-state and more-state proteins from simple spectroscopic techniques...plus the structure of the equilibrium intermediates at the same time Source: Arch. Biochem. Biophys. 531 (2013) 4-13
Authors: Schroeter, M.M.; Orlova, A.; Egelman, E.H.; Beall, B.; Chalovich, J.M. Title: Organization of F-Actin by Fesselin (avian smooth muscle synaptopodin 2) Source: Biochem. 52 (2013) 4955-4961
Authors: Wong, J.; Agus, M.S.D.; Steil, G.M. Title: Cardiac parameters in children recovered from acute illness as measured by electrical cardiometry and comparisons to the literature Source: J. Clin. Mon. Comput. 27 (2013) 81-91
Authors: Yokoyama, H.; Ito, N.; Soeda, S.; Ozaki, M.; Suzuki, Y.; Watanabe, M.; Kashiwakura, E.; Kawada, T.; Ikeda, N.; Takuoka, K.; Kitigawa, Y.; Yamada, Y. Title: Prediction of antiplatelet effects of aspirin in vivo based on in vitro results Source: Clinical and Applied Thromb./Hem. 19 (2013) 600-607
Authors: Yoon, J.Y.; Kim, J.; An, D.R.; Lee, S.J.; Kim, H.S.; Im, H.N.; Yoon, H.J.; Kim, J.Y.; Kim, S.J.; Han, B.W.; Suh, S.W. Title: Structural and fractional characterization of HP0377, a thioredoxin-fold protein from Heliobacter pylori Source: Acta Crystal. D 69 (2013) 735-746
Authors: Ananthan, S.; Saini, S.K.; Dersch, C.M.; Xu, H.; McGlinchey, N.; Giuvelis, D.; Bilsky, E.J. Title: 14-Alkoxy- and 14-Acyloxypyridomorphinans: mu Agonist/delta Antagonist Opioid Analgesics with Diminished Tolerance and Dependence Side Effects Source: J. Med. Chem. 55 (2012) 8350-8363 Description: fit of 2 parameter logistic function
Authors: Bae, S.K.; Cha, H.N.; Ju, T.J.; Kim, Y.W.; Kim, H.S.; Kim, Y.D.; Dan, J.M.; Kim, J.Y.; Kim, S.; Park, S.Y. Title: Deficiency of inducible nitric oxide synthase attenuates immobilization-induced skeletal muscle atrophy in mice Source: J. Appl. Physiol. 113 (2012) 114-123
Authors: Bajzer, Z.; Strehler, E.E. Title: About and beyond the Henri-Michaelis-Menten rate equation for single-substrate enzyme kinetics Source: Biochem. Biophys. Res. Comm. 417 (2012) 982-985
Authors: Cambell, J.L.; Clewell, R.A.; Gentry, P.R.; Andersen, M.E.; Clewell, H.J. Title: Physiologically Based Pharmacokinetic/Toxicokinetic Modeling Source: Computational Toxicology, Methods Molec. Biol. 929 (2012) 439-499
Authors: Castellano, J.M.; Deane, R.; Gottesdiener, A.J.; Verghese, P.B.; Stewart, F.R.; West, T.; Paoletti, A.C.; Kasper, T.R.; DeMattos, R.B.; Zlokovic, B.V.; Holtzman, D.M. Title: Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A {beta} clearance in a mouse model of {beta}-amyloidosis Source: PNAS 109 (2012) 15502-15507 Description: compartmental model
Authors: Davis, E.M.; Viswanath, S.K. Title: Heat Transfer Based Scale-Down of Chemical Reactions Source: Org. Process Res. Dev. 16 (2012) 1360-1370
Authors: Iyer, M.R.; Lee, Y.S.; Deschamps, J.R.; Dersch, C.M.; Rothman, R.B.; Jacobson, A.E.; Rice, K.C. Title: Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl) morphan with high affinity and selective mu-antagonist activity Source: Eur. J. Med. Chem. 50 (2012) 44-54
Authors: Kanderian, S.S.; Weinzmer, S.A.; Steil, G.M. Title: The Identifiable Virtual Patient Model: Comparison of Simulation and Clinical Closed-Loop Study Results Source: J. Diabetes Sci. Tech. 6 (2012) 371-379
Authors: Kimura, K.; Takayanagi, R.; Yokoyama, H.; Yamada, Y. Title: Theory-based analysis of anti-inflammatory effect of infliximab on Crohn's disease and rheumatoid arthrities Source: Rheum. Intl. 32 (2012) 145-150
Authors: Rothman, R.B.; Partilla, J.S.; Baumann, M.H.; Lightfoot-Siordia, C.; Blough, B.E. Title: Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy "Partial" Substrates for the Biogenic Amine Transporters Source: J. Pharm. Exp. 341 (2012) 251-262
Authors: Severinsen, K.; Kraft, J.F.; Koldso, H.; Vinberg, K.A.; Rothman, R.B.; Partilla, J.S.; Wiborg, O.; Blough, B.; Schiott, B.; Sinning, S. Title: Binding of the Amphetamine-like 1-Phenyl-piperazine to Monoamine Transporters Source: ACS Chem. Neurosci. 3 (2012) 693-705
Authors: Spivak, C.E.; Kim, W.; Liu, Q.R.; Lupica, C.R.; Doyle, M.E. Title: Blockade of beta-cell K ATP channels by the endocannabinoid, 2-arachidonoylglycerol Source: Biochem. Biophys. Res. Comm. 423 (2012) 13-18
Authors: Stefanovski, D.; Youn, J.H.; Rees, M.; Watanabe, R.M.; Ader, M.; Ionut, V.; Jackson, A.U.; Boehnke, M.; Collins, F.S.; Bergman, R.N. Title: Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics Source: Diabetes Care 35 (2012) 1015-1020
Authors: Yubero-Lahoz, S.; Ayestas, M.A.; Blough, B.E.; Partilla, J.S.; Rothman, R.B.; de la Torre, R.; Baumann, M.H. Title: Effects of MDMA and related analogs on plasma 5-HT: Relevance to 5-HT transporters in blood and brain Source: Eur. J. Pharm. 674 (2012) 337-344
Authors: Akiyoshi, T.; Saito, T.; Murase, S.; Miyazaki, M.; Murayama, N.; Yamazaki, H.; Guengerich, F.P.; Nakamuira, K.; Yamamoto, K.; Ohtani, H. Title: Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants Source: Drug Metab. 39 (2011) 724-728
Authors: Baumann, M.H.; Ayestas, M.A.; Partilla, J.S.; Sink, J.R.; Shulgin, A.T.; Daley, P.F.; Brandt, S.D.; Rothman, R.B.; Ruoho, A.E.; Cozzi, N.V. Title: The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue Source: Neuropsychopharm. 37 (2011) 1192-1203
Authors: Cellmer, T.; Buscaglia, M.; Henry, E.R.; Hofrichter, J.; Eaton, W.A. Title: Making connections between ultrafast protein folding kinetics and molecular dynamics simulations Source: PNAS 108 (2011) 6103-6108 Description: weighted polynomial fit of protein folding times
Authors: Cheng, K.; Lee, Y.S.; Rothman, R.B.; Dersch, C.M.; Bittman, R.W.; Jacobson, A.E.; Rice, K.C. Title: Probes for Narcotic Receptor Mediated Phenomena 41. Unusual Inverse mu-Agonists and Potent mu-Opioid Antagonists by Modification of the N-Substituent in Enantiomeric 5-(3-Hydroxyphenyl) Morphans Source: J. Med. Chem. 54 (2011) 957-969 Description: estimate EC-50 and Emax
Authors: Loutseiko, M.; Voskanyan, G.; Keenan, B.; Steil, G.M. Title: Closed-Loop Insulin Delivery Utilizing Pole Placement to Compensate for Delays in Subcutaneous Insulin Delivery Source: J. Diabetes Sci. Tech. 5 (2011) 1342-1351
Authors: Kim, J.H.; Deschamps, J.R.; Rothman, R.B.; Dersch, C.M.; Folk, J.E.; Cheng, K.; Jacobson, A.E.; Rice, K.C. Title: Probes for narcotic receptor mediated phenomena. 42: Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans Source: Bioorg. Med. Chem. 19 (2011) 3434-3443
Authors: Mbah, A.U.; Ejim, E.C.; Onodugo, O.D.; Ezugwu, F.O.; Eze, M.I.; Nkwo, P.O.; Ugbajah, W.C. Title: Two logistic models for the prediction of hypothyroidism in pregnancy Source: BMC Research Notes 4 (2011) 205
Authors: Ricci, M.; Martini, S.; Bonechi, C.; Braconi, D.; Santucci, A.; Rossi, C. Title: In vivo NMR study of yeast fermentative metabolism in the presence of ferric ions Source: J. Biosci. 36 (2011) 97-103
Authors: Rothman, R.B.; Cadet, J.L.; Dersch, C.M.; McCoy, M.T.; Lehrmann, E.; Becker, K.G.; Bader, M.; Alenina, N.; Baumann, M.H. Title: Altered Gene Expression in Pulmonary Tissue of Tryptophan Hydroxylase-1 Knockout Mice: Implications for Pulmonary Arterial Hypertension Source: PLoS One (2011) 10.1371/journal.pone.0017735
Authors: Bilsky, E.J.; Giuvelis, D.; Osborn, M.D.; Dersch, C.M.; Xu, H.; Rothman, R.B. Title: In Vitro and In Vivo Assessment of mu Opioid Receptor Constitute Activity Source: Methods Enzym. 484 (2010) 413-443
Authors: Borrego-Diaz, E.; Chalovich, J.M. Title: Kinetics of regulated actin transitions measured by probes on tropomyosin Source: Biophys. J. 98 (2010) 2601-2609
Authors: Chun, P.W.; Lewis, M.S. Title: Planck-Benzinger Thermal Work Function: Thermodynamic Characterization of the Carboxy-Terminus of p53 Peptide Fragments Source: Protein J. 29 (2010) 617-630
Authors: Djuric, I.; Mihajlovic, I.; Bogdanovic, D.; Zivkovic, Z. Title: Modeling the process of kaolinite leaching from a copper mine flotation waste Source: Clay Minerals 45 (2010) 107-114
Authors: Meany, H.; Balis, F.M.; Aikin, A.; Whitcomb, P.; Murphy, R.H.; Steinberg, S.M.; Widemann, B.C.; Fox, E. Title: Pediatric phase I trial design using maximum target inhibition as the primary endpoint Source: JNCI 102 (2010) 909-912
Authors: Meany, H.J.; Sackett, D.L.; Maris, J.M.; Ward, Y.; Krivoshik, A.; Cohn, S.L.; Steinberg, S.M.; Balis, F.M.; Fox, E. Title: Clinical Outcome in Children with Recurrent Neuroblastoma Treated with ABT-751 and Effect of ABT-751 on Proliferation of Neuroblastoma Cell Lines and on Tubulin Polymerization In Vitro Source: Pediatr. Blood Canc. 54 (2010) 47-54
Authors: Rebrin, K.; Sheppard, N.F.; Steil, G.M. Title: Use of subcutaneous interstitial fluid glucose to estimate blood glucose: revisiting delay and sensor offset Source: J. Diabetes Sci. Tech. 4 (2010) 1087-1098
Authors: Rothman, R.B.; Baumann, M.H.; Blough, B.E.; Jacobson, A.E.; Rice, K.C.; Partilla, J.S. Title: Evidence for noncompetitive modulation of substrate-induced serotonin release Source: Synapse 64 (2010) 862-869
Authors: Sally, E.J.; Xu, H.; Dersch, C.M.; Hsin, L.W.; Chang, L.T.; Prisinzano, T.E.; Simpson, D.S.; Giuvelis, D.; Rice, K.C.; Jacobson, A.E.; Cheng, K.; Bilsky, E.J.; Rothman, R.B. Title: Identification of a novel "almost neutral" mu-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor Source: Synapse 64 (2010) 280-288
Authors: Wang, B.; Pikal, M.J. Title: The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: I. dimer formation in sodium ethacrynate Source: J. Pharm. Sci. 99 (2010) 663-682
Authors: Bhattacharya, R.; Kwon, J.; Li, X.; Wang, E.; Patra, S.; Bida, J.P.; Bajzer, Z.; Claesson-Welsh, L; Mukhopadhyay, D. Title: Distinct role of PLC beta 3 in VEGF-mediated directional migration and vascular sprouting Source: J. Cell Sci. 122 (2009) 1025-1034
Authors: Carley, A.N.; Kleinfeld, A.M. Title: Flip-Flop Is the Rate-Limiting Step for Transport of Free Fatty Acids across Lipid Vesicle Membranes Source: Biochem. 48 (2009) 10437-10445
Authors: Desmarchelier, A.; Cuadra, M.G.; Delatour, T.; Mottier, P. Title: Simultaneous quantitative determination of melamine and cyanuric acid in cow's milk and milk-based infant formula by liquid chromotography-electrospray ionization tandem mass spectrometry Source: J. Agric. Food Chem. 57 (2009) 7186-7193
Authors: Gastaldelli, A.; Martini, S.; Donati, A.; Marchettini, N.; Rossi, C.; Bastianoni, S. Title: A new approach to study in vivo cellular metabolism using modellistic analysis of magnetic resonance spectra Source: Math. Biosci. 222 (2009) 36-41
Authors: Liu, J.; Mullen, S.; Meng, Q.; Critser, J.; Dinnyes, A. Title: Determination of oocyte membrane permeability coefficients in a rabbit model Source: Cryobiol. 59 (2009) 127-134
Authors: Pikal, M.J.; Rigsbee, D.; Akers, M.J. Title: Solid state chemistry of proteins. IV. What is the meaning of thermal denaturation in freeze dried proteins? Source: J. Pharm. Sci. 98 (2009) 1387-1399
Authors: Rothman, R.B.; Dersch, C.M.; Ananthan, S.; Partilla, J.S. Title: Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine- induced dopamine release Source: J. Pharm. Exp. 329 (2009) 718-728
Authors: Shintaku, K.; Hori, S.; Tsujimoto, M.; Nagata, H.; Satoh, S.; Tsukimori, K.; Nakano, H.; Fujii, T.; Taketani, Y.; Ohtani, H.; Sawada, Y. Title: Transplacental pharmacokinetics of diclofenac in perfused human placenta Source: Drug Metab. 37 (2009) 962-968
Authors: Sung, H.K.; Kim, Y-W; Choi, S.J.; Kim, J-Y; Jeune, K.H.; Won, K-C; Kim, J.K.; Koh, G.Y.; Park, S-Y Title: COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice Source: Am. J. Physiol. Endo. Metab. 297 (2009) E402-E409
Authors: Tietz, D. Title: An innovative method for quality control of conjugated Haemophilus influenzae vaccines: A short review of two-dimensional nanoparticle electrophoresis Source: J. Chrom. A 1216 (2009) 9028-9033
Authors: Wang, B.; Tchessalov, S.; Cicerone, M.T.; Warne, N.W.; Pikal, M.J. Title: Impact of sucrose level on storage stability of proteins in frieze-dried solids: II. Correlation of aggregation rate with protein structure and molecular mobility Source: J. Pharm. Sci. 98 (2009) 3145-3166
Authors: Deane, R.; Sagare, A.; Hamm, K.; Parisi, M.; Lane, S.; Finn, M.B.; Holtzman, D.M.; Zlokovic, B.V. Title: apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain Source: J. Clin. Inv. 118 (2008) 4002-4013
Authors: Fontana, G.; Savona, G.; Rodriguez, B.; Dersch, C.M.; Rothman, R.B. Title: Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of Opioid Receptor affinity Source: Tetrahedron 64 (2008) 10041-10048
Authors: Froehlich, JP; Mahaney, JE; Keceli, G; Pavlos, CM; Goldstein, R; Redwood, AJ; Sumbilla, C; Lee, DI; Tocchetti, CG; Kass, DA; Paolocci, N; Toscano, JP. Title: Phospholamban Thiols Play a Central Role in Activation of the Cardiac Muscle Sarcoplasmic Reticulum Calcium Pump by Nitroxyl Source: Biochem. 47 (2008) 13150-13152
Authors: Gao, Y.; Kuwabara, H.; Spivak, C.E.; Xiao, Y.; Kellar, K.; Ravert, H.; Kumar, A.; Alexander, M.; Hilton, J.; Wong, D.F.; Dannals, R.F.; Horti, A.G. Title: Discovery of (-)-7-Methyl-z-exo-[3'-(6-[18-F] fluoropyridin-2-yl)-5'-pyridinyl]-7 azabicyclo [2.2.1]heptene, a Radiolabelled Antagonist for Cerebral Nicotinic Acetylcholine Receptor (alpha-4 beta-2-nAchR) with Optimal Positron Emission Topography Imaging Properties Source: J. Med. Chem. 51 (2008) 4751-4764
Authors: Guan, H.; Kiss-Toth, E.; Dower, S.K. Title: Analysis of innate immune signal transduction with autocatalytic expression vectors Source: J. Immunol. Meth. 330 (2008) 96-108
Authors: Hunnicutt, G.R.; Koppel, D.E.; Kwitny, S.; Cowan, A.E. Title: Cyclic 3',5'-AMP causes ADAM1/ADAM2 to rapidly diffuse within the plasma membrane of guinea pig sperm Source: Biol. Reprod. 79 (2008) 999-1007
Authors: Jiang, B.; Xiao, N.; Liu, H.; Zhou, Z.; Mao, X.; Liu, M. Title: Optimized Quatitative DEPT and Quantitative POMMIE Experiments for 13-C NMR Source: Anal. Chem. 80 (2008) 8293-8298 Description: NMR spin coupling coefficients
Authors: Lee, J.H.; Kang, G.B.; Lim, H.H.; Jin, K.S.; Kim, S.H.; Ree, M.; Park, C.S.; Kim, S.J.; Eom, S.H. Title: Crystal Structure of the GluR0 Ligand-Binding Core from Nostoc punctiforme in Complex with L-Glutamate: Structural Dissection of the Ligand Interaction and Subunit Interface Source: J. Molec. Biol. 376 (2008) 308-316
Authors: Mahaney, J.E.; Thomas, D.T.; Farrance, I.K.; Froehlich, J.P. Title: Intermolecular Interactons in the Mechanism of Skeletal Muscle Sarcoplasmic Reticulum Ca 2+ ATPase (SERCA1): Evidence for a Tripromoter Source: Biochem. 47 (2008) 13711-13712
Authors: McDonald, C.B.; Seldeen, K.L.; Deegan, B.J.; Lewis, M.S.; Farooq, A. Title: Grb2 adaptor undergoes conformational change upon dimerization Source: Arch. Biochem. Biophys. 475 (2008) 25-35
Authors: Meany, H.J.; Fox, E.; McCully, C.; Tucker, C.; Balis, F.M. Title: The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates Source: Canc. Chem. Pharm. 62 (2008) 387-392
Authors: Pariser, J.J.; Partilla, J.S.; Dersch, C.M.; Ananthan, S.; Rothman, R.B. Title: Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release Source: J. Pharm. Exp. 326 (2008) 286-295
Authors: Rutherford, J.M.; Wang, J.; Xu, H.; Dersch, C.M.; Partilla, J.S.; Rice, K.C.; Rothman, R.B. Title: Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors Source: Peptides 29 (2008) 1424-1431
Authors: Xu, H.; Wang, X.; Partilla, J.S.; Bishop-Mathis, K.; Benaderet, T.S.; Dersch, C.M.; Simpson, D.S.; Prisinzano, T.E.; Rothman, R.B. Title: Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors Source: Brain Res. Bull. 77 (2008) 49-54
Authors: Atsumi, T.; Cho, Y-R; Leng, L.; McDonald, C.; Yu, T.; Danton, C.; Hong, E-G; Mitchell, R.A.; Metz, C.; Niwa, H.; Takeuchi, J.; Onodera, S.; Umino, T.; Yoshioka, N.; Koike, T.; Kim, J.K.; Bucala, R. Title: The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation Source: J. Immunol. 179 (2007) 5399-5406
Authors: Baylor, S.M.; Hollingworth, S. Title: Simulation of Ca2+ movements within the sarcomere of fast-twitch mouse fibers stimulated by action potentials Source: J. Gen. Physiol. 130 (2007) 283-302
Authors: Caride, A.J.; Filoteo, A.G.; Penniston, J.T.; Strehler, E.E. Title: The Plasma Membrane Ca2+ Pump Isoform 4a Differs from Isoform 4b in the Mechanism of Calmodulin Binding and Activation Kinetics: IMPLICATIONS FOR Ca2+ SIGNALING Source: J. Biol. Chem. 282 (2007) 25640-25648 Description: Compartmental model
Authors: Chalovich, J.M. Title: Equilibrium Binding of Proteins to F-Actin Source: Methods Molec. Biol. 392 (2007) 1-22
Authors: Chen, H.; Purtteman, J.J.P.; Heimfeld, S.; Folch, A.; Gao, D. Title: Development of a microfluidic device for determination of cell osmotic behavior and membrane transport properties Source: Cryobiol. 55 (2007) 200-209
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Authors: Tietz, D.; Title: Computer-assisted 2-D agarose electrophoresis of Haemophilus influenzae type B meningitis vaccines and analysis of polydisperse particle populations in the size range of viruses: A review Source: Electrophoresis 28 (2007) 512-524
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Authors: Piantadosi, S. Title: Clinical Trials: A Methodological Perspective, 2nd ed. Source: Wiley Series in Probability and Statistics (2005)
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Authors: Wee, S.; Anderson, K.G.; Baumann, M.H.; Rothman, R.B.; Blough, B.E.; Woolverton, W.L. Title: Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs Source: J. Pharm. Exp. 313 (2005) 848-854
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Authors: Adamson, P.C.; Blaney, S.M.; Widemann, B.C.; Kitchen, B.; Murphy, R.F.; Hannah, A.L.; Cropp, G.E.; Patel, M.; Gillespie, A.F.; Whitcomb, P.G.; Balis, F.M. Title: Pediatric phase I trial and pharmacokinetic study of the platelet-derived growth factor (PDGF) receptor pathway inhibitor SU101 Source: Canc. Chem. Pharm. 53 (2004) 482-488
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Authors: Baumann, M.H.; Clark, R.D.; Budzynski, A.G.; Partilla, J.S.; Blough, B.E.; Rothman, R.B. Title: N-Substituted Piperazines Abused by Humans Mimic the Molecular Mechanism of 3,4-Methylenedioxymethamphetamine (MDMA, or "Ectasy") Source: Neuropsychopharm. 30 (2004) 550-560
Authors: Campos, L.A.; Bueno, M.; Lopez-Llano, J.; Jimenez, M.A.; Sancho, J. Title: Structure of Stable Protein Folding Intermediates by Equilibrium Phi-Analysis: The Apoflavodoxin Thermal Intermediate Source: J. Molec. Biol. 344 (2004) 239-255
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Authors: Chaveiro, A.; Liu, J.; Mullen, J.; Woelders, H.; Critser, J. Title: Determination of Bull Sperm Membrane Permeability to Water and Cryoprotectants using a Concentration-dependent Self-Quenching Fluorophore Source: Cryobiol. 48 (2004) 72-80 Description: Kedem Kachalsky model
Authors: Cole, J.L. Title: Analysis of heterogeneous interactions Source: Methods Enzym. 384 (2004) 212-232
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Authors: Cupp, D.; Kampf, J.P.; Kleinfeld, A.M. Title: Fatty Acid-Albumin Complexes and the Determination of the Transport of Long Chain Free Fatty Acids across Membranes Source: Biochem. 43 (2004) 4473-4481
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Authors: McPhie, P. Title: CD studies on films of amyloid proteins and polypeptides: Quantitative g-factor analysis indicates a common folding motif Source: Biopolymers 75 (2004) 140-147
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Authors: Perez-Jimenez, R.; Godoy-Ruiz, R.; Ibarra-Molero, B.; Sanchez-Ruiz, J.M. Title: The Efficiency of Different Salts to Screen Charge Interactions in Proteins: A Hofmeister Effect? Source: Biophys. J. 86 (2004) 2414-2429
Authors: Pikal, M.J.; Chang, L.; Tang, X. Title: Evaluation of glassy-state dynamics from the width of the glass transition: Results from theoretical simulation of differential scanning calorimetry and comparisons with experiment Source: J. Pharm. Sci. 93 (2004) 981-994
Authors: Ricci, M.; Martini, S.; Bonechi, C.; Trabalzini, L.; Santucci, A.; Rossi, C. Title: Inhibition Effects of Ethanol on the Kinetics of Glucose Metabolism by S. cerevisiae: NMR and Modelling Study Source: Chem. Phys. Lett. 387 (2004) 377-382 Description: compartmental model, ode reaction kinetics
Authors: Roehl, M.H.A.; Wang, J.Y.; Wagner, G. Title: Discovery of Small-Molecule Inhibitors of the NFAT-Calcineurin Interaction by Competitive High-Throughput Fluorescence Polarization Screening Source: Biochem. 43 (2004) 16067-16075
Authors: Rothman, R.B.; Jayanthi, S.; Cadet, J.L.; Wang, X.; Dersch, C.M.; Baumann, M.H. Title: Substituted Amphetamines that Produce Long-Term Serotonin Depletion in Rat Brain ("Neurotoxicity") Do Not Decrease Serotonin Transporter Protein Expression Source: Ann. NY Acad. 1025 (2004) 151-161
Authors: Rowland, M.; Balant, L.; Peck, C. Title: Physiologically based pharmacokinetics in drug development and regulatory science: A workshop report (Georgetown University, Washington, DC, May 29-30, 2002) Source: AAPS Pharmsci 6 (2004) 56-67
Authors: Spivak, C.E.; Beglan, C.L. Title: Kinetics of beta-funaltrexamine binding to wild-type and mutant mu-opioid receptors expressed in Chinese hamster ovary cells Source: Synapse 52 (2004) 123-135
Authors: Steil, G.M.; Hwu, C.; Janowski, R.; Hariri, F.; Jinagouda, S.; Darwin, C.; Tadros, S.; Rebrin, K.; Saad, M.F. Title: Evaluation of insulin sensitivity and beta-cell function indexes obtained from minimal model analysis of a meal tolerance test Source: Diabetes 53 (2004) 1201-1207
Authors: Sugiura, M.; Ohno, Y.; Yamada, Y.; Suzuki, H.; Iga, T. Title: Pharmacokinetic/Pharmacodynamic Analysis of Neutrophil Proliferation Induced by rh h-CSF in Patients Receiving Antineoplastic Drugs Source: J. Pharm. Soc. Japan 124 (2004) 599-604 Description: compartmental model
Authors: Thompson, P.; Berg, S.; Aleksic, A.; Kerr, J.; McGuffey, L.; Dauser, R.; Nuchtern, J.; Hauser, F.; Blaney, S. Title: Plasma and Cerebrospinal Fluid Pharmacokinetic Study of BNP1350 in non-human primates Source: Canc. Chem. Pharm. 53 (2004) 527-532 Description: bi-exponential model
Authors: Topp, B.G.; McArthur, M.D.; Finegood, D.T. Title: Metabolic adaptations to chronic glucose infusion in rats Source: Diabetologia 47 (2004) 1602-10
Authors: Viappiani, C.; Bettati, S.; Bruno, S.; Ronda, L.; Abbruzzetti, S.; Mozzarelli, A.; Eaton, W.A. Title: New insights into allosteric mechanisms from trapping unstable protein confirmations in silica gels Source: PNAS 101 (2004) 14414-14419 Description: photodissociation differential equations
Authors: Xu, H.; Wang, X.; Wang, J.; Rothman, R.B. Title: Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned mu opioid receptor Source: Synapse 52 (2004) 209-217
Authors: Bergman, R.N. Title: The Minimal Model of Glucose Regulation: A Biography Source: Math Modeling in Nutrition and the Health Sciences, Advances in Experimental Medicine and Biology 537 (2003) 1-19
Authors: Blaney, S.; Heideman, R.; Berg, S.; Adamson, P.; Gillespie, A.; Geyer, J.; Packer, R.; Matthay, K.; Jackle, K.; Cole, D.; Kuttesch, N.; Poplack, D.; Balis, F. Title: Phase I Clinical Trial of Intrathecal Topotecan in Patients with Neoplastic Meningitis. Source: J. Clin. Oncol. 21 (2003) 143-147 Description: compartmental model
Authors: Cowan, A.E.; Koppel, D.E.; Setlow, B.; Setlow, P. Title: A soluble protein is immobile in dormant spores of Bacillus subtilis but is mobile in germinated spores: Implications for cell dormancy Source: PNAS 100 (2003) 4209-4214 Description: analysis of fluorescence redistribution
Authors: Ellmerer, M.; Hamilton-Wessler, M.; Kim, S.P.; Dea, M.K.; Kirkman, E.; Perianayagam, A.; Markussen, J.; Bergman, R.N. Title: Mechanism of action in dogs of slow-acting insulin analog 0346 Source: J. Clin. Endo. Metab. 88 (2003) 2256-2262
Authors: Guzman-Casado, M.; Parody-Morreale, A.; Robic, S.; Musqusee, S.; Sanchez-Ruiz, J.M. Title: Energetic Evidence for Formation of a pH-dependent Hydrophobic Cluster in the Denatured State of Thermus thermophilus Ribonuclease H Source: J. Molec. Biol. 329 (2003) 731-743
Authors: Henderson, T.J.; Venable, R.M.; Egan, W. Title: Conformational Flexibility of the Group B Meningococcal Polysaccharide in Solution Source: JACS 125 (2003) 2930-2939
Authors: Huang, C.Y.; Zhou, R.; Yang, D.C.H.; Boon Chock, P. Title: Application of the Continuous Variation Method to Cooperative Interactions: Mechanism of Fe(II)-ferrozine Chelation and Conditions Leading to Anomolous Binding Ratios Source: Biophys. Chem. 100 (2003) 143-149
Authors: Kim, J.K.; Fillmore, J.J.; Gavrilova, O.; Chao, L.; Higashimori, T.; Choi, H.; Kim, H-J; Yu, C.; Chen, Y.; Qu, X.; Haluzik, M.; Reitman, M.L.; Shulman, G.I. Title: Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice Source: Diabetes 52 (2003) 1311-1318
Authors: Knott, G.; Kerner, D. Title: Solving and Fitting France's Rumen Model with MLAB Source: Mathematical Modeling in Nutrition and the Health Sciences, ed. by J.A. Novotny, M.H. Green, R.C. Boston; NY: Kluwers Academic (2003) Description: multicompartmental ode model
Authors: Kuznetsov, V.A. Title: Family of Skewed Distributions Associated with the Gene Expression and Proteome Evolution Source: Signal Processing 83 (2003) 889-910
Authors: Lipovac, M.N.; Holland, T.; Poleksic, A.; Killian, C.; Lajtha, A. Title: The Possible Role of Glutamate Uptake in Metaphit-Induced Seizures Source: Neurochem. Res. 28 (2003) 723-731 Description: Michaelis-Menten kinetics
Authors: Martin, B.J.; Cheli, C.; Davis, R.; Ward, M.; Kokatnur, M.; Mercante, D.; Lifsey, D.; Rayford, W. Title: cPSA and fPSA elimination in African-American men Source: Prost. Canc. 6 (2003) 163-168
Authors: Patel, M.; McCully, C.; Godwin, K.; Balis, F. Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Temozolamide in Non-Human Primates Source: J. Neuro-oncology 61 (2003) 203-207 Description: two compartment model with first order elimination for plasma-concentration time data.
Authors: Penheiter, A.R.; Bajzer, Z.; Filoteo, A.G.; Thorogate, R.; Torok, K.; Caride, A.J. Title: A Model for the Activation of Plasma Membrane Calcium Pump Isoform 4b by Calmodulin Source: Biochem. 42 (2003) 12115-12124
Authors: Pillonetto, G.; Sparacino, G.; Corbelli, C. Title: Numerical non-identifiability regions of the minimal model of glucose kinetics: superiority of Bayesian estimation Source: Math. Biosci. 184 (2003) 53-67
Authors: Rosenblatt, J. Title: Aspects of Effective Modeling Source: Math Modeling in Nutrition and the Health Sciences, Advances in Experimental Medicine and Biology 537 (2003) 43-61
Authors: Rothman, R.B.; Baumann, M.H. Title: Monoamine transporters and psychostimulant drugs Source: Eur. J. Pharm. 479 (2003) 23-40
Authors: Rothman, R.B.; Clark, R.D.; Partilla, J.S.; Baumann, M.H. Title: (+)-Fenfluramine and its major metabolic, (+)-norfenfluramine, are potent substrates for norepinephrine transporters Source: J. Pharm. Exp. 305 (2003) 1191-1199
Authors: Rothman, R.B.; Jayanthi, S.; Wang, X.; Dersch, C.M.; Cadet, J.L.; Prisinzano, T.; Rice, K.C.; Baumann, M.H. Title: High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain Source: Synapse 50 (2003) 233-239
Authors: Rothman, R.B.; Vu, N.; Partilla, J.S.; Roth, B.L.; Hufeisen, S.J.; Compton-Toth, B.A.; Birkes, J.; Young, R.; Glennon, R.A. Title: In vitro characterization of ephedrine-related stereoisomers at biogenic amine tranporters and the receptorome reveals selective actions as norepinephrine transporter substrates Source: J. Pharm. Exp. 307 (2003) 138-145
Authors: Rothman, R.B.; Vu, N.; Wang, X.; Xu, H. Title: Endogenous CART peptide regulates mu opioid and serotonin 5-HT 2A receptors Source: Peptides 24 (2003) 413-417
Authors: Schooley, K.; Zhu, P.; Dower, S.K.; Qwarnstrom, E.E. Title: Regulation of nuclear translocation of nuclear factor-kB rel A: evidence of complex dynamics at the single-cell level Source: Biochem. J. 369 (2003) 331-339
Authors: Steil, G.M.; Rebrin, K.; Janowski, R.; Darwin, C.; Saad, M.F. Title: Modeling beta-cell insulin secretion--implications for closed-loop glucose homeostasis Source: Diabetes Technol. Ther. 5 (2003) 953-964
Authors: Steil, G.M.; Rebrin, K.; Mastrototaro, J.; Bernaba, B.; Saad, M.F. Title: Determination of plasma glucose during rapid glucose excursions with a subcutaneous glucose sensor Source: Diabetes Technol. Ther. 5 (2003) 27-31
Authors: Thomas, J.B.; Atkinson, R.N.; Vinson, N.A.; Catanzaro, J.L.; Perrella, C.L.; Fix, S.E.; Mascarella, S.W.; Rothman, R.B.; Xu, H.; Dersch, C.M.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I. Title: Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4- (3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4- tetrahydro-3-isoquinoline carboxamide as a Novel Potent and Selective Opioid Kappa Receptor Antagonist Source: J. Med. Chem. 46 (2003) 3127-3137
Authors: Thomaseth, K. Title: Multidisciplinary modelling of biomedical systems Source: Comp. Meth. Prog. Biomed. 71 (2003) 189-201
Authors: Thompson, P.; Balis, F.; Serabe, B.M.; Berg, S.; Adamson, P.; Klenke, R.; Aiken, A.; Packer, R.; Murry, D.J.; Jakacki, R.; Blaney, S.M. Title: Pharmacokinetics of phenylacetate administered as a 30-minute infusion in children with refractory cancer Source: Canc. Chem. Pharm. 52 (2003) 417-423
Authors: Tsai, A.G.; Vandegriff, K.D.; Intaglietta, M.; Winslow, R.M. Title: Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics Source: Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H1411-H1419
Authors: Wang, C-H; Leung, N.; Lapointe, N.; Szeto, L.; Uffleman, K.D.; Giacca, A.; Rouleau, J.L.; Lewis, G. Title: Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker Fatty rats: Studies comparing a vasopeptidase inhibitor, and angiotensin II type I receptor blocker Source: Circulation 107 (2003) 1923-1929
Authors: Xu, H.; Lu, Y.F.; Rothman, R.B. Title: Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu-opioid receptor Source: Synapse 47 (2003) 1-9
Authors: Yang, L.; Ross, K.; Qwarnstrom, E. Title: RelA Control of I-kappa-beta-alpha Phosphorylation: A Positive Feedback Loop for High Afinity NF-kappa-beta Complexes Source: J. Biol. Chem. 278 (2003) 30881-30888
Authors: Avogaro, A.; Watanabe, R.M.; Gottardo, L.; de Kreutzenberg, S.; Tiengo, A.; Pacini, G. Title: Glucose tolerance during moderate alcohol intake; insights on insulin action from glucose/lactate dynamics Source: J. Clin. Endo. Metab. 87 (2002) 1233-1238
Authors: Bergasa, N.V.; Rothman, R.B.; Mukerjee, E.; Vergalla, J.; Jones, E.A. Title: Up-regulation of central mu-opioid receptors in a model of hepatic encephalopathy: A potential mechanism for increased sensitivity to morphine in liver failure Source: Life Sci. 70 (2002) 1701-1708
Authors: Craig, T.A.; Benson, L.M.; Venyaminov, S.Y.; Klimtchuk, E.S.; Bajzer, Z.; Prendergast, F.G.; Naylor, S.; Kumer, R. Title: The Metal-binding Properties of DREAM (Downstream Regulatory Element Antagonist Modulator) Source: J. Biol. Chem. 277 (2002) 10955-10966
Authors: Dea, M.K.; Hamilton-Wessler, M.; Ader, M.; Moore, D.; Schaffer, L.; Loftager, M.; Volund, A.; Bergman, R.N. Title: Albumin binding of acylated insulin (NN304) does not deter action to stimulate glulcose uptake Source: Diabetes 51 (2002) 762-769
Authors: Demant, E.J.F.; Richieri, G.V.; Kleinfeld, A.M. Title: Stopped-flow kinetic analysis of long-chain fatty acid dissociation from bovine serum albumin Source: Biochem. J. 363 (2002) 809-815
Authors: Fox, E.; Bungay, P.M.; Bacher, J.; McCully, C.L.; Dedrick, R.L.; Balis, F.M. Title: Zidovudine concentration in brain extracellular fluid measured by microdialysis: steady-state and transient results in rhesus monkey Source: J. Pharm. Exp. 301 (2002) 1003-1011
Authors: Goran, M.I.; Bergman, R.N.; Cruz, M.L.; Watanabe, R. Title: Insulin resistance and associated compensatory responses in African-American and Hispanic children Source: Diabetes Care 25 (2002) 2184-2190
Authors: Kamiya, Y.; Puzianowska-Kuznicka, M.; McPhie, P.; Nauman, J.; Cheng, S-Y; Nauman, A. Title: Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma Source: Carcinogenesis 23 (2002) 25-33
Authors: Kuznetsov, V.A.; Pickatov, V.V.; Senko, O.V.; Knott, G.D. Title: Analysis of the Evolving Proteomes: Predictions of the Number of Protein Domains in Nature and the Number of Genes in Eukaryotic Organisms Source: J. Biol. Sys. 10 (2002) 381-407
Authors: Kuznetsov, V.A.; Knott, G.D.; Bonner, R.F. Title: General Statistics of Stochastic Process of Gene Expression in Eukaryotic Cells Source: Genetics 161 (2002) 1321-1332 Description: fit of Pareto-like probability function
Authors: Lebowitz, J.; Lewis, M.S.; Schuck, P. Title: Modern analytical ultracentrifugation in protein science Source: Protein Sci. 11 (2002) 2067-2079
Authors: Liu, J.; Christian, J.A.; Critser, J.K. Title: Canine RBC osmotic tolerance and membrane permeability Source: Cryobiol. 44 (2002) 258-268
Authors: Maldonado, S.; Irun, M.P.; Campos, L.A.; Rubio, J.A.; Luquita, A.; Lostao, A.; Wang, R.; Garcia-Moreno, B.E.; Sancho, J. Title: Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects Source: Protein Sci. 11 (2002) 1260-1273
Authors: Maruster, S.; Negru, V.; Petcu, D.; Sandru, C. Title: Intelligent Front-End for Solving Nonlinear Systems of Differential and Algebraic Equations Source: J. Math. Sci. 108 (2002) 1139-51
Authors: Meadows, D.L.; Paugh, J.R.; Joshi, A.; Mordaunt, J. Title: A novel method to evaluate residence time in humans using a nonpenetrating fluorescent tracer Source: Inv. Ophthal. Vis. Sci. 43 (2002) 1032-1039
Authors: Moskovitz, J.; Yim, M.B; Boon Chock, P. Title: Free Radicals and Disease Source: Arch. Biochem. Biophys. 397 (2002) 354-359 Description: solve odes describing rates of free radical reactions
Authors: Oz, M.; Zhang, L.; Spivak, C.E. Title: Direct non-competitive inhibition of 5-HT3 receptor-mediated responses by forskolin and steroids Source: Arch. Biochem. Biophys. 404 (2002) 293-301
Authors: Resetar, A.M.; Stephens, J.M.; Chalovich, J.M. Title: Troponin-Tropomyosin: An Allosteric Switch or a Steric Blocker? Source: Biophys. J. 83 (2002) 1039-1049 Description: Hill equation parameter estimation.
Authors: Rothman, R.B.; Katsnelson, M.; Vu, N.; Partilla, J.S.; Dersch, C.M.; Blough, B.E.; Baumann, M.H. Title: Interaction of the anorectic medication, phendimetrazine, and its metabolites with monamine transporters in rat brain Source: Eur. J. Pharm. 447 (2002) 51-57
Authors: Schuck, P.; Perugini, M.A.; Gonzales, N.R.; Howlett, G.J.; Schubert, D. Title: Size-Distribution Analysis of Proteins by Analytical Ultracentrifugation: Strategies and Application to Model Systems Source: Biophys. J. 82 (2002) 1096-1111
Authors: Solan, A.; Ratia, K.; Fairman, R. Title: Exploring the Role of Alanine in the Structure of the Lac Repressor Tetramerization Domain, a Ferritin-like Alacoil Source: J. Mol. Biol. 317 (2002) 601-612
Authors: Rothman, R.B.; Dersch, C.M.; Carroll, F.I.; Ananthan, S. Title: Studies of the biogenic amine transporters. VIII: Identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding Source: Synapse 43 (2002) 268-274
Authors: Rothman, R.B.; Carroll, F.I.; Morales, M.; Rowley, D.L.; Rice, K.C.; Dersch, C.M.; Donovan, D.M. Title: Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice Source: Synapse 44 (2002) 94-105
Authors: Rothman, R.B.; Vu, N.; Xu, H.; Baumann, M.H.; Lu, Y.F. Title: Endogenous corticotropin releasing factor regulates adrenergic and opioid receptors Source: Peptides 23 (2002) 2177-2180
Authors: Thorolfsson, M.; Ibarra-Molero, B.; Fojan, P.; Petersen, S.B.; Sanchez-Ruiz, J.M.; Martinez, A. Title: L-Phenylalanine Binding and Domain Organization in Human Phenylalanine Hydroxylase: A Differential Scanning Calorimetry Study Source: Biochem. 41 (2002) 7573-7585
Authors: Valles, S.; Caunt, C.J.; Walker, M.H.; Qwarnstrom, E.E. Title: PDGF Enhancement of IL-1 Receptor Levels in Smooth Muscle Cells Involves Induction of an Attachment-Regulated, Heparan Sulphate Binding Site (IL-1RIII) Source: Lab. Invest. 82 (2002) 855-862
Authors: Zhang, X-Y; Kaneshige, M.; Kamiya, Y.; Kaneshige, K.; McPhie, P.; Cheng, S-Y Title: Differential expression of thyroid hormone receptor isoforms dictates the dominant negative activity of mutant beta receptor Source: Mol. Endocrin. 16 (2002) 2077-2092
Authors: Allen, D.D.; Smith, Q.R. Title: Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique Source: J. Neurochem. 76 (2001) 1032-1041
Authors: Baumann, M.H.; Ayestas, M.A.; Dersch, C.M.; Rothman, R.B. Title: 1-(m-Chlorophenyl) piperazine (mCPP) Dissociates In Vivo Serotonin Release from Long-Term Serotonin Depletion in Rat Brain Source: Neuropsychopharm. 24 (2001) 492-501
Authors: Baumann, M.H.; Rothman, R.B.; Pablo, J.P.; Mash, D.C. Title: In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats Source: J. Pharm. Exp. 297 (2001) 531-539
Authors: Beall, B.; Chalovich, J.M. Title: Fesselin, a Synaptopodin-like Protein, Stimulates Actin Nucleation and Polymerization Source: Biochem. 40 (2001) 14252-14259
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Authors: Caride, A.J.; Penhieter, A.R.; Filoteo, A.G.; Bajzer, Z.; Enyedi, A.; Penniston, J.T. Title: The Plasma Membrane Calcium Pump Displays Memory of Past Calcium Spikes Source: J. Biol. Chem. 276 (2001) 39797-39804
Authors: Georgescu, R.E.; Garcia-Mira, M.M.; Tasayco, M.L.; Sanchez-Ruiz, J.M. Title: Heat capacity analysis of oxidized Escherichia coli thioredoxin fragments (1-73,74-108) and their noncovalent complex Source: Eur. J. Biochem. 268 (2001) 1477-1485
Authors: Godsland, I.F.; Walton, C. Title: Maximizing the Success Rate of Minimal Model Insulin Sensitivity Measurement in Humans: the Importance of Basal Glucose Levels Source: Clinical Science 101 (2001) 1-9 Description: Bergman Minimal Model
Authors: Hebert, A.M.; Strohmaier, J.; Whitman, M.C.; Chen, T.; Gubina, E.; Hill, D.W.; Lewis, M.S.; Kozlowski, S. Title: Kinetics and Thermodynamics of Beta-2-Microglobulin Binding to the Alpha-3 Domain of Major Histocompatibility Complex Class 1 Heavy Chain Source: Biochem. 40 (2001) 5233-5242
Authors: Helfert, S.; Estevez, A.M.; Bakker, B.; Michels, P.; Clayton, C. Title: Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei Source: Biochem. J. 357 (2001) 117-125
Authors: Irun, M.P.; Garcia-Mira, M.M.; Sanchez-Ruiz, J.M.; Sancho, J. Title: Native hydrogen bonds in a molten globule: the apoflavodoxin thermal intermediate Source: J. Molec. Biol. 306 (2001) 877-888
Authors: Irun, M.P.; Maldonado, S.; Sancho, J. Title: Stabilization of apoflavodoxin by replacing hydrogen-bonded charged Asp or Glu residues by the neutral isosteric Asn or Gln Source: Protein Eng. 14 (2001) 173-181
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Authors: Kirillov, S.A.; Musiyenko, I.S.; Photiadis, G.M.; Pavlatou, E.A. Title: Ionic Interactions in Molten Complex Chlorides from Vibrational Dephasing Source: J. Chem. Phys. 114 (2001) 3683-3691 Description: fit of Kubo equation.
Authors: Kuznetsov, V.A.; Knott, G.D. Title: Modeling Tumor Regrowth and Immunotherapy Source: Math. Comput. Mod. 33 (2001) 1275-1287 Description: solved odes for tumor cell population growth.
Authors: Lee, S.P.; Fuior, E.; Lewis, M.S.; Han, M.K. Title: Analytical Ultracentrifugation Studies of Translin: Analysis of Protein-DNA Interactions Using a Single-Stranded Fluorogenic Oligonucleotide Source: Biochem. 40 (2001) 14081-14088
Authors: Lin, J.T.; Sharma, R.; Grady, J.J.; Awasthi, S. Title: A flow cell assay for evaluation of whole cell drug efflux kinetics: Analysis of paclitaxel efflux in CCRF-CEM leukemia cells Source: Drug Metab. 29 (2001) 103-110
Authors: Minematsu, T.; Ohtani, H.; Yamada, Y.; Sawada, Y.; Sato, H.; Iga, T. Title: Quantitative Relationship Between Myocardial Concentration of Tacrolimus and QT Prolongation in Guinea Pigs: Pharmacokinetic/Pharmacodynamic Model Incorporating a Site of Adverse Effect Source: J. Pharmacokin. Pharmacodyn. 28 (2001) 533-554
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Authors: Rothman, R.B.; Baumann, M.H.; Dersch, C.M.; Romero, D.V.; Rice, K.C.; Carroll, F.I.; Partilla, J.S. Title: Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin Source: Synapse 39 (2001) 32-41
Authors: Schuck, P.; Taraporewala, Z.; McPhie, P.; Patton, J.T. Title: Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes Source: J. Biol. Chem. 276 (2001) 9679-9687
Authors: Shcherbakova, P.V.; Hall, M.C.; Lewis, M.S.; Bennett, S.E.; Martin, K.J.; Bushel, P.R.; Afshari, C.A.; Kunkel, T.A. Title: Inactivation of DNA mismatch repair by increased expression of yeast MLH1 Source: Mol. Cell. Biol. 21 (2001) 940-951
Authors: Song, M.S.; Dallmann, H.G.; McHenry, C.S. Title: Carboxyl-terminal Domain III of the delta-prime subunit of the DNA polymerase III holoenzyme binds delta Source: J. Biol. Chem. 276 (2001) 40668-40679
Authors: Tang, Y.; Ghirlanda, G.; Vaidehi, N.; Kua, J.; Mainz, D.T.; Goddard, W.A.; DeGrado, W.F.; Tirrell, D.A. Title: Stabilization of Coiled-Coil Peptide Domains by Introduction of Trifluoroleucine Source: Biochem. 40 (2001) 2790-2796
Authors: Taniuchi, H.; Shi, Y.; San Miguel, G.I.; Ferretti, J.A.; Mack, J.W.; Fisher, A.; Shah, M.; Schechter, A.N.; Shiloach, J. Title: A study of the influence of the hydrophobic core residues of yeast iso-2-cytochrome c on phosphate binding: a probe of the hydrophobic core-surface charge interactions Source: J. Protein Chem. 20 (2001) 203-215
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Authors: Xu, H.; Hashimoto, A.; Rice, K.C.; Jacobson, A.E.; Thomas, J.B.; Carroll, F.I.; Lai, J.; Rothman, R.B. Title: Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [35 S] GTP-gamma-S functional binding assay Source: Synapse 39 (2001) 64-69
Authors: Xu, H.; Lu, Y.F.; Rice, K.C.; Ananthan, S.; Rothman, R.B. Title: SoRI9409, a non-peptide mu receptor agonist/ delta receptor antagonist, fails to stimulate [35-S]-GTP-gamma-S binding at cloned opioid receptors Source: Brain Res. Bull. 55 (2001) 507-511
Authors: Xu, H.; Lu, Y.F.; Thomas, J.B.; Carroll, F.I.; Rice, K.C.; Rothman, R.B. Title: Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N- diethylbenzamide and related compounds at the cloned human delta- opioid receptor Source: Synapse 40 (2001) 269-274
Authors: Bakker, B.M.; Mensonides, F.I.C.; Teusinle, B.; van Hoek, P.; Michels, P.A.M.; Westerhoff, H.V. Title: From the cover: compartmentation protects trypanosomes from the dangerous design of glycolysis Source: PNAS 97 (2000) 2087-2092 Description: ordinary differential equation model
Authors: Baumann, M.H.; Ayestas, M.A.; Dersch, C.M.; Brockington, A.; Rice, K.C.; Rothman, R.B. Title: Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: Therapeutic implications Source: Synapse 36 (2000) 102-143
Authors: Baumann, M.H.; Ayestas, M.A.; Dersch, C.M.; Partilla, J.S.; Rothman, R.B. Title: Serotonin Transporters, Serotonin Release, and the Mechanism of Fenfluramine Neurotoxicity Source: Ann. NY Acad. 914 (2000) 172-186
Authors: Center, R.J.; Earl, P.L.; Lebowitz, J.; Schuck, P.; Moss, B. Title: The human immunodeficiency virus type I gp120 V2 domain mediates gp41-independent intersubunit contacts Source: J. Virol. 74 (2000) 4448-4455
Authors: Dallmann, H.G.; Kim, S.; Prichard, A.E.; Marians, K.J.; McHenry, C.S. Title: Characterization of the unique C terminus of the Escherichia coli T DnaX protein: monomeric C-T binds alpha and Dna beta and can partially replace T in reconstituted replication forks Source: J. Biol. Chem. 275 (2000) 15512-15519
Authors: Dibrov, Pavel; Murtazina, Rakhilya; Kinsella, James; Fliegel, Larry Title: Characterization of a Histidine Rich Cluster of Amino Acids in the Cytoplasmic Domain of the Na+/H+ Exchanger Source: Biosci. Reports 20 (2000) 185-197 Description: Hill equation
Authors: Dimitriadis, E.K.; Lewis, M.S. Title: Optimal data analysis using transmitted light intensities in analytical ultracentrifuge Source: Methods Enzym. 321 (2000) 121-136
Authors: Ellis, J.; Seidenberg, M. Title: Interactions of alcuronium, TMB-8, and other allosteric ligands with muscarinic acetylcholine receptors: studies with chimeric receptors Source: Mol. Pharm. 58 (2000) 1451-1460
Authors: Fan, Y.X.; McPhie, P.; Miles, E.W. Title: Regulation of Tryptophan Synthesis by Temperature, Monovalent Cations, and an Allosteric Ligand. Evidence from Arrhenius Plots, Absorption Spectra, and Primary Kinetic Isotope Effects Source: Biochem. 39 (2000) 4692-4703
Authors: Geibel, S.; Barth, A.; Amslinger, S.; Jung, A.H.; Burzik, C.; Clarke, R.J.; Givens, R.S.; Fendler, K. Title: P3-[2-(4-hydroxyphenyl)-2-oxo] ethyl ATP for the Rapid Activiation of the Na+, K+-ATPase Source: Biophys. J. 79 (2000) 1346-1357
Authors: Guzman-Casado, M.; Sanchez-Ruiz, J.M.; Harrous, M.E.; Gimenez-Gallego, G.; Parody-Morreale, A. Title: Energetics of myo-inositol hexasulfate binding to human acidic fibroblast growth factor Source: Eur. J. Biochem. 267 (2000) 3477-3486
Authors: Green, T.J.; Macpherson, S.; Qiu, S.; Lebowitz, J.; Wertz, G.W.; Luo, M. Title: Study of the assembly of vesicular stomatitis virus N protein: role of the P protein Source: J. Virol. 74 (2000) 9515-9524
Authors: Heylinger, Simone O.; Ni, Qing; Rothman, Richard B. Title: Resolution of two [35-S] GTP-gamma-S Binding Sites and Their Response to Chronic Morphine Treatment: A Binding Surface Analysis Source: Brain Res. Bull. 51 (2000) 357-362 Description: 1- and 2-site binding models
Authors: Huang, K.P.; Huang, F.L.; Li, J.; Schuck, P.; McPhie, P. Title: Calcium-Sensitive Interaction Between Calmodulin and Modified Forms of Rat Brain Neurogranin/RC3 Source: Biochem. 39 (2000) 7291-7299
Authors: Jhee, K.H.; McPhie, P.; Miles, E.W. Title: Domain Architecture of the Heme-Independent Yeast Cystathionine Beta-Synthase Provides Insights into Mechanisms of Catalysis and Regulation Source: Biochem. 39 (2000) 10548-10556
Authors: Kim, J.K.; Michael, M.D.; Previs, S.F.; Peroni, O.D.; Mauvais-Jarvis, F.; Neschen, S.; Kahn, B.B.; Kahn, C.R.; Shulman, G.I. Title: Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle Source: J. Clin. Inv. 105 (2000) 1791-1797
Authors: Kim, J.; Gavrilova, O.; Chen, Y.; Reitman, M.; Shulman, G. Title: Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice Source: J. Biol. Chem. 275 (2000) 8456-8460
Authors: Kinsella, T.; Schupp, J.; Davis, T.; Berry, S.; Hwang, H.; Warren, K.; Balis, F.; Barnett, J.; Sands, H. Title: Preclinical Study of the Systemic Toxicity and Pharmacokinetics of 5-Iodo-2-deoxypyrimidinone-2'-deoxyribose as a Radiosensitizing Prodrug in Two, Non-Rodent Animal Species: Implications for Phase I Study Design Source: Clin. Canc. Res. 6 (2000) 3670-3679.
Authors: Kirillov, S.A.; Nielsen, O.F.; Faurskov, O. Title: Boson Peak in the Low Frequency Raman Spectra of Ordinary Liquids Source: J. Mol. Struct. 526 (2000) 317-321 Description: curve fit peaks in Raman spectrum of formamide..
Authors: Kirillov, S.V.; Yannopoulos, S.N. Title: Charge-Current Contribution to Low-Frequency Raman Scattering from Glass-Forming Ionic Liquids Source: Phys. Rev. B 61 (2000) 11391-11399 Description: curve fit peaks in Raman spectra.
Authors: Lewis, Marc S.; Junghans, Richard P. Title: Ultracentrifugal Analysis of Molecular Mass of Glycoproteins of Unknown or Ill-Defined Carbohydrate Consumption Source: Methods Enzym. 321 (2000) 136-149 Description: ultracentrifuge model
Authors: Marintchev, A.; Robertson, A.; Dimitriadis, E.K.; Prasad, R.; Wilson, S.H.; Mullen, G.P. Title: Domain specific interaction in the XRCL1-DNA polymerase beta complex Source: Nucleic Acids Res. 28 (2000) 2049-2059
Authors: Marshall, A. David; McPhie, Peter; Jakoby, William B. Title: Redox Control of Aryl Sulfotransferase Specificity Source: Arch. Biochem. Biophys. 382 (2000) 95-104 Description: ligand binding to multiple sites
Authors: Matsumoto, E.; Kiyota, T.; Lee, S.; Sugihara, G.; Yamashita, S.; Meno, H.; Aso, Y.; Sakamoto, H.; Ellerby, H.M. Title: Study on the packing geometry, stoichiometry, and membrane interaction of three analogs related to a pore-forming small globular protein Source: Biopolymers 56 (2000/2001) 96-108
Authors: McDonald, C.; Dunaif, A.; Finegood, D.T. Title: Minimal model estimates of insulin selectivity are insensitive to errors in glucose effectiveness Source: J. Clin. Endo. Metab. 85 (2000) 2504-2508
Authors: Pfaff, R.T.; Agca, Y.; Liu, J.; Woods, E.J.; Peter, A.T.; Critser, J.K. Title: Cryobiology of rat embryos I: determination of zygote membrane permeability coefficients for water and cryoprotectants, their activation energies, and the development of improved cryopreservation methods Source: Biol. Reprod. 63 (2000) 1294-1302
Authors: Partilla, J.S.; Dersch, C.M.; Yu, H.; Rice, K.C.; Rothman, R.B. Title: Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038 Source: Brain Res. Bull. 53 (2000) 821-826
Authors: Pritchard, A.E.; Dallmann, H.G.; Glover, B.P.; McHenry, C.S. Title: A novel assembly mechanism for the DNA polymerase III holoenzyme DnaX complex: association of delta delta prime with DnaX4 forms DnaX3 delta delta prime Source: EMBO Journal 19 (2000) 6536-6545
Authors: Riva, Luca; Blaney, Susan M.; Dauser, Robert; Nuchtern, Jed G.; Durfee, John; McGuffey, Leticia; Berg, Stacey L. Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of CI-994 (N-Acetyldinaline) in the Nonhuman Primate Source: Clin. Canc. Res. 6 (2000) 994-997 Description: 5-compartment model, multiexponential function fit
Authors: Rothman, R.B.; Partilla, J.S.; Baumann, M.H.; Dersch, C.M.; Carroll, F.I.; Rice, K.C. Title: Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse Source: Synapse 35 (2000) 222-227
Authors: Rothman, R.B.; Partilla, J.S.; Dersch, C.M.; Carroll, F.I.; Rice, K.C.; Baumann, M.H. Title: Methamphetamine Dependence: Medication Development Efforts Based on the Dual Deficit Model of Stimulant Addiction Source: Ann. NY Acad. 914 (2000) 71-81
Authors: Salom, D.; Hill, B.R.; Lear, J.D.; DeGrado, W.F. Title: pH-Dependent Tetramerization and Amentadine Binding of the Transmembrane Helix of M2 from the Influenza A Virus Source: Biochem. 39 (2000) 14160-14170
Authors: She, M.; Trimble, D.; Yu, L.C.; Chalovich, J.M. Title: Factors Contributing to Troponin Exchange in Myofibrils and in Solution Source: J. Musc. Res. & Cell Mot. 21 (2000) 737-745
Authors: Shibata, M.; Yamada, S.; Kumar, S.R.; Calero, M.; Bading, J.; Frangione, B.; Holtzman, D.M.; Miller, C.A.; Strickland, D.K.; Ghiso, J.; Zlokovic, B.V. Title: Clearance of Alzheimer's amyloid-beta 1-40 peptide from brain by LDL receptor-related protein-1 at the blood brain barrier Source: J. Clin. Inv. 106 (2000) 1489-1499
Authors: Slack, J; Schooley, K.; Bonnert, T.; Mitcham, J.; Qwarnstrom, E.; Sims, J.; Dower, S. Title: Identification of Two Major Sites in the Type 1 Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways Source: J. Biol. Chem. 275 (2000) 4670-4678
Authors: Stern, M.D. Title: The Model of Snyder et.al. Does Not Simulate Graded Ca2+ Release from the Cardiac Sarcoplasmic Reticulum in Intact Cells Source: Biophys. J. 79 (2000) 3353-3354
Authors: Warren, K.E.; McCully, C.M.; Walsh, T.J.; Balis, F.M. Title: Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates Source: Antimicrob. Ag. and Chem. 44 (2000) 1100-1101
Authors: Westerhoff, H.V.; Riethorst, A.; Jongsma, A.P.M. Title: Relating multidrug resistance phenotypes to the kinetic properties of their drug-efflux pumps Source: Eur. J. Biochem. 267 (2000) 5355-5368
Authors: Widemann, B.C.; Sung, E.; Anderson, L.; Salzer, W.L.; Balis, F.M.; Montijo, K.S.; McCully, C.; Hawkins, M.; Adamson, P.C. Title: Pharmacokinetics and metabolism of the methotrexate metabolite 2,4-diamino-N 10-methylpteroic acid Source: J. Pharm. Exp. 294 (2000) 894-901
Authors: Yoshigi, M.; Knott, G.D.; Keller, B.B. Title: Lumped Parameter Estimation for the Embryonic Chick Vascular System-A Time Domain Approach Using MLAB Source: Comp. Meth. Prog. Biomed. 63 (2000) 29-41 Description: Windkessel ode circuit models
Authors: Agca, Y.; Liu, J.; Critser, E.S.; McGrath, J.J.; Critser, J.K. Title: Temperature-Dependent Osmotic Behavior of Germinal Vesicle and Metaphase II Stage Bovine Oocytes in the Presence of Me2SO in Relationship to Cryobiology Source: Mol. Reprod. 53 (1999) 59-67 Description: Kedem Katchalsky model of membrane permeability coefficient
Authors: Ananthan, S.; Kezar, H.S.; Carter, R.L.; Saini, S.K.; Rice, K.C.; Wells, J.L.; Davis, P.; Xu, H.; Dersch, C.M.; Bilsky, E.J.; Porreca, F.; Rothman, R.B. Title: Synthesis, Opioid Receptor Binding, and Biological Activities of Naltrexone-Derived Pyrido- and Pyrimidomorphinans Source: J. Med. Chem. 42 (1999) 3527-3538
Authors: Bakker, B.M.; Michels, P.A.M.; Opperdoes, F.R.; Westerhoff, H.V. Title: What controls glycolysis in bloodstream form Trypanosoma brucei? Source: J. Biol. Chem. 274 (1999) 14551-14559
Authors: Barrera-Hernandez, G.; Park, K.S.; Dace, A.; Zhan, Q.; Cheng, S-Y Title: Thyroid hormone-induced cell proliferation in GC cells is mediated by changes in G1 cyclin/cyclin-dependent kinase levels and activity Source: Endocrin. 140 (1999) 5267-5274
Authors: Barrett, William C.; DeGnore, Jon P.; Keng, Yen-Fang; Zhang, Zhong-Yin; Kim, Moon B.; Chock, P.Boon Title: Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphate 1B Source: J. Biol. Chem. 274 (1999) 34543-34546 Description: kinetic rate constants
Authors: Barrett, W.C.; DeGnore, J.P.; Konig, S.; Fales, H.M.; Keng, Y.F.; Zhang, Z.Y.; Yim, M.B.; Chock, P.B. Title: Regulation of PTPIB via Glutathionylation of the Active Site Cysteine 215 Source: Biochem. 38 (1999) 6699-6705
Authors: Bastianoni, Simone; Donati, Alessandro; Gastaldelli, Amalia; Marchettini, Nadia; Martini, Silvia; Rossi, Claudio Title: A Modellistic View of the Kinetics of Metabolic Processes: Differences in Glucose and Xylose Degradation Pathway Source: Chem. Phys. Lett. 310 (1999) 38-42 Description: non-linear differential equation model
Authors: Bastianoni, S.; Martini, S.; Porcelli, M.; Rossi, C. Title: Modeling the Complex Behavior of Microorganisms Source: Ann. NY Acad. 879 (1999) 387-391 Description: three coupled non-linear differential equations
Authors: Berg, Stacey L.; Reid, Joel; Godwin, Karen; Murry, Daryl J.; Poplack, David G.; Balis, Frank M.; Ames, Matthew M. Title: Pharmacokinetics and Cerebrospinal Fluid Penetration of Daunorubicin, Idarubicin, and their Metabolites in the Nonhuman Primate Model Source: J. Ped. Hematology/Oncology 21 (1999) 26-30 Description: multiexponential model
Authors: Chen, Tong-Bin; Bajzer, Zeljko; Macura, Slobodan; Vuk-Paulovic, Stanimir Title: Differences in Metabolism of 5-fluorouracil and 5-fluorouridine and Regulation by Glucosamine in Human Colon Cancer Multicell Tumor Spheroids Source: NMR in Biomedicine 12 (1999) 157-167 Description: differential equation models
Authors: Clarke, R.J.; Lupfert, C. Title: Influence of Anions and Cations on the Dipole Potential of Phosphatidylcholine Vesicles: A Basis for the Hofmeister Effect Source: Biophys. J. 76 (1999) 2614-2624
Authors: Coop, A.; Rothman, R.B.; Dersch, C.; Partilla, J.; Porreca, F.; Davis, P.; Jacobson, A.E.; Rice, K.C. Title: Delta Opioid Affinity and Selectivity of 4-Hydroxy-3- methoxindolomorphion Analogues Related to Naltrindole Source: J. Med. Chem. 42 (1999) 1673-1679
Authors: Dieckmann, G.R.; Lear, J.D.; Zhong, Q.; DeGrado, W.F.; Sharp, K.A. Title: Exploration of the structural features defining the conduction properties of a synthetic ion channel Source: Biophys. J. 76 (1999) 618-630
Authors: Donovan, D.M.; Miner, L.L.; Perry, M.P.; Revay, R.S.; Sharpe, L.G.; Przedborski, S.; Kostic, V.; Philpot, R.M.; Kirstein, C.L.; Rothman, R.B.; Schindler, C.W.; Uhl, G.R. Title: Cocaine reward and MPTP toxicity: alternation by regional variant dopamine transporter overexpression Source: Mol. Brain Res. 73 (1999) 37-49
Authors: Ellis, J.; Seidenberg, M. Title: Competitive and allosteric interactions of 6-chloro- 5,10-dihydro-5-[(1-methyl-4-piperidinyl)acetyl]-11h-dibenzo[b,e][1,4] diazepine-11-one hydrochloride (UH-AH37) at muscarinic receptors, via distinct epitopes Source: Biochem. Pharm. 57 (1999) 181-186
Authors: Fan, Y.X.; McPhie, P.; Miles, E.W. Title: Guanidine Hydrochloride Exerts Dual Effects on the Tryptophan Synthesis alpha-2-beta-2 Complex as a Cation Activation and as a Modulator of the Active Site Conformation Source: Biochem. 38 (1999) 7881-7890
Authors: Gandhi, Chris J.; Shuck, Kevin; Lear, James D.; Dieckmann, Gregg R.; DeGrado, William F.; Lamb, Robert A.; Pinto, Lawrence H. Title: Cu(II) Inhibition of the Proton Translocation Machinery of the Influenza A Virus M2 Protein Source: J. Biol. Chem. 274 (1999) 5474-5482 Description: differential equations for 2-state binding of Cu+2 to M2 ion channel protein
Authors: Heyliger, S.O.; Jackson, C.; Rice, K.C.; Rothman, R.B. Title: Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: Further evidence of kappa receptor heterogeneity Source: Synapse 34 (1999) 256-265
Authors: Hulme, E.C. Title: Receptor Binding Technology: Analysis of Binding Data Source: Methods Molec. Biol. 106 (1999) 139-185
Authors: Ibarra-Molero, B.; Loladze, V.V.; Makatadze, G.I.; Sanchez-Ruiz, J.M. Title: Thermal versus Guanidine-Induced Unfolding of Ubiquitin. An Analysis in Terms of the Contribution from Charge-Charge Interactions to Protein Stability Source: Biochem. 38 (1999) 8138-8149
Authors: Ibarra-Molero, B.; Makhatadze, G.I.; Sanchez-Ruiz, J.M. Title: Cold denaturation of ubiquitin Source: Biochim. Biophys. Acta-Protein Struct. 1429 (1999) 384-390
Authors: Ito, Shinya; Woodland, Cindy; Sarkadi, Balazs; Hockmann, Guido; Walker, Scott E.; Koren, Gideon Title: Modeling of P-glycoprotein-involved Epithelial Drug Transport in MDCK Cells Source: Am. J. Physiol. 277 (1999) F84-F96
Authors: Kabyemela, Bernard M.; Adschiri, Todafumi; Malaluan, Roberto M.; Arai, Kunio Title: Glucose and Fructose Decomposition in Subcritical and Supercritical Water-Detailed Reaction Pathway, Mechanisms, and Kinetics Source: Ind. Eng. Res. 38 (1999) 2888-2895
Authors: Kirillov, S.A. Title: Time Correlation Functions from Band-Shape Fits without Fourier Transform Source: Chem. Phys. Lett. 303 (1999) 37-42 Description: fit of line shape function with K1(x) Bessel function as a factor.
Authors: Kirillov, S.A.; Perova, T.S.; Nielsen, O.F.; Praestgaard, E.; Rasmussen, U.; Kolomiyets, T.M.; Voyiatzis, G.A.; Anastasiadis, S.H. Title: Fitting the Low-Frequency Raman Spectra to Boson Peak Models- Glycerol, Triacetin, and Polystyrene Source: J. Mol. Struct. 479 (1999) 271-278 Description: fit lineshape functions to peaks in spectra.
Authors: Kirillov, S.A.; Voyiatzis, G.A.; Kolomiyets, T.M.; Anastasiadis, S.H. Title: Spatial Correlations and Exact Solution of the Problem of the Boson Peak Profile in Amorphous Media Source: Phys. Lett. A 262 (1999) 186-190 Description: curve fitting.
Authors: Kuznetsov, Vladimir; Puri, Raj K. Title: Kinetic Analysis of High Affinity Forms of Interleukin (IL)-13 Receptors: Supression of IL-13 Binding by IL-2 Receptor Gamma Chain Source: Biophys. J. 77 (1999) 154-172
Authors: Leinweber, B.; Tang, J.X.; Stafford, W.F.; Chalovich, J.M. Title: Calponin Interaction with alpha-Actinin-Actin: Evidence for a Structural Role for Calponin Source: Biophys. J. 77 (1999) 3208-3217
Authors: Minton, A.P. Title: Adsorption of globular proteins on locally planar surfaces. II. Models for the effect of multiple adsorbate conformations on adsorption equilibria and kinetics Source: Biophys. J. 76 (1999) 176-187
Authors: Pound, J.D.; Challa, A.; Holder, M.J.; Armitage, R.J.; Dower, S.K.; Fanslow, W.C.; Kikutani, H.; Paulie, S.; Gregory, C.D.; Gordan, J. Title: Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human beta cells Source: Int. Immunol. 11 (1999) 11-20
Authors: Prince, R.J.; Sine, S.M. Title: Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models Source: J. Biol. Chem. 274 (1999) 19623-19629
Authors: Ranatunga, W.; Lebowitz, J.; Axe, B.; Pavlik, P.; Kar, S.R.; Scovell, W.M. Title: Reexamination of the high mobility group-1 protein for self-association and characterization of hydrodynamic properties Source: Biochim. Biophys. Acta-Protein Struct. 1432 (1999) 1-12
Authors: Rebrin, Kerstin; Steil, Garry M.; Van Antwerp, William P.; Mastrototaro, John J. Title: Subcutaneous Glucose Predicts Plasma Glucose Independent of Insulin: Implications for Continuous Monitoring Source: Am. J. Physiol. Endo. Metab. 277 (1999) E561-E571 Description: nonlinear least squares analysis of differential equation model
Authors: Romero, D.V.; Partilla, J.S.; Zheng, Q.X.; Heyliger, S.O.; Ni, Q.; Rice, K.C.; Lai, J.; Rothman, R.B. Title: Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective mu/kappa antagonist in the [35 S]-GTP-gamma-S functional binding assay Source: Synapse 34 (1999) 83-94
Authors: Rothman, R.B.; Ayestas, M.A.; Dersch, C.M.; Baumann, M.H. Title: Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates: implications for primary pulmonary hypertension Source: Circulation 100 (1999) 869-875
Authors: Rothman, R.B.; Baumann, M.H.; Dersch, C.M.; Appel, J.; Houghten, R.A. Title: Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library Source: Synapse 33 (1999) 239-246
Authors: Thompson, Curtis B.; Choi, Cheolsoo; Youn, Jang H.; McDonough, Alicia A. Title: Temporal Responses of Oxidative vs. Glycolytic Skeletal Muscles to K+ Deprivation- Na+ Pumps and Cell Cations Source: Am. J. Physiol. Cell Physiol. 276 (1999) C1411-C1419
Authors: Valles, S.; Tsoi, C; Huang, W.Y.; Wyllie, D.; Carlotti, F.; Askari, J.A.; Humphries, M.S.; Dower, S.K.; Qwarnstrom, E.E. Title: Recruitment of a heparin sulphate subunit to the interleukin-1 receptor complex: regulation by fibronectin attachment Source: J. Biol. Chem. 274 (1999) 20103-20109
Authors: Wibbenmeyer, J.A.; Schuck, P.; Smith-Gill, S.J.; Willson, R.C. Title: Salt links dominate affinity of antibody HyHEL-5 for lysozyme through enthalpic contributions Source: J. Biol. Chem. 274 (1999) 26838-26842
Authors: Widemann, Brigette C.; Balis, Frank M.; Godwin, Karen S.; McCully, Cindy; Adamson, Peter C. Title: The Plasma Pharmacokinetics and Cerebrospinal Fluid Penetration of the Thymidylate Synthase Inhibitor Raltitrexed (Tomudex) in a Nonhuman Primate Model Source: Canc. Chem. Pharm. 44 (1999) 439-443 Description: 3-compartment pharmacokinetic model, EWT
Authors: Woods, E.J.; Liu, J.; Gilmore, J.A.; Reid, T.J.; Gao, D.Y.; Critser, J.K. Title: Determination of Human Platelet Membrane Permeability Coefficients Using the Kedem-Katchalsky Formalism: Estimates from Two- vs Three-Parameter Fits Source: Cryobiol. 38 (1999) 200-208 Description: Kedem-Katchalsky model for cell membrane permeability.
Authors: Xu, Heng; Lu, Yi-Feng; Partilla, John S.; Zhang, Qiao-Xi; Weng, Jia-Bei; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Chen, Kai-Xian; Lui, Zhi-Qiang; Rothman, Richard B. Title: Opioid Peptide Receptor Studies. 11: Involvement of Tyr148, Trp318, and His319 of the Rat mu-Opioid Receptor in Binding of mu-Selective Ligands Source: Synapse 32 (1999) 23-28 Description: 1-site binding model, 2-parameter logistic model
Authors: Xu, S.; Gu, J.; Rhodes, T.; Belknap, G.; Rosenbaum, G.O.; White, H.; Yu, L.C. Title: The M-ADP-Pi State is Required for Helical Order in the Thick Filaments of Skeletal Muscle Source: Biophys. J. 77 (1999) 2665-2676
Authors: Zhang, X.; Rice, K.C.; Calderon, S.N.; Kayakiri, H.; Smith, L.; Coop, A.; Jacobson, A.E.; Rothman, R.B.; Davis, P.; Dersch, C.M.; Porreca, F. Title: Probes for Narcotic Receptor Mediated Phenomena. 26. Synthesis and Biological Evaluation of Diarylmethylpiperazines and Diarylmethylpiperidines as Novel, Nonpeptidic Delta-Opioid Receptor Ligands Source: J. Med. Chem. 42 (1999) 5455-5463
Authors: Agca, Y.; Liu, J.; McGrath, J.J.; Peter, A.T.; Critser, E.S.; Critser, J.K. Title: Membrane Permeability Characteristics of Metaphase II Mouse Oocytes at Various Temperatures in the Presence of Me2SO Source: Cryobiol. 36 (1998) 287-300 Description: Kedem Katchalsky differential model of membrane
Authors: Agca, Y.; Liu, J.; Peter, A.T.; Critser, E.S.; Critser, J.K. Title: Effect of Developmental Stage on Bovine Oocyte Plasma Membrane Water and Cryoprotectant Permeability Characteristics Source: Mol. Reprod. 49 (1998) 408-415 Description: Kedem Katchalsky differential equation model of membrane
Authors: Ananthan, S.; Johnson, C.A.; Carter, R.L.; Clayton, S.D.; Rice, K.C.; Xu, H.; Davis, P.; Porreca, F.; Rothman, R.B. Title: Synthesis, Opioid Receptor Binding, and Bioassay of Naltrindole Analogues Substituted in the Indolic Benzene Moiety Source: J. Med. Chem. 41 (1998) 2872-2881
Authors: Balagopalnkrishna, C.; Abugo, O.O.; Horsky, J.; Manoharan, P.T.; Nagababu, E.; Rifkin, J.M. Title: Superoxide Produced in the Heme Pocket of the Beta-Chain of Hemoglobin Reacts with the Beta-93 Cystein to Produce a Thiyl Radical Source: Biochem. 37 (1998) 13194-13202
Authors: Baylor, S.M.; Hollingworth, S. Title: Model of sarcomeric Ca2+ movements, including ATP Ca2+ binding and diffusion, during activation of frog skeletal muscle Source: J. Gen. Physiol. 112 (1998) 297-316
Authors: Berg, Stacey L.; Blaney, Susan M.; Adamson, Peter C.; O'Brien, Michelle; Poplack, David G.; Arndt, Carola; Blatt, Julie; Balis, Frank M. Title: Phase I Trial and Pharmacokinetic Study of Pyrazoloacridine in Children and Young Adults with Refractory Cancers Source: J. Clin. Oncol. 16 (1998) 181-186 Description: 2-compartment model, Hill constant estimate
Authors: Blaney, S.M.; Takimoto, C.; Murry, D.J.; Kuttesch, Nancy; McCully, Cynthia; Cole, Diane E.; Godwin, Karen; Balis, Frank M. Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in Nonhuman Primates Source: Canc. Chem. Pharm. 41 (1998) 464-468 Description: area under moment curve, rate constants
Authors: Blaney, Susan M.; Takimoto, Chris; Murry, Daryl J.; Kuttesch, Nancy; McCully, Cynthia; Cole, Diane E.; Godwin, Karen; Balis, Frank M. Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of 9-aminocamptothein (9-AC), irinotecan (CPT-11), and SN-38 in Nonhuman Primates Source: Canc. Chem. Pharm. 41 (1998) 464-468 Description: area under moment curve, rate constants
Authors: Chalovich, J.M.; Sen, A.; Resetar, A.; Leinweber, B.; Fredricksen, R.S.; Lu, F.; Chen, Y.D. Title: Caldesmon: binding to actin and myosin and effects on elementary steps in the ATPase cycle Source: Acta Physiol. Scand. 164 (1998) 427-435
Authors: Choi, Sun-Jo; Mazzio, Elizabeth; Kolta, Malak G.; Soliman, Karam F.A. Title: Prenatal Cocaine Exposure Affects Postnatal Dopaminergic Systems in Various Regions of the Rat Brain Source: Ann. NY Acad. 844 (1998) 293-302 Description: 1,2,and 3-site binding models
Authors: Coggan, A.; Brooks, G.A.; Friedlander, A.L. Title: Letter to the editor Source: J. Appl. Physiol. 84 (1998) 1480-1482
Authors: Corera, A.T.; Do Rego, J.C.; Bonnet, J.J. Title: Specificity and ion dependence of binding GBR analogs Source: Methods Enzym. 296 (1998) 203-219
Authors: Dieckmann, G.R.; McRorie, D.K.; Lear, J.D.; Sharp, K.A.; DeGrado, W.F.; Pecoraro, V.L. Title: The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils Source: J. Molec. Biol. 280 (1998) 897-912
Authors: Dimitriadis, E.K.; Prasad, R.; Vaske, M.K.; Chen, L.; Tomkinson, A.E.; Lewis, M.S. Title: Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta Source: J. Biol. Chem. 273 (1998) 20540-20550
Authors: Eisenthal, R.; Cornish-Bowden, A. Title: Prospects for antiparasitic drugs: the case of Trypanosoma brucei, the causative agent of african sleeping sickness Source: J. Biol. Chem. 273 (1998) 5500-5505
Authors: Frisbie, S.M.; Xu, S.; Chalovich, J.M.; Yu, L.C. Title: Characterizations of cross-bridges in the presence of saturating concentrations of MgAMP-PNP in rabbit permeabilized psoas muscle Source: Biophys. J. 74 (1998) 3072-3082
Authors: Ghirlanda, G.; Lear, J.D.; Lombardi, A.; DeGrado, W.F. Title: From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin Source: J. Molec. Biol. 281 (1998) 379-391
Authors: Gilmore, J.A.; Liu, J.; Peter, A.T.; Critser, J.K. Title: Determination of Plasma Membrane Characteristics of Boar Spermatozoa and Their Relevance to Cryopreservation Source: Biol. Reprod. 58 (1998) 28-36 Description: Kedem Katchalsky differential equation model of membrane
Authors: Grandori, R.; Khalifah, P.; Boice, J.A.; Fairman, R.; Giovanelli, K.; Carey, J. Title: Biochemical Characterization of WrbA, Founding Member of a new Family of Multimeric Flavodoxin-like Proteins Source: J. Biol. Chem. 273 (1998) 20960-20966
Authors: Gropp, T.; Cornelius, F.; Fendler, K. Title: K+ dependence of electrogenic transporters by the Na K - ATPase Source: Biochim. Biophys. Acta-Biomembranes (1998) 184-200
Authors: Hammou, H.O.; del Pino, I.M.P.; Sanchez-Ruiz, J.M. Title: Hydration changes upon protein unfolding: Cosolvent effect analysis Source: New J. Chem. 22 (1998) 1453-1461
Authors: Heyliger, S.O.; Payza, K.; Rothman, R.B. Title: The Effect of FMRFamide Analogs on [35 S]GTP- gamma-S Stimulation in Squid Optic Lobes Source: Peptides 19 (1998) 739-747
Authors: Ikeda, H.; Fernandez, R.; Barchi, J.J.; Huang, X.; Marquez, V.E.; Wilk, A. Title: The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2 Source: Nucleic Acids Res. 26 (1998) 2237-2244
Authors: Kabyemela, B.M.; Takigawa, M.; Adschiri, T.; Malaluan, R.M.; Arai, K. Title: Mechanism and Kinetics of Cellobiose Decomposition in Sub- and Supercritical Water Source: Ind. Eng. Res. 37 (1998) 357-361 Description: kinetics, rate equations
Authors: Kleinfeld, A.M.; Storms, S.; Watts, M. Title: Transport of Long-Chain Native Fatty Acids across Human Erythrocyte Ghost Membranes Source: Biochem. 37 (1998) 8011-8019
Authors: Lu, Yi Feng; Xu, Heng; Liu-Chen, Lee-Yuan; Chen, Chongguang; Partilla, John S.; Brine, George A.; Carroll, F. Ivy; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Sadee, Wolfgang; Rothman, Richard B. Title: Opioid Peptide Receptor Studies. 7. The Methylfentanyl Congener RTI-4614-4 and its Four Enantiomers Bind to Different Domains of the Rat mu Opioid Receptor Source: Synapse 28 (1998) 117-124 Description: multiple site binding
Authors: Mueller, Brigitta U.; Anderson, Barry D.; Farley, Maureen Q.; Murphy, Robert; Zuckerman, Judy; Jarosinski, Paul; Godwin, Karen; McCully, Cindy L.; Mitsuya, Hiroaki; Pizzo, Philip A.; Balis, Frank M. Title: Pharmacokinetics of the Protease Inhibitor KNI-272 in Plasma and Cerebrospinal Fluid in Human Immunodeficiency Virus-Infected Children after Intravenous and Oral Dosing Source: Antimicrob. Ag. and Chem. 42 (1998) 1815-1818 Description: 2-compartment model
Authors: Mueller, Brigitta U.; Lewis, Linda L.; Yuen, Geoffrey J.; Farley, Maureen; Keller, Amy; Church, Joseph A.; Goldsmith, Jonathan C.; Venzon, David J.; Rubin, Marc; Pizzo, Philip A.; Balis, Frank Title: Serum and Cerebrospinal Fluid Pharmacokinetics of Intravenous and Oral Lamivudine in Human Immunodeficiency Virus-Infected Children Source: Antimicrob. Ag. and Chem. 42 (1998) 3187-3192 Description: 2-compartment model
Authors: Ni, Qing; Xu, Heng; Partilla, John S.; Rice, Kenner C.; Matecka, Dorota; Calderone, Silvia N.; Porreca, Frank; Liu, Josephine; Schmidhammer, Helmut; Krasonig, Roland; Rothman, Richard B. Title: Opioid Peptide Receptor Studies. 9. Identification of a Novel Non-mu-Non-delta-like Opioid Peptide Binding Site in Rat Brain Source: Peptides 19 (1998) 1079-1090 Description: two-parameter logistic and 1- and 2-site binding
Authors: Pfaff, R.T.; Liu, J.; Gao, G.; Peter, A.T.; Li, T.K.; Critser, J.K. Title: Water and DMSO membrane permeability characteristic of in-vivo and in-vitro-derived and culture murine oocytes and embryos Source: Mol. Hum. Reprod. 4 (1998) 51-59
Authors: Rossi, C.; Porcelli, M.; Mocenni, C.; Marchetti, N.; Loiselle, S.; Bastianoni, S. Title: A Modelling Approach for the analysis of xylose-ethanol bioconversion Source: Ecological Modeling 113 (1998) 157-162 Description: Michaelis-Menten, exponential, Odum models
Authors: Rothman, Richard B.; Silverhorne, Mayme L.; Glowa, John R.; Matecka, Dorota; Rice, Kenner C.; Carroll, F. Ivy; Partilla, John S.; Uhl, George R.; Vanderbergh, David J.; Dersch, Christina Title: Studies of the Biogenic Amine Transporters. VII. Characterization of a Novel Cocaine Binding Site Identified with [125-I]RTI-55 in Membranes Prepared from Human, Monkey, and Guinea Pig Caudate Source: Synapse 28 (1998) 322-338 Description: 1- and 2-site binding models
Authors: Saad, M.F.; Riad-Gabriel, M.G.; Khan, A.; Sharma, A.; Michael, R.; Jinagouda, S.D.; Boyadjian, R.; Steil, G.M. Title: Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity Source: J. Clin. Endo. Metab. 83 (1998) 453-459
Authors: Sorgen, P.L.; Bubb, M.R.; McCormick, K.A.; Edison, A.S.; Cain, B.D. Title: Formation of the b Subunit Dimer is Necessary for Interaction with F1-ATPase Source: Biochem. 37 (1998) 923-932 Description: Ultra analytical centrifugation to determine oligomer subunit mass.
Authors: Steil, G.M.; Rebrin, K.; Mittelman, S.D.; Bergman, R.N. Title: Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity Source: Diabetes 47 (1998) 714-720
Authors: Stone, A.L.; Melton, D.J.; Lewis, M.S. Title: Structure-function Relations of Heparin-Mimetic Sulfated Xylan Oligosaccharides: Inhibition of Human Immunodeficiency Virus-1 Infectivity in vitro Source: Glycoconjugate J. 15 (1998) 697-712 Description: Sedimentation data analysis from ultracentrifuge.
Authors: Thomas, J.B.; Fall, M.J.; Cooper, J.B.; Rothman, R.B.; Mascarella, S.W.; Xu, H.; Partilla, J.S.; Dersch, C.M.; McCullogh, K.B.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I. Title: Identification of an Opioid Kappa Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl) piperidine Source: J. Med. Chem. 41 (1998) 5188-5197
Authors: Thomas, J.B.; Mascarella, S.W.; Rothman, R.B.; Partilla, J.S.; Xu, H.; McCullough, K.B.; Dersch, C.M.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I. Title: Investigation of the N-Substituent Conformation Governing Potency and Mu-Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl- 4-(3-hydroxyphenyl)-piperidine Opioid Antagonists Source: J. Med. Chem. 41 (1998) 1980-1990
Authors: Thomas, J.B.; Zheng, X.; Mascarella, S.W.; Rothman, R.B.; Dersch, C.M.; Partilla, J.S.; Flippen-Anderson, J.L.; George, C.F.; Cantrell, B.E.; Zimmerman, D.M.; Carroll, F.I. Title: N-Substituted 9 Beta-Methyl-5-(3-hydroxyphenyl) Morphans Are Opioid Receptor Pure Antagonists Source: J. Med. Chem. 41 (1998) 4143-4149
Authors: Torrents, A.; Anderson, B.G.; Hapeman, C.J. Title: Kinetics of Bromacil Ozonolysis Source: J. Agric. Food Chem. 46 (1998) 1630-1636
Authors: Troispoux, Carine; Reiter, Eric; Combarnous, Yves; Guillon, Florian Title: Beta-2 adrenergic receptors mediate cAMP, tissue-type plasminogen activator and transferin production in rat Sertoli cells Source: Mol. Cell. Endoc. 142 (1998) 75-86 Description: Scatchard analysis programmed with MLAB by M. McNamara (Liege, Be)
Authors: Urbani, A.; Bazzo, R.; Nardi, M.C.; Cicero, D.O.; DeFrancesco, R.; Steinkuler, C.; Barbato, G. Title: The metal binding site of the hepatitis C virus NS3 Protease: A spectroscopic investigation Source: J. Biol. Chem. 273 (1998) 18760-18769
Authors: Watanabe, Richard M.; Steil, Garry M.; Bergman, Richard N. Title: Critical Evaluation of the Combined Model Approach for Estimation of Prehepatic Insulin Secretion Source: Am. J. Physiol. Endo. Metab. 274 (1998) E172-E183
Authors: Xu, Heng; Lu, Yi-Feng; Partilla, John S.; Pinto, Julia; Calderone, Sylvia N.; Matecka, Dorota; Rice, Kenner C.; Lai, Josephine; Porreca, Frank; Ananthan, Subramaniam; Rothman, Richard B. Title: Optioid Peptide Receptor Studies. 8. One of the Mouse Brain delta-NCX Binding Sites is Similar to the Cloned Mouse Opioid delta Receptor Source: Peptides 19 (1998) 343-350 Description: 1- and 2-site binding models, 2 parameter logistic equation
Authors: Yao, Shao; Ghosh, Indraneel Title: A Self-Replicating Peptide under Ionic Control Source: Angew. Chem. Intl. 37 (1998) 478-481 Description: values of dissociation rate constants fit from denaturation data in 2-state model for monomer-tetramer transition,
Authors: Ader, M.; Ni, T.C.; Bergman, R.N. Title: Glucose Effectiveness Associated under Dynamic and Steady State Conditions; Compatibility of Uptake versus Production Components Source: J. Clin. Inv. 99 (1997) 1187-1199
Authors: Altieri, A.S.; Mazzulla, M.J.; Zhou, H.; Costantino, N.; Court, D.L.; Byrd, R.A.> Title: Sequential assignments and secondary structure of the RNA-binding transcriptional regulator Nus B Source: FEBS Lett. 415 (1997) 221-226
Authors: Bakker, B.M.; Michels, P.A.M.; Opperdoes, F.R.; Westerhoff, H.V. Title: Glycolysis in Bloodstream from Trypanosoma brucei can be Understood in Terms of the Glycolytic Enzymes Source: J. Biol. Chem. 272 (1997) 3207-3215 Description: Michaelis-Menten kinetics simulations with MLAB.
Authors: Bhat, M.K.; McPhie, P.; Chang, S Title: Critical Role of Glutamine 252 in the Hormone-Dependent Transcriptional Activity of the Thyroid Hormone Beta-1 Nuclear Receptor Source: Biochem. 36 (1997) 4233-4239
Authors: Calderone, S.N.; Rice, K.C.; Rothman, R.B.; Porreca, F.; Flippen-Anderson, J.L.; Kayakiri, H.; Xu, H.; Becketts, K.; Smith, L.E.; Bilsky, E.J.; Davis, P.; Horvath, R. Title: Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Receptor Binding, and Bioassay of the Highly Selective Delta-Agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl- 2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamid (SNC 80) and Related Novel Nonpeptide Delta-Opioid Receptor Ligands Source: J. Med. Chem. 40 (1997) 695-704
Authors: Cohen, David M.; Bergman, Richard N. Title: Improved Estimation of Anaplerosis in Heart Using 13C NMR Source: Am. J. Physiol. Endo. Metab. 273 (1997) E1228-E1242 Description: MLAB ode script for 180 diff eqs, but did not use.
Authors: Cowan, A.E.; Nakhimovsky, L.; Myles, D.G.; Koppel, D.E. Title: Barriers to diffusion of plasma membrane proteins form early during guinea pig spermiogenesis Source: Biophys. J. 73 (1997) 507-516
Authors: Dimitriadis, E.K.; Lewis, M.S. Title: Non-linear Curve-fitting Methods for Data from the XL-A Analytical Centrifuge Source: Prog. in Colloid & Polymer Sci. 107 (1997) 20-26
Authors: Frisbie, S.M.; Chalovich, J.M.; Brenner, B.; Yu, L.C. Title: Modulation of cross-bridge affinity for MgGTP by Ca2+ in skinned fibers of rabbit psoas muscle Source: Biophys. J. 72 (1997) 2255-61
Authors: Froehlich, Jeffrey P.; Taniguchi, Kazuya; Fendler, Klaus; Mchaney, James E.; Thomas, David D.; Albers, R. Wayne Title: Complex Kinetic Behavior in the Na, K, and Ca-ATPases Source: Ann. NY Acad. 834 (1997) 280-296 Description: kinetics of catalysis
Authors: Gastaldelli, Amalia; Schwartz, Jean-Marc; Caveggion, Elisabetta; Traber, Lillian D.; Traber, Daniel L.; Rosenblatt, Judah; Toffolo, Giana; Cobelli, Claudio; Wolfe, Robert R. Title: Glucose Kinetics in Interstitial Fluid Can Be Predicted by Compartmental Modeling Source: Am. J. Physiol. 272 (1997) E494-E505 Description: model concentration of tracer in time
Authors: Grem, J.L.; McAtee, N.; Murphy, R.F.; Balis, F.M.; Cullen, E.; Chen, A.P.; Hamilton, J.M.; Steinberg, S.M.; Quinn, M.; Sorensen, J.M.; Arbuck, S.G.; Lawrence, D.; Pang, J.; Allegra, C.J. Title: A pilot study of gamma-1b-interferon in combination with fluorouracil, leucovorin, and alpha-2a-interferon Source: Clin. Canc. Res. 3 (1997) 1125-1134
Authors: Hartung, K.; Froehlich, J.P.; Fendler, K. Title: Time-resolved charge translocation by the Ca-ATPase from sarcoplasmic reticulum after an ATP concentration jump Source: Biophys. J. 72 (1997) 2503-2514
Authors: Hegedus, Lajos; Ford, Harry, Jr.; Hartman, Neil R.; Kelley, James A. Title: Reverse-Phase High-Performance Liquid Chromatographic Determination of the New Antitumor Agent Cyclopentyl Cytosine in Biological Fluids Source: J. Chrom. B 692 (1997) 169-179 Description: biexponential, 2 compartment open model, weighted least squares fit, area under curve-trapezoidal rule.
Authors: Herd, A.Y.; Milligan, R.G. Title: The Institute of Medical Illustrators and Glasgow Caledonian University BSc in Medical Illustration Assessment System Source: J. Vis. Comm. Med. 20 (1997) 108-113
Authors: Ibarra-Molero, S.; Sanchez-Ruiz, J.M. Title: Are There Equilibrium Intermediate States in the Urea-Induced Unfolding of Hen Egg-White Lysozyme Source: Biochem. 36 (1997) 9616-9624
Authors: Javadpour, Maryam; Barkley, Mary D. Title: Self-Assembly of Designed Antimicrobial Peptides in Solution and Micelles Source: Biochem. 36 (1997) 9540-9549 Description: concentration distributions were fit to various mathematical models.
Authors: Kabymela, Bernard M.; Adschiri, Todafumi; Malaluan, Roberto; Arai, Kunio Title: Degradation Kinetics of Dihydroxyacetone and Glyceraldehyde in Subcritical and Supercritical Water Source: Ind. Eng. Res. 36 (1997) 2025-2030
Authors: Katsura, Y.; Zhang, X.; Homma, K.; Rice, K.C.; Calderon, S.N.; Rothman, R.B.; Yamamura, H.Z.; Davis, P.; Flippen-Anderson, J.L.; Xu, H.; Becketts, K.; Foltz, E.J.; Porreca, F. Title: Probes for Narcotic Receptor-Mediated Phenomena. 25. Synthesis and Evaluation of N-Alkyl-Substituted (alpha-Piperazinylbenzyl) benzamides as Novel, Highly Selective Delta-Opioid Receptor Agonists Source: J. Med. Chem. 40 (1997) 2936-2947
Authors: Kitchen, B.J.; Balis, F.M.; Poplack, D.G.; O'Brien, M.; Craig, C.E.; Adamson, P.C. Title: A pediatric phase I trial and pharmacokinetic study of thioguanine administered by continous i.v. infusion Source: Clin. Canc. Res. 3 (1997) 713-717
Authors: Kleinfeld, A.M.; Chu, P.; Romero, C. Title: Transport of Long-Chain Native Fatty Acids across Lipid Bilayer Membranes Indicates that Transbilayer Flip-flop is Rate Limiting Source: Biochem. 36 (1997) 14146-14158
Authors: Kleinfeld, A.M.; Chu, P.; Storch, J. Title: Flip-flop is Slow and Rate Limiting for the Movement of Long Chain Anthroyloxy Fatty Acids across Lipid Vesicles Source: Biochem. 36 (1997) 5702-5711
Authors: Lear, James D.; Schneider, J.P.; Kienker, P.K.; DeGrado, W.F. Title: Electrostatic Effects on Ion Selectivity and Rectification in Designed Ion Channel Peptides Source: JACS 119 (1997) 3212-3217 Description: equation fit with MLAB to ion-channel measurement data.
Authors: Lee, S.P.; Xiao, J.; Knudson, J.R.; Lewis, M.S.; Han, M.K. Title: Zn 2+ Promotes the Self-Association of Human Immunodeficiency Virus Type-1 Integrase in Vitro Source: Biochem. 36 (1997) 173-180
Authors: Lin, K-H; Zhu, X-G; Hsu, H-C; Chen, S-L; Shieh, H-Y; Chen, S-T; McPhie, P.; Cheng, S-Y Title: Dominant negative activity of mutant thyroid hormone alpha-1 receptors from patients with hepatocellular carcinoma Source: Endocrin. 138 (1997) 5308-5315
Authors: Liu, Jun; Zieger, Michael A.J.; Lakey, Jonathan RT; Woods, Erik J.; Critser, John K. Title: The Determination of Membrane Permeability Coefficients of Canine Pancreatic Islet Cells and Their Application to Islet Cryopreservation Source: Cryobiol. 35 (1997) 1-13 Description: gear method in MLAB for Boyle van't Hoff plots.
Authors: Marshall, A. David; Darbyshire, John F.; Hunter, Ann P.; McPhie, Peter; Jakoby, William B. Title: Control of Activity through Oxidative Modification at the Conserved Residue Cys-66 of Aryl Sulfotransferase IV Source: J. Biol. Chem. 272 (1997) 9153-9160 Description: Scatchard equation.
Authors: Matecka, Dorota; Lewis, David; Rothman, Richard B.; Dersch, Christina M.; Wojnicki, Francis H.E.; Glowa, John R.; DeVries, A. Courtney; Pert, Agu; Rice, Kenner C. Title: Heteroaromatic Analogs of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-Phenylpropyl) Piperazines (GBR 12935 and GBR 12909) as High-Affinity Dopamine Reuptake Inhibitors Source: J. Med. Chem. 40 (1997) 705-716 Description: PCMLAB, fit 2 parameter logistic to obtain IC50 and slope factor.
Authors: Mittelman, S.D.; Fu, Y.Y.; Rebrin, K.; Steil, G.; Bergman, R.N. Title: Indirect Effect of Insulin to Suppress Endogenous Glucose Production Is Dominant, Even with Hyperglucagonemia Source: J. Clin. Inv. 100 (1997) 3121-3130
Authors: Mozley, P.D.; Sadek, A.M.; Alavi, A.; Gurt, R.C.; Muenz, L.R.; Bunow, B.J.; Kim, H.J.; Stecker, M.H.; Jolles, P.; Newberg, A. Title: Effects of aging on the cerebral distribution of technetium-99m hexamethylpropylene amine oxime in healthy humans Source: Eur. J. Nuc. Med. 24 (1997) 754-761
Authors: Ni, T.C.; Ader, M.; Bergman, R.N. Title: Reassessment of Glucose Effectiveness and Insulin Sensitivity from Minimal Model Analysis: A Theoretical Evaluation of the Single-Compartment Glucose Distribution Assumption Source: Diabetes 46 (1997) 1813-1821
Authors: Noureddini, H.; Zhu, D. Title: Kinetics of transesterification of soybean oil Source: JAOCS 74 (1997) 1457-1463
Authors: Paalman, S.P.; Sung, C.; Clarke, N.D. Title: Specificity of DNA Repair Methyltransferases Determined by Competitive Inactivation with Oligonucleotide Substrates: Evidence that Escherichia coli Ada Repairs O-6-Methylguanine and O-4-Methyl thymine with Similar Efficiency Source: Biochem. 36 (1997) 11118-1124
Authors: Piantadosi, S. Title: Clinical Trials-A Methodologic Perspective Source: book published by John Wiley & Sons, NY (1997) Description: uses MLAB for pharmacokinetic models and briefly discusses the software.
Authors: Saad, M.F.; Steil, G.M.; Kades, W.W.; Ayad, M.F.; Elsewaty, W.A.; Boyadjian, R.; Jinagouda, S.D.; Bergman, R.N. Title: Differences Between the Tolbutamide-Boosted and the Insulin-Modified Minimal Model Protocols Source: Diabetes 46 (1997) 1167-1171
Authors: Sakaguchi, K.; Sakamoto, H.; Lewis, M.S.; Anderson, C.W.; Erickson, J.W.; Appella, E.; Xie, D. Title: Phosphorylation of Serine 392 Stabilizes the Tetramer Formation of Tumor Supressor Protein p53 Source: Biochem. 36 (1997) 10117-10124
Authors: Schneider, J.P.; Lear, J.D.; DeGrado, W.F. Title: A Designed Buried Salt Bridge in a Hetero-dimeric Coiled-coil Source: JACS 119 (1997) 5742-5743
Authors: Seok, Y.J.; Sondej, M.; Badawi, P.; Lewis, M.S.; Briggs, M.C.; Jaffe, H.; Peterkofsky, A. Title: High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylate by the histidine phosphocarrier protein, HPr Source: J. Biol. Chem. 272 (1997) 26511-26521
Authors: Spivak, C.E.; Beglan, C.L.; Seidleck, B.K.; Hirshbein, L.D.; Blaschak, C.J.; Uhl, G.R.; Surratt, C.K. Title: Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity Source: Mol. Pharm. 52 (1997) 983-992
Authors: Stern, M.D.; Pizarro, G.; Rios, E. Title: Local control model of excitation-contraction coupling in skeletal muscle Source: J. Gen. Physiol. 110 (1997) 415-440
Authors: Terry, David R.; Spector, Ilan; Higa, Tatsuo; Bubb, Michael R. Title: Misakinolide A is a Marine Macrolide That Caps but Does Not Sever Filamentous Actin Source: J. Biol. Chem. 272 (1997) 7841-7845 Description: estimate Kd of the interaction between misakinolide A and actin.
Authors: Yoshigi, Masaaki; Keller, Bradley B. Title: Characterization of Embryonic Aortic Impedance with Lumped Parameter Models Source: Am. J. Physiol. 273 (1997) H19-H27 Description: Windkessel ode circuit models
Authors: Zhu, X.G.; McPhie, P.; Lin, K.H.; Cheng, S.Y. Title: The differential hormone-dependent transcriptional activation of thyroid hormone receptor isoforms is mediated by interplay of their domains Source: J. Biol. Chem. 272 (1997) 9048-9054
Authors: Ahmed, A.S.; McPhie, P.; Miles, E.W. Title: Mechanism of activation of the tryptophan synthase alpha-2 beta-2 complex: solvent effects of the co-substrate beta-mercaptoethanol Source: J. Biol. Chem. 271 (1996) 29100-29106
Authors: Ahmed, S.A.; McPhie, P.; Miles, E.W. Title: A Thermally Induced Reversible Conformational Transition of the Tryptophan Synthase Beta-2 Subunit Probe by the Spectroscopic Properties of Pyridoxal Phosphate and by Enzymatic Activity Source: J. Biol. Chem. 271 (1996) 8612-8617 Description: MLAB fit parameters in Arrhenius equation.
Authors: Bastiononi, Simone; Donati, Alessandro; Gastaldelli, Amalia; Marchettini, Nadia; Renzoni, Debora; Rossi, Claudio Title: Modeling Interpretation of Microbe Metabolism Detected by Nuclear Magnetic Resonance Source: Biochem. Biophys. Res. Comm. 227 (1996) 53-58 Description: differential equation model
Authors: Bastiononi, Simone; Gastaldelli, Amalia; Bonechi, Claudia; Mocenni, Chiarra; Rossi, Claudio Title: Kinetic Analysis and Comparison of Models of Xylose Metabolism by Klebsiella planticola Source: Biochem. Biophys. Res. Comm. 227 (1996) 41-46 Description: Michaelis-Menten and ode kinetics models.
Authors: Bertha, C.M.; Ellis, M.; Flippen-Anderson, J.L.; Porreca, F.; Rothman, R.B.; Davis, P.; Xu, H.; Becketts, K.; Rice, K.C. Title: Probes for Narcotic Receptor-Mediated Phenomena. 21. Novel Derivatives of 3-(1,2,3,4,5,11-Hexahydro-3-methyl-2, 6-methano-6J-azocino[4,5-b] indol-6-yl)-phenols with Improved Delta-Opioid Receptor Selectivity Source: J. Med. Chem. 39 (1996) 2081-2086
Authors: Bier, M.; Teusink, B.; Kholodenko, B.N.; Westerhoff, H.V. Title: Control of analysis of glycolytic oscillations Source: Biophys. Chem. 62 (1996) 15-24
Authors: Boice, Judith A.; Dieckmann, Gregg R.; DeGrado, William F.; Fairman, Robert Title: Thermodynamic Analysis of a Designed Three-Stranded Coiled Coil Source: Biochem. 35 (1996) 14480-14485 Description: PCMLAB, global fits of thermal unfolding data.
Authors: Boice, Judith A.; Fairman, Robert Title: Structural Characterization of the Tumor Supressor p16, an Ankyrin-Like Repeat Protein Source: Protein Sci. 5 (1996) 1776-1784 Description: circular dichroism signal at 222nm recorded at 25 degrees C for 500 seconds. data fit applying specialized algorithm. sedimentation equilibrium equation not fit with MLAB.
Authors: Brenner, B.; Xu, S.; Chalovich, J.M.; Yu, L.C. Title: Radial equilibrium lengths of actomyosin cross-bridges in muscle Source: Biophys. J. 71 (1996) 2751-2758
Authors: Chattoraj, D.K.; Ghirlando, R.; Park, K.; Dibbens, J.A.; Lewis, M.S. Title: Dissociation Kinetics of RepA Dimers: Implications for Mechanisms of Activation of DNA Binding by Chaperones Source: Genes to Cells 1 (1996) 189-199
Authors: Chinkes, D.L.; Aarsland, A.; Rosenblatt, J.; Wolfe, R.R. Title: Comparison of mass isotopomer dilution methods used to compute VLDL production in vivo Source: Am. J. Physiol. Endo. Metab. 271 (1996) E373-E383
Authors: Goodman, Carl B.; Emilien, Betsey; Becketts, Karen; Cadet, Jean L.; Rothman, Richard B. Title: Downregulation of Mu-Opioid Binding Sites Following Chronic Administration of Neuropeptide FF (NPFF) and Morphine Source: Peptides 17 (1996) 389-397 Description: PCMLAB, 1-site binding model
Authors: Hendler, R.W.; Mukhopadhyay, A.K.; Smith, P.D.; Cascio, H.E. Title: A monitoring system for energy transduction by bacteriorhodopsin liposomes Source: J. Biochem. Biophys. Meth. 33 (1996) 89-104
Authors: Hollingsworth, S.; Zhao, Mingdi; Baylor, S.M. Title: The Amplitude and Time Course of the Myoplasmic Free [Ca+2] Transient in Fast-Switch Fibers of Mouse Muscle Source: J. Gen. Physiol. 108 (1996) 455-469
Authors: Ibarra-Molero, B.; Sanchez-Ruiz, J.M. Title: A model-independent nonlinear extrapolation procedure for the characterization of protein folding energetics from solvent-denaturation data Source: Biochem. 35 (1996) 14689-14702
Authors: Jarnik, Michal; Kartasova, Tonja; Steinert, Peter M.; Lichti, Ulrike; Steven, Alasdair C. Title: Differential Expression and Cell Envelope Incorporation of Small Proline-Rich Protein 1 in Different Cornified Epithelia Source: J. Cell Sci. 109 (1996) 1381-1391
Authors: Jin, H.; Emanuele, J.J.; Fairman, R.; Roberson, J.G.; Hail, M.E.; Ho, H.T.; Falk, P.J.; Villafranca, J.J. Title: Structural Studies of Escherichia coli UDP-N-Acetylmuramate: L-Alanine Ligase Source: Biochem. 35 (1996) 1423-1431
Authors: Junghans, R.P.; Stone, A.L.; Lewis, M.S. Title: Biophysical Characterization of a Recombinant Soluble Interleukin 2 Receptor (Tac) Source: J. Biol. Chem. 271 (1996) 10453-10460 Description: ultracentrifuge sedimentation experimental data fit to model.
Authors: Kim, J.K.; Wi, J.K.; Youn, J.H. Title: Plasma Free Fatty Acids Decrease Insulin-Stimulated Skeletal Muscle Glucose Uptake by Suppressing Glycolysis in Conscious Rats Source: Diabetes 45 (1996) 446-453
Authors: Kong, Siow-Kee; Yim, Moon Bin; Stadtman, Earl R.; Chock, P. Boon Title: Peroxynitrite Disables the Tyrosine Phosphorylation Regulatory Mechanism: Lymphocyte-specific Tyrosine Kinase Fails to Phosphorylate Nitrated cdc2(6-20) NH2 Peptide Source: PNAS 93 (1996) 3377-3382 Description: PCMLAB, integrated differential equations describing reaction scheme.
Authors: Lutgring, R.; Lipton, M.; Chmielewski, J. Title: Differential self assembly of amphiphilic helical peptides Source: Amino Acids 10 (1996) 295-304
Authors: Matecka, Dorota; Rothman, Richard B.; Redesca, Lilian; de Costa, Brian R.; Dersch, Christina M.; Partilla, John S.; Pert, Agu; Glowa, John R.; Wojnicki, Francis H.E.; Rice, Kenner C. Title: Development of Novel, Potent, and Selective Dopamine Reuptake Inhibitors through Alteration of the Piperazine Ring of [1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-Fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl) Piperazines (GBR 12935 and GBR 12909) Source: J. Med. Chem. 39 (1996) 4704-4716 Description: PCMLAB, fit 2 parameter logistic to find IC50 and slope factor.
Authors: Omelyanenko, V.; Kopeckova, P.; Gentry, C.; Shiah, J.G.; Kopecek, J. Title: HPMA Copolymer-Anticancer Drug-OV-TL16 Antibody Conjugates; I. Influence of the Method of Synthesis on the Binding Affinity to OVCAR-3 Ovarian Carcinoma Cells in Vitro Source: J. Drug Targeting 3 (1996) 357-373
Authors: Rebrin, K.; Steil, G.M.; Mittelman, S.D.; Bergman, R.N. Title: Causal Linkage between Insulin Suppression of Lipolysis and Supression of Liver Glucose Output in Dogs Source: J. Clin. Inv. 98 (1996) 741-749
Authors: Richieri, Gary V.; Ogata, Ronald T.; Kleinfeld, Alan M. Title: Kinetics of Fatty Acid Interactions with Fatty Acid Binding Proteins from Adipocyte, Heart, and Intestine Source: J. Biol. Chem. 271 (1996) 11291-11300 Description: MLAB fit of rate constants in kinetic rate odes, verified fit solution with Macsyma.
Authors: Richieri, Gary V.; Ogata, Ronald T.; Kleinfeld, Alan M. Title: Thermodynamics and Kinetic Properties of Fatty Acid Interactions with Rat Liver Fatty Acid Binding Protein Source: J. Biol. Chem. 271 (1996) 31068-31074 Description: MLAB fit of rate constants in kinetic rate odes.
Authors: Sackett, D.L.; Kosk-Kosicka, D. Title: The active species of plasma membrane Ca2+-ATPase are a dimer and a monomer-calmodulin complex Source: J. Biol. Chem. 271 (1996) 9987-9991
Authors: Schuck, Peter; Minton, Allen P. Title: Analysis of Mass Transport-Limited Binding Kinetics in Evanescent Wave Biosensors Source: Anal. Biochem. 240 (1996) 262-272 Description: 2 compartment model and ode model fit with MLAB.
Authors: Steil, G.M.; Ader, M.; Moore, D.M.; Rebrin, K.; Bergman, R.N. Title: Transendothelial Insulin Transport Is Not Saturable In Vivo Source: J. Clin. Inv. 97 (1996) 1497-1503
Authors: Steil, G.M.; Richey, J.; Kim, J.K.; Wi, J.K.; Rebrin, K.; Bergman, R.N.; Youn, J.H. Title: Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics Source: Am. J. Physiol. Endo. Metab. 271 (1996) E855-E864
Authors: Vasandani, V.M.; Wu, Y-N; Mikulski, S.M.; Youle, R.J.; Sung, C. Title: Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily Source: Canc. Res. 56 (1996) 4180-4186
Authors: Veeranna; Shelty, K.T.; Amin, N.; Grant, P.; Albers, R.W.; Pant, H.C. Title: Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by munc-18 Source: Neurochem. Res. 21 (1996) 629-636
Authors: Wexler, Leonard H.; Andrich, Mary P.; Venzon, David; Berg, Stacey L.; Weaver-McClure, Linda; Chan, Clara C.; Dilsizian, Vasken; Avila, Nilo; Jarosinski, Paul; Balis, Frank M.; Poplack, David G.; Horowitz, Marc E. Title: Randomized Trial of the Cardioprotective Agent ICRF-187 in Pediatric Sarcoma Patients with Doxorubicin Source: J. Clin. Oncol. 14 (1996) 362-372 Description: plasma concentration fit to mono, biexponential models.
Authors: Wolfe, R.R.; Chinkes, D.; Baba, H.; Rosenblatt, J.; Zhang, X.J. Title: Response of phosphoenolpyruvate cycle activity to fasting and to hyperinsulemia in human subjects Source: Am. J. Physiol. Endo. Metab. 271 (1996) E159-E176
Authors: Zhang, X.J.; Chinkes, D.L.; Sakurai, Y.; Wolfe, R.R. Title: An isotopic method for measurement of muscle protein fractional breakdown rate in vivo Source: Am. J. Physiol. Endo. Metab. 270 (1996) E759-E767
Authors: Zhao, Mingdi; Hollingsworth, S.; Baylor, S.M. Title: Properties of Tri- and Tetracarboxylate Ca+2 Indicators in Frog Skeletal Muscle Fibers Source: Biophys. J. 70 (1996) 896-916 Description: MLAB for figures and data analysis.
Authors: Ahmed, S.A.; McPhie, P.; Miles, E.W. Title: Subunit Assembly in the Tryptophan Synthase Alpha-2 Beta-2 Complex Source: J. Biol. Chem. 270 (1995) 7944-7949 Description: MLAB fit 3 binding models.
Authors: Banik, Utpal; Zhu, De-Min; Chock, P. Boon; Miles, Edith Wilson Title: The Tryptophan Synthase Alpha2 Beta2 Complex: Kinetic Studies with a Mutant Enzyme (Beta K87T) to Provide Evidence for Allosteric Activation by an Aminoacrylate Intermediate Source: Biochem. 34 (1995) 12704-12711 Description: solving odes for reaction scheme using Adams-Gear method. Also used Enzyme Kinetics program from Trinity Software and Cricket Graph III from Computer Associates.
Authors: Berg, Stacey L.; Gerson, Stanton L.; Godwin, Karen; Cole, Diane E.; Liu, Lili; Balis, Frank M. Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of O6-Benzyl-Guanine and Time Course of Peripheral Blood Mononuclear Cell O6-Methylguanine-DNA Methyltransferase Inhibition in the Nonhuman Primate Source: Canc. Res. 55 (1995) 4606-4610 Description: compartmental model, first order kinetics
Authors: Berg, Stacey L.; Tolcher, Anthony; O'Shaughnessy, Joyce A.; Denicoff, Andrea M.; Noone, Marianne; Ognibene, Frederick P.; Cowan, Kenneth H. Title: Effect of R-verapamil on the Pharmacokinetics of Paclitaxel in Women with Breast Cancer Source: J. Clin. Oncol. 13 (1995) 2039-2042 Description: 2 compartment open model, fit ordinary differential rate equations, determined half lives and rate constants, computed area under curve.
Authors: Bertha, C.M.; Flippen-Anderson, J.L.; Rothman, R.B.; Porreca, F.; Davis, P.; Xu, H.; Becketts, K.; Cha, X.Y.; Rice, K.C. Title: Probes for Narcotic Receptor-Mediated Phenomena. 20. Alteration of Opioid Receptor Subtype Selectivity of the 5-(3-Hydroxyphenyl) Morphans by Application of the Message-Address Concept: Preparation of Delta-Opioid Receptor Ligands Source: J. Med. Chem. 38 (1995) 1523-1537
Authors: Bertha, C.M.; Vilner, B.J.; Mattson, M.V.; Bowen, W.D.; Becketts, K.; Xu, H.; Rothman, R.B.; Flippen-Anderson, J.L.; Rice, K.C. Title: (E)-8-Benzylidene Derivatives of 2-Methyl-5-(3-hydroxyphenyl) morphans: Highly Selective Ligands for the Sigma-2 Receptor Subtype Source: J. Med. Chem. 38 (1995) 4776-4785
Authors: Bhat, M.K.; McPhie, P.; Ting, Y-T; Zhu, X-G; Chang, S-Y Title: Structure of the Carboxy-Terminal Region of Thyroid Hormone Nuclear Receptors and Its Possible Role in Hormone- Dependent Intermolecular Interactions Source: Biochem. 34 (1995) 10591-10599 Description: ligand binding.
Authors: Bishop, P.; Ghosh, I.; Jones, C.; Chmielewski, J. Title: Basic-Helix-Loop-Helix Region o Tal: Evaluation of Structure and DNA Affinity Source: JACS 117 (1995) 8283-8284
Authors: Blaney, Susan M.; Cole, Dianne E.; Godwin, Karen; Sung, Cynthia; Poplack, David G.; Balis, Frank M. Title: Intrathecal Administration of Topotecan in Nonhuman Primates Source: Canc. Chem. Pharm. 36 (1995) 121-124 Description: half lives of the lactone and total drug estimated by nonlinear least squares analysis.
Authors: Blaney, Susan M.; Daniel, Michael J.; Harker, Andrew J.; Godwin, Karen; Balis, Frank M. Title: Pharmacokinetics of Lamivudine and BCH-189 in Plasma and Cerebrospinal Fluid of Nonhuman Primates Source: Antimicrob. Ag. and Chem. 39 (1995) 2779-2782 Description: plasma concentration time data fit to differential equation model.
Authors: Brine, George A.; Stark, Peter A., Liu, Young; Carroll, F. Ivy; Singh, P.; Xu, Heng; Rothman, Richard B. Title: Enantiomers of Diastereomeric cis-N-[1-(2-Hydroxy- 2-phenylethyl)-3-methyl-4-piperidyl]-N-phenylpropanimides: Synthesis, X-ray Analysis, and Biological Activities Source: J. Med. Chem. 38 (1995) 1547-1557 Description: 2 parameter logistic, IC50, Hill slope
Authors: Bubb, Michael R.; Korn, Edward D. Title: Kinetic Model for the Inhibition of Actin Polymerization by Actobindin Source: Biochem. 34 (1995) 3921-3926 Description: differential equations for kinetic rate equations, fit constants.
Authors: Bucher, W.E.; Currao, A.; Nesper, R.; Ruegger, H.; Venanzi, L.M.; Younger, E. Title: K2-K3 Isomerism in Rhodium (l) Tris (pyrazolyl) borate Complexes of the Type Tp3R,4R,5RRh(LL) (LL-2CO,COD, and NBD) and Their Dynamic Behavior in Solution. X-Ray Crystal Structure of TpMeRh (NBD) Source: Inorg. Chem. 34 (1995) 66-74
Authors: Cha, Xian Yuan; Xu, Heng; Rice, Kenner C.; Porreca, Frank; Lai, Josephine; Aranthan, Subramaniam; Rothman, Richard B. Title: Opioid Peptide Receptor Studies. 1. Identification of a Novel Delta-Opioid Receptor Binding Site in Rat Brain Membranes Source: Peptides 16 (1995) 191-198 Description: one site binding model.
Authors: Chalovich, J.M.; Chen, Y-D; Dudek, R.; Luo, H. Title: Kinetics of binding of caldesmon to actin Source: J. Biol. Chem. 270 (1995) 9911-9916
Authors: Coffey, R.L.; Purich, D.L. Title: Non-cooperative binding of the MAP-2 microtubule-binding region to microtubules Source: J. Biol. Chem. 270 (1995) 1035-1040
Authors: Cohen, David M.; Bergman, Richard N. Title: Estimation of TCA Cycle Flux, Aminotransferase Flux, and Anaplerosis in Heart: Validation With Syntactic Model Source: Am. J. Physiol. 268 (1995) E397-E409 Description: fit sum of exponentials to graphs of enrichment of C-2 and C04 vs. time.
Authors: Emmert-Buck, Michael R.; Emonard, Herve P.; Corcoran, Marta L.; Krutzsch, Henry C.; Foidart, Jean-Michel; Statler-Stevenson, William G. Title: Cell Surface Binding of TIMP-2 and pro-MMP-2/TIMP-2 Complex Source: FEBS Lett. 364 (1995) 28-32 Description: analysis of binding data.
Authors: Fairman, Robert; Chao, Hann-Guang; Mueller, Luciano; Lavoie, Thomas B.; Shen, Liyang; Novotny, Jiri; Matsueda, Gary R. Title: Characterization of a New Four-Chain Coiled Coil: Influence of Chain Length on Stability Source: Protein Sci. 4 (1995) 1457-1469 Description: PCMLAB, peptide concentration dependent data and GuCl denatured data fit to sum of first and fourth powers of concentration of monomer.
Authors: Greco, W.R.; Bravo, G.; Parsons, J.C. Title: The search for synergy: a critical review from a response surface perspective Source: Pharmacol. Rev. 47 (1995) 331-385
Authors: Hawkins, Mary E.; Mitsuya, Hiroaki; McCully, Cynthia M.; Godwin, Karen S.; Murakami, Kunichika; Poplack, David G.; Balis, Frank M. Title: Pharmacokinetics of Dideoxypurine Nucleoside Analogs in Plasma and Cerebrospinal Fluid of Rhesus Monkeys Source: Antimicrob. Ag. and Chem. 39 (1995) 1259-1268 Description: comparmental models for CSF and plasma concentration in time, area under curve, Mann-Whitney test.
Authors: Igout, A.; Frankenne, F.; L'Hermite-Baleriaux, M.; Martin, A.; Hennen, G. Title: Somatogenic and Lactogenic Activity of the Recombinant 22 kDa Isoform of Human Placental Growth Hormone Source: Growth Reg. 5 (1995) 60-65 Description: scatchard analysis.
Authors: Kienker, P.K.; Lear, J.D. Title: Charge selectivity of the designed uncharged peptide ion channel Ac-(LSSLLSL)3-CONH2 Source: Biophys. J. 68 (1995) 1347-1358
Authors: Koga, M.; Wilk, A.; Moore, M.F.; Seremin, C.L.; Zhou, L.; Beaucage, S.L. Title: Synthesis and Physicochemical Properties of Alternating alpha beta-oligodeoxyribonucleotides with Alternating (3->3) and (5->5) Internucleotidic Phosphodiester Linkages Source: J. Org. Chem. 60 (1995) 1520-1530
Authors: Lu, F.W.M.; Freedman, M.V.; Chalovich, J.M. Title: Characterization of Calponin Binding to Actin Source: Biochem. 34 (1995) 11864-11871
Authors: Mahaney, James E.; Froehlich, Jeffrey P.; Thomas, David D. Title: Conformational Transitions of the Sarcoplasmic Reticulum Ca-ATPase Studied by Time-Resolved EPR and Quenched-Flow Kinetics Source: Biochem. 34 (1995) 4864-4879 Description: pre-steady state behavior of phosphorylation reaction modeled using mono- and bi-exponential functions.
Authors: Ni, Q.; Xu, H.; Partilla, J.S.; Calderon, S.N.; Porreca, F.; Rice, K.C.; Bertha, C.M.; McNutt, R.W.; Ananthan, S.; Rothman, R.B. Title: Opioid Peptide Receptor Studies. 2. [3-H]SNC-121, A Novel, Selective, and High Affinity Ligand for Opioid Delta Receptors Source: Analgesia 1 (1995) 185-193 Description: not found in print or on web.
Authors: Ni, Qing; Xu, Heng; Partilla, John S.; de Costa, Brian; Rice, Kenner C.; Kayakiri, Hiroshi; Rothman, Richard B. Title: Opioid Peptide Receptor Studies. 3. Interaction of Opioid Peptides and Other Drugs With Four Subtypes of the Kappa-2 Receptor in Guinea Pig Brain Source: Peptides 16 (1995) 1083-1095 Description: PCMLAB, binding surfaces fit to various models.
Authors: Piantadosi, Steven; Crowley, John Title: An Implicitly Defined Parametric Model for Censored Survival Data and Covariates Source: Biometrics 51 (1995) 249-258 Description: analytic derivatives, root finding, and graphics
Authors: Rebrin, Kerstin; Steil, Garry M.; Getty, Lisa; Bergman, Richard N. Title: Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin Source: Diabetes 44 (1995) 1038-1045 Description: paired t-tests and regression lines were calculated with PCMLAB.
Authors: Reiter, Eric; McNamara, Michael; Closset, Jean; Hennen, Georges Title: Expression and Functionality of Luteinizing Hormone/Chronic Gonadotropin Receptor in the Rat Prostate Source: Endocrin. 136 (1995) 917-923 Description: 2 Scatchard models: single site of high affinity and low capacity, single site with additional nonsaturable component
Authors: Rothman, Richard B.; Silverthorn, Mayme L.; Baumann, Michael H.; Goodman, Carl B.; Cadet, Jean L.; Matecka, Dorota; Rice, Kenner C.; Carroll, F. Ivy; Wang, Jia-Bei; Uhl, George R.; Partilla, John S.; Dersch, Christina M. Title: Studies of the Biogenic Amine Transporters: VI. Characterization of a Novel Cocaine Binding Site, Identified with [125-I] RTI-55, in Membranes Prepared from Whole Rat Brain Minus Caudate Source: J. Pharm. Exp. 274 (1995) 385-395 Description: PCMLAB, binding surface analysis
Authors: Rothman, Richard B.; Xu, Heng; Wang, Jia Bei; Partilla, John S.; Kayakiri, Hiroshi; Rice, Kenner C.; Uhl, George R. Title: Ligand Selectivity of Cloned Human and Rat Opioid Mu Receptors Source: Synapse 21 (1995) 60-64 Description: PCMLAB, 1-site binding model, 2-parameter logistic
Authors: Ruvirov, Sergei B.; Ahmed, S. Ashraf; McPhie, Peter; Miles, Edith Wilson Title: Monovalent Cations Partially Repair a Conformational Defect in a Mutant Tryptophan Synthase Alpha-2 Beta-2 Complex (Beta-E109A) Source: J. Biol. Chem. 270 (1995) 17333-17338 Description: fit noncooperative binding rate constants with MLAB.
Authors: Sahajwalla, C.G.; Helton, E.D.; Purich, E.D.; Hoppel, C.L.; Cabana, B.E. Title: Comparison of L-carnitine pharmacokinetics with and without baseline correction following administration of single 20 mg/kg intravenous dose Source: J. Pharm. Sci. 84 (1995) 634-639
Authors: Sidossis, L.S.; Coggan, A.R.; Gastaldelli, A.; Wolfe, R.R. Title: A new correction factor for use in tracer estimations of plasma fatty acid oxidation Source: Am. J. Physiol. Endo. Metab. 269 (1995) E649-E656
Authors: Sidossis, L.S.; Coggan, A.R.; Gastaldelli, A.; Wolfe, R.R. Title: Pathway of Free Fatty Acid Oxidation in Human Subjects Source: J. Clin. Inv. (1995) 278-284
Authors: Silverthorn, Mayme L.; Dersch, Christina M.; Baumann, Michael H.; Cadet, Jean L.; Partilla, John S.; Rice, Kenner C.; Carroll, F. Ivy; Becketts, Karen M.; Brockington, Alicia; Rothman, Richard B. Title: Studies of the Biogenic Amine Transporters. V. Demonstration of Two Binding Sites for the Cocaine Analog [125-I] RTI-55 Associated with the 5-HT Transporter in Rat Brain Membranes Source: J. Pharm. Exp. 273 (1995) 213-222 Description: PCMLAB, binding model.
Authors: Wagner, F.; Falkner, R.; Falkner, G. Title: Information about previous phosphate fluctuations is stored via an adaptive response of the high-affinity phosphate uptake system of the cyanobacterium Anacystis nidulans Source: Planta 197 (1995) 147-155
Authors: Watanabe, R.M.; Lovejoy, J.; Steil, G.M.; DiGirolamo, M.; Bergman, R.N. Title: Insulin Sensitivity Accounts for Glucose and Lactate Kinetics After Intravenous Glucose Injection Source: Diabetes 44 (1995) 954-962
Authors: Westerhoff, H.V.; van Echteld, C.J.A.; Jeneson, J.A.L. Title: On the expected relationship between Gibbs energy of ATP hydrolysis and muscle performance Source: Biophys. Chem. 54 (1995) 137-142
Authors: Xu, Heng; Goodman, Carl B.; Partilla, John S.; Ni, Qi; Kayakiri, Hiroshi; Rice, Kenner C.; Rothman, Richard B. Title: G-Beta-[125-I]-3,14-Dihydroxy-17-Methyl-4,5-Alpha- Epoxymorphinean ([125-I] IOXY-AGD): A Potent and Selective Radioligand for Opioid Mu Receptors Source: Synapse 19 (1995) 105-111 Description: one and two component models, dissociation data, PCMLAB.
Authors: Youn, J.H.; Kim, J.K.; Steil, G.M. Title: Assessment of extracellular glucose distribution and glucose transport activity in conscious rats Source: Am. J. Physiol. Endo. Metab. 268 (1995) E712-E721
Authors: Young, Sidney Title: Review of MLAB: A Mathematical Modelling Laboratory Source: J. Chem. Inf. Comput. Sci. 35 (1995) 781-782
Authors: Abugo, Omoefe O.; Rifkind, Joseph M. Title: Oxidation of Hemoglobin and the Enhancement Produced by Nitroblue Tetrazolium Source: J. Biol. Chem. 269 (1994) 24845-24853 Description: kinetic data fit to ode model.
Authors: Akunne, Hyacinth C.; Dersch, Christine M.; Cadet, Jean L.; Baumann, Michael H.; Char, George U.; Partilla, John S.; de Costa, Brian; Rice, Kenner C.; Carroll, F. Ivy; Rothman, Richard B. Title: Studies of the Biogenic Amine Transporters. III. Demonstration of Two Binding Sites for [3H] GBR12935 and [3H] BTCP in Rat Caudate Membranes Source: J. Pharm. Exp. 268 (1994) 1462-1475 Description: PCMLAB, multiple site binding analysis.
Authors: Akunne, Hyacinth C.; Monn, J.A.; Thurkauf, Andrew; Jacobson, Arthur E.; Rice, Kenner C.; Linders, Joannes T.M.; Jiang, Q.; Porreca, F.; Rothman, Richard B. Title: An Electrophilic Affinity Ligand Based on (+)-MK801 Distinguishes PCP Site 1 from PCP Site 2 Source: Neurochem. Res. 19 (1994) 385-389 Description: [3H]TCP binding surfaces fit.
Authors: Bertha, C.M.; Mattson, M.V.; Flippen-Anderson, J.L.; Rothman, R.B.; Xu, H.; Cha X.Y.; Becketts, K.; Rice, K.C. Title: A Marked Change of Receptor Affinity of the 2-Methyl-5- (3-hydroxyphenyl) morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Elucidation of a New Class of Sigma Receptor Ligands Source: J. Med. Chem. 37 (1994) 3163-3170
Authors: Boyd, Derek R.; Davies, R. Jeremy H.; Hamilton, Lynne; McCullough, John J.; Malone, John F.; Porter, H. Patricia; Smith, Allison; Carl, John M.; Sayer, Jane M.; Jerina, Donald M. Title: Synthesis and Solvolysis of Acridine 1,2- and 3,4-Oxides: Crystal Structure and Solvolysis of Acridine 1,2-Oxide Source: J. Org. Chem. 59 (1994) 984-990 Description: rate constants determined by reciprocal plots or curve-fitting.
Authors: Dersch, C.M.; Akunne, H.C.; Partilla, J.S.; Char, G.U.; de Costa, B.R.; Rice, K.C.; Carroll, F.I.; Rothman, R.B.; Title: Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H] mazindol binding to the dopamine transporter by a competitive mechanism: Preliminary evidence for different binding domains Source: Neurochem. Res. 19 (1994) 201-208
Authors: Ding, L.; Sepo, B.L.; Ahmed, S.A.; Coleman, W.B. Title: Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosugar epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase Source: J. Biol. Chem. 269 (1994) 24384-24390
Authors: Grem, J.L.; McAtee, N.; Murphy, R.F.; Hamilton, J.M.; Balis, F.; Steinberg, S.; Arbuck, S.G.; Setser, A.; Jordan, E.; Chen, A.; Kobler, D.R.; Kotite, B.; Allegra, C.J. Title: Phase I and Pharmacokinetic Study of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Given in Combination With Fluorouracil Plus Calcium Leucovorin in Metastatic Gastrointestinal Adenocarcinoma Source: J. Clin. Oncol. 12 (1994) 560-568 Description: Kaplan-Meier survival curves, plasma concentration curves fit to monoexponential function.
Authors: Kim, Soon-Jong; Lewis, Marc S.; Knutson, Jay R.; Porter, Denise K.; Kumar, Amalendra; Wilson, Samuel H. Title: Characterization of the Tryptophan Fluorescence and Hydrodynamic Properties of Rat DNA Polymerase Beta Source: J. Mol. Biol. 244 (1994) 224-235 Description: PCMLAB, ultracentrifuge sedimentation data analysis
Authors: Kienker, P.; Tomaselli, G.; Jurman, M.; Yellen, G. Title: Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism Source: Biophys. J. 66 (1994) 325-334
Authors: Kim, S.Y.; Kim, I.G.; Chung, S.I.; Steinert, P.M. Title: The structure of the transglutaminase I enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity Source: J. Biol. Chem. 269 (1994) 27979-27986
Authors: Lori, F.; Malykh, A.; Cara, A.; Sun, D.; Weinstein, J.N.; Lisziewicz, J.; Gallo, R.C. Title: Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication Source: Science 266 (1994) 801-805
Authors: Magill, N.G.; Cowen, A.E.; Koppel, D.E.; Setlow, P. Title: The internal pH of the forespore compartment of Bacillus megaterium decreases by about 1 pH unit during sporulation Source: J. Bacteriol. 176 (1994) 2252-2258
Authors: Nishimura, N.; Simpson, I.A. Title: Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells Source: Biochem. J. 302 (1994) 271-277
Authors: Regan, L.; Rockwell, A.; Wasserman, Z.; Degrado, W. Title: Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein Source: Protein Sci. 3 (1994) 2419-2427
Authors: Romijh, J.A.; Chinkes, D.L.; Schwartz, J.M.; Wolfe, R.R. Title: Lactate-pyruvate interconversion in blood: implications for in vivo tracer studies Source: Am. J. Physiol. Endo. Metab. 266 (1994) E334-E340
Authors: Rothman, Richard B.; Cadet, Jean L.; Akunne, Hyacinth C.; Silverthorn, Mayme L.; Baumann, Michael H.; Carroll, F. Ivy; Rice, Kenner C.; de Costa, Brian R.; Partilla, John S.; Wang, Jia-Bei; Uhl, George; Glowa, John R.; Dersch, Christine M. Title: Studies of the Biogenic Amine Transporters. IV. Demonstration of a Multiplicity of Binding Sites in Rat Caudate Membranes for the Cocaine Analog [125-I] RTI-55 Source: J. Pharm. Exp. 270 (1994) 296-309 Description: 1-site and 2-site binding models.
Authors: Sakamoto, H.; Lewis, M.S.; Kodama, K.; Appella, E.; Sakaguchi, K. Title: Specific Sequences from the Carboxyl Terminus of Human p53 Gene Product Form Anti-Parallel Tetramers in Solution Source: PNAS 91 (1994) 8974-8978
Authors: Spivak, C.E. Title: Desensitization and non-competitive blockade of GABA-A receptors in ventral mid brain neurons by a neurosteroid dehydroepiandrosterone sulfate Source: Synapse 16 (1994) 113-122
Authors: Spoelstra, E.C.; Westerhoff, H.V.; Pinedo, H.M.; Dekker, H.; Lankelma, J. Title: The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate Source: Eur. J. Biochem. 221 (1994) 363-373
Authors: Steil, G.M.; Murray, J.; Bergman, R.N.; Buchanan, T.A. Title: Repeatability of Insulin Sensitivity and Glucose Effectiveness From the Minimial Model: Implications for Study Design Source: Diabetes 43 (1994) 1365-1371
Authors: Steven, Alasdair C.; Steinert, Peter M. Title: Protein Composition of Cornified Cell Envelopes of Epidermal Keratinocytes Source: J. Cell Sci. 107 (1994) 693-700 Description: amino acid compositions fit to data with constraints.
Authors: Sumida, Ken D.; Donovan, Casey M. Title: Endurance Training Fails to Inhibit Skeletal Muscle Glucose Uptake During Exercise Source: J. Appl. Physiol. 76 (1994) 1876-1881 Description: Plasma 2-[3-H]DG data fitted to a double exponential equation with subsequent determination of y-intercept and integral.
Authors: Sung, C.; Blaney, S.M.; Cole, D.E.; Balis, F.M.; Dedrick, R.L. Title: A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid Source: Canc. Res. 54 (1994) 5118-5122
Authors: Wadhwani, Kishena C.; Rapoport, Stanley I. Title: Transport Properties of Vertebrate Blood-Nerve Barrier: Comparison with Blood-Brain Barrier Source: Prog. Neurob. 43 (1994) 235-279 Description: plasma concentration as time-dependent multiexponential process.
Authors: Wagner, F.; Gimona, M.; Ahorn, H.; Peschek, G.A.; Falkner, G. Title: Isolation and functional reconstitution of a phosphate binding protein of the cyanobacterium Anacystis ridulans induced during phosphate-limited growth Source: J. Biol. Chem. 269 (1994) 5509-5511 Description: Scatchard plot
Authors: Youn, J.H.; Kim, J.K.; Buchanan, T.A. Title: Time Courses of Changes in Hepatic and Skeletal Muscle Insulin Action and GLUT4 Protein in Skeletal Muscle After STZ Injection Source: Diabetes 43 (1994) 564-571
Authors: Adamson, Peter C.; Boylan, John F.; Balis, Frank M.; Murphy, Robert F.; Godwin, Karen A.; Gudas, Loraine J.; Poplack, David G. Title: Time Course of Induction of Metabolism of All-Trans-Retinoic Acid and the Up-Regulation of Cellular Retinoic Acid-Binding Protein Source: Canc. Res. 53 (1993) 472-476 Description: Michaelis Menten model, Vmax, Km, area under curve
Authors: Anderson, Sally M.; Kant, G. Jean; De Souza, Errol B. Title: Effects of Chronic Stress on Anterior Pituitary and Brain Corticotropin-Releasing Factor Receptors Source: Pharm. Biochem. Behav. 44 (1993) 755-761 Description: estimates for dissociation constant, Kd, and maximum concentration, Bmax, of [125-I] on CRF binding sites in membrane preparations from anterior pituitary gland were determined by nonlinear curve-fitting using MLAB.
Authors: Berg, Stacey L.; Balis, Frank M.; Godwin, Karen S.; Poplack, David G. Title: Pharmacokinetics, Cerebrospinal Fluid Penetration, and Metabolism of Piroxantrone in the Rhesus Monkey Source: Inv. New Drugs 11 (1993) 255-261 Description: post infusion concentration time data fit to multiexponential model.
Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Godwin, Karen S.; Poplack, David G. Title: Pharmacokinetics of PEG-L-Asparaginase and Plasma and Cerebrospinal Fluid L-Asparagine Concentrations in the Rhesus Monkey Source: Canc. Chem. Pharm. 32 (1993) 310-314 Description: Postplateau plasma PEG-asp concentration time data fit to monoexponential, area under curve via trapezoidal rule.
Authors: Berg, Stacey L.; Savarese, Diane M.F.; Balis, Frank M.; Denicoff, Andrea M.; Hillig, Marianne; O'Shaughnessy, Joyce A.; Poplack, David G.; Cowan, Kenneth H. Title: Pharmacokinetics of Piroxantrone in a Phase I Trial of Piroxantrone and Granulocyte-Colony Stimulating Factor Source: Canc. Res. 53 (1993) 2587-2590 Description: postinfusion concentration-time data fit to bi-, tri-exponential functions.
Authors: Blaney, Susan M.; Balis, Frank M.; Cole, Diane E.; Craig, Catherine; Reid, Joel M.; Ames, Matthew M.; Krailo, Mark; Reaman, Gregory; Hammond, Denman; Poplack, David G. Title: Pediatric Phase I Trial and Pharmacokinetic Study of Topotecan Administered as a 24-Hour Continuous Infusion Source: Canc. Res. 53 (1993) 1032-1036 Description: post infusion concentration time data fit to mono-, bi-exponential model.
Authors: Blaney, Susan M.; Cole, Diane E.; Balis, Frank M.; Godwin, Karen; Poplack, David G. Title: Plasma and Cerebrospinal Fluid Pharmacokinetic Study of Topotecan in Nonhuman Primates Source: Canc. Res. 53 (1993) 725-727 Description: plasma concentration vs time data from topotecan bolus experiment fit to mono-, bi-exponential equations.
Authors: Bradley, D.C.; Poulin, R.A.; Bergman, R.N. Title: Dynamics of Hepatic and Peripheral Insulin Effects Suggest Common Rate-Limiting Step In Vivo Source: Diabetes 42 (1993) 296-306
Authors: Bradley, David C.; Steil, Garry M.; Bergman, Richard N. Title: Quantitation of Measurement Error with Optimal Segments: Basis for Adaptive Time Course Smoothing Source: Am. J. Physiol. 264 (1993) E902-E911 Description: simulations performed with MLAB.
Authors: Brenner, Bernhard; Yu, Leepo C. Title: State-Dependent Radial Elasticity of Attached Cross-Bridges in Single Skinned Fibres of Rabbit Psoas Muscle--Erratum Source: J. Physiol. 465 (1993) 749-765 Description: responses of fibres to applied radial force fit to exponential.
Authors: Brenner, B.; Yu, L.C. Title: Structural Changes in the Actomyosin Cross-Bridges Associated with Force Generation Source: PNAS 90 (1993) 5252-5256 Description: fit reflection peaks to Lorentzian with amplitude, width and centroid as parameters.
Authors: Coda, Barbara A.; Hill, Harlan F.; Hunt, Earl B.; Kerr, E. Beth; Jacobson, Robert C.; Chapman, C. Richard Title: Cognitive and Motor Function Impairments During Continuous Opioid Analgesic Infusions Source: Hum. Psychopharm. 8 (1993) 383-400 Description: biexponential model of plasma concentration of opioid versus time.
Authors: Conley, Barbara A.; Egorin, Merrill J.; Whitacre, Margaret Y.; Carter, D. Canville; Zuhowski, Eleanor G.; Van Echo, David A. Title: Phase I and Pharmacokinetic Trial of Liposome-Encapsulated Doxorubicin Source: Canc. Chem. Pharm. 33 (1993) 107-112 Description: doxorubicinol area under curve determined by trapezoidal rule
Authors: Fairman, Robert; Beran-Steed, Rita K.; Anthony-Cahill, Spencer J.; Lear, James D.; Stafford, Walter F., III; DeGrado, William F.; Benfield, Pamela A.; Brenner, Stephen L. Title: Multiple Oligomeric States Regulate the DNA Binding of Helix-Loop-Helix Peptides Source: PNAS 90 (1993) 10429-10433 Description: obtained dissociation constants by curve fitting.
Authors: Heideman, Richard L.; McCully, Cynthia; Balis, Frank M.; Poplack, David G. Title: Cerebrospinal Fluid Pharmacokinetics and Toxicology of Intraventricular and Intrathecal Arabinosyl-5-Azacytosine (Fazarabine, NSC 281272) in the Nonhuman Primate Source: Inv. New Drugs 11 (1993) 135-140 Description: half-life, CSF disappearance for AAC fit to multi-exponential functions.
Authors: Hendler, R.W.; Bose, S.K.; Shrager, R.I. Title: Multiwavelength analysis of the kinetics of reduction of cytochrome aa3 by cytochrome c Source: Biophys. J. 65 (1993) 1307-1317
Authors: Jackus, J.; Wolff, E.C.; Park, M.H.; Folk, J.E. Title: Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines Source: J. Biol. Chem. 268 (1993) 13151-13159
Authors: Jensen, P.R.; Michelson, O.; Westerhoff, H.V. Title: Control analysis of the dependence of Escherichia coli physiology on the H(+)-ATPase Source: PNAS 90 (1993) 8068-8072 Description: data fit to second order polynomial
Authors: Laderman, K.A.; Davis, B.R.; Krutzsch, H.C.; Lewis, M.S.; Griko, Y.V.; Privalov, P.L.; Anfinsen, C.B. Title: The purification and characterization of an extremely thermostable alpha-amylase from the hyperthermophylic archaebacterium Pyrococcus furiosus Source: J. Biol. Chem. 268 (1993) 24394-24401
Authors: Litvinov, S.V.; Hikens, J. Title: The epithelial sialomucin, episialian, is sialylated during recycling Source: J. Biol. Chem. 268 (1993) 21364-21371
Authors: Lu, Zichen; Nagata, Shinji; McPhie, Peter; Miles, Edith Wilson Title: Lysine 87 in the Beta Subunit of Tryptophan Synthase That Forms an Internal Aldimine with Pyridoxal Phosphate Serves Critical Roles in Transamination, Catalysis, and Product Release Source: J. Biol. Chem. 268 (1993) 8727-8734 Description: fluorescence spectra and fluorimeter measurements analyzed with PCMLAB.
Authors: McPhie, P.; Parkinson, C.; Lee, B.K.; Chang, S-Y Title: Structure of the Hormone Binding Domain of Human Beta-1 Thyroid Hormone Nuclear Receptor: Is It an Alpha/Beta Barrel? Source: Biochem. 32 (1993) 7460-7465 Description: analysis of circular dichroism spectra in terms of secondary structure using MLAB.
Authors: Mulder, H.S.; van Grondelle, R.; Westerhoff, H.V.; Lankelma, J. Title: A plasma membrane "vacuum cleaner" for daunorubicin in non-P-glucoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells Source: Eur. J. Biochem. 218 (1993) 871-882
Authors: Ni, Q.; Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B. Title: Selective Labeling of Kappa-2 Opioid Receptors in Rat Brain by [125-I] IOXY: Interaction of Opioid Peptides and Other Drugs With Multiple Kappa-2a Binding Sites Source: Peptides 14 (1993) 1279-1293 Description: binding surfaces fit to various models, PCMLAB, IC50, slope factor, 2 parameter logistic.
Authors: Ni, Qi; Xu, Heng; Partilla, J.S.; Stank, P.A.; Carroll, F.I.; Brine, G.A.; Rothman, R.B. Title: Stereochemical Requirements for Pseudoirreversible Inhibition of Opioid Mu Receptor Binding in the 3-Methlyfentanyl Congeners RTI-46144 and Its Enantiomers: Evidence for Different Binding Domains Source: Synapse 15 (1993) 296-306 Description: PCMLAB used to determine Kd, Bmax.
Authors: Nishimura, H.; Pallardo, F.V.; Seidner, G.A.; Vannucci, S.; Simpson, I.A.; Birnbaum, M.J. Title: Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes Source: J. Biol. Chem. 268 (1993) 8514-8520
Authors: Otsu, Kinya; Kinsella, James L.; Heller, Phillip; Froehlich, Jeffrey P. Title: Sodium Dependence of the Na+ H+ Exchange in the Pre-steady State Source: J. Biol. Chem. 268 (1993) 3184-3193 Description: MLAB used for simulating time course of Na+ accumulation.
Authors: Oviedo, Angelica; Glowa, John; Herkenham, Miles Title: Chronic Cannabinoid Administration Alters Cannabinoid Receptor Binding in Rat Brain: A Quantitative Autoradiographic Study Source: Brain Res. 616 (1993) 293-302 Description: Kd-Bmax values fit in 1-site binding model using MLAB.
Authors: Rothman, Richard B.; Brady, Linda S.; Xu, Heng; Long, Joseph B. Title: Chronic Intracerebroventricular Infusion of the Antiopioid Peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), Downregulates Mu Opioid Binding Sites in Rat Brain Source: Peptides 14 (1993) 1271-1277 Description: fit to one-site binding model, PCMLAB.
Authors: Rothman, Richard B.; Lewis, Bruce; Dersch, Chris; Xu, Heng; Redesca, Lilian; de Costa, Brian R.; Rice, Kenner C.; Kilburn, Robert B.; Akunne, Hyacinth; Pert, Agu Title: Identification of a GBR12935 Homolog, LR1111, Which is Over 4,000-Fold Selective for the Dopamine Transporter, Relative to Serotonin and Norepinephrine Transporters Source: Synapse 14 (1993) 34-39 Description: PCMLAB, inhibition curves fit to 2 parameter logisitic.
Authors: Rothman, Richard B.; Xu, Heng; Char, George U.; Kim, Andrew; de Costa, Brian R.; Rice, Kenner C.; Zimmerman, Dennis M. Title: Phenylpiperidine Opioid Antagonists That Promote Weight Loss in Rats Have High Affinity for the Kappa-2B (Enkephalin-Sensitive) Binding Site Source: Peptides 14 (1993) 17-20 Description: 2 parameter logistic, best fit IC50 and slope factor.
Authors: Steil, G.M.; Meador, M.A.; Bergman, R.N. Title: Thoracic Duct Lymph: Relative Contribution from Splanchnic and Muscle Tissue Source: Diabetes 42 (1993) 720-731
Authors: Steil, Garry M.; Volund, Aage; Kehr, Stephen E.; Bergman, Richard Title: Reduced Sample Number for Calculation of Insulin Sensitivity and Glucose Effectiveness From the Minimal Model Source: Diabetes 42 (1993) 250-256 Description: statistics, minimal model with MLAB.
Authors: Stevens, Rom A.; Petty, Robert H.; Hill, Harlan F.; Kao, Tzu-Cheng; Schaffer, Randy; Hahn, Marc B.; Harris, Paul Title: Redistribution of Sufentanil to Cerebrospinal Fluid and Systemic Circulation After Administration in Dogs Source: Anesth. Analg. 76 (1993) 323-327 Description: triexponential model.
Authors: van Dam, K.; van der Vlag, J.; Kholodenko, B.N.; Westerhoff, H.V. Title: The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two Source: Eur. J. Biochem. 212 (1993) 791-799
Authors: Vas Gomes, A.; de Waal, A.; Berden, J.A.; Westerhoff, H.V. Title: Electric Potentiation, Cooperativity, and Synergism of Magainin Peptides in Protein-Free Liposomes Source: Biochem. 32 (1993) 5365-5372
Authors: Weinman, S.A.; Graf, J.; Veith, C.; Boyer, J.L. Title: Electroneutral uptake and electrogenic secretion of a fluorescent bile salt by rat hepatocyte couplets Source: Am. J. Physiol. Gastro. Liver Physiol. 264 (1993) G220-G230
Authors: Weiss, R.G.; Kalil-Filho, R.; Herskowitz, A.; Chyacko, V.P.; Litt, M.; Stern, M.D. Title: Tricarboxylic acid cycle activity in postischemic rat hearts Source: Circulation 87 (1993) 270-282
Authors: Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B. Title: Differential Binding of Opioid Peptides and Other Drugs to Two Subtypes of Opioid Delta-ncx Binding Sites in Mouse Brain: Further Evidence for Delta Receptor Heterogeneity Source: Peptides 14 (1993) 893-907 Description: single inhibition curves fit to 2-parameter logistic equation, 1 and 2 site binding models, PCMLAB.
Authors: Xu, Sengen; Brenner, Bernhard; Yu, Leepo C. Title: State-Dependent Radial Elasticity of Attached Cross-Bridges in Single Skinned Fibres of Rabbit Psoas Muscle Source: J. Physiol. 461 (1993) 283-299 Description: responses of fibres to applied radial force fit to single exponential.
Authors: Yoo, Seung Hyun; Lewis, Marc S. Title: Dimerization and Tetramerization Properties of the C-Terminal Region of Chromogramin A: A Thermodynamic Analysis Source: Biochem. 32 (1993) 8816-8822 Description: PCMLAB, ultracentrifuge sedimentation data analysis
Authors: Youn, J.H.; Buchanan, T.A. Title: Fasting Does Not Impair Insulin-Stimulated Glucose Uptake But Alters Intracellular Glucose Metabolism in Conscious Rats Source: Diabetes 42 (1993) 757-763
Authors: Adamson, Peter C.; Balis, Frank M.; Smith, Malcolm A.; Murphy, Robert F.; Godwin, Karen A.; Poplack, David G. Title: Dose-Dependent Pharmacokinetics of All-Trans-Retinoic Acid Source: JNCI 84 (1992) 1332-1335 Description: fit Michaelis Menten differential equation.
Authors: Akunne, Hyacinth C.; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B. Title: [3H] Cocaine Labels a Binding Site Associated With the Serotonin Transporter in Guinea Pig Brain: Allosteric Modulation by Paroxetine Source: Neurochem. Res. 17 (1992) 1275-1283 Description: 1,2,3 site binding models, IC50, Hill coefficients
Authors: Attri, A.K.; Lewis, Marc S. Title: Analytical Ultracentrifugation in Biochemistry and Polymer Science Source: Chapter 9 of book edited by Harding, Rowe, and Horton, (1992) 138-146 Description: ultracentrifuge modeling
Authors: Bailey, James J.; Fletcher, John E.; Chuck, Emil T.; Shrager, Richard I. Title: A Kinetic Model of CD4+Lymphocytes with the Human Immunodeficiency Virus (HIV) Source: BioSystems 26 (1992) 177-183 Description: 5 coupled ordinary differential equations describing cell populations.
Authors: Balis, Frank M.; Pizzo, Philip A.; Butler, Karina M.; Hawkins, Mary E.; Brouwers, Pim; Husson, Robert N.; Jacobsen, Freda; Blaney, Susan M.; Gress, Janet; Jarosinski, Paul; Poplack, David G. Title: Clinical Pharmacology of 2',3'-Dideoxyinosine in Human Immunodeficiency Virus-Infected Children Source: J. Infect. Dis. 165 (1992) 99-104 Description: postinfusion ddI concentration fit to mono and biexponential curves
Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Parker, George A.; Murphy, Robert F.; Poplack, David G. Title: Intrathecal 5-Fluorouracil in the Rhesus Monkey Source: Canc. Chem. Pharm. 31 (1992) 127-130 Description: concentration time data fit to mono and biexponential models.
Authors: Berg, S.L.; Balis, F.M.; Zimm, S.; Murphy, R.F.; Holeenberg, J.; Sato, J.; Reaman, G.; Steinherz, P.; Gillespie, A.; Doherty, K. Title: Phase I/II trial and pharmacokinetics of intrathecal diaziquone in refractory meningeal malignancies Source: J. Clin. Oncol. 10 (1992) 143-148
Authors: Chen, Bau-Lu; Baase, Walter A.; Nicholson, Hale; Schellman, John A. Title: Folding Kinetics of T4 Lysozyme and Nine Mutants at 12 Degrees C Source: Biochem. 31 (1992) 1464-1476 Description: thermodynamic function fit to find rate constants.
Authors: Chung, Laura Ann; Lear, James D.; DeGrado, William F. Title: Fluorescence Studies of the Secondary Structure and Orientation of a Model Ion Channel Peptide in Phospholipid Vesicles Source: Biochem. 31 (1992) 6608-6616 Description: root and fit operators to find dissociation constants.
Authors: Fink, M.L.; Shao, Y.Y.; Kersh, G.J. Title: A fluorometric, high-performance liquid chromatographic assay for transglutaminase activity Source: Anal. Biochem. 201 (1992) 270-276
Authors: Fisher, Alice; Taniuchi, Hiroshi Title: A Study of Core Domains and the Core Domain-Domain Interaction of Cytochrome c Fragment Complex Source: Arch. Biochem. Biophys. 296 (1992) 1-16
Authors: Goffin, V.; Norman, M.; Martial, J.A. Title: Alanine-Scanning Mutagenesis of Human Prolactin: Importance of the 58-74 Region for Bioactivity Source: Mol. Endocrin. 6 (1992) 1381-1392 Description: Scatchard analysis of binding data with MLAB, competition curves analyzed with LIGAND.
Authors: Grem, Jean L.; Chu, Edward; Boarman, Donna; Balis, Frank M.; Murphy, Robert F.; McAtee, Nanette; Allegra, Carmen J. Title: Biochemical Modulation of Fluorouracil with Leucovorin and Interferon: Preclinical and Clinical Investigations Source: Semin. Oncol. 19 (1992) 36-44 Description: 5-FU plasma concentration in time fit to monoexponential, computed area under curve.
Authors: Hill, Harlan F.; Coda, Barbara A.; Mackie, Adam M.; Iverson, Karen Title: Patient-Controlled Analgesic Infusions: Alfentanil Versus Morphine Source: Pain 49 (1992) 301-310 Description: bi, triexponential models of plasma opioid concentration vs. time.
Authors: Holmes, William R.; Segev, Idan; Rall, Wilfrid Title: Interpretation of Time Constant and Electronic Length Estimates in Multicylinder or Branched Neuronal Structures Source: J. Neurophysiol. 68 (1992) 1401-1420 Description: estimates of T0, T1, C0, C1 determined by variety of methods including MLAB.
Authors: Huub, J.S.; Erik, L.L.S.; Gerard, J.F.B.; Nicolaas, J.H.R.; Westerhoff, H.V. Title: METASIM: object-oriented modelling of cell regulation Source: Comput. Appl. Biosci. 8 (1992) 443-449
Authors: Ilondo, Mapoko M.; Vandershueren-Lodeweyckx, Magda; Courtoy, Pierre J.; De Meyts, Pierre Title: Cellular Processing of Growth Hormone in IM-9 Cells: Evidence for Exocytosis of Internalized Hormone Source: Endocrin. 130 (1992) 2037-2044 Description: [125-I] hGH internalization
Authors: Jayaram, Hiremagalur N.; Lapis, Erzsebet; Tricot, Guido; Kneebore, Patricia; Paulik, Edith; Zhen, Weining; Engeler, George P.; Hoffman, Ronald; Weber, George Title: Clinical Pharmacokinetic Study of Tiazofurin Administered as a 1-Hour Infusion Source: Int. J. Cancer 51 (1992) 182-188 Description: plasma clearance as 2 compartment model.
Authors: Juweid, M.; Neumann, R.; Paik, C.; Perez-Bacete, M.J.; Sato, J.; van Osdol, W.; Weinstein, J.N. Title: Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier Source: Canc. Res. 52 (1992) 5144-5153
Authors: Kagemaya, S.; Weinstein, J.N.; Shirasaka, T.; Kempf, D.J.; Norbeck, D.W.; Plattner, J.J.; Erickson, J.; Mitsuya, H. Title: In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations Source: Antimicrob. Ag. and Chem. 36 (1992) 926-933
Authors: McPhie, Peter; Shrager, Richard I. Title: An Investigation of the Thermal Unfolding of Swine Pepsinogen Using Circular Dichroism Source: Arch. Biochem. Biophys. 293 (1992) 46-53 Description: SVD analysis
Authors: Paredes, Angel M.; Simon, Martha N.; Brown, Dennis T. Title: The Mass of the Sindbis Virus Nucleocapsid Suggests It Has T=4 Icosahedral Symmetry Source: Virol. 187 (1992) 329-332 Description: fit gaussian to histogram.
Authors: Perreault, C.L.; Mulieri, L.A.; Alpert, N.R.; Ransil, B.J.; Allen, P.D.; Morgan, J.P. Title: Cellular basis of negative inotropic effect of 2,3-butanedione monoxime in human myocardium Source: Am. J. Physiol. Heart Circ. Physiol. 263 (1992) H503-H510
Authors: Port, J.D.; Debellis, C.C.; Klein, J.; Peeters, G.A.; Barry, W.H.; Bristow, M.R. Title: Pharmacological characterization of chick and frog beta adrenergic receptors in primary cultures of myocardial cells Source: J. Pharm. Exp. 262 (1992) 217-224
Authors: Rothman, Richard B.; Bykov, Victor; Xue, B.G.; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Kleinman, Joel E.; Brady, Linda S. Title: Interaction of Opioid Peptides and Other Drugs With Multiple Kappa Receptors in Rat and Human Brain: Evidence for Species Differences Source: Peptides 13 (1992) 977-987 Description: binding studies, F-test
Authors: Rothman, Richard B.; Mahboubi, Artin; Bykov, Victor; Kim, Chong-Ho; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C. Title: Probing the Opioid Receptor Complex With (+)-Trans SUPERFIT. II. Evidence that Mu Ligands Are Noncompetitive Inhibitors of the Delta-cx Opioid Peptide Binding Site Source: Peptides 13 (1992) 1137-1143 Description: inhibition curves fit to 2 parameter logistic
Authors: Samarel, A.M.; Spragia, M.L.; Maloney, V.; Kamal, S.A.; Engelmann, G.L. Title: Contractile arrest accelerates myosin heavy chain degradation in neonatal rat heart cells Source: Am. J. Physiol. Cell Physiol. 263 (1992) C642-C652
Authors: Smith, Q.R.; Nagura, H.; Takada, Y.; Duncan, M.W. Title: Facilitated Transport of Neurotoxin, beta-N- Methylamino-L-Alanine, Across the Blood-Brain Barrier Source: J. Neurochem. 58 (1992) 1330-1337
Authors: Tanner, J.W.; Thomas, D.D.; Goldman, Y.E. Title: Transients in orientation of a fluorescent cross- bridge probe following photolysis of caged nucleotides in skeletal muscle fibres Source: J. Molec. Biol. 223 (1992) 185-203
Authors: Theibert, A.B.; Estevez, V.A. Mourey, R.J.; Marecek, J.F.; Barrow, R.K.; Prestwich, G.D.; Snyder, S.H. Title: Photoaffinity labeling and characterization of isolated inositol 1,3,4,5-tetrakisphosphate- and inositol hexakisphosphate-binding proteins Source: J. Biol. Chem. 267 (1992) 9071-9079
Authors: Tropea, Joseph E.; Nashed, Nashaat T.; Louis, John M.; Sayer, Jane M.; Jerina, Donald M. Title: Effect of Salt on the Kinetic Parameters of Retroviral and Mammalian Aspartic Acid Proteases Source: Bioorg. Chem. 20 (1992) 67-76 Description: inhibition constants, pseudo-first order rate constants.
Authors: Wadhwani, Kishena C.; Murphy, Vincent A.; Smith, Quentin R.; Rapoport, Stanley I. Title: Saturable Transport of Manganese (II) Across Blood-Nerve Barrier of Rat Peripheral Nerve Source: Am. J. Physiol. 262 (1992) R284-R288 Description: determine saturation-kinetic parameters for Mn influx.
Authors: Weiss, R.G.; Gloth, S.T.; Kalil-Filho, R.; Chacko, V.P.; Stern, M.D.; Gerstenblith, G. Title: Indexing tricarboxylic acid cycle flux in intact hearts by carbon-13 nuclear magnetic resonance Source: Circ. Res. 70 (1992) 392-408
Authors: Wu, Xiaomao; Gutfreund, H.; Chock, P.B. Title: Kinetic Method for Differentiating Mechanisms for Ligand Exchange Reactions: Application to Test for Substrate Channeling in Glycolysis Source: Biochem. 31 (1992) 2123-2128 Description: numerical analysis carried out by solving the differential equations describing the mechanism being considered using the integrator in MLAB.
Authors: Xu, Heng; Partilla, John S.; de Costa, Brian R.; Rice, Kenner C.; Rothman, Richard B. Title: Interaction of Opioid Peptides and Other Drugs With Multiple Delta-ncx Binding Sites in Rat Brain: Further Evidence for Heterogeneity Source: Peptides 13 (1992) 1207-1213 Description: fit data to 1 and 2 site models.
Authors: Yanagishita, M. Title: Glycosylphosphatidylinositol-anchored and core protein- intercalated heparin sulphate proteoglycans in rat ovarian granulosa cells have distinct secretory, endocytotic, and intracellular degradative pathways Source: J. Biol. Chem. 267 (1992) 9505-9511
Authors: Yoo, S.H.; Lewis, Marc S. Title: Effects of pH and Ca2+ on Monomer-Dimer and Monomer-Tetramer Equilibria of Chromogranin A* Source: J. Biol. Chem. 267 (1992) 11236-11241 Description: ultracentrifuge data analysis.
Authors: Zaharevitz, Daniel W.; Anderson, Lawrence W.; Malinowski, Nancy M.; Hyman, Roosevelt; Strong, John M.; Cysyk, Richard L. Title: Contribution of De-Novo and Salvage Synthesis to the Uracil Nucleotide Pool in Mouse Tissues and Tumors in Vivo Source: Eur. J. Biochem. 210 (1992) 293-296 Description: linear regression
Authors: Abbruzzese, A.; Hanauske-Abel, H.M.; Park, M.H.; Henke, S.; Folk, J.E. Title: The active site of deoxyhypusyl hydroxylase: use of catecholpeptides and their component chelator and peptide moieties as molecular probes Source: Biochim. Biophys. Acta-Protein Struct. 1077 (1991) 159-166
Authors: Akunne, Hyacinth C.; Reid, Audrey A.; Thurkauf, Andrew; Jacobson, Arthur E.; de Costa, Brian R.; Rice, Kenner C.; Heyes, Melvin P.; Rothman, Richard B. Title: [3H]1-[2-(2-Thienyl)Cyclohexyl] Piperidine Labels Two High-Affinity Binding Sites in Human Cortex: Further Evidence for Phencyclidine Binding Sites Associated With the Biogenic Amine Reuptake Complex Source: Synapse 8 (1991) 289-300 Description: 1 and 2 site binding model.
Authors: Aldroubi, A.; Unser, M.; Tietz, D.; Trus, B. Title: Computerized methods for analyzing two-dimensional agarose gel electropherograms Source: Electrophoresis 12 (1991) 39-46
Authors: Ashizawa, Kiyoto; McPhie, Peter; Lin, Kwang-huei; Cheng, Sheue-yann Title: An in Vitro Novel Mechanism of Regulating the Activity of Pyruvate Kinase M2 by Thyroid Hormone and Fructose 1,6-Bisphosphate Source: Biochem. 30 (1991) 7105-7111 Description: Michaelis Menten equation
Authors: Attri, Arun K.; Lewis, Marc S.; Korn, Edward D. Title: The Formation of Actin Oligomers Studied by Analytical Ultracentrifugation Source: J. Biol. Chem. 266 (1991) 6815-6824 Description: ultracentrifuge sedimentation velocity data analysis.
Authors: Becerra, S. Patricia; Kumar, Amalendra; Lewis, Marc S.; Widem, Steven G.; Abbotts, John; Karawya, Essam M.; Hughes, Stephen H.; Shiloach, Joseph; Wilson, Samuel H. Title: Protein-Protein Interactions of HIV-1 Reverse Transcriptase: Implication of Central and C-Terminal Regions in Subunit Binding Source: Biochem. 30 (1991) 11707-11719 Description: PCMLAB, ultracentrifuge data analysis.
Authors: Berg, Stacey L.; Balis, Frank M.; McCully, Cynthia L.; Godwin, Karen S.; Poplack, David G. Title: Pharmacokinetics of Pyrazoloacridine in the Rhesus Monkey Source: Canc. Res. 51 (1991) 5467-5470 Description: post infusion concentration-time data fit to bi- and tri-exponential functions.
Authors: Brenner, Bernhard; Yu, Leepo C. Title: Characterization of Radial Force and Radial Stiffness in Ca2+ Activated Skinned Fibres of the Rabbit Psoas Muscle Source: J. Physiol. 441 (1991) 703-718 Description: cross-bridge theory of muscle contraction, response of single fibres to applied radial force by dextran T500 fit to function of two exponentials plus a constant.
Authors: Bubb, Michael R.; Lewis, Marc S.; Korn, Edward D. Title: The Interaction of Monomeric Actin with Two Binding Sites on Acanthamoeba Actobindin Source: J. Biol. Chem. 266 (1991) 3820-3826 Description: sedimentation equilibrium determination of the Mr of labeled and unlabeled actobinbin.
Authors: Chung, Soo Il; Park, Myung Hee; Folk, J.E.; Lewis, Marc S. Title: Eukaryotic Initiation Factor 5A: The Molecular Form of the Hypusine-Containing Protein from Human Erythrocytes Source: Biochim. Biophys. Acta-Protein Struct. 1076 (1991) 448-451 Description: elution profiles of eIF-5A recorded at 280nm, values of Kd as functions of MW of standards fit to logistic.
Authors: Climent, I.; Sjoeberg, B.M.; Huang, C.Y. Title: Carboxyl-terminal Peptides as Probes for Escherichia coli Ribonucleotide Reductase Subunit Interaction: Kinetic Analysis of Inhibition Studies Source: Biochem. 30 (1991) 5164-5171
Authors: Closset, J.; Dumbrowicz, D.; Vandenbroek, M.; Hennen, G. Title: Effects of Bovine, Human, and Rat Growth Hormones on Immature Hypophysectomized Rat Testis Source: Growth Reg. 1 (1991) 29-37 Description: analysis of binding data using MLAB.
Authors: Coche, Thierry; Deroubaix, Xavier; Depiereux, Eric; Feytmans, Ernest Title: Compartmental Analysis of Steady-State Taurocholate Transport Kinetics by Isolated Rat Hepatocytes Source: Hepatology 13 (1991) 1203-1214 Description: differential equations for compartmental model.
Authors: Das, Joachim; Busse, Heinrich-Gustav Title: Analysis of the Dynamics of Relaxation Type Oscillation in Glycolysis of Yeast Extracts Source: Biophys. J. 60 (1991) 369-379 Description: linear algebraic systems of equations for concentrations of substances in chemical system
Authors: Deroubaix, Xavier; Coche, Thierry; Depiereux, Eric; Feytmans, Ernest Title: Saturation of Hepatic Transport of Taurocholate in Rats in Vivo Source: Am. J. Physiol. 260 (1991) G189-G196 Description: compartmental model, Michaelis Menten parameters
Authors: Duncan, Mark W.; Villacreses, Nelly E.; Pearson, Philip G.; Wyatt, Lance; Rapoport, Stanley I.; Kopin, Irwin J.; Markey, Sanford P.; Smith, Quentin R. Title: 2-Amino-3-(Methylamino)-Propanoic Acid (BroAA) Pharmacokinetics and Blood-Brain Barrier Permeability in the Rat Source: J. Pharm. Exp. 258 (1991) 27-35 Description: plasma concentration fit to 3 component exponential equation using MLAB.
Authors: Green, Susan M.; Ginsburg, Ann; Lewis, Marc S.; Hensley, Preston Title: Roles of Metal Ions in the Maintenance of the Tertiary and Quaternary Structure of Arginase from Saccharomyces cerevisiae Source: J. Biol. Chem. 266 (1991) 21474-21481 Description: equilibrium sedimentation studies, ultracentrifuge data.
Authors: Grem, Jean L.; McAtee, Nanette; Murphy, Robert F.; Balis, Frank M.; Steinberg, Seth M.; Hamilton, J. Michael; Sorensen, J. Mel; Santor, Oliver; Kramer, Barnett S.; Goldstein, Lori J.; Gay, Laura M.; Caubo, Kathleen M.; Goldspiel, Barry; Allegra, Carmen J. Title: A Pilot Study of Interferon Alpha-2a in Combination with Fluorouracil Plus High-Dose Leucovorin in Metastatic Gastrointestinal Carcinoma Source: J. Clin. Oncol. 9 (1991) 1811-1820 Description: plasma concentration time data fit to monoexponential decay function.
Authors: Hill, Harlan F.; Coda, Barbara A.; Tanaka, Akira; Shaffer, Randy Title: Multiple-Dose Evaluation of Intravenous Hydromorphone Pharmacokinetics in Normal Human Subjects Source: Anesth. Analg. 72 (1991) 330-336 Description: triexponential model, area under curve
Authors: Ilondo, M. Mapoko; Smal, Jean; De Meyts, Pierre; Courtoy, Pierre J. Title: Comparison of the Effects of Hypertonic Sucrose and Intracellular Potassium Depletion on Growth Hormone Receptor Binding Kinetics and Down-Regulation in IM-9 Cells: Evidence for a Sequential Block of Receptor-Mediated Endocytosis Source: Endocrin. 128 (1991) 1597-1602 Description: dissociation kinetics modeled using biexponential model
Authors: Kanzaki, Hiroshi; McPhie, Peter; Miles, Edith Wilson Title: Effect of Single Amino Acid Substitutions at Positions 49 and 60 on the Thermal Unfolding of the Tryptophan Synthase Alpha Subunit from Salmonella typhimurium Source: Arch. Biochem. Biophys. 284 (1991) 174-180 Description: ellipticities of native and denatured proteins fit using MLAB.
Authors: Kayastha, Arvind M.; Sawa, Yoshiro; Nagata, Shinji; Miles, Edith Wilson Title: Site-Directed Mutagenesis of the Beta Subunit of Tryptophan Synthase from Salmonella typhimurium Source: J. Biol. Chem. 266 (1991) 7618-7625 Description: fluorescence intensity data were collected on a solution of the apoE350Q Alpha-2, Beta-2 complex in the presence of pyridoxal phosphate concentration ranging from .05 to 2.2 microM, dissociation constants determined.
Authors: Kerr, Beth; Hill, Harlan; Coda, Barbara; Celogero, Mark; Chapman, C. Richard; Hunt, Earl; Buffington, Veronica; Mackie, Adam Title: Concentration-Related Effects of Morphine on Cognition and Motor Control in Human Subjects Source: Neuropsychopharm. 5 (1991) 157-166 Description: biexponential model of plasma concentration-time.
Authors: Kocsis, Eva; Trus, Benes L.; Steer, Clifford J.; Bisher, Margaret E.; Steven, Alasdair C. Title: Image Averaging of Flexible Fibrous Macromolecules: The Clathrin Triskelion Has an Elastic Proximal Segment Source: J. Struct. Biol. 107 (1991) 6-14 Description: fit line shape to sum of 3 Gaussians.
Authors: Koziol, James A.; Hacke, W. Title: A Bivariate Version of Andrews Plots Source: IEEE Biomed. 38 (1991) 1271-1274 Description: 3d graphics
Authors: Lapointe, D.S.; Olson, M.S. Title: Compartmental Analysis of 45-Ca 2+ Efflux in Perfused Rat Liver: Effects of Hormonal Stimulation Source: Cell Calcium 12 (1991) 743-753 Description: exponetial function fit with MLAB and SAAM/CONSAM.
Authors: Lin, Kwang-Huei; Parkinson, Clifford; McPhie, Peter; Cheng, Sheue-yann Title: An Essential Role of Domain D in the Hormone-Binding Activity of Human Beta-1 Thyroid Hormone Nuclear Receptor Source: Mol. Endocrin. 5 (1991) 485-492 Description: affinity constants for binding of T3 to intact and truncated h-TR-Beta-1.
Authors: Mihalyi, Elemer; Tercero, Juan Carlos; Diaz-Maurino, Teresa Title: Clotting of fibrinogen. 5. Changes in pH Associated with Clotting of Fibrinogen. Kinetic Studies of the pH Shift and Correlation of the pH Change with the Release of Fibrinopeptides and the Ensuing Polymerization Source: Biochem. 30 (1991) 4753-4762 Description: mathematical analysis of the pH shift recordings, fibrinopeptide release, and optical density increase curves was performed by curve fitting with MLAB.
Authors:Morrison, F. Title: Review of MLAB Interpreter for Modelling Dynamic Systems Source:J. Business Forecasting Methods and Systems 10 (1991) Winter, 27
Authors: Murphy, V.A.; Smith, Q.R.; Rapoport, S.I. Title: Saturable Transport of Ca Into CSF in Chronic Hypo- and Hypercalcemia Source: J. Neurosci. R. 30 (1991) 421-426 Description: data fit to Michaelis Menten equation.
Authors: Murphy, Vincent A.; Wadhwani, Kishena C.; Smith, Quentin R.; Rapoport, Stanley I. Title: Saturable Transport of Manganese (II) Across the Rat Blood-Brain Barrier Source: J. Neurochem. 57 (1991) 948-954 Description: values of Vmax, Km, and Kns nonlinear least squares curve fit.
Authors: O'Dwyer, Peter J.; LaCreta, Frank; Engstrom, Paul F.; Peter, Ruth; Tartaglia, Laura; Cole, Diane; Litwin, Samuel; DeVito, Joseph; Poplack, David; DeLap, Robert J.; Comis, Robert L. Title: Phase I/Pharmacokinetic Reevaluation of ThioTEPA Source: Canc. Res. 51 (1991) 3171-3176 Description: plasma concentration-time, area under curve, linear, exponential and Hill parameters.
Authors: Painter, G.R.; Wright, L.L.; Hopkins, S.; Furman, P.A. Title: Initial binding of 2'-deoxynucleoside 5'-triphosphate to human immunodeficiency virus type I reverse transcriptase Source: J. Biol. Chem. 266 (1991) 19362-19368
Authors: Rafalski, M.; Ortiz, A.; Rockwell, A.; van Ginkel, L.C.; Lear, J.D.; DeGrado, W.F.; Wilscut, J. Title: Membrane Fusion Activity of the Influenza Virus hemagglutinin: Interaction of HA2 N-Terminal Peptides with Phospholipid Vesicles Source: Biochem. 30 (1991) 10211-10220
Authors: Ross, P.D.; Howard, F.B.; Lewis, M.S. Title: Thermodynamics of Antiparallel Hairpin-Double Helix Equilibria in DNA Oligonucleotides from Equilibrium Centrifugation Source: Biochem. 30 (1991) 6269-6275
Authors: Rothman, Richard B.; Bykov, Victor; Mahboubi, Artin; Long, Joseph B.; Jiang, Qi; Porreca, Frank; de Costa, Brian R.; Jacobson, Arthur E. Title: Interaction of Beta-Funal Trexamine With [3H] CycloFOXY Binding in Rat Brain: Further Evidence that Beta-FNA Alkylates the Opioid Receptor Complex Source: Synapse 8 (1991) 86-99 Description: binding surfaces were fit to appropriate equations using MLAB.
Authors: Rothman, Richard B.; Long, Joseph B.; Bykov, Victor; Xu, Heng; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W. Title: Upregulation of the Opioid Receptor Complex by the Chronic Administration of Morphine: A Biochemical Marker Related to the Development of Tolerance and Dependence Source: Peptides 12 (1991) 151-160 Description: 2 component dissociation model
Authors: Rothman, Richard B.; Mahboubi, Artin; Bykov, Victor; Kim, Chong-Ho; Jacobson, Arthur E.; Rice, Kenner C. Title: Probing the Opioid Receptor Complex With (+)-Trans-Superfit. I. Evidence That [D-Pen2,D-Pen5] Enkephalin Interacts with High Affinity at the Delta-cx Binding Site Source: Peptides 12 (1991) 359-364 Description: surfaces fit to one site binding model
Authors: Rothman, Richard; Mele, Andrea; Reid, Audrey R.; Akunne, Hyacinth; Greig, Nigel; Thurkauf, Andrew; de Costa, Brian R.; Rice, Kenner C.; Pert, Agu Title: GBR12909 Antagonizes the Ability of Cocaine to Elevate Extracellular Levels of Dopamine Source: Pharm. Biochem. Behav. 40 (1991) 387-397 Description: 1,2,3-site binding models
Authors: Rothman, Richard B.; Reid, Audrey; Mahboubi, Artin; Kim, Chong-Ho; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C. Title: Labeling by [3H] 1,3-Di(2-tolyl)guanidine of Two High Affinity Binding Sites in Guinea Pig Brain: Evidence for Allosteric Regulation by Calcium Channel Antagonists and Pseudoallosteric Modulation by Sigma Ligands Source: Mol. Pharm. 39 (1991) 222-232 Description: F-test, 1,2, and 3-site binding model.
Authors: Rothman, Richard B.; Xu, Heng; Seggel, Mark; Jacobson, Arthur E.; Rice, Kenner C.; Brine, George A.; Carroll, F. Ivy Title: RTI-4614-4: An Analog of (+)-Cis-3-Methylfentanyl with a 27,000-Fold Binding Selectivity for Mu Versus Delta Opioid Binding Sites Source: Life Sci. 48 (1991) PL111-PL116 Description: 2 parameter logistic, IC50, slope factor, ligand binding analysis.
Authors: Sackett, D.L.; Lippoldt, R.E. Title: Thermodynamics of Reversible Monomer-Dimer Association of Tubulin Source: Biochem. 30 (1991) 3511-3517
Authors: Schwartz, Michael W.; Bergman, Richard N.; Kahn, Steven E.; Taborsky, Gerald J., Jr.; Fisher, Lloyd D.; Sipols, Alfred J.; Woods, Stephen C.; Steil, Gary M.; Porte, Daniel, Jr. Title: Evidence for Entry of Plasma Insulin into Cerebrospinal Fluid through an Intermediate Compartment in Dogs Source: J. Clin. Inv. 88 (1991) 1272-1281 Description: 3 compartment model
Authors: Takada, Y.; Greig, N.H.; Vistica, D.T.; Rapoport, S.I.; Smith, Q.R. Title: Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier Source: Canc. Chem. Pharm. 29 (1991) 89-94
Authors: Tietz, Dietmar Title: Analysis of One-Dimensional Gels and Two-Dimensional Serwer-type Gels on the Basis of the Extended Ogston Model Using Personal Computers Source: Electrophoresis 12 (1991) 28-39 Description: Ferguson plots
Authors: Tietz, Dietmar; Gombocz, Erich; Chrambach, Andreas Title: Procedures and Computer Program for Deriving the Ferguson Plot from Gel Electrophoresis in a Single Pore Gradient Gel: Application to Agarose Gel and a Polystyrene Particle Source: Electrophoresis 12 (1991) 710-721 Description: GRADFIT for Macintosh
Authors: Ward, Frank T.; Kelley, James A.; Roth, Jeri S.; Lombardo, Frederic A.; Weiss, Raymond B.; Leyland-Jones, Brian; Chun, Hoo G. Title: A Phase I Bioavailability and Pharmacokinetic Study of Hexamethylene Bisacetamide (NSC 95580) Administered via Nasogastric Tube Source: Canc. Res. 51 (1991) 1803-1810 Description: Area under curve calculated using trapezoidal rule, plasma concnetration fit to monoexponetial.
Authors: Xu, Heng; Ni, Qing; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B. Title: Preliminary Ligand Binding Data for Subtypes of the Delta Opioid Receptor in Rat Brain Membranes Source: Life Sci. 49 (1991) PL141-PL146 Description: 2 parameter logistic equation, IC50, slope, 1 and 2 site binding, PCMLAB.
Authors: Zaharko, Daniel S.; Keller, James A.; Tomaszewski, Joseph E.; Hegedus, Lajos; Hartman, Neil R. Title: Cyclopentenyl Cytosine: Interspecies Predictions Based on Rodent Plasma and Urine Kinetics Source: Inv. New Drugs 9 (1991) 9-17 Description: statistical fitting, simulation using differential equations, graphical output
Authors: Ashizawa, Kiyoto; Kato, Hirokazu; McPhie, Peter; Cheng, Sheue-yann Title: Regulation of Thyroid Hormone Binding to its Cytosolic Binding Protein by L-Alpha-Alanine Source: Biochem. Biophys. Res. Comm. 167 (1990) 587-592 Description: affinity constants obtained with MLAB.
Authors: Ashorn, P.; Moss, B.; Weinstein, J.N.; Chaudhary, V.K.; Fitzgerald, D.J.; Pastan, I.; Berger, E.A. Title: Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors Source: PNAS 87 (1990) 8889-8893 Description: COMBO drug analysis
Authors: Aulabaugh, Ann; Schloss, John V. Title: Oxalyl Hydroxamates as Reaction-Intermediate Analogues for Ketol-Acid Reductoisomerase Source: Biochem. 29 (1990) 2824-2830 Description: exponential model, Michaelis constants
Authors: Beckers, Albert; Stevenaert, Achille; Foidart, Jean-Michel; Hennen, Georges; Frankenne, Francis Title: Placental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women Source: J. Clin. Endo. Metab. 71 (1990) 725-731 Description: significant GH peaks were identified with Pulsar program in connection with MLAB
Authors: Beckers, A.; Stevenaert, A.; Pirens, G.; Flandroy, P.; Sulon, J.; Hennen, G. Title: Cyclical Cushing's Disease and Its Successful Control Under Sodium Valproate Source: J. Endocrin. Inv. 13 (1990) 923-929 Description: Pulsar program and MLAB used to detect cortisol peaks.
Authors: Biosca, J.A.; Eisenberg, E.; Reedy, M.C.; Reedy, M.K. Title: Binding of ADP and adenosine 5'-[beta, gamma-imido] triphosphate to insect flight muscle fibrils Source: Eur. J. Biochem. 189 (1990) 395-399
Authors: Blaney, Susan M.; Balis, Frank M.; Hegedus, Lajos; Heideman, Richard L.; McCully, Cynthia; Murphy, Robert F.; Kelley, James A.; Poplack, David G. Title: Pharmacokinetics and Metabolism of Cyclopentenyl Cytosine in Nonhuman Primates Source: Canc. Res. 50 (1990) 7915-7919 Description: plasma disappearance of CPE-C following iv bolus dose, fit to biexponential function.
Authors: Blaszczak, L.C.; Brown, R.F.; Cook, G.K.; Hornback, W.J.; Indelicato, J.M.; Jordan, C.L.; Katner, A.S.; Kinnick, M.D.; McDonald, J.H. Title: Comparative Reactivity of 1-carba-1-dethiacephelosporins with Cephalosporins Source: J. Med. Chem. 33 (1990) 1656-1662
Authors: Carpen, Mary E.; Poplack, David G.; Pizzo, Philip A.; Balis, Frank M. Title: High Performance Liquid Chromotographic Method for Analysis of 2',3'-Dideoxyinosine in Human Body Fluids Source: J. Chrom. B 526 (1990) 69-75 Description: using reciprocally weighted linear regression analysis, the peak height ratios of ddI to internal standard vs. concentration gave a correlation coefficient of .998.
Authors: Daly, P.F.; Zugmaier, G.; Sandler, D.; Carpen, M.; Myers, C.E.; Cohen, J.S. Title: Regulation of the cytidine phospholipid pathways in human cancer cells and effects of 1-beta-d-Arabinofuranosylcytosine: a noninvasive 31-P nuclear magnetic resonance study Source: Canc. Res. 50 (1990) 552-557
Authors: Ellis, John; Huyler, Joanne H.; Kemp, Dorothy E.; Weiss, Samuel Title: Muscarinic Receptors and Second-Messenger Responses of Neurons in Primary Culture Source: Brain Res. 511 (1990) 234-240 Description: data from receptor binding studies analyzed according to equations describing competitive interactions at one or more sites.
Authors: Hawkins, Mary E.; Poplack, David G.; Pizzo, Philip A.; Balis, Frank M. Title: High-Performance Liquid Chromotographic Method for the Analysis of 2',3'-Dideoxycytidine in Human Plasma Source: J. Chrom. B 532 (1990) 442-444 Description: linear regression of peak height ratios of internal standard versus concentration of ddc gave correlation coefficient of .97.
Authors: Hill, H.F.; Saeger, L.; Bjurstrom, R.; Donaldson, G.; Chapman, C.R.; Jacobson, R. Title: Steady-State Infusions of Opioids in Human Volunteers. I. Pharmacokinetic Tailoring Source: Pain 43 (1990) 57-67 Description: concentration-time data fit to biexponential model.
Authors: Ilett, K.F.; Ong, R.T.T.; Batty, K.T.; Taylor, J.D. Title: Effect of Urine pH on the Stability of Doxorubicin and Its Recovery from Bladder Instillations Source: Br. J. Urol. 65 (1990) 478-482 Description: urinary concentration data fit to biexponential equation.
Authors: Kambadur, Ravi; Lewis, Marc; Chang, Sulie; Flavin, Martin Title: Characterization of Putative Cytoskeletal Proteins from a Trypanosomatid and Their Comparative Binding to Microtubules and Soluble Tubulin Source: J. Biol. Chem. 265 (1990) 20959-20965 Description: dissociation constant and maximum number of sites fit as parameters.
Authors: Kaplan, Ofer; Navon, Gil; Lyon, Robbe C.; Faustino, Patrick J.; Straba, Eric J.; Cohen, Jack S. Title: Effects of 2-Deoxyglucose on Drug Sensitive and Drug Resistant Human Breast Cancer Cells: Toxicity and Magnetic Resonance Spectroscopy Studies of Metabolism Source: Canc. Res. 50 (1990) 544-551
Authors: Kim, H.C.; Lewis, M.S.; Gorman, J.J.; Park, S.C.; Girard, J.E.; Folk, J.E.; Chung, S.I. Title: Protransglutaminase E from Guinea Pig Skin Source: J. Biol. Chem. 265 (1990) 21971-21978-152
Authors: Lin, C.; Stone, R.A.; Wax, M.B. Title: Angiotensin binding sites in rabbit anterior uvea and human ciliary epithelial cells Source: Inv. Ophthal. Vis. Sci. 31 (1990) 147-152
Authors: Lowry, R.J.; Sarkar, D.P.; Chen, Y.; Blumenthal, R. Title: Observation of single influenza virus-cell fusion and measurement by fluorescence videomicroscopy Source: PNAS 87 (1990) 1850-1854 Description: cell fluorescence data analysis
Authors: Marquez, V.E.; Tseng, C.K.H.; Mitsutya, H.; Aoki, S.; Kelley, J.A.; Ford, H.; Roth, J.S.; Broder, S.; Johns, D.G.; Driscoll, J.S. Title: Acid-Stable 2' Fluoro Purine Dideoxynucleosides as Active Agents Against HIV Source: J. Med. Chem. 33 (1990) 978-985
Authors: Martin, Roger L.; Ilett, Kenneth F.; Minchin, Rodney F. Title: Characterisation of Putrescine Uptake by Cultured Adult Mouse Hepatocytes Source: Biochim. Biophys. Acta 1051 (1990) 52-59 Description: Kinetics parameters +/- standard error for putrescine uptake assuming Michaelis Menten kinetics determines with MLAB.
Authors: Metwally, M.E.; Wolfe, N.L. Title: Hydrolysis of Chlorostilbene Oxide II. Modeling of Hydrolysis in Aquifer Samples and in Sediment/Water Systems Source: Env. Tox. Chem. 9 (1990) 963-973 Description: pseudo first order fit of expoxide accumulation in ground water versus time.
Authors: Pizzo, Philip A.; Butler, Karina; Balis, Frank; Brouwers, Emile; Hawkins, Mary; Eddy, Janie; Einloth, Michele; Falloon, Judy; Husson, Robert; Jarosinski, Paul; Meer, Jacob; Moss, Howard; Poplack, David G.; Santacroce, Sheila; Weiner, Lori; Wolters, Pam Title: Dideoxycytidine Alone and in an Alternating Schedule with Zidovudine in Children with Symptomatic Human Immunodeficiency Virus Infection Source: J. Pediatrics 117 (1990) 799-808 Description: postinfusion data from iv dose fit to monoexponential equation, compute area under curve.
Authors: Rahman, A.; Treat, J.; Roh, J.K.; Potkul, L.A.; Alvord, W.G.; Forst, D.; Woolley, P.V. Title: A phase I clinical trial and pharmacokinetic evaluation of liposome-encapsulated doxorubicin Source: J. Clin. Oncol. 8 (1990) 1093-1100
Authors: Reid, A.A.; Mattison, M.V.; de Costa, B.R.; Thurkauf, A.; Jacobson, A.E.; Monn, J.A.; Rice, K.C.; Rothman, R.B. Title: Specificity of Phencyclidine-Like Drugs and Benzomorphan Opiates for Two High Affinity Phencyclidine Binding Sites in Guinea Pig Brain Source: Neuropharm. 29 (1990) 811-817 Description: Kd and Bmax estimated.
Authors: Reid, Audrey A.; Monn, James A.; Jacobson, Arthur E.; Rice, Kenner C.; Rothman, Richard B. Title: Pseudoallosteric Modulation by (+)-MK801 of NMDA-Coupled Phencyclidine Binding Sites Source: Life Sci. 47 (1990) PL77-PL82 Description: dissociation curves fit to 1-,2-component dissociation models as mono- and bi-exponential functions.
Authors: Richards, Ernest W.; Hamm, Michael W.; Fletcher, John E.; Otto, David A. Title: The Binding of Palaritoyl-CoA to Bovine Serum Albumin Source: Biochim. Biophys. Acta 1044 (1990) 361-367 Description: data obtained from fluorescence enhancement studies were fitted to mathematical models using MLAB
Authors: Rodgers, R.P.; Levin, Jack Title: A Critical Reappraisal of the Bleeding Time Source: Sem. Thromb. 16 (1990) 1-20 Description: linear least squares analysis.
Authors: Rothman, Richard B.; Bykov, Victor; de Costa, Brian R.; Jacobson, Arthur E.; Rice, Kenner C.; Brady, Linda S. Title: Interaction of Endogenous Opioid Peptides and Other Drugs with Four Kappa Opioid Binding Sites in Guinea Pig Brain Source: Peptides 11 (1990) 311-331 Description: each surface fit to 2-site binding model.
Authors: Rothman, R.B.; Long, J.B.; Bykov, V.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W. Title: Pretreatment of Rats with the Irreversible Mu-Receptor Antagonist, Beta-FNA, Fails to Prevent Naltrexone-Induced Upregulation of Mu-Opioid Receptors Source: Neuropharm. 29 (1990) 805-810 Description: one site binding model.
Authors: Saari, Leonard L.; Cotterman, Josephine C.; Primiani, Michael M. Title: Mechanism of Sulfonylurea Herbicide Resistance in the Broadleaf Weed, Kochia scoparia Source: Plant Physiol. 93 (1990) 55-61 Description: determine Michaelis constants.
Authors: Sato, S.; Kador, P.F. Title: Inhibition of aldehyde reductase by aldose reductase inhibitors Source: Biochem. Pharm. 40 (1990) 1033-1042
Authors: Sayer, J.M.; Lehr, R.E.; Kumar, S.; Yagi, H.; Yeh, H.J.C.; Holder, G.M.; Duke, C.C.; Silverton, J.V.; Gibson, C.; Jerina, D.M. Title: Comparative Solvolytic Reactivity of Bay-Region Diol Epoxides Derived from Dibenz-[a,j]-Anthracene and Dibenzacridines Source: JACS 112 (1990) 1177-1185 Description: rate law, fit rate constants to measured kinetic data.
Authors: Wadhwani, K.C.; Smith, Q.R.; Rapoport, S.I. Title: Facilitated transport of L-phenylalanine across blood-nerve barrier of rat peripheral nerve Source: Am. J. Physiol. Reg. Integ. Comp. Physiol. 258 (1990) R1436-R1444
Authors: Weir, Roger L.; Anderson, Sally M.; Daly, John W. Title: Inhibition of N6-[3H] Cyclohexyladenosine Binding by Carbamazepine Source: Epilepsia 31 (1990) 503-512 Description: single and dual state receptor models fitted to data.
Authors: Wolff, Edith C.; Park, Myung Hee; Folk, J.E. Title: Cleavage of Spermidine as the First Step in Deoxyhypusine Synthesis Source: J. Biol. Chem. 265 (1990) 4793-4799 Description: For kinetic studies, the concentration of substrates and enzyme fraction were varied and assays were conducted for 60 minutes, data fitted to Michaelis Menten equation with MLAB.
Authors: Zaharevitz, Daniel W.; Chisena, Christine A.; Cysyk, Richard L. Title: Rapid Increase of Cellular UDP-Glucuromide After Mitogen Stimulation of Quiescent 3T3 Mouse Fibroblasts Source: Biochem. Int. 20 (1990) 1067-1076 Description: least squares curve fitting.
Authors: Zlokovic, Berislav V.; Hyman, Shigeyo; McComb, J. Gordon; Lipovac, Milo N.; Tang, Gordon; Dauson, Hugh Title: Kinetics of Arginine-Vasopressin Uptake at the Blood-Brain Barrier Source: Biochim. Biophys. Acta 1025 (1990) 191-198 Description: best fit values for Vmax, Km, Kd, Michaelis parameters.
Authors: Abbruzzese, A.; Pauk, M.H.; Beninati, S.; Folk, J.E. Title: Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide Source: Biochim. Biophys. Acta-Protein Struct. (1989) 248-255
Authors: Aparacio, J.; Muhammed, M. Title: Extraction Kinetics of Zinc from Aqueous Perchlorate Solution by D2EHPA Dissolved in Isopar-H Source: Hydrometallurgy 21 (1989) 385-399 Description: evaluated rate constants and order of reactions by curve-fitting.
Authors: Balis, F.M.; McCully, C.; Gough, L.; Pizzo, P.A.; Poplack, P.G. Title: Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys Source: Antimicrob. Ag. and Chem. 33 (1989) 810-812
Authors: Balis, Frank M.; Pizzo, Philip A.; Eddy, Janie; Wilfert, Cathy; McKinney, Ross; Scott, Gwendolyn; Murphy, Robert F.; Jarosinski, Paul F. Title: Pharmacokinetics of Zidovudine Administered Intravenously and Orally in Children with Human Immunodeficiency Virus Infection Source: J. Pediatrics 114 (1989) 880-884 Description: post infusion data fit to biexponential function.
Authors: Balis, Frank M.; Pizzo, Philip A.; Murphy, Robert F.; Eddy, Janie; Jarosinski, Paul F.; Falloon, Judith; Broder, Samuel; Poplack, David G. Title: The Pharmacokinetics of Zidovudine Administered by Continuous Infusion in Children Source: Ann. Int. Med. 110 (1989) 279-285 Description: Zidovudine disappearance following bolus adminstration fit to biexponential function.
Authors: Basile, A.S.; Bolger, G.T.; Lueddens, H.W.; Skolnick, P. Title: Electrophysiological actions of Ro5-4864 on cerebellar Purkinje neurons: evidence for "peripheral" benzodiazepine receptor-mediated depression Source: J. Pharm. Exp. 248 (1989) 463-469
Authors: Benkelfat, Chawlei; Aulakh, Charanjit S.; Bykov, Victor; Rice, Kenner C.; de Costa, Brian R.; Rothman, Richard B. Title: Apparent Down-Regulation of Rat Brain Mu- and Kappa-Opioid Binding Sites Labelled with [3H]-Cyclo-FOXY Following Chronic Administration of the Potent 5-Hydroxytryptamine Reuptake Blocker, Clomipramine Source: J. Pharm. Pharmacol. 41 (1989) 865-867 Description: binding surfaces fit to binding equations
Authors: Boal, Jila H.; Williamson, Margaret; Boyd, Victoria L.; Ludeman, Susan M.; Egan, William Title: 31-P NMR Studies of the Kinetics of Bisalkylation by Isophosphoramide Mustard: Comparisons With Phosphoramide Mustard Source: J. Med. Chem. 32 (1989) 1768-1773 Description: 31-P NMR data fit to solution of system of 3, first order differential equations.
Authors: Bristow, M.R.; Hershberger, R.E.; Port, J.D.; Minobe, W.; Rasmussen, R. Title: Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in non failing and failing human ventricular myocardium Source: Mol. Pharm. 35 (1989) 295-303
Authors: Cheng, S.Y.; McPhie, P. Title: Rhodamine B-labeled thyroid hormone forms high molecular weight aggregates in solution: A possible source of artifacts in binding experiments Source: Anal. Biochem. 176 (1984) 440-443
Authors: Closset, J.; Hennen, G. Title: Biopotency of Highly Purified Porcine FSH and Human LH on Gonadal Function Source: J. Endocrin. 120 (1989) 89-96 Description: Scatchard analysis was performed on data from binding inhibition experiments.
Authors: Deroubaix, Xavier; Coche, Thierry; Depiereux, Eric; Feytmans, Ernest Title: Compartmental Modeling of the Hepatic Transport of Taurocholate in the Rat in Vivo Source: Am. J. Physiol. 257 (1989) G210-G220 Description: compartmental models
Authors: Egorin, Merrill J.; Forest, Alan; Belani, Chandra P.; Ratain, Mark J.; Abrams, Jeffrey S.; Van Echo, David A. Title: A Limited Sampling Stategy for Cyclophosphamide Pharmacokinetics Source: Canc. Res. 49 (1989) 3129-3133 Description: computer modeling of the decline in plasma conc of cyclophosphamide.
Authors: Ehrenberg, L.; Harms-Ringdahl, M.; Fedorcsak, I.; Granath, F. Title: Kinetics of the Copper- and Iron-Catalyzed Oxidation of Cysteine by Dioxygen Source: Acta Chem. Scand. 43 (1989) 177-187 Description: parameters k0 and K were estimated by minimizing sum of squares, Michaelis Menten, Lineweaver Burk
Authors: Evans, John A.; Eisenberg, Evan Title: Intermediate Oxygen Exchange Catalyzed by the Actin-Activated Skeletal Myosin Adenosine Triphosphatase Source: Biochem. 28 (1989) 7741-7747 Description: The oxygen isotopic composition was used to calculate a partition coefficient and a theoretical distribution assuming a single path using algorithms written in MLAB.
Authors: Evoniuk, G.; Moody, E.J.; Skolnick, P. Title: Ultraviolet irradiation selectively disrupts the gamma- aminobutyric acid/benzodiazepine receptor-linked chloride ionophore Source: Mol. Pharm. 35 (1989) 695-700
Authors: Fernandez, L.A.; Elizaldi, M.P.; Aparacio, J.L. Title: Hydrochloric Acid Transport Through a Trilaurylamine-Supported Liquid Membrane from Aqueous Lithium Chloride Media Source: J. Membrane Sci. 44 (1989) 213-232 Description: obtained accurate estimate of parameters in flux equations using MLAB.
Authors: French-Mullen, J.M.; Rogawski, M.A. Title: Interaction of phencyclidine with voltage-dependent potassium channels in cultured rat hippocampal neurons: comparison with block of the NMDA receptor-ionophore complex Source: J. Neurosci. 9 (1989) 4051-4061
Authors: Gitterman, M.; Shrager, R.I.; Weiss, G.H. Title: Influence of noise on systems described by a Mathieu equation Source: Phys. Lett. A 142 (1989) 84-88
Authors: Hardwick, J.C.; Ehrlich, Y.H.; Hendley, E.D. Title: Extracellular ATP Stimulates Norepinephrine Uptake in PC12 Cells Source: J. Neurochem. 53 (1989) 1512-1518
Authors: Heideman, Richard L.; Cole, Diane E.; Balis, Frank; Sato, Judy; Reaman, Gregory H.; Packer, Roger J.; Singher, Lawrence J.; Ettinger, Lawrence J.; Gillespie, Andrea; Sam, Joseph; Poplack, David G. Title: Phase I and Pharmacokinetic Evaluation of Thiotepa in the Cerebrospinal Fluid and Plasma of Pediatric Patients: Evidence for Dose-Dependent Plasma Clearance of Thiotepa Source: Canc. Res. 49 (1989) 736-741 Description: thiotepa plasma disappearance fit to biexponential model.
Authors: Heideman, Richard L.; Roth, Jeri S.; Ford, Harry, Jr.; Kinnard, Richard D.; Litterst, Charles L.; Kelley, James A. Title: Reverse Phase HPLC Determination and Murine Pharmacokinetics of Arabinosyl-5-Azacytosine Source: J. Liq. Chrom. 12 (1989) 1613-1633 Description: Initial pharmacokinetic parameters for ara-AC in mice were estimated from plasma conc. vs time curve, then fit to triexponential function representing 3 compartment open model.
Authors: Hubbard, M.J.; Klee, C.B. Title: Characterization of a high-affinity monoclonal antibody to calcineurin whose epitope defines a new structural domain of calcineurin A Source: Eur. J. Biochem. 185 (1989) 411-418
Authors: Jaroszewski, J.W.; Ettlinger, M.G. Title: Medium Effects on Formation of Cyclic Enolates from (2E,4Z)-3-formyl-2,4-hexadienedioates, a Novel Ring-Chain Equilibrium: Importance of hydrogen bonding, solvent dipolarity/ polarizability and ion-pairing effects. Stereoisomerism of 3-formyl-2,3-hexadienedioates Source: J. Org. Chem. 54 (1989) 1506-1518
Authors: Koulu, Markku; Bjelogrlic, Nina; Agren, Hans; Saavedra, Juan M.; Potter, William Z.; Linnoila, Markku Title: Diurnal Variation in the Concentrations of Catecholamines and Indolearines in the Median Eminence and in the Intermediate and Posterior Lobes of the Pituitary Gland of the Male Rat Source: Brain Res. 503 (1989) 246-252 Description: fit concentrations to sums of trignometric functions with variable amplitude and phase and DC offset
Authors: Lincoln, G.A.; Libre, E.A.; Merriam, G.R. Title: Long-term reproductive cycles in rams after pinealectomy or superior cervical ganglionectomy Source: J. Reprod. Fertil. 85 (1989) 687-704
Authors: Majumdar, Chirabrata; Stein, Cy A.; Cohen, Jack S.; Broder, Samuel; Wilson, Samuel H. Title: Stepwise Mechanism of HIV Reverse Transcriptase: Primer Function of Phosphorothioate Oligodeoxynucleotide Source: Biochem. 28 (1989) 1340-1346 Description: fit kinetic constants to polymerization reaction rate laws.
Authors: Mathies, Margaret; Hogg, Nancy Title: Absence of Monocyte Procoagulant Activity During the Immune Response to Influenza Virus Source: J. Clin. Microbiol. 27 (1989) 615-621 Description: linear regression experimental clotting times converted to units of PCA activity.
Authors: McPhie, P. Title: A reversible unfolding reaction of swine pepsin; implications for pepsinogen's folding mechanism Source: Biochem. Biophys. Res. Comm. 158 (1989) 115-119
Authors: Mori, K.; Boiziau, C.; Cazenave, C.; Matsukura, M.; Subasinghe, C.; Cohen, J.S.; Broder, S.; Toulme, J.J.; Stein, C.A. Title: Phosphoroselenoate oligodeoxynucleotides: synthesis, physico-chemical characterization, anti-sense inhibitory properties and anti-HIV activity Source: Nucleic Acids Res. 17 (1989) 8207-8219
Authors: Newcomb, William W.; Brown, Jay C.; Booy, Frank P.; Steven, Alasdair C. Title: Nucleocapsid Mass and Capsomer Protein Stoichiometry in Equine Herpes Virus 1: Scanning Transmission Electron Microscopic Study Source: J. Virol. 63 (1989) 3777-3783 Description: histograms were drawn and statistical analysis of data
Authors: Orban, Laszlo; Fawcett, John S.; Tietz, Dietmar; Chrambach, Andreas Title: Sieving of Ionic Constituents Across Moving Boundaries in Gel Electrophoresis Source: Electrophoresis 10 (1989) 254-259 Description: evaluating Ferguson plot (mobility vs. gel concentration) of HEM-chloride-bicinate moving boundary. includes do-file.
Authors: Otsu, Kinya; Kinsella, James; Sacktor, Bertam; Froehlich, Jeffrey P. Title: Transient State Kinetic Evidence for an Oligomer in the Mechanism of Na+ H+ Exchange Source: PNAS 86 (1989) 4818-4822 Description: computer simulations of time-dependent Na+ accumulation, bimolecular reactions simulated with pseudo-first order approximation.
Authors: Pember, Stephen O.; Johnson, Kenneth A.; Villafranca, Joseph J.; Benkovic, Stephen J. Title: Mechanistic Studies on Phenylalanine Hydroxylase from Chromobacterium violaceum. Evidence for the Formation of an Enzyme-Oxygen Complex Source: Biochem. 28 (1989) 2124-2130 Description: Michaelis constants, kinetic constants for each of the sustrates were determined by computer fit of data to overall steady state equation.
Authors: Reed, Dana Kim; Newton, Cathy; Fraga, Mark; Glastad, Karl; Bagheri, Ali; Harris, Sonja; Reed, Brent C. Title: An Analysis of the Relationship Between the Cellular Distribution and the Rate of Turnover for the Separate Classes of Unoccupied, Noncovalently Occupied, and Covalently Occupied Insulin Receptor Source: J. Biol. Chem. 264 (1989) 12673-12679 Description: apparent first order rate constants for various receptor processes.
Authors: Roberts, I.M.; Jacobson, P.; Cornette, J. Title: Secondary structures of rat lipolytic enzymes: Circular dichroism studies and relation to hydrophobic moments Source: Biochem. Biophys. Res. Comm. 162 (1989) 95-101
Authors: Rothman, Richard B.; Bykov, Victor; Long, Joseph B.; Brady, Linda S.; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W. Title: Chronic Adminstration of Morphine and Naltrexone Up-Regulate Mu-Opioid Binding Sites Labeled by [3-H][D-Ala-2,MePhe-4,Gly-ol-5] Enkephalin: Further Evidence for Two Mu-Binding Sites Source: Eur. J. Pharm. 160 (1989) 71-82 Description: best fit estimates of Bmax and Kd
Authors: Rothman, Richard B.; France, Charles P.; Bykov, Victor; de Costa, Brian R.; Jacobson, Arthur E.; Woods, James H.; Rice, Kenner C. Title: Pharmacological Activities of Optically Pure Enantiomers of the Kappa Opioidagonist, U50,488, and its Cis Diastereomer: Evidence for Three Kappa Receptor Subtypes Source: Eur. J. Pharm. 167 (1989) 345-353 Description: one or two-site binding model
Authors: Rothman, R.B.; Long, J.B.; Holaday, J.W.; Bykov, V.; de Costa, B. R.; Kim, C.-H.; Jacobson, A.E.; Rice, K.C. Title: A Study of the Interaction of the Alkylating Agent, NIH10236, with Opioid Receptors in Vitro and in Vivo Source: Neuropharm. 28 (1989) 1349-1356 Description: IC50 and slope factors fit displacement curve to 2-parameter logistic.
Authors: Rothman, Richard B.; Reid, Audrey A.; Monn, James A.; Jacobson, Arthur E.; Rice, Kenner C. Title: The Psychotomimetic Drug Phencyclidine Labels Two High Affinity Binding Sites in Guinea Pig Brain: Evidence for N-Methyl-D-Aspartate-Coupled and Dopamine Reuptake Carrier-Associated Phencylclidine Binding Sites Source: Mol. Pharm. 36 (1989) 887-896 Description: 2 site binding model, estimate Bmax, Kd values
Authors: Sackett, D.L.; Lippoldt, R.E.; Gibson, C.; Lewis, M.S. Title: Easily assembled digital data acquisition system for the analytical ultracentrifuge Source: Anal. Biochem. 180 (1989) 319-325
Authors: Sato, S.; Kador, P.F. Title: Rat lens aldehyde reductase Source: Inv. Ophthal. Vis. Sci. 30 (1989) 1618-1622
Authors: Saunders, Nicholas A.; Ilett, Kenneth F.; Minchin, Rodney F. Title: Pulmonary Alveolar Macrophages Express a Polyamine Transport System Source: J. Cell. Physiol. 139 (1989) 624-631 Description: Henri-Michaelis-Menten equation, Boxenbaum, all data fitted with MLAB.
Authors: Saunders, Nicholas; McGeachie, John K.; Ilett, Kenneth F.; Minchin, Rodney F. Title: Localization of Spermidine Uptake in Rabbit Lung Slices Source: Am. J. Physiol. 257 (1989) C579-C587 Description: Henri-Michaelis-Menten equations fitted using MLAB
Authors: Skinner, Michael H.; Hsieh, Mark; Torseth, John; Pauloin, Danielle; Bhatiz, Gulshan; Harkonen, Scott; Merigan, Thomas C.; Blaschke, Terrence F. Title: Pharmacokinetics of Ritabulin Source: Antimicrob. Ag. and Chem. 33 (1989) 1237-1241 Description: Prophet-parameter estimates of half-life, oral bioavailability, area under curve
Authors: Tietz, Dietmar; Chrambach, Andreas Title: Computer Assisted Evaluation of Polydisperse Two-Dimensional Gel Patterns of Polysaccharide-Protein Conjugate Preparations with Regard to Size and Net Charge Source: Electrophoresis 10 (1989) 667-680 Description: computed particle and gel fiber specific parameters from positions of standards and unknowns on 2D gel. includes do-file.
Authors: Wadler, Scott; Egorin, Merrill J.; Zuhowski, Eleanor G.; Tortorello, Laura; Salva, Kathryn; Runowicz, Carolyn D.; Wiernik, Peter H. Title: Phase I Clinical and Pharmacokinetic Study of Thiotepa Administered Intraperitoneally in Patients with Advanced Malignancies Source: J. Clin. Oncol. 7 (1989) 132-139 Description: loss of thiotepa from peritoneal cavity fit to biexponential model.
Authors: Wax, M.B.; Molinoff, P.B.; Alvarado, J.; Polansky, J. Title: Characterization of beta-adrenergic receptors in cultured human trabecular cells and in human trabecular meshwork Source: Inv. Ophthal. Vis. Sci. 30 (1989) 51-57
Authors: Wilder, Robert T.; Venkataramu, S.D.; Dalton, Larry R.; Birktoff, Jens J.; Trommer, Wofgang E.; Park, Jane H. Title: Catalytic Mechanism and Interactions of NAD+ with Glyceraldehyde-3-Phosphate Dehydrogenase: Correlation of EPR Data and Enzymatic Studies Source: Biochim. Biophys. Acta-Protein Struct. and Molec. Enzym. 997 (1989) 65-77 Description: Adair equation, binding constants
Authors: Yang, Y.J.; Hope, I.D.; Ader, M.; Bergman, R.N. Title: Insulin Transport across Capillaries is Rate Limiting for Insulin Action in Dogs Source: J. Clin. Inv. 84 (1989) 1620-1628
Authors: Yu, Leepo C.; Brenner, Bernhard Title: Structures of Actomyosin Crossbridges in Relaxed and Rigor Muscle Fibers Source: Biophys. J. 55 (1989) 441-453 Description: integrated intensities of each reflection were subsequently obtained by fitting to Lorentzian line shape function.
Authors: Zlokovic, Berislav V.; Maokic, Jasmina B.; Djuricic, Bogdan; Pavson, Hugh Title: Kinetic Analysis of Leucine-Enkephalin Cellular Uptake at the Luminal Side of the Blood-Brain Barrier of an in Situ Perfused Guinea-Pig Brain Source: J. Neurochem. 53 (1989) 1333-1340 Description: best fit for Vmax, Km, and Kd were obtained for leu-enkephalin by fitting to brain vascular perfusion data.
Authors: Abernethy, D.R.; Egan, J.M.; Dickinson, T.H.; Carrum, G. Title: Substrate-selective inhibitor by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans Source: J. Pharm. Exp. 244 (1988) 994-999
Authors: Anderson, S.M.; Leu, J.R.; Kant, G.J. Title: Chronic Stress Increases the Binding of the A1 Adenosine Receptor Agonist, [3-H] Cyclohexyladenosine, to Rat Hypothalamus Source: Pharm. Biochem. Behav. 30 (1988) 169-175 Description: saturation curves fit to single and dual site receptor models.
Authors: Babior, Bernard M.; Kuves, Rahul; Curnutte, John T. Title: Kinetics of Activation of the Respiratory Burst Oxidase in a Fully Soluble System from Human Neutrophils Source: J. Biol. Chem. 263 (1988) 1713-1718 Description: nonlinear regression
Authors: Balis, Frank M.; Mirro, Joseph, Jr.; Reaman, Gregory H.; Evans, William E.; McCully, Cynthia; Doherty, Karen M.; Murphy, Robert F.; Jeffries, Susan; Poplack, David G. Title: Pharmacokinetics of Subcutaneous Methotrexate Source: J. Clin. Oncol. 6 (1988) 1882-1886 Description: biexponential model, bioavailability, area under curve.
Authors: Basile, A.S.; Gammel, S.H.; Mullen, K.D.; Jones, E.A.; Skolnick, P. Title: Differential responsiveness of cerebral Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy Source: J. Neurosci. 8 (1988) 2414-2421
Authors: Bendler, J.T.; Dishon, M.; Kester, H.; Weiss, G.H. Title: A first passage time problem for random walk occupancy Source: J. Stat. Phys. 50 (1988) 1069-1087
Authors: Biosca, J.A.; Greene, L.E.; Eisenberg, E. Title: Binding of ADP and 5'-adenyl imidophosphate to rabbit muscle myofibrils Source: J. Biol. Chem. 263 (1988) 14231-14235
Authors: Blanchard, James; Boyle, Jay O.; Van Wagenen, Stan Title: Determination of the Partition Coefficients, Acid Dissociation Constants, and Intrinsic Solubility of Carbenoxolone Source: J. Pharm. Sci. 77 (1988) 548-552 Description: solubility vs. pH data fit to model, Henderson-Hasselbach equation.
Authors: Brady, Linda S.; Rothman, Richard B.; Herkenham, Miles Title: Physiological Regulation of Neurohypophyseal Kappa Opiate Receptors Source: Brain Res. 443 (1988) 398-402 Description: fit data to one-site competitive binding model.
Authors: Brewer, C.B.; Peterson, J.A. Title: Single turnover kinetics of the reaction between oxycytochrome P-450cam and reduced putidaredoxin Source: J. Biol. Chem. 263 (1988) 791-798
Authors: Chock, P.B.; Gutfreund, H. Title: Reexamination of the kinetics of the transfer of NADH between its complexes with glycerol-3-phosphate dehydrogenase and with lactate dehydrogenase Source: PNAS 85 (1988) 8870-8874 Description: dissociation constants
Authors: Danks, Janine A.; Tortella, F.C.; Long, J.B.; Bykov, V.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W.; Rothman, R.B. Title: Chronic Administration of Morphine and Naltrexone Up-Regulate [3-H] [D-Ala2-D-Leu5] Enkephalin Binding Sites by Different Mechanisms Source: Neuropharm. 27 (1988) 965-974 Description: binding surfaces fit to 1 site binding model to find Bmax and Kd.
Authors: Davis, M.D.; Kaufman, S. Title: The tyrosine-dependent oxidation of tetrahydropterins by lysolecithin-activated rat liver phenyl alanine hydroxylase Source: J. Biol. Chem. 263 (1988) 17312-17316
Authors: Del Vecchio, Silvana; Reynolds, James C.; Blasberg, Ronald G.; Neumann, Ronald D.; Cartasquillo, Jorge A.; Hellstrom, Ingegard; Larson, Steven M. Title: Measurement of Local Mr 97,000 and 250,000 Protein Antigen Concentration in Sections of Human Melanoma Tumor Using in Vitro Quantitative Autoradiography Source: Canc. Res. 48 (1988) 5475-5481 Description: results of staturation study, Bmax and Kd
Authors: Dodion, P.; de Valeriola, D.; Crespeigne, N.; Peeters, B.; Wery, F.; Van Berchem, C.; Piccart, M.; Tueni, E.; Gopggi, J.; Kenis, Y. Title: Phase I Clinical and Pharmacokinetic Trial of Oral Menogaril Administered on Three Consecutive Days Source: Eur. J. Cancer 24 (1988) 1019-1026 Description: weighted least squares fit of plasma concentration curves to biexponential model.
Authors: Ellis, John Title: Method for Comparing Selectivities of Unlabelled Subpopulation Selective Ligands: Application to Muscarinic Receptors Source: J. Receptor Res. 8 (1988) 885-900 Description: 2 site binding of 2 competitors, simulations on MLAB
Authors: Evoniuk, G.; Skolnick, P. Title: Anion Regulation of Agonist and Inverse Agonist Binding to Benzodiazepine Receptors Source: J. Neurochem. 51 (1988) 1169-1175
Authors: Evoniuk, G.; Skolnick, P. Title: Picrate and niflumate block anion modulation of radioligand binding to the gamma-aminobutyric acid/benzodaizepine receptor complex Source: Mol. Pharm. 34 (1988) 837-842
Authors: Frankenne, F.; Closset, J.; Gomez, F.; Scippo, M.L.; Smal, J.; Hennen, G. Title: The Physiology of Growth Hormones (GHs) in Pregnant Women and Partial Characterization of the Placental GH Variant Source: J. Clin. Endo. Metab. 66 (1988) 1171-1180 Description: affinity constants determined from Scatchard plots analysis
Authors: Gillis, Anne M.; Kates, Robert E. Title: Effect of pH on the Myocardial Uptake and Pharmacodynamics of Propafenone in the Isolated Rabbit Heart Source: J. Cardiovasc. Pharm. 12 (1988) 526-534 Description: exponential model, time-integral.
Authors: Greig, Nigel H.; Fredericks, Wendy R.; Halloway, Harold W.; Soncrant, Timothy T.; Rapoport, Stanley I. Title: Delivery of Human Interferon-Alpha to Brain by Transient Osmotic Blood-Brain Barrier Modification in the Rat Source: J. Pharm. Exp. 245 (1988) 581-586 Description: exponential decay curve fit of brain concnetration data
Authors: Greig, Nigel H.; Sweeney, Daniel J.; Rapoport, Stanley I. Title: Comparative Brain and Plasma Pharmacokinetics and Anticancer Activities of Chlorambucil and Melphalan in the Rat Source: Canc. Chem. Pharm. 21 (1988) 1-8 Description: single n biexponential equation, melphalan and chlorambucil concentration-time data
Authors: Hahn, Elisabeth; Wurts, Linda; Tietz, Dietmar; Chrambach, Andreas Title: Linear Ferguson Plots of Polystyrene Sulfate Size Standards for the Quantitative Agarose Gel Electrophoresis of Subcellular Particles Source: Electrophoresis 9 (1988) 243-255 Description: Ferguson plots, MLAB do-file
Authors: Harris, N.L.; Brenner, D.E.; Anthony, L.B.; Collins, J.C.; Halter, S.; Hande, K.R. Title: The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin in rabbits Source: Canc. Chemot. Pharm. 21 (1988) 323-328
Authors: Hauser, S.C.; Ransil, B.J.; Ziorys, J.C.; Golan, J.L. Title: Interaction of uridine 5'-diphosphoglucuronic acid with microsomal UDP-glucuronosyltransferase in primate liver: the facilitating role of uridine 5'-diphospho-N-acetylglucosamine Source: Biochim. Biophys. Acta-General Subjects (1988) 141-148
Authors: Heideman, Richard L.; Balis, Frank M.; McCully, Cynthia; Poplack, David G. Title: Preclinical Pharmacology of Arabinosyl-5-Azacytidine in Nonhuman Primates Source: Canc. Res. 48 (1988) 4294-4298 Description: plasma concentration time data fit to multi-exponential functions.
Authors: Heideman, Richard L.; Kelley, James A.; Packer, Roger J.; Reaman, Gregory H.; Roth, Jeri S.; Balis, Frank; Ettinger, Lawrence J.; Doherty, Karen M.; Jeffries, Susan L.; Poplack, David G. Title: A Pediatric Phase I and Pharmacokinetic Study of Spirohydantoin Mustard Source: Canc. Res. 48 (1988) 2292-2295 Description: SHM plasma conc. fit to biexponential model
Authors: Horwitz, Barry Title: Neuroplasticity and the Progression of Alzhiemer's Disease Source: Int. J. Neurosci. 41 (1988) 1-14 Description: density of neuritic placques in its cortical projection area as a function of per cent loss of cells in a subpopulation of cholinergic forebrain
Authors: Huguenin, P.N.; Zulliger, H.W.; Niederer, R. Title: In Vitro-in Vivo Correlation Exemplified by Sustained Release Formulations of Suprofen Source: Arzneim.-Forsch. 38 (1988) 305-308 Description: dissolution data as function of percentage dissolved fit to Weibull distribution.
Authors: Indelicato, J.M.; Parsini, C.E. Title: The Acylating Potential of gamma-lactam Antibacterials: Base Hydrolysis of Bicyclic Pyrazolidinones Source: J. Med. Chem. 31 (1988) 1227-1230
Authors: Janzon, Bo; Schantz, Birger; Seeman, Torsten Title: Scale Effects in Ballistic Wounding Source: J. Trauma 28 (1988) S29-S32 Description: standard statistical methods were used, and computations of linear regression, mean, and standard error of the mean with MLAB.
Authors: Koster, Johanna; Destree, Olivier H.J.; Westerhoff, Hans V. Title: Kinetics of Histone Gene Expression during Early Development of Xenopus laevis Source: J. Theor. Biol. 135 (1988) 139-167 Description: used integrate statement to find RNA concs. as a function of time.
Authors: Lapointe, David S.; Hildebrandt, Ellen; Buxton, Dennis B.; Patel, Tarun B.; Waymack, Parvan P.; Olson, Merle S. Title: Measurement of Branched-Chain Alpha-Keto Acid Dehydrogenase Flux Rates in Perfused Heart and Liver Source: Methods Enzym. 166 (1988) 484-497 Description: fit sum of exponentials using SAAM, MLAB, curve peeling of the data, half-life of 14-CO2 washout from liver.
Authors: Lee, Edward J.; Egorin, Merrill J.; Van Echo, David A.; Cohen, Adam E.; Tait, Nancy; Schiffer, Charles A. Title: Phase I and Pharmacokinetic Trial of Carboplatin in Refractory Adult Leukemia Source: JNCI 80 (1988) 131-135 Description: computer modeling of decline in plasma concentration of unfilterable and total platinum accumulate as sum of two exponentials.
Authors: Lenox, R.H.; Hendley, D.; Ellis, J. Title: Desensitization of Muscarinic Receptor-Coupled Phosphoinositide Hydrolysis in Rat Hippocampus: Comparisons with the alpha-1-Andrenergic Response Source: J. Neurochem. 50 (1988) 558-564
Authors: Litterst, Charles L.; Magin, Richard Title: Alterations in Plasma Pharmacokinetics of Cisplatin in Tumor Bearing Rats Source: Canc. Chem. Pharm. 22 (1988) 1-4 Description: plasma decay of radioactivity over 96 hour time course fit to 3 compartment model.
Authors: Maes, M.; Amand, Y.; Underwood, L.E.; Maiter, D.; Ketelslegers, J.-M. Title: Decreased Serum Insulin-Like Growth Factor I Response to Growth Hormone in Hypophysectomized Rats Fed a Low Protein Diet: Evidence for a Postreceptor Defect Source: Acta Endocrin. 117 (1988) 320-326 Description: binding inhibition experiments expressed as bound vs free hormone concentration, analysis of curves with MLAB.
Authors: Majumdar, Chirabrata; Abbotts, John; Broder, Samuel; Wilson, Samuel H. Title: Studies on the Mechanism of Human Immunodeficiency Virus Reverse Transcriptase Source: J. Biol. Chem. 263 (1988) 15657-15665 Description: Michaelis Menten constants.
Authors: Marvizon, J.C.; Skolnick, P. Title: [3 H]glycine binding is modulated by Mg 2+ and other ligands of the NMDA receptor-cation channel complex Source: Eur. J. Pharm. 151 (1988) 157-158
Authors: Marvizon, J.C.; Skolnick, P. Title: Enhancement of t-[35 S] Butylbicyclophosphorothionate and [3 H] Strychnine Binding by Monovalent Anions Reveals Similarities Between gamma-Aminobutyric Acid- and Glycine-Gated Chloride Channels Source: J. Neurochem. 50 (1988) 1632-1639
Authors: Marvizon, J.C.; Skolnick, P. Title: Anion regulation of [3H] strychnine binding to glycine- gated chloride channels is explained by the presence of two anion binding sites Source: Mol. Pharm. 34 (1988) 806-813
Authors: McIntyre, T.D.; Trullas, R.; Skolnick, P. Title: Differences in Biophysical Properties of the Benzodiazepine/y-Aminobutyric Acid Receptor Chloride Channel Complex in the Long-Sleep and Short-Sleep Mouse Lines Source: J. Neurochem. 51 (1988) 642-647
Authors: McIntyre, T.D.; Trullas, R.; Skolnick, P. Title: Asymmetrical activation of GABA-gated chloride channels in cerebral cortex Source: Pharm. Biochem. Behav. 30 (1988) 911-916
Authors: Merril, Carl R.; Bisher, Magaret E.; Harrington, Michael; Steven, Alasdair C. Title: Coloration of Silver-Stained Protein Bands in Polyacrylamide Gels is Caused by Light Scattering from Silver Grains of Characteristic Sizes Source: PNAS 85 (1988) 453-457 Description: statistical analysis using MLAB.
Authors: Mihalyi, Elemer Title: Clotting of Bovine Fibrinogen: Kinetic Analysis of the Release of Fibrinopeptides by Thrombin and of the Calcium Uptake Upon Clotting at High Fibrinogen Concentrations Source: Biochem. 27 (1988) 976-982 Description: 3 data sets were analyzed by nonlinear least squares curve fitting, 1,2, and 3 exponential models.
Authors: Miles, Edith Wilson; McPhie, Peter; Yutani, Katsuhide Title: Evidence that Glutamic Acid 49 of Tryptophan Synthase Alpha Subunit is a Catalytic Residue Source: J. Biol. Chem. 263 (1988) 8611-8614 Description: circular dichroism data at 285nm, 289nm collected. To determine maximum changes in ellipticity at each wavelength, results fitted to quadratic root formula.
Authors: Monsma, F.J.; Abood, L.G.; Hoss, W. Title: Inhibition of phosphoinositide turnover by selective muscarinic antagonists in the rate striatum: Correlation with receptor occupancy Source: Biochem. Pharm. 37 (1988) 2437-2443
Authors: Moody, E.J.; Suzdak, P.D.; Paul, S.M.; Skolnick, P. Title: Modulation of the Benzodiazepine/gamma-Aminobutyric Acid Receptor Chloride Channel Complex by Inhalation Anesthetics Source: J. Neurochem. 51 (1988) 1386-1393
Authors: Mostow, William R.; Ferguson, Allan G.; Lesch, Michael; Decker, Robert S.; Samarel, Allen M. Title: Nonrandom Turnover of Actin and Tubulin in Cultured Rabbit Cardiac Fibroblasts Source: Am. J. Physiol. 255 (1988) C202-C213 Description: precursor-product turnover model fit and total protein accumulation curve = a*(1-exp(-b*x))-c*(1-exp(-d*x))+k
Authors: Nguyen, B.; Biswal, S.; Gutierrez, P.L. Title: The influence of diaziquone free radicals on the in vitro activity of diaziquone Source: Xenobiotica 18 (1988) 593-602
Authors: Nicklaus, K.J.; McGonigle, P.; Molinoff, P.B. Title: [3H]SCH 23390 labels both dopamine-1 and 5-hydroxytryptamine 1c receptors in the choroid plexus Source: J. Pharm. Exp. 247 (1988) 343-348
Authors: Offord, S.J.; Ordway, G.A.; Frazer, A. Title: Application of [125I] iodocyanopirdolol to measure 5-hydroxy tryptamine 1B receptors in the brain of rat Source: J. Pharm. Exp. 244 (1988) 144-153
Authors: Ordway, G.A.; Frazer, A. Title: Effects of prenalterol on beta adrenergic responsiveness and receptors in the cerebral cortex of the rat Source: Neuropharm. 27 (1988) 529-536
Authors: Orzi, F.; Lucignani, G.; Dow-Edwards, D.; Namba, H.; Nehlig, A.; Patlak, C.S.; Pettigrew, K.; Schrier, F.; Sokoloff, L. Title: Local Cerebral Glucose Utilization in Controlled Graded Levels of Hyperglycemia in the Conscious Rat Source: J. Cereb. Bl. Fl. 8 (1988) 346-356 Description: least squares fit of integrated plasma concentration in time.
Authors: Panton, L.J.; Rossan, R.N.; Escajadillo, A.; Matsumoto, Y.; Lee, A.T.; Labroo, V.M.; Kirk, K.L.; Cohen, L.A.; Aikawa, M.; Howard, R.J. Title: In vitro and in vivo studies of the effects of halogenated histidine analogs on Plasmodium falciparum Source: Antimicrob. Ag. and Chem. 32 (1988) 1655-1659
Authors: Persson, Karl-Axel; Berg, Sven; Tornqvist, Margareta; Scalia-Tomba, Gian-Paolo; Ehrenberg, Lars Title: Note on Ethene and Other Low-Molecular Weight Hydrocarbons in Environmental Tobacco Smoke Source: Acta Chem. Scand. 42B (1988) 690-696 Description: fit ordinary differential equation for concentration of hydrocarbon in air.
Authors: Rahman, Aquilur; Roh, Jae Kyung; Wolpert-De Filippes, Mary K.; Goldin, Abraham; Venditti, John M.; Woolley, Paul V. Title: Therapeutic and Pharmacological Studies of Tetrachloro (d,l-trans) 1,2-Diaminocyclohexane Platinum (IV) (Tetraplatin), a New Platinum Analogue Source: Canc. Res. 48 (1988) 1745-1752 Description: plasma levels fit to biexponential model with constraints
Authors: Rechthand, Emanuel; Smith, Quentin R.; Rapoport, Stanley I. Title: A Compartmental Analysis of Solute Transfer and Exchange Across Blood-Nerve Barrier Source: Am. J. Physiol. 255 (1988) R317-R325 Description: MLAB was used for curve fitting of models of nerve plasma exchange and calculating plasma concentration time integrals.
Authors: Reeves, Philip T.; Minchin, Rodney F.; Ilett, Kenneth F. Title: Induction of Sulfamethazine Acetylation by Hydrocortisone in the Rabbit Source: Drug Metab. 16 (1988) 110-115 Description: Michaelis Menten equation fitted to data using MLAB, Km and Vmax estimated
Authors: Rogawski, M.A. Title: Transient outward current (Ja) in clonal anterior pituitary cells: blockade by aminopyridine analogs Source: Naunyn-Schmiedeberg's Arch. Pharm. 338 (1988) 125-132
Authors: Rothman, Richard B.; Bykov, Victor; Hauck-Newman, Amy; Jacobson, A.E.; Rice, Kenner C. Title: Interaction of Enantiomeric Pairs of Opiates with Phencyclidine Binding Sites in Rat Brain: Identification of (+) Pentazocine as a Ligand Potentially Suitable for Imaging Sigma Binding Sites Using Positron Emission Tomography Source: Neuropeptides 12 (1988) 1-5 Description: binding surfaces were fit to a one-site model.
Authors: Rothman, Richard B.; Bykov, Victor; Ofri, Danielle; Rice, Kenner C. Title: LY164929-A Highly Selective Ligand for the Lower Affinity [3H]D-Ala2-D-Leu-5-Enkephalin Binding Site Source: Neuropeptides 11 (1988) 13-16 Description: ligand binding models
Authors: Rothman, Richard B.; Bykov, Victor; Rice, Kenner C.; Jacobson, Arthur E.; Kooper, Grace N.; Bowen, Wayne D. Title: Tritiated-6-Beta-Fluoro-6-Desoxy-Oxymorphone ([3H]FOXY)- A New Ligand and Photoaffinity Probe for the MU Opioid Receptors Source: Neuropeptides 11 (1988) 1-6 Description: ligand binding models
Authors: Rothman, Richard B.; Long, Joseph B.; Bykov, Victor; Jacobson, Arthur E.; Rice, Kenner C.; Holaday, John W. Title: Beta-FNA Binds Irreversibly to the Opiate Receptor Complex: In Vivo and In Vitro Evidence Source: J. Pharm. Exp. 247 (1988) 405-416 Description: weighted least squares curve fitting of 1 or 2 site competitive binding models
Authors: Samuni, A.; Krishna, C.M.; Riesz, P.; Finkelstein, E.; Russo, A. Title: A novel metal-free low molecular weight superoxide dismutase mimic Source: J. Biol. Chem. 263 (1988) 17921-17924
Authors: Sayer, J.M.; Grossman, S.J.; Adusei-Poku, K.S.; Jerina, D.M. Title: Kinetics and Mechanism of Solvolysis of Precocene I 3,4-Oxide: Change in Rate-Determining Step and Trapping of an Intermediate in an Epoxide Solvolysis Reaction Source: JACS 110 (1988) 5068-5074 Description: analysis of the data by double-reciprocal plots or MLAB gave values of rate constant.
Authors: Schaefer, Erik M.; Moehring, Joan M.; Moehring, Thomas J. Title: Binding of Diptheria Toxin to CHO-K1 and Vero Cells is Dependent on Cell Density Source: J. Cell. Physiol. 135 (1988) 407-415 Description: binding of 125-I-labelled DTX to low density vero cells curves drawn and analyzed by nonlinear curve fit.
Authors: Schloss, John V. Title: Comparative Affinities of the Epimeric Reaction-Intermediate Analogs 2- and 4- Carboxy-D-Arabinitol 1,5-Bisphosphate for Spinach Ribulose 1,5-Bisphosphate Carboxylase Source: J. Biol. Chem. 263 (1988) 4145-4150 Description: fit several models comprised of exponentials.
Authors: Snell, S.M.; Marini, M.A. Title: A Convenient Spectroscopic Method for the Estimation of Hemoglobin Concentrations in Cell-Free Solutions Source: J. Biochem. Biophys. Meth. 17 (1988) 25-34 Description: the pK' calculated for a variety of wavelengths is 7.99 +/- .08 using curve-fitting algorithm in MLAB.
Authors: Steer, Clifford J.; Bisher, Margaret E.; Trus, Benes L.; Hainfeld, James F.; Wall, Joseph S.; Steven, Alasdair C. Title: Membrane Contents of Distinct Subpopulations of Coated Vesicles Determined by Scanning Transmission Electron Microscopy Source: Biochim. Biophys. Acta-Biomembranes 938 (1988) 167-180 Description: histograms and statistical procedures.
Authors: Stein, C.A.; Subasinghe, C.; Shinozuka, K.; Cohen, J.S. Title: Physicochemical properties of phosphorothioate oligodeoxynucleotides Source: Nucleic Acids Res. 16 (1988) 3209-3221
Authors: Stojilkovic, S.S.; Izumi, S.; Catt, K.J. Title: Participation of voltage-sensitive calcium channels in pituitary hormone release Source: J. Biol. Chem. 263 (1988) 13054-13061
Authors: Thakker, Dhiren R.; Boehlert, Charles; Mirsadeghi, Seid; Levin, Wayne; Ryan, Deni E.; Thomas, Paul E.; Yagi, Haruhiko; Pannell, Lewis K.; Sayer, Jane M.; Jerina, Donald M. Title: Differential Stereoselectivity on Metabolism of Triphenylene by Cytochromes P-450 in Liver Microsomes from 3-Methylcholantrene- and Phenobarbital-Treated Rats Source: J. Biol. Chem. 263 (1988) 98-105 Description: time courses of mole fraction of oxide formed, described by first order differential rate equations.
Authors: Weiss, Raymond B.; Greene, Raymond F.; Knight, Robert D.; Collins, Jerry M.; Pelosi, John J.; Sulkes, Aaron; Curt, Gregory A. Title: Phase I and Clinical Pharmacology Study of Intravenous Flavone Acetic Acid (NSC 347512) Source: Canc. Res. 48 (1988) 5878-5882 Description: mono or biexponential model of postinfusion plasma concentration.
Authors: Zimran, Ari; Torem, Shlomo; Beutler, Ernest Title: The in Vivo Ageing of Red Cell Enzymes: Direct Evidence of Biphasic Decay from Polycythaemic Rabbits with Reticulocytosis Source: Br. J. Hae. 69 (1988) 67-70 Description: sums of one and two exponential terms fitted to Hx, G6PD, and p5'N activity data using MLAB, F statistics
Authors: Abramson, Stewart N.; McGonigle, Paul; Molinoff, Perry B. Title: Evaluation of Models for Analysis of Radioligand Binding Data Source: Mol. Pharm. 31 (1987) 103-111 Description: ternary complex model, two-independent-receptor model
Authors: Anderson, Lawrence W.; Zaharevitz, Daniel W.; Strong, John M. Title: Glutamine and Glutamate: Automated Quantification and Isotopic Enrichments by Gas Chromotography/Mass Spectrometry Source: Anal. Biochem. 163 (1987) 358-368 Description: linear regression analysis
Authors: Anderson, S.M.; Leu, J.R.; Kant, G.J. Title: Effects of Stress on [3-H] Cyclohexyladenosine Binding to Rat Brain Membranes Source: Pharm. Biochem. Behav. 26 (1987) 829-833 Description: single and dual site (or state) receptor models were fitted to data by using a computer assisted nonlinear least squares curve fitting technique.
Authors: Ando, S.; McPhie, P.; Chaiken, I.M. Title: Sequence redesign and the assembly mechanism of the oxytocin/bovine neurophysin I. Biosynthetic precursor Source: J. Biol. Chem. 262 (1987) 12962-12969 Description: solving van't Hoff equation
Authors: Arndt, Carola A.S.; Colvin, O. Michael; Balis, Frank M.; Lester, Cynthia M.; Johnson, Gloria; Poplack, David G. Title: Intrathecal Administration of 4-Hydroperoxycyclophosphamide in Rhesus Monkeys Source: Canc. Res. 47 (1987) 5932-5934 Description: CSF disappearance curves following iv 4-HC administration were fit to monoexponential curve.
Authors: Bille, Vincent; Plainchamp, Dominique; Remacle, Jose Title: Affinity and Stability Modifications of Immobilized Alcohol Dehydrogenase through Multipoint Copolymerization Source: Biochim. Biophys. Acta-Protein Struct. and Molec. Enzym. 915 (1987) 393-398 Description: Michaelis parameters
Authors: Bjornbom, Pehr Title: Modelling of a Double-Layered PTFE-Bonded Oxygen Electrode Source: Electroch. Acta 32 (1987) 115-119 Description: Kinetic equation for a flooded catalyst aggregate.
Authors: Bozzato, Richard P.; Tinker, David O. Title: Purification and Properties of Two Phospholipid Transfer Proteins from Yeast Source: Biochem. Cell Biol. 65 (1987) 195-202 Description: Transfer activities were determined by measurement of the fractional transfer (in triplicate) at a number of time points (usually 3 or 4) and calculating the true initial velocity by curve fitting.
Authors: Bozzato, Richard P.; Woolley, Drew; Tinker, David O. Title: Catalytic Properties of the Yeast Phospholipid Transfer Protein Source: Biochem. Cell Biol. 65 (1987) 203-210 Description: reaction time points were fitted to f*(1-exp(-k*t)).
Authors: Brenner, Dean E.; Anthony, Lowell B.; Halter, Susan; Harris, N. Lindsay; Collins, Jerry C.; Hande, Kenneth R. Title: Effect of Allyl Alcohol-induced Sublethal Hepatic Damage Upon Doxorubicin Metabolism and Toxicity in the Rabbit Source: Canc. Res. 47 (1987) 3259-3265 Description: Doxorubicin plasma conc. fit to biexponential model, calculated area under curve.
Authors: Bruno, Jordi Title: Beryllium (II) Hydrolysis in 3.0 mol/dm^3 Perchlorate Source: JCS Dalton (1987) 2431-2437 Description: graphical interpretation made with MLAB.
Authors: Bruno, Jordi; Grenthe, Ingmar; Munoz, Maria Title: Studies of Metal Carbonate Equilibria. Part 16. The Beryllium (II) Water-Carbon Dioxide (g) System in Neutral-to-Alkaline 3.0 mol/dm^3 Perchlorate Media at 25 degrees C Source: JCS Dalton (1987) 2445-2449 Description: used MLAB to calculate unknown solubility constants by least squares fit.
Authors: Bruno, Jordi; Grenthe, Ingmar; Sandstrom, Magnus; Ferri, Diego Title: Studies of Metal Carbonate Equilibria. Part 15. The Beryllium (II)-Water-Carbon Dioxide (g) System in Acidic 3.0 mol/dm^3 Perchlorate Media Source: JCS Dalton (1987) 2439-2444 Description: fit rate constants.
Authors: Buysschaert, Martin; Moulant, Michel; Urbain, Jean Luc; Pauwels, Steny; de Roy, Luc; Ketelslegers, Jean Marie; Lambert, Andre E. Title: Impaired Gastric Emptying in Diabetic Patients with Cardiac Autonomic Neuropathy Source: Diabetes Care 10 (1987) 448-452 Description: initial radioactivity in stomach at time t fit to 2^(-t/thalf)^beta.
Authors: Byrd, James C.; Bykov, Victor; Rothman, Richard B. Title: Rat Brain PCP Receptors: Alterations in Binding Parameters Following Chronic Administration of Opiate Agonists and Antagonists Source: Neuropeptides 10 (1987) 201-205 Description: displacement curves analyzed with MLAB.
Authors: Chelly, J.E.; Hill, D.C.; Abernethy, D.R.; Dlewati, A.; Doursout, M.F.; Merin, R.G. Title: Pharmacodynamic and pharmacokinetic interactions between lidocaine and verapamil Source: J. Pharm. Exp. 243 (1987) 211-216
Authors: Cadet, J.L.; Rothman, R.B. Title: Increased cortical serotonin-2- (5-HT-2) receptors in the iminodipropionitrile (IDPN)-model of persistent dyskinesia in the rat Source: Neuropeptides 10 (1987) 175-180
Authors: Colombatti, Marco; Johnson, Virginia G.; Skopicki, Hal A.; Fendley, Brian; Lewis, Marc S.; Youle, Richard J. Title: Identification and Characterization of a Monoclonal Antibody Recognizing a Galactose-Binding Domain of the Toxin Ricin Source: J. Immunol. 138 (1987) 3339-3344 Description: analytical ultracentrifuge scans obtained after equation was attained.
Authors: Dodion, Pierre F.; Abrams, Jeffrey; Gerard, Beatrice; Crespeigne, Nadine; Peeters, Bernadette; Van Berchem, Christine; Kenis, Yvon Title: Clinical and Pharmacokinetic Phase I Trial with the Diethyl-Amino Ester of Flavone Acetic Acid (LM985, NSC293015) Source: Eur. J. Cancer 23 (1987) 837-842 Description: single exponential fit by weighted least squares.
Authors: Dodion, P.; Bron, D.; Mattelaer, M.A.; Loos, M.; Delforge, A.; Rozencweig, M.; Stryckmans, P.; Kenis, Y. Title: Sensitivity of Normal Human Bone Marrow Myeloid Progenitor Cells to Anthracycline, Cisplatin, Anthracene, and Flavone Acetic Acid Derivatives, and Its Relevance for the Prediction of Human Plasma Concentrations of Anticancer Drugs Source: Eur. J. Cancer 23 (1987) 1901-1908 Description: semi-logarithmic linear regression
Authors: Egorin, Merrill J.; Conley, Barbara A.; Forest, Alan; Zuhowski, Eleanor G.; Sinibaldi, Vickie; Van Echo, David A. Title: Phase I Study and Pharmacokinetics of Menogaril (NSC 269148) in Patients with Hepatic Dysfunction Source: Canc. Res. 47 (1987) 6104-6110 Description: plasma conc. of menogaril, Hill equation, Nelder-Mead.
Authors: Egorin, Merrill J.; Sigman, Lawrence M.; Van Echo, David A.; Forest, Alan; Whitacre, Margaret Y.; Aisner, Joseph Title: Phase I Clinical and Pharmacokinetic Study of Hexamethylene Bisacetamide (NSC 95580) Administered as Five-Day Continuous Infusion Source: Canc. Res. 47 (1987) 617-623 Description: plasma conc. of HMBA decline modeled with MLAB, Nelder-Mead with ADAPT.
Authors: Fernandez, L.; Aparacio, J.; Muhammed, M. Title: The Role of Feed Metal Concentration in the Coupled Transport of Zinc through a Bis-(2-Ethylhexyl) Phosphoric Acid Solid Supported Liquid Membrane from Aqueous Perchlorate Media Source: Sep. Science and Tech. 22 (1987) 1577-1595 Description: fit model flux equations to whole set of experimental data
Authors: Greene, Raymond F.; Miser, Angela W.; Lester, Cindy M.; Balis, Frank M.; Poplack, David G. Title: Cerebrospinal Fluid and Plasma Pharmacokinetics of Morphine Infusions in Pediatric Cancer Patients and Rhesus Monkeys Source: Pain 30 (1987) 339-348 Description: triexponential equation, area under curve
Authors: Greig, Nigel H.; Momma, Seiji; Sweeney, Daniel J.; Smith, Quentin R.; Rapoport, Stanley I. Title: Facilitated Transport of Melphelan at the Rat Blood-Brain Barrier by the Large Neutral Amino Acid Carrier System Source: Canc. Res. 47 (1987) 1571-1576 Description: melphelan concentration-time data fit to biexponential, determined plasma half-life, Michaelis Menten kinetics
Authors: Greig, N.H.; Sweeney, D.J.; Rapoport, S.I. Title: Melphelan Concentration Dependent Plasma Protein Binding in Healthy Humans and Rats Source: Eur. J. Clin. Pharm. 32 (1987) 179-185 Description: Scatchard plots
Authors: Grigorescu, F.; Herzberg, U.; King, G.; Meistas, M.; Elders, J.; Frazer, T.; Kahn, C.R. Title: Defects in Insulin Binding and Autophosphorylation of Erythrocyte Insulin Receptors in Patients with Syndromes of Severe Insulin Resistance and Their Parents Source: J. Clin. Endo. Metab. 64 (1987) 549-556 Description: logistic equation for total insulin conc. versus 125-I insulin bound/free.
Authors: Herblin, W.F.; Kauer, J.C.; Tam, S.W. Title: Photoinactivation of the Mu Opioid Receptor Using a Novel Synthetic Morphiceptin Analog Source: Eur. J. Pharm. 139 (1987) 273-279 Description: [3-H] Naloxone binding data fit to simple equation for single binding site.
Authors: Heuser, J.E.; Keen, J.H.; Amende, L.M.; Lippoldt, R.E.; Prasad, K. Title: Deep-etch visualization of 27S clathrin: a tetrahedral tetramer Source: J. Cell Biol. 105 (1987) 1999-2009
Authors: Ho, S.P.; DeGrado, W.F. Title: Design of a 4-helix bundle protein: Synthesis of Peptides which Self-Associate into a Helical Protein Source: JACS 109 (1987) 6751-6758
Authors: Horwitz, B.; Grady, C.L.; Schlageter, N.L.; Duara, R.; Rapoport, S.I. Title: Intercorrelations of Regional Cerebral Glucose Metabolic Rates in Alzheimer's Disease Source: Brain Res. 407 (1987) 294-306 Description: correlation matrix plots.
Authors: Hubbard, Michael J.; Klee, Claude B. Title: Calmodulin Binding By Calcineurin Source: J. Biol. Chem. 262 (1987) 15062-15070 Description: curve fitting and graphics with MLAB, equilibrium binding data fit to Hill equation.
Authors: Jimenez, B.D.; Cirmo, C.P.; McCarthy, J.F. Title: Effects of Feeding and Temperature on Uptake, Elimination, and Metabolism of benzo(alpha)pyrene in the bluegill sunfish (Lepomis macrochirus) Source: Aquat. Tox. 10 (1987) 41-57 Description: two compartment model, fish and water; curve fit decrease in radioactivity with time to polynomial
Authors: Juillerat, Marcel A.; Taniuchi, Hiroshi Title: Intramolecular Flip Between Two Alternative Forms of Complex Formed from a Heme Fragment and Apoprotein of Horse Cytochrome c Source: J. Biol. Chem. 262 (1987) 13440-13448 Description: fit parameters in integrated form of van't Hoff equation.
Authors: Kasid, Usha N.; Dritschilo, Anatoly; Rhim, Johng S. Title: Human Epidermal Keratinocytes Retain Radiation Resistance Following in Vitro Immortalization and Malignant Transformation Source: Radiation Res. 111 (1987) 565-571 Description: survival curve s = (1-(1-exp(-d/d0))^n).
Authors: Kelley, James A.; Litterst, Charles L.; Roth, Jeri S.; Vistica, David T.; Poplack, David G.; Cooney, David A.; Nadkarni, Mohan; Balis, Frank M.; Broder, Samuel; Johns, David G. Title: The Disposition and Metabolism of 2',3'-Dideoxycytidine, an in Vitro Inhibitor of Human T-Lymphotrophic Virus Type III Infectivity, in Mice and Monkeys Source: Drug Metab. 15 (1987) 595-601 Description: biexponential model for plasma concentration.
Authors: Kriauciunas, Kristina M.; Grigorescu, Florin; Kahn, C. Ronald Title: Effects of Heparin on Insulin Binding and Biological Activity Source: Diabetes 36 (1987) 163-168 Description: Scatchard plots
Authors: Levin, Arthur A.; Kilpper, Robert W.; Miller, Richard K. Title: Fetal Toxicity of Cadmium Chloride: The Pharmacokinetics in the Pregnant Wistar Rat Source: Teratology 36 (1987) 163-170 Description: biexponential model of blood concentration data
Authors: Lipnick, R.L.; Watson, K.R.; Strausz, A.K. Title: A QSAR Study of the Acute Toxicity of Some Industrial Organic Chemicals to Goldfish. Narcosis, Electrophile, and Proelectrophile Mechanisms Source: Xenobiotica 17 (1987) 1011-1025 Description: quantitative structure-activity relationships, log P parameter
Authors: Marquez, V.E.; Tseng, C.K.H.; Kelley, J.A.; Mitsuya, K.H.; Broder, S.; Roth, J.S.; Driscoll, J.S. Title: 2',3'-Dideoxy-2'-fluoro-ara-a. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV) Source: Biochem. Pharm. 36 (1987) 2719-2722
Authors: Martin, Roy W.; Hill, Harlan F.; Yee, Hsiao Ching; Saeger, Louis C.; Walter, M. Hildegard; Chapman, C. Richard Title: An Open-Loop Computer-Based Drug Infusion System Source: IEEE Biomed. 34 (1987) 642-649 Description: biexponential model of plasma concentration.
Authors: Morel, N.; Godfraind, T. Title: Prolonged depolarization increases the pharmacological effects of calcium channels of vascular smooth muscle Source: J. Pharm. Exp. 243 (1987) 711-715
Authors: Morris, Marilyn E.; Pang, K. Sandy Title: Competition Between Two Enzymes for Substrate Removal in Liver: Modulating Effects Due to Substrate Recruitment of Hepatocyte Activity Source: J. Pharm. Biopharm. 15 (1987) 473-496 Description: fit Km and Vmax in Michaelis Menten equation for 3 models.
Authors: Moyer, James D.; Peizes, Ofer; Dean, Nicholas M.; Malinowski, Nancy Title: D-Myo-Inositol (1,4)-Bisphosphate 1-Phosphatase. Partial Purification from Rat Liver and Characterization Source: Biochem. Biophys. Res. Comm. 146 (1987) 1018-1026 Description: linear regression
Authors: Murphy, D.L.; Garrick, N.A.; Hill, J.L.; Tamarkin, L. Title: Marked enhancement by clorgyline of nocturnal and daytime melatonin release in rhesus monkeys Source: Psychopharm. 92 (1987) 382-387
Authors: Namba, Hiroki; Lucignanni, Giovanni; Nehlig, Astrid; Patlak, Clifford; Pettigrew, Karen; Kennedy, Charles; Sokoloff, Louis Title: Effects of Insulin on Hexose Transport Across Blood-Brain Barrier in Normoglycemia Source: Am. J. Physiol. 252 (1987) E299-E303 Description: ci(t) = k1*exp(-k2*t)*integral(x,0,t,cp(t)*exp(k2*t)).
Authors: Nelson, E.B.; Egan, J.M.; Abernethy, D.R. Title: The effect of propylene glycol on antipyrine clearance in humans Source: Clin. Pharm. Ther. 41 (1987) 571-573
Authors: Odman, Suarte; Levitan, Herbert; Robinson, Peter J.; Michel, Mary Ellen; Ask, Per; Rapoport, Stanley I. Title: Peripheral Nerve as an Osmometer: Role of Endoneurial Capillaries in Frog Sciatic Nerve Source: Am. J. Physiol. 252 (1987) C335-C341 Description: fit initial rate of change of nerve diameter as quadratic function of time.
Authors: Peters, W.P.; Henner, W.D.; Grochow, L.B.; Olsen, G.; Edwards, S.; Stanbuck, H.; Steuart, A.; Gockerman, J.; Moore, J.; Bast, J.C.; Seiger, H.F.; Colvin, O.M. Title: Clinical and pharmacological effects of high dose single agent busulfan with autologous born marrow support in the treatment of solid tumors Source: Canc. Res. 47 (1987) 6402-6406
Authors: Piantadosi, Steven Title: Generalizing Growth Functions Assuming Parameter Heterogeneity Source: Growth 51 (1987) 50-63 Description: fitting data
Authors: Piantadosi, Steven; Patterson, Blossom Title: A Method for Predicting Accrual, Cost, and Paper Flow in Clinical Trials Source: Contr. Clin. Tr. 8 (1987) 202-215 Description: the numerical tasks involved in this procedure are greatly simplified by using MLAB.
Authors: Plowman, Jacqueline; Harrison, Steadman D., Jr.; Trader, Mary W.; Griswold, Daniel P., Jr.; Chadwick, Marjory; McComish, Madeline F.; Silveira, Denise M.; Zaharko, Daniel Title: Preclinical Antitumor Activity and Pharmacological Properties of Deoxyspergualin Source: Canc. Res. 47 (1987) 685-689 Description: plasma data fitted to bi-exponential model.
Authors: Rechthand, Emanuel; Smith, Quentin R.; Latker, Carole H.; Rapoport, Stanley I. Title: Altered Blood-Nerve Barrier Permeability to Small Molecules in Experimental Diabetes Mellitus Source: J. Neuropath. and Exp. Neurol. 46 (1987) 302-314 Description: integrated plasma concentrations from t=0 to T calculated for each animal from arterial plasma samples employing MLAB.
Authors: Rechthand, Emanuel; Smith, Quentin R.; Rapoport, Stanley I. Title: Transfer of Nonelectrolytes from Blood into Peripheral Nerve Endoneurium Source: Am. J. Physiol. 252 (1987) H1175-H1182 Description: plasma concentration-time integral calculated with MLAB from arterial plasma samples.
Authors: Rothman, Richard B.; Bykov, Victor; Cadet, Jean L.; Kleinman, Joel E. Title: A Postmortem Study of the Effect of Chronic Opiate Abuse on Psychotomimetic Binding Sites of Human Frontal Cortex Source: Neuropeptides 10 (1987) 261-264 Description: Binding parameters Kd and Bmax were determined by fitting each surface to a one site binding model.
Authors: Rothman, Richard B.; Jacobson, Arthur E.; Rice, Kenner C.; Herkenham, Miles Title: Autoradiographic Evidence for Two Classes of Mu Opioid Binding Sites in Rat Brain Using [125-I] FK33824 Source: Peptides 8 (1987) 1015-1021 Description: data were fit to two-site binding model.
Authors: Rothman, R.B.; McLean, S.; Bykov, V.; Lessor, R.A.; Jacobson, A.E.; Rice, K.C.; Holaday, J.W. Title: Chronic morphine upregulates a mu-opiate binding site labeled by [3 H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography Source: Eur. J. Pharm. 142 (1987) 73-81
Authors: Schroyens, Wilfried A.; Dodion, Pierre F.; Sanders, Charlotte; Loos, Micheline; Dethier, Nathalie E.; Delforge, Alain R.; Stryckmans, Pierre A.; Kenis, Yvon Title: In Vitro Chemosensitivity Testing of Flavone Acetic Acid (LM975; NSC347512) and Its Diethylaminethyl Ester Derivative (LM985; NSC293015) Source: Eur. J. Cancer 23 (1987) 1135-1139 Description: semilogarithmic linear regression.
Authors: Shubat, P.J.; Banner, W., Jr.; Huxtable, R.J. Title: Pulmonary Vascular Responses Induced by the Pyrrolizidine Alkaloid, Monocrotaline in Rats Source: Toxicon 25 (1987) 995-1002 Description: nonlinear regression of dose-response curve
Authors: Smith, Quentin R.; Momma, Seiji; Aoyagi, Masaki; Rapoport, Stanley I. Title: Kinetics of Neutral Amino Acid Transport Across the Blood-Brain Barrier Source: J. Neurochem. 49 (1987) 1651-1658 Description: Vmax, Km, Kd were obtained by fitting Michaelis Menten to perfusion data
Authors: Smith, Robert; Preston, Robin R.; Schulz, Stephanie; Gagnon, Michael L.; Van Houlten, Judith Title: Correlations Between Cyclic AMP Binding and Chemoreception in Paramecium Source: Biochim. Biophys. Acta 928 (1987) 171-178 Description: CPM versium -log(cAMP molarity) binding curve
Authors: Thomas, David J.; Fisher, Henry L.; Sumler, Martha R.; Mushak, Paul; Hall, Larry L. Title: Sexual Differences in the Excretion of Organic and Inorganic Mercury by Methyl Mercury-Treated Rats Source: Env. Res. 43 (1987) 203-216 Description: percent injected dose fit to linear combination of two exponentials.
Authors: Tietz, Dietmar Title: Gel electrophoresis of intact subcellular particles Source: J. Chrom. B 418 (1987) 305-344
Authors: Tietz, Dietmar; Chrambach, Andreas Title: Computer simulation of the variable agarose fiber dimensions on the basis of mobility data derived from gel electrophoresis and using Ogston theory Source: Anal. Biochem. 161 (1987) 395-411
Authors: Tietz, Dietmar; Gombocz, Erich; Chrambach, Andreas Title: Characterization of Subcellular Particles by Size, Charge, and Apparent Compressibility on the Basis of Mobility in Agarose Gel Electrophoresis: Procedures of Computer Simulation Source: Electrophoresis 8 (1987) 271-285 Description: fit nonlinear Ferguson plots.
Authors: Tobacman, L.S. Title: Activation of Actin-Cardiac Myosin Subfragment 1 Magnesium- ATPase rate by Calcium Shows Cooperativity Intrinsic to the Thin Filament Source: Biochem. 26 (1987) 492-497
Authors: Trullas, R.; Havoundjian, H.; Skolnick, P. Title: Stress-Induced Changes in t-[35 S] Butyl bicyclophosphorothionate Binding to gamma-Aminobutyric Acid-Gated Chloride Channels Are Mimicked by In Vitro Occupation of Benzodiazepine Receptors Source: J. Neurochem. 49 (1987) 968-974
Authors: Trullas, R.; Havoundjian, H.; Zamir, N.; Paul, S.; Skolnick, P. Title: Environmentally-induced modification of the benzodiazepine/GABA receptor coupled chloride ionophore Source: Psychopharm. 91 (1987) 384-390
Authors: Valcour, A.A.; Woodworth, R.C. Title: Proton Nuclear Magnetic Resonance Spectroscopy of Human Transferrin N-Terminal Half-Molecule: Titration and Hydrogen-Deuterium Exchange Source: Biochem. 26 (1987) 3120-3125 Description: Deuterium ion concentration, proton ion concentration, versus chemical shift fit to expression involving Hill coefficient.
Authors: Wax, M.B.; Molinoff, P.B. Title: Distribution and properties of beta-adrenergic receptors in human iris-ciliary body Source: Inv. Ophthal. Vis. Sci. 28 (1987) 420-430
Authors: Weber, Annemarie; Northrop, Jennifer; Bishop, Marilyn F.; Ferrone, Frank A.; Mooseker, Mark S. Title: Nucleation of Actin Polymerization by Villin and Elongation at Subcritical Monomer Concentration Source: Biochem. 26 (1987) 2528-2536 Description: used Marquardt routine from Bevington instead of MLAB
Authors: Weber, E.J.; Wolfe, N.L. Title: Kinetic Studies of the Reduction of Aromatic Azo Compounds in Anaerobic Sediment/Water Systems Source: Env. Tox. Chem. 6 (1987) 911-919 Description: pseudo first order rate law change in concentration vs. time
Authors: Wroblewska, B.; Kumami, K.; Cvejic, V.; Mrsulja, B.B.; Spatz, M. Title: Cerebrocortical Modulation of S2-Receptors and Turnover Rate of 5-Hydroxytryptamine in Ischemia Source: Neurochem. Res. 12 (1987) 21-25 Description: wherever biphasic shape of the curves suggested more than 1 binding site fit multiple site binding model, Scatchard analysis
Authors: Abramson, Fred P. Title: Kinetic Models of Induction: 1. Persistence of the Inducing Substance Source: J. Pharm. Sci. 75 (1986) 223-228 Description: odes, Michaelis Menten equation.
Authors: Abramson, Fred P.; Lutz, Michael P. Title: The Kinetics of Induction by Rifampin of Alpha-1-Acid Glycoprotein and Antipyrine Clearance in the Dog Source: Drug Metab. 14 (1986) 46-51 Description: one compartment model with first order absorption.
Authors: Abramson, F.P.; Lutz, M.P. Title: The Effects of Phenytoin Dosage on the Induction of Alpha-1-Acid Glycoprotein and Antipyrine Clearance in the Dog Source: Eur. J. Drug 11 (1986) 135-143 Description: weighted fit of one compartment model, 2 odes
Authors: Agren, Hans; Mefford, Ivan N.; Rudorfer, Matthew V.; Linnoila, Markku; Potter, William Z. Title: Interacting Neurotransmitter Systems. A Non-Experimental Approach to the 5HIAA-HVA Correlation in Human CSF Source: J. Psych. Res. 20 (1986) 175-193 Description: nonlinear curves generated with MLAB, linear and logistic regression
Authors: Balis, Frank M.; Lester, Cynthia M.; Poplack, David G. Title: Pharmacokinetics of Trimetrexate (NSC 352122) in Monkeys Source: Canc. Res. 46 (1986) 169-174 Description: Plasma concentration-time data from the iv bolus experiments were fitted to both bi- and tri-exponential functions
Authors: Bille, Vincent; Remacle, Jose Title: Simple-Kinetic Descriptions of Alcohol Dehydrogenase After Immobilization on Tresyl-Chloride-Activated Agarose Source: Eur. J. Biochem. 160 (1986) 343-348 Description: Michaelis Menten equation
Authors: Brenner, Dean E.; Collins, Jerry C.; Hande, Kenneth R. Title: The Effects of Cimetidine Upon the Plasma Pharmacokinetics of Doxorubicin in Rats Source: Canc. Chem. Pharm. 18 (1986) 219-222 Description: 2 compartment, bi-exponential model
Authors: Bristow, Michael R.; Ginsburg, Robert; Umans, Victor; Fowler, Michael; Minobe, Wayne; Rasmussen, Randy; Zera, Pauline; Menlove, Ronald; Shah, Pir; Jamieson, Stuart; Stinson, Edward B. Title: Beta-1 and Beta-2 Adrenergic Receptor Subpopulations in Nonfailing and Failing Human Ventricular Myocardium: Coupling of Both Receptor Subtypes to Muscle Contraction and Selective Beta-1 Receptor Down-Regulation in Heart Failure Source: Circ. Res. 59 (1986) 297-309 Description: ICYP bound vs log(ligand conc) curve fit
Authors: Bron, Dominique; Dodion, Pierre; Rozencweig, Marcel; Delforge, Alain; Mattelaer, Marie-Anne; Kenis, Yvon; Stryckmans, Pierre Title: Quantitation of Differential Sensitivity of Normal Marrow Myeloid Progenitor Cells to Anthracene Derivatives Source: Inv. New Drugs 4 (1986) 11-16 Description: Student's t, semilogarithmic linear regression, colony formation versus drug concentration.
Authors: Chang, Seung K.; Chung, Soo Il Title: Cellular Transglutaminase Source: J. Biol. Chem. 261 (1986) 8112-8121 Description: all curve fitting of Michaelis constants from kinetic data, MLAB
Authors: Coca-Prados, M.; Wax, M.B. Title: Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta-2-adrenergic receptors Source: PNAS 83 (1986) 8754-8758 Description: ligand binding analysis
Authors: Cohen, Brian E.; Egorin, Merrill J.; Kohlhepp, Elizabeth A.; Aisner, Joseph; Gutierrez, Peter L. Title: Human Plasma Pharmacokinetics and Urinary Excretion of Thiotepa and its Metabolites Source: Cancer Trt. Rep. 70 (1986) 859-864 Description: computer modeling of the decline in plasma concentration of thiotepa, area under curve, 2 compartment model
Authors: Collins, Jerry M.; Klecker, Raymond W.; Yarchoan, Robert; Lowe, H. Clifford; Fauci, Anthony S.; Redfield, Robert R.; Broder, Samuel; Myers, Charles E. Title: Clinical Pharmacokinetics of Suramin in Patients with HTLV-III/LAV Infection Source: J. Clin. Pharm. Ther. 26 (1986) 22-26 Description: simulation of data based on 2 compartment model, disappearance curves
Authors: Contreras, M.L.; Wolfe, B.B.; Molinoff, P.B. Title: Kinetic analysis of the interactions of agonists and antagonists with beta adrenergic receptors Source: J. Pharm. Exp. 239 (1986) 136-143
Authors: Contreras, M.L.; Wolfe, B.B.; Molinoff, P.B. Title: Thermodynamic properties of agonist interactions with the beta adrenergic receptor-coupled adenylate cyclase system. I. High- and low-affinity states of agonist binding to membrane- bound beta adrenergic receptors Source: J. Pharm. Exp. 237 (1986) 154-164
Authors: Dodion, P.; Sessa, C.; Joss, R.; Crespeigne, N.; Willems, Y.; Kitt, M.; Abrams, J.; Finet, C.; Brewer, J.E.; Adams, W.J.; Earhart, R.H.; Rozencweig, M.; Kenis, Y.; Cavalli, F. Title: Phase I Study of Intravenous Menogaril Administered Intermittently Source: J. Clin. Oncol. 4 (1986) 767-774
Authors: Egorin, Merrill J.; Van Echo, David A.; Whitacre, Margaret Y.; Forrest, Alan; Sigman, Lawrence M.; Engisch, Kathrin L.; Aisner, Joseph Title: Human Pharmacokinetics, Excretion, and Metabolism of the Anthracycline Antibiotic Menogaril (7-OMEN, NSC269148) and Their Correlation with Clinical Toxicities Source: Canc. Res. 46 (1986) 1513-1520 Description: 7-OMEN plasma concentration decline modeled with MLAB and ADAPT
Authors: Fernandez, L.; Aparacio, J.; Muhammed, M. Title: Coupled Zinc Transport Through a Bis(2-Ethylhexyl)-Phosphoric Acid Solid-Supported Liquid Membrane from Aqueous Perchlorate Media Source: J. Membrane Sci. 27 (1986) 77-91 Description: unknown parameters were calculated by fitting experimental data to model function, permeability equations.
Authors: Gillis, Anne M.; Kates, Robert E. Title: Influence of Protein Binding on the Myocardial Uptake and Pharmacodynamics of Propafenone Source: J. Cardiovasc. Pharm. 8 (1986) 1163-1167 Description: efferent perfusate propafenone concentration-time data fit to c = c0*(1-exp(-k*t)).
Authors: Gillis, Anne M.; Kates, Robert E. Title: Myocardial Uptake Kinetics and Pharmacodynamics of Propafenone in the Isolated Perfused Rabbit Heart Source: J. Pharm. Exp. 237 (1986) 708-712 Description: efferent perfusate concentration fit to c = c0*(1-exp(-k*t)).
Authors: Graber, Stephen G.; Woodworth, Robert C. Title: Myoglobin Expression in L6 Muscle Cell Source: J. Biol. Chem. 261 (1986) 9150-9154 Description: A standard curve is generated for each assay using a weighted regression routine in MLAB.
Authors: Grigorescu, Florin; Flier, Jeffrey S.; Kahn, C. Ronald Title: Characterization of Binding and Phosphorylation Defects of Erythrocyte Insulin Receptors in the Type A Syndrome of Insulin Resistance Source: Diabetes 35 (1986) 127-138 Description: Stoichiometric binding parameters were determined by a statistical curve fitting procedure in MLAB.
Authors: Haimovich, B.; Tanaka, J.C.; Barchi, R.L. Title: Developmental Appearance of Sodium Channel Subtypes in Rat Skeletal Muscle Cultures Source: J. Neurochem. 47 (1986) 1148-1153
Authors: Harris, C.C.; LaVeck, G.; Groopman, J.; Wilson, V.L.; Mann, D. Title: Measurement of aflatoxin B1. Its metabolites and DNA adducts by synchronous fluorescence spectrophotometry Source: Canc. Res. 46 (1986) 3249-3253
Authors: Harris, R.C.; Seiffer, J.L.; Lechene, C. Title: Coupling of Na-H exchange and Na-K pump activity in cultured rat proximal tubule cells Source: Am. J. Physiol. Cell Physiol. 251 (1986) C815-C824
Authors: Herblin, W.F. Title: Characterization of Benzodiazepine Binding Sites After Shortwave Photo-Affinity Labeling with Flunitrazepam Source: Life Sci. 38 (1986) 507-514 Description: binding parameters derived by fitting to two-site logistic equation
Authors: Horwitz, Barry; Duara, Ranjan; Rapoport, Stanley I. Title: Age Differences in Intercorrelations Between Regional Cerebral Metabolic Rates for Glucose Source: Ann. Neurol. 19 (1986) 60-67 Description: displays of correlation matrices were obtained using MLAB
Authors: Huang, M.-T.; Wood, A.W.; Chang, R.L.; Yagi, H.; Sayer, J.M.; Jerina, D.M.; Conney, A.H. Title: Inhibitory Effect of 3-Hydroxybenzo(Alpha)Pyrene on the Mutagenicity and Tumorgenicity of (+-)-7-Beta,8-Alpha-Dihydroxy-9-Alpha, 10-Alpha-Epoxy-7,8,9,10-Tetrahydrobenzo(Alpha)Pyrene Source: Canc. Res. 46 (1986) 558-566 Description: odes for second order rate equations
Authors: Huhtaniemi, I.T.; Rajaniemi, H.J.; Catt, K.J. Title: Kinetic and autoradiographic studies on binding of hCG to the testicular LH receptors of neonatal rats Source: J. Reprod. Fertil. 78 (1986) 73-82
Authors: Hynes, M.R.; Banner, W.; Yamamura, H.I.; Duckles, S.P. Title: Characterization of muscarinic receptors of the rabbit ear artery smooth muscle and endothelium Source: J. Pharm. Exp. 238 (1986) 100-105
Authors: Ilondo, M. Mapoko; Courtoy, Pierre J.; Geiger, Dominique; Carpentier, Jean-Louis; Rousseau, Guy G.; De Meyts, Pierre Title: Intracellular Potassium Depletion in IM-9 Lymphocytes Suppresses the Slowly Dissociating Component of Human Growth Hormone Binding and the Down-Regulation of its Receptors But Does Not Affect Insulin Receptors Source: PNAS 83 (1986) 6460-6464 Description: association kinetics in K+ depleted cells
Authors: Jacques, B.; Depiereux, E.; Feytmans, E. Title: Effects of a sewage plant treatment on physico-chemical quality and community structure of the polluted river Haute-Semois Source: Acta Oecologia Applicata 7 (1986) 261-279. Description: dendrograms and cluster analysis
Authors: Johnson, C.; Cooper, J.B.; Winter, C.G. Title: Effects of an ATP site affinity analog on some conformational and enzymatic properties of the canine kidney (Na+ K+)-ATPase Source: Biochim. Biophys. Acta-Biomembranes 860 (1986) 549-557
Authors: Juillerat, Marcel A.; Taniuchi, Hiroshi Title: A Study on the Role of Evolutionary Invariant Leucine 32 of Cytochrome c Source: J. Biol. Chem. 261 (1986) 2697-2711 Description: equilibrium data curve fitted to van't Hoff plots, MLAB
Authors: Kapetavnovic, Izet M.; Yonekawa, Wayne D.; Kupferberg, Harvey J.; Cos, Lynn; Rollins, Douglas E.; Tolman, Keith G. Title: Single and Multiple Dose Kinetics of a New Antiepileptic Drug, Org 6370, and Its Desmethyl Metabolite, Org 6363 Source: Ther. Drug Mon. 8 (1986) 140-144 Description: compartmental model
Authors: Kelley, James A.; Driscoll, John S.; McCormack, John J.; Roth, Jeri S.; Marquez, Victor E. Title: Furanose-Pyranose Isomerization of Reduced Pyrimidine and Cyclic Urea Ribosides Source: J. Med. Chem. 29 (1986) 2351-2358 Description: the change of absolute peak height kinetically analyzed with MLAB.
Authors: Kelley, Susan L.; Peters, William P.; Anderson, Janet; Furlong, Eileen A.; Frei, Emil, III; Henner, William D. Title: Pharmacokinetics of Dibromodulcitol in Humans: A Phase I Study Source: J. Clin. Oncol. 4 (1986) 753-761 Description: regression analysis using MLAB, STAT80, DASH
Authors: Kinsella, James L.; Cujdik, Timothy; Sacktor, Bertram Title: Kinetic Studies on the Stimulation of Na+-H+ Exchange Activity in Renal Brush Border Membranes Isolated from Thyroid Hormone-Treated Rats Source: J. Membrane Biol. 91 (1986) 183-191 Description: kinetic constants determined with MLAB
Authors: Koziol, James A. Title: An Introduction to Multivariate Growth Curve Analysis Source: Growth 50 (1986) 259-272 Description: Potthoff-Roy multivariate growth curve model
Authors: Kreis, Willi; Budman, Daniel R.; Schulman, Philip; Freeman, Jean; Greist, Anne; Nelson, Robert L.; Marks, Mary; Kevill, Lydia Title: Clinical Pharmacology of Vinzolidine Source: Canc. Chem. Pharm. 16 (1986) 70-74 Description: weighted least squares regression of triexponential model
Authors: Krumins, S.A.; Lutz, R.A.; Costa, T.; Rodbard, D. Title: Interaction of Dimeric and Monomeric Enkephalins with NG108-15 Hybrid Cells: A Kinetic Analysis Source: Neurochem. Res. 11 (1986) 839-850 Description: ligand binding analysis with MLAB and LIGAND
Authors: Lagast, H.; Dodion, P.; Klastersky, J. Title: Comparison of Pharmacokinetics and Bactericidal Activity of Teicoplanin and Vancomycin Source: Antimicrob. Ag. and Chem. 18 (1986) 513-520 Description: Plasma conc fit to 2,3 compartment models, Student's t and Wilcoxon tests
Authors: Lane, E.A.; Parashos, I. Title: Drug pharmacokinetics and the carbon dioxide breath test Source: J. Pharm. Biopharm. 14 (1986) 29-49
Authors: Larsson, S.; Aperia, A.; Lechene, C. Title: Ionic transport in individual renal epithelial cells from adult and young rats Source: Acta Physiol. Scand. 126 (1986) 321-332
Authors: Larsson, S.; Aperia, A.; Lechene, C. Title: Studies on final differentiation of rat renal proximal tubular cells in culture Source: Am. J. Physiol. Cell Physiol. 251 (1986) C455-C464
Authors: Lee, Edward J.; Van Echo, David A.; Egorin, Merrill J.; Nayar, Balchandran; Shulman, Philip; Schiffer, Charles A. Title: Diaziquone Given as a Continuous Infusion is an Active Agent for Relapsed Adult Acute Nonlymphocytic Leukemia Source: Blood 67 (1986) 182-187 Description: diaziquone conc in plasma-time
Authors: Lewis, Marc S.; Youle, Richard J. Title: Ricin Subunit Association. Thermodynamics and the role of the disulphide bond in toxicity Source: J. Biol. Chem. 261 (1986) 11571-11577 Description: ultracentrifuge data analysis
Authors: Liang, B.T.; Molinoff, P.B. Title: Beta adrenergic receptor subtypes in the atria: evidence for close coupling of beta-1 and beta-2 adrenergic receptors to adenylate cyclase Source: J. Pharm. Exp. 238 (1986) 886-892
Authors: Lohmander, L.S.; Hascall, V.C.; Yanagishita, M.; Kuettner, K.E.; Kimura, J.H. Title: Post-translational events in proteoglycan synthesis: Kinetics of synthesis of chondroitin sulfate and oligosaccharides on the core protein Source: Arch. Biochem. Biophys. 250 (1986) 211-227
Authors: Lynch, Christopher J.; Sobo, Gwenn E.; Exton, John H. Title: An Endogenous Ca2+-Sensitive Proteinase Converts the Hepatic Alpha-1-Adrenergic Receptor to Guanine Nucleotide-Insensitive Forms Source: Biochim. Biophys. Acta 885 (1986) 110-120 Description: [3-H] Prazosin binding to plasma membranes was performed and data were analyzed using MLAB.
Authors: Maes, M.; Underwood, L.E.; Ketelslegers, J.-M. Title: Low Serum Somatomedin-C in Insulin-Dependent Diabetes: Evidence for a Postreceptor Mechanism Source: Endocrin. 118 (1986) 377-382 Description: The number and affinity of the specific binding sites were determined from the saturation curves by nonlinear curve fitting.
Authors: Marini, M.A.; Evans, W.J.; Berger, R.L. Title: The Determination of Binding Constants with a Differential Thermal and Potentiometric Titration Apparatus. II. EDTA, EGTA, and Calcium Source: J. Biochem. Biophys. Meth. 12 (1986) 135-146 Description: ionization constants and heats of ionization derived by simulataneous fit of potentiometric and titration curves.
Authors: Martin, C.J.; Evans, W.J. Title: Phytic Acid-Zinc Ion Interactions: A Calorimetric and Titrimetric Study Source: J. Inorg. Biochem. 26 (1986) 169-183 Description: all calculations, including corrections for non-zero baseline, curve-fitting procedures, and solutions to diff. eqs. for heat-loss corrections done with MLAB.
Authors: McGonigle, Paul A.; Neve, Kim A.; Molinoff, Perry B. Title: A Quantitative Method of Analyzing the Interaction of Slightly Selective Radioligands with Multiple Receptor Subtypes Source: Mol. Pharm. 30 (1986) 329-337 Description: Scatchard analysis, 2 site model
Authors: Mossman, K.L. Title: Gustatory Tissue Injury in Man-Radiation Dose Response Relationships and Mechanisms of Taste Loss Source: Br. J. Cancer Suppl. 7 (1986) 9-11 Description: logistic model
Authors: Nashed, Nashaat T.; Michaud, Dennis P.; Levin, Wayne; Jerina, Donald M. Title: 7-Dehydrocholesterol 5,6 Beta-Oxide as a Mechanism-Based Inhibitor of Microsomal Cholesterol Oxide Hydrolase Source: J. Biol. Chem. 261 (1986) 2510-2513 Description: kinetics, time vs conc., fit rate constants
Authors: Neve, K.A.; McGonigle, P.; Molinoff, P.B. Title: Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors Source: J. Pharm. Exp. 238 (1986) 46-53
Authors: Pang, K. Sandy; Terrell, Julia A.; Nelson, Sidney D.; Feuer, Kathleen F.; Clements, Mary-Jean; Endrenyi, Laszlo Title: An Enzyme-Distributed System for Lidocaine Metabolism in the Perfused Rat Liver Preparation Source: J. Pharm. Biopharm. 14 (1986) 107-130 Description: computer for simulations for distribution of metabolic activities for metabolism of lidocaine and metabolites.
Authors: Pang, K. Sandy; Yuen, Vincent; Fayz, Shirin; Te Koppele, Johan M.; Mulder, Gerard J. Title: Absorption and Metabolism of Acetominophen by the in Situ Perfused Rat Small Intestine Preparation Source: Drug Metab. 14 (1986) 102-111 Description: weighted least squares fit rate constants for absorption of intestinal preparations
Authors: Parmacek, M.S.; Magid, N.M.; Lesch, M.; Decker, R.S.; Samarel, A.M. Title: Cardiac protein synthesis and degradation during thyroxine- induced left ventricular hypertrophy Source: Am. J. Physiol. Cell Physiol. 251 (1986) C727-C736
Authors: Perez, Pilar; Hoffman, Robert W.; Titus, Julie A.; Segal, David M. Title: Specific Targeting of Human Peripheral Blood T Cells By Heteroaggregates Containing Anti-T3 Crosslinked to Anti-Target Cell Antibodies Source: J. Exp. Med. 163 (1986) 166-178 Description: In some experiments, curves of percent lysis versus effector target were analyzed by fitting them to a hyperbolic function.
Authors: Phillips, Robert S.; Cohen, Louis A. Title: Intramolecular General Acid and General Base Catalyses in the Hydrolysis of 2-Halotryptophans and Their Analogues Source: JACS 108 (1986) 2023-2030 Description: log of rate constant versus pH fit to rate equations
Authors: Poerio, Elia; Parr, Gary R.; Taniuchi, Hiroshi Title: A Study of Roles of Evolutionary Invariant Proline 30 and Glycine 34 of Cytochrome C Source: J. Biol. Chem. 261 (1986) 10976-10989 Description: curve fitting.
Authors: Prasad, Kondury; Lippoldt, Roland E.; Edelhoch, Harold Title: An Intermediate Polymer in the Assembly of Clathrin Baskets Source: Biochem. 25 (1986) 5214-5219 Description: ultracentrifuge, digitize scans, convert (x,y) coordinates to concentration form of optical density at 280nm as function of radial position.
Authors: Rabiet, Marie Josephe; Blashill, Alisan; Furie, Bruce; Furie, Barbara C. Title: Prothrombin Fragment 1.2.3, a Major Product of Prothrombin Activation in Human Plasma Source: J. Biol. Chem. 261 (1986) 13210-13215 Description: the radioactivity profiles from gels were calculated, normalized, and visualized with MLAB.
Authors: Rahman, Aquilur; Carmichael, Don; Harris, Mary; Roh, Jae Kyung Title: Comparative Pharmacokinetics of Free Doxorubicin and Doxorubicin Entrapped in Cardiolipin Liposomes Source: Canc. Res. 46 (1986) 2295-2299 Description: 2 and 3 compartment model plasma level decrease in tissue levels following administration.
Authors: Reddy, K.V.; Hendler, R.W.; Bunow, B. Title: Complete analysis of the cytochrome components of beef heart mitochondria in terms of spectra and redox properties. Cytochrome aa3 Source: Biophys. J. 49 (1986) 705-715
Authors: Robinson, P.J.; Rapoport, S.I. Title: Kinetics of Protein Binding Determine Rates of Uptake of Drugs by Brain Source: Am. J. Physiol. 251 (1986) R1212-1220 Description: Michaelis Menten and other models.
Authors: Rothman, Richard B.; Cadet, Jean Lud Title: Chronic Iminodipropionitrile (IDPN) Causes no Changes in the Rat Brain Phencyclidine (PCP) Receptor Source: Neuropeptides 7 (1986) 259-263
Authors: Roy, S.; Weinstein, S.; Borah, B.; Nickol, J.; Appella, E.; Sussman, J.L.; Miller, M.; Shindo, H.; Cohen, J.S. Title: Mechanism of Oligonucleotide Loop Formation in Solution Source: Biochem. 25 (1986) 7417-7423
Authors: Russell, C.H. Title: Advances in Scientific Software Packages Source: Computer Applications in the Polymer Lab, Chapter 4, pages 23-30. ACS Symposium Series, volume 313 (1986).
Authors: Shenvi, Ashok B. Title: Alpha-Aminoboronic Acid Derivatives: Effective Inhibitors of Aminopeptidases Source: Biochem. 25 (1986) 1286-1291 Description: kinetic data fitted to reciprocal Michaelis Menten equation
Authors: Shrager, Richard I.; Hendler, Richard W. Title: Processing and Analysis of Potentiometric Data Source: Biophys. J. 49 (1986) 687-691 Description: Sum of Nernstians, SVD method.
Authors: Silver, J.; Buckler, C.E. Title: Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses Source: PNAS 83 (1986) 1423-1427 Description: Bayesian model
Authors: Smith, Quentin R.; Rapoport, Stanley I. Title: Cerebrovascular Permeability Coefficients to Sodium, Potassium, and Chloride Source: J. Neurochem. 46 (1986) 1732-1742 Description: time course of plasma concentration as sum of exponentials.
Authors: Smith, Quentin R.; Takasato, Yoshio Title: Kinetics of Amino Acid Transport at the Blood-Brain Barrier Studied Using an in Situ Brain Perfusion Technique Source: Ann. NY Acad. 481 (1986) 186-201 Description: Best fit values for Vmax, Km, and Kd can be obtained by fitting equation 6 to saline perfusion data with weighted nonlinear least squares.
Authors: Stevenaert, A.; Beckers, A.; Vandalem, J.L.; Hennen, G. Title: Early Normalization of Luteinizing Hormone Pulsatility after Successful Transphenoid Surgery in Women with Microprolactinomas Source: J. Clin. Endo. Metab. 62 (1986) 1044-1047 Description: Significant LH peaks were identified with the Pulsar program in connection with MLAB
Authors: Suarez-Isla, Benjamin A.; Orozco, Carlos; Heller, Phillip F.; Froehlich, Jeffrey P. Title: Single Calcium Channels in Native Sarcoplasmic Reticulum Membranes from Skeletal Muscle Source: PNAS 83 (1986) 7741-7745 Description: data fitted to a hyperbola.
Authors: Tabata, Hitoshi; Holloway, Harold; Fredericks, Wendy R.; French, A. Wayne; Rapoport, Stanley I. Title: Regional Cerebral Blood Flow in Awake Beagles of Different Ages Source: Brain 109 (1986) 771-784 Description: bi-exponential plus constant model of plasma concentration in time.
Authors: Takei, Hidenori; Fredericks, Wendy R.; Rapoport, Stanley I. Title: The Lumped Constant in the Deoxyglucose Procedure Declines with Age in Fischer-344 Rats Source: J. Neurochem. 46 (1986) 931-938 Description: fit exponential model to glucose and [14-C]DG concentrations in time.
Authors: Tchekmedyian, N. Simon; Egorin, Merrill J.; Cohen, Brian E.; Kaplan, Richard S.; Poplin, Elizabeth; Aisner, Joseph Title: Phase I Clinical and Pharmacokinetic Study of Cyclophosphamide Administered by Five-Day Continuous Intravenous Infusion Source: Canc. Chem. Pharm. 18 (1986) 33-38 Description: computer modeling of the decline in plasma concentration of cyclophosphamide by weighted least squares.
Authors: Tejani-Butt, S.M.; Brunswick, D.J. Title: Synthesis and Beta-andrenergic Receptor Blocking Potency of 1-(substituted amino)-3-(4-indolyloxy) propan-2-ols Source: J. Med. Chem. 29 (1986) 1524-1527
Authors: Thomas, David J.; Fisher, Henry L.; Sumler, Martha R.; Marcus, Allan H.; Mushak, Paul; Hall, Larry L. Title: Sexual Differences in the Distribution and Retention of Organic and Inorganic Mercury in Methyl Mercury-Treated Rats Source: Env. Res. 41 (1986) 219-234 Description: Fit retention as a linear combination of exponentials.
Authors: Thraves, Peter J.; Mossman, Kenneth L.; Brennan, Terrance; Dritschilo, Anatoly Title: Differential Radiosensitization of Human Tumor Cells by 3-Aminobenzamide and Benzamide Inhibitors of Poly (ADP-Ribosylation) Source: Int. J. Radiat. Biol. 50 (1986) 961-972 Description: survival curves from colony count data.
Authors: Tien, M; Kirk, T.K.; Bull, C.; Fee, J.A. Title: Steady-state and transient-state kinetic studies on the oxidation of 3,4-dimethoxybenzyl alcohol catalyzed by the ligninase of Phanerocheate chrysosporium Burds Source: J. Biol. Chem. 261 (1986) 1687-1693
Authors: Tietz, D.; Gottlieb, M.H.; Fawcett, J.S.; Chrambach, A. Title: Electrophoresis on uncrosslinked polyacrylamide: Molecular sieving and its potential applications Source: Electrophoresis 7 (1986) 217-220
Authors: Tietz, D.; Chrambach, A. Title: Analysis of convex Ferguson plots in agarose gel electrophoresis by empircal computer modeling Source: Electrophoresis 7 (1986) 241-250
Authors: Valcour, Andre A.; Woodworth, Robert C. Title: Internal Proton Magnetic Resonance Probes for pH Titration Proteins Source: J. Mag. Res. 66 (1986) 536-541 Description: fit chemical shift as function of minimum shift, maximum shift, proton concentration, and association rate constant
Authors: Vandalem, J.L.; McNamara, M.; Petit, R.; Hennen, G. Title: Developmental Changes in Gonadotrophins and Testicular Gonadotrophin Receptors in the Pig, From Neonatal to Adult Life Source: J. Endocrin. 111 (1986) 301-308 Description: Scatchard analysis, parallel line assay, and analysis of variance.
Authors: Van Dyk, D.E.; Schloss, J.V. Title: Deuterium isotope effects in the carboxylase reaction of ribulose-1,5-bisphosphate carboxylase/oxygenase Source: Biochem. 25 (1986) 5145-5156
Authors: Vasallo, P.M.; Post, R.L. Title: Calcium ion as a probe of the monovalent cation center of sodium, potassium ATPase Source: J. Biol. Chem. 261 (1986) 16957-16962
Authors: Verdin, E.M.; Maratos-Flier, E.; Carpentier, J.L.; Kahn, C.R. Title: Persistent infection with a nontransforming RNA virus leads to impaired growth factor receptors and response Source: J. Cell. Physiol. 128 (1986) 457-465
Authors: Villeneuve, Jean-Pierre; Verbeeck, Roger K.; Wilkinson, Grant R.; Branch, Robert A. Title: Furosemide Kinetics and Dynamics in Patients with Cirrhosis Source: Clin. Pharm. Ther. 40 (1986) 14-20 Description: Renal clearance, urinary excretion best fit parameters.
Authors: Wahlund, L.-O.; Saaf, J.; Eneroth-Grimfors, E.; Nilsson, B.A.; Bevegard, S. Title: Reduced Platelet MAO Activity During Pregnancy Source: Acta Physiol. Scand. 126 (1986) 135-138 Description: Lineweaver-Burk plots, kinetic constants
Authors: Weiss, G.H.; Salazar, A.M.; Vance, S.C.; Grafman, J.H.; Jabbari, B. Title: Predicting posttraumatic epilepsy in penetrating head injury Source: Arch. Neurol. 43 (1986) 771-773
Authors: Walsh, J.; Gosling, J.P. Title: The influence of radioiodination on the adsorption of IgG and serum albumin to polystyrene Source: Anal. Biochem. 158 (1986) 413-423
Authors: Westerhoff, Hans V.; Tsong, Tian Yow; Chock, P.B.; Chen, Yi-der; Astumian, R.D. Title: How Enzymes Can Capture and Transmit Free Energy From an Oscillating Electric Field Source: PNAS 83 (1986) 4734-4738 Description: solved 2 diff. eqs.
Authors: Whitesell, J.K.; Buchanan, C.M. Title: Synthesis of (-)- and (+)-frontalin Source: J. Org. Chem. 51 (1986) 5443-5445
Authors: Yeh, Herman J.C.; Balari, Suresh K.; Yagi, Haruhiko; Greene, Ruth M.E.; Sharma, Narain D.; Boyd, Derek R.; Jerina, Donald M. Title: Use of Chiral Lanthanide Shift Reagents in the Determination of Enantiomer Composition and Absolute Configuration of Epoxides and Arene Oxides Source: J. Org. Chem. 51 (1986) 5439-5443 Description: values of limiting chemical shift and rate constant were determined by fitting data observed as function of added shift reagent.
Authors: Zaharko, Daniel S.; Griesheber, Charles K.; Plowman, Jacqueline; Cradock, James C. Title: Therapeutic and Pharmacokinetic Relationships of Flavone Acetic Acid: An Agent with Activity Against Solid Tumors Source: Cancer Trt. Rep. 70 (1986) 1415-1421 Description: fit plasma concentration in time to biexponential model.
Authors: Abraham, E.H.; Breslow, J.L.; Epstein, J.; Chang-Sing, P.; Lechene, C. Title: Preparation of individual human diploid fibroblasts and study of ion transport Source: Am. J. Physiol. Cell Physiol. 248 (1985) C154-C164
Authors: Abramson, S.N.; Molinoff, P.B. Title: Properties of beta-adrenergic receptors of cultured mammalian cells Source: J. Biol. Chem. 260 (1985) 14580-14588
Authors: Aizenbud, Boris M.; Gershon, Nahum D. Title: Diffusion of Molecules on Biological Membranes of Nonplanar Form Source: Biophys. J. 48 (1985) 543-546 Description: 3D graphics
Authors: Balis, Frank M.; Lange, Beverly J.; Packer, Roger J.; Holcenberg, John S.; Ettinger, Lawrence J.; Sallan, Stephen E.; Heideman, Richard L.; Zimm, Solomon; Smithson, William A.; Cogliano-Shutta, Nancy A.; Reaman, Gregory H.; Poplack, David G. Title: Pediatric Phase I Trial and Pharmacokinetic Study of Tiazofurin (NSC 286193) Source: Canc. Res. 45 (1985) 5169-5172 Description: bi- and tri-exponential equations fit to plasma disappearance
Authors: Borah, B.; Chen, C.W.; Egan, W.; Miller, M.; Wlodawer, A.; Cohen, J.S. Title: Nuclear Magnetic Resonance and Neutron Diffraction Studies of the Complex Ribonuclease A with Uridine Vanadate, a Transition-State Analog Source: Biochem. 24 (1985) 2058-2067
Authors: Borowski, Marianne; Furie, Barbara C.; Goldsmith, George H.; Furie, Bruce Title: Metal and Phospholipid Binding Properties of Partially Carboxylated Human Prothrombin Variants Source: J. Biol. Chem. 260 (1985) 9258-9264 Description: data from dialysis experiments analyzed using 2 site binding model
Authors: Brenner, Dean E.; Galloway, Sherri; Cooper, John; Noone, Richard; Hande, Kenneth R. Title: Improved High-Performance Liquid Chromatography Assay of Doxorubicin: Detection of Circulating Aglycones in Human Plasma and Comparison with Thin-Layer Chromatography Source: Canc. Chem. Pharm. 14 (1985) 139-145 Description: 3 compartment, first order elimination kinetic model, Student's t
Authors: Bunow, B.; Segev, I.; Fleshman, J.W. Title: Modeling the Electrical Behavior of Anatomically Complex Neurons Using a Network Analysis Program: Excitable Membrane Source: Biol. Cybern. 53 (1985) 41-56 Description: Hodgkin-Huxley equation, coefficients of polynomial
Authors: Casale, T.B.; Rodbard, D.; Kaliner, M. Title: Characterization of histamine H-1 receptors on human peripheral lung Source: Biochem. Pharm. 34 (1985) 3285-3292
Authors: Chan, Kenneth K.; Bolger, Michael B.; Pang, K. Sandy Title: Statistical Moment Theory in Chemical Kinetics Source: Anal. Chem. 57 (1985) 2145-2151 Description: several sets of data on kinetic systems were generated, including 3 consecutive first order reactions, parallel first order
Authors: Chen, Raymond F.; Scott, Carrie H. Title: Atlas of Fluorescence Spectra and Lifetimes of Dyes Attached to Protein Source: Anal. Lett. 18 (1985) 393-421 Description: Correction and graphics
Authors: Cheng, Sheue-yann Title: Structural Similarities Between the Plasma Membrane Binding Sites for L-Thyroxine and 3,3',5-Triiodo-L-Thyronine in Cultured Cells Source: J. Receptor Res. 5 (1985) 1-26 Description: binding data were fitted to Scatchard equation
Authors: Chiueh, C.C.; Ohata, M.; Jonas, L.A.; Greenblatt, D.J.; Rapoport, S.I. Title: Brain Uptake of Flurazepam and of N1-Desalkyl Flurazepam after Administration of Flurazepam to the Cat Source: Drug Metab. 13 (1985) 1-4 Description: fit plasma conc.-time data to multiexponential equation
Authors: Chu, David T.W.; Shikama, Hisataka; Khatra, Balwart S.; Exton, John H. Title: Effects of Altered Thyroid Status on Beta-Adrenergic Actions on Skeletal Muscle Glycogen Metabolism Source: J. Biol. Chem. 260 (1985) 9994-10000 Description: Receptor density and ICYP affinity quantified
Authors: Collins, Jerry M.; Riccardi, Riccardo; Trown, Patrick; O'Neill, Dondra; Poplack, David G. Title: Plasma and Cerebrospinal Fluid Pharmacokinetics of Recombinant Interferon Alpha A in Monkeys: Comparison of Intravenous, Intramuscular, and Intraventricular Delivery Source: Cancer Drug Del. 2 (1985) 247-253 Description: half-times were calculated by weighted least squares regression
Authors: Crabtree, G.R.; Comeau, C.M.; Fowlker, D.M.; Fornace, A.J.; Malley, J.D.; Kant, J.A. Title: Evolution and structure of the fibrinogen genes: Random insertion of introns or selective loss? Source: J. Molec. Biol. 185 (1985) 1-19
Authors: Cumming, J.R.; Eckert, R.T.; Evans, L.S. Title: Kinetics of Potassium Uptake in Red Spruce Seedlings Source: Can. J. Bot. 63 (1985) 512-516 Description: data were fit to various models by weighted nonlinear least squares, Michaelis-Menten equation
Authors: Curt, Gregory A.; Kelley, James A.; Fine, Robert L.; Huguenin, Philipp N.; Roth, Jeri S.; Balist, Gerald; Jenkins, Jean; Collins, Jerry M. Title: A Phase I and Pharmacokinetic Study of Dihydro-5-Azacytidine (NSC 264880) Source: Canc. Res. 45 (1985) 3359-3363 Description: postinfusion plasma conc-time data fit to biexponential model
Authors: Davids, N.; Beger, R.L.; Marini, M.A. Title: Application of the finite element simulation method to the adiabatic and potentiometric corrections of calorimetric titration data Source: J. Biochem. Biophys. Meth. 10 (1985) 261-272
Authors: de Monasterio, F.M.; McCrane, E.P.; Newlander, J.K.; Schein, S.J. Title: Density Profile of Blue-Sensitive Cones Along the Horizontal Meridian of Macaque Retina Source: Inv. Ophthal. Vis. Sci. 26 (1985) 289-302 Description: fit of various model functions to distribution of cone densities as a function of retinal eccentricity
Authors: de Nayer, Phillipe; Dozin, Beatrice Title: Thyroid Hormones and Brain Development: Modulation of the Binding Activity of the T3 Nuclear Receptor by Chromatin-Associated Factors Source: Mol. Physiol. 7 (1985) 303-310 Description: Affinity constant of the T3 receptor was derived from a Scatchard plot of the data, weighted non-linear least squares fit
Authors: Depiereu, E.; Feytmans, E. Title: Gradual modification of the structure of benthic invertebrate communities according to water quality of the Ourthe and Lesse rivers (Belgian Meuse) Source: Acta Oecologia Applicata 6(1985) 81-98. Description: cluster analysis, principal component analysis, dendrograms, histograms
Authors: Dodion, P.; Davis, T.A.; Rozencweig, M.; Crespeigne, N.; Kenis, Y.; Bachur, N.R. Title: Human Pharmacokinetics of Esorubicin (4'-deoxydoxorubicin) Source: Inv. New Drugs 3 (1985) 361-368 Description: esorubicin plasma conc.-time date fit to tri-exponential model
Authors: Dodion, Pierre; Egorin, Merrill J.; Engisch, Kathrin L.; Bachur, Nicholas R. Title: Metabolism and Disposition of Menogaril (NSC 269148) in the Rabbit Source: Canc. Res. 45 (1985) 5352-5357 Description: computer simulation of decline in plasma conce of 7-OMEN
Authors: Dodion, Pierre; Egorin, Merrill J.; Riggs, Charles E, Jr.; Ferraro, Thomas A.; Tamburini, Julie M.; Bachur, Nicholas R. Title: Comparative Murine Metabolism and Disposition of Class II Anthracycline Antibiotics Source: Canc. Chem. Pharm. 15 (1985) 153-160 Description: computer modeling of plasma conc. of ACL and MST to determine peak concentration, half-life, and area under curve
Authors: Dower, Steven K.; Hefeneider, Steven H.; Alpert, Alan R.; Urdal, David L. Title: Quantitative Measurement of Human Interleukin 2 Receptor Levels with Intact and Detergent Solubilized Human T-Cells Source: Mol. Immunol. 22 (1985) 937-947 Description: 2 site binding model
Authors: Dower, Steven K.; Segal, David M. Title: Interaction of Monoclonal Antibodies with MHC Class I Antigens on Mouse Spleen Cells Source: J. Immunol. 134 (1985) 431-435 Description: 2 site binding model
Authors: Egan, Pamela C.; Costanza, Mary E.; Dodion, Pierre; Egorin, Merrill J.; Bachur, Nicholas R. Title: Doxorubicin and Cisplatin Excretion into Human Milk Source: Canc. Treat. Rpts. 69 (1985) 1387-1389 Description: plasma and milk drug conc were modelled as single exponential
Authors: Egorin, Merrill J.; Cohen, Brian E.; Kohlhepp, Elizabeth A.; Gutierrez, Peter L. Title: Gas-Liquid Chromatographic Analysis of N,N',N''-Triethylene Thiophosphoramide and N,N',N'' Triethylene Phosphoramide in Biological Samples Source: J. Chrom. B 343 (1985) 196-202 Description: computer modeling of plasma conc. of thioTEPA and TEPA
Authors: Ellis, John; Lenox, Robert H. Title: Characterization of the Interactions of Gallamine with Muscarinic Receptors from Brain Source: Biochem. Pharm. 34 (1985) 2214-2217 Description: monoexponential best fits of time course of inhibition by gallamine of muscarainic receptor binding
Authors: Ferrone, F.A.; Hofrichter, J.; Eaton, W.A. Title: Kinetics of sickle hemoglobin polymerization I. Studies using temperature-jump and laser photolysis techniques Source: J. Molec. Biol. 183 (1985) 591-610
Authors: Flessner, M.F.; Dedrick, R.L.; Schultz, J.S. Title: A distributed model of peritoneal-plasma transport: analysis of experimental data in the rat Source: Am. J. Physiol. Renal Physiol. 248 (1985) F413-F424
Authors: Flessner, M.F.; Dedrick, R.L.; Schultz, J.S. Title: Exchange of macromolecules between peritoneal cavity and plasma Source: Am. J. Physiol. Heart Circ. Physiol. 248 (1985) H15-H25
Authors: Flessner, M.F.; Fenstermacher, J.D.; Dedrick, R.L.; Blasberg, R.G. Title: A distributed model of peritoneal-plasma transport: tissue concentration gradients Source: Am. J. Physiol. Renal Physiol. 248 (1985) F425-F435
Authors: Fram, Robert J.; Kufe, Donald W. Title: Effect of 1-Beta-D-Arabinofuranosyl Cytosine and Hydroxyurea on the Repair of X-Ray-Induced DNA Single-Strand Breaks in Human Leukemic Blasts Source: Biochem. Pharm. 34 (1985) 2557-2560 Description: relative retention values were calculated for 14-C-labeled DNA at 50% elution of 3-H-internal standards treated with Gy plotted according to a decreasing exponential function.
Authors: Freund, Kurt; Mizzer, John; Dick, William; Thorpe, Colin Title: Inactivation of General Acyl-CoA Dehydrogenase from Pig Kidney by 2-Alkynoyl Coenzyme A Derivatives: Initial Aspects Source: Biochem. 24 (1985) 5996-6002 Description: absorbance traces fit to two sequential first order reactions where product of first reaction absorbs at 800 nm
Authors: Froehlich, Jeffrey P.; Heller, Phillip F. Title: Transient-State Kinetics of the ADP-Insensitive Phosphoenzyme in Sarcoplasmic Reticulum: Implications for Transient-State Calcium Translocation Source: Biochem. 24 (1985) 126-136 Description: kinetic constants of the ATPase partial reactions were determined by computer simulation of the dephosphorylation time course
Authors: Gianni, L.; Zweier, J.L.; Levy, A.; Myers, C.E. Title: Characterization of the cycle of iron-mediated electron transfer from Adriamycin to molecular oxygen Source: J. Biol. Chem. 260 (1985) 6820-6826
Authors: Gillis, Anne M.; Yee, Yin-Gail; Kates, Robert E. Title: Binding of Antiarrhythmic Drugs to Purified Human Alpha-1-Acid Glycoprotein Source: Biochem. Pharm. 34 (1985) 4279-4282 Description: fit binding parameters
Authors: Grygiel, John J.; Balis, Frank M.; Collins, Jerry M.; Lester, Cynthia M.; Poplack, David G. Title: Pharmacokinetics of Tiazofurin in the Plasma and Cerebrospinal Fluid of Rhesus Monkeys Source: Canc. Res. 45 (1985) 2037-2039 Description: area under curve of plasma-conc.-time, trapezoidal rule, triexponential model
Authors: Gutierrez, P.L.; Cohen, B.E.; Sosnovsky, G.; Davis, T.A.; Egorin, M.J. Title: On the search for new anticancer drugs. 14: The plasma pharmacokinetics and tissue distribution of spin-labeled thio-TEPA (SL-O-TT) Source: Canc. Chemot. Pharm. 15 (1985) 185-191
Authors: Heller, Stephen R. Title: The Chemical Information System and Spectral Databases Source: J. Chem. Inf. Comput. Sci. 25 (1985) 224-231
Authors: Henner, W.D.; Furlong, E.A.; Kelley, S.L.; Rosowsky, A. Title: Assay for Mitolactol and Its Bifunctional Alkylating Metabolites in Plasma Source: J. Pharm. Sci. 74 (1985) 983-986 Description: concentration-time data fit to bi-exponential model
Authors: Hinesly, T.D.; Hansen, L.G.; Bray, D.J.; Redborg, K.E. Title: Transfer of Sludge-Borne Cadmium Through Plants to Chickens Source: J. Agric. Food Chem. 33 (1985) 173-180
Authors: Hobbs, Ann S.; Albers, R. Wayne; Froehlich, Jeffrey P.; Heller, Phillip F. Title: ADP Stimulates Hydrolysis of the "ADP-insensitive" Phospho-enzyme in Na+, K+-ATPase and Ca2+-ATPase Source: J. Biol. Chem. 260 (1985) 2035-2037 Description: biexponential fitting of dephosphorylation time course
Authors: Hoeg, J.M.; Demosky, S.J.; Edge, S.B.; Gregg, R.E.; Osborne, J.C.; Brewer, H.B. Title: Characterization of a human hepatic receptor for high density lipoproteins Source: Arterioscler. Thromb. Vasc. Biol. 5 (1985) 228-237
Authors: Honnor, R.C.; Dhillon, G.S.; Londos, C. Title: cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady state relationship with lipolytic and anti lipolytic modulators Source: J. Biol. Chem. 260 (1985) 15130-15138
Authors: Janzon, Bo; Torsten, Seeman Title: Muscle Devitalization in High-energy Missile Wounds, and its Dependence on Energy Transfer Source: J. Trauma 25 (1985) 138-144 Description: least squares regression analysis and plotting
Authors: Kimes, Alane S.; Sweeney, Daniel; Rapoport, Stanley I. Title: Brain Palmitate Incorporation in Awake and Anesthetized Rats Source: Brain Res. 341 (1985) 164-170 Description: plasma palmitate radioactivities at different times after iv injectionof [14-C] palmitate were fit to biexponential equation
Authors: Kinsella, J.L.; Freiberg, J.M.; Sacktor, B. Title: Glucocorticoid Activation of Na+/H+ Exchange in Renal Brush Border Vesicles: Kinetic Effects Source: Am. J. Physiol. 248 (1985) F233-F239 Description: fit rates of Na+ uptake to a Hill-type equation
Authors: Klecker, Raymond W., Jr.; Collins, Jerry M. Title: Quantification of Suramin by Reverse-Phase Ion-Pairing High-Performance Liquid Chromatography Source: J. Liq. Chrom. 8 (1985) 1685-1696 Description: Standard curve data fit to mx+b=y
Authors: Klecker, Raymond W.; Jenkins, Jean F.; Kinsella, Timothy J.; Fine, Robert L.; Strong, John M.; Collins, Jerry M. Title: Clinical Pharmacology of 5-Iodo-2'-Deoxyuridine and 5-Iodouracil and Endogenous Pyrimidine Modulation Source: Clin. Pharm. Ther. 38 (1985) 45-51 Description: fit Michaelis Menten parameters
Authors: Krumins, Solveig A.; Rodbard, David Title: Comparative Studies of the Binding of Dimeric and Monomeric Enkephalins to Neuroblastoma-Glioma NG108-15 Cells Source: J. Neurochem. 45 (1985) 101-107 Description: Maximum amount of a radioligand capable of binding was computed and fit to y(x) = (a-d)/(1+(x/c)^b)+d.
Authors: Lamore, P.J.J.; Verweij, C.; Brocaar, M.P. Title: Investigations of the Residual Hearing Capacity of Severely Hearing-Impaired and Profoundly Deaf Subjects Source: Audiology 24 (1985) 343-361 Description: curve fit hearing loss to A-B*exp(-(x-1)/c), x is frequency.
Authors: Laskey, John W.; Eders, Frank W. Title: Hatch Weight Selection: Effect on Post-Hatch Growth in the Japanese Quail (Coturnix Coturnix Japonica) Source: Comp. Biochem. Physiol. 82A (1985) 101-104 Description: fit data to Gompertz growth equation--Wt = W0*exp((A0/a)*(1-exp(-a*t))).
Authors: Lauterberg, B.H.; Smith, C.V.; Todd, E.L.; Mitchell, J.R. Title: Oxidation of hydrazine metabolites formed from isoniazid Source: Clin. Pharm. Ther. 38 (1985) 566-571
Authors: Lee, K.N.; Fesus, L.; Yancey, S.T.; Girard, J.E.; Chung, S.I. Title: Development of Selective Inhibitors of Transglutaminase Source: J. Biol. Chem. 260 (1985) 14689-14694 Description: Michaelis Menten equation.
Authors: Liang, B.T.; Frame, L.H.; Molinoff, P.B. Title: Beta 2-adrenergic receptors contribute to catacholamine- stimulated shortening of action potential duration in dog atrial muscle Source: PNAS 82 (1985) 4521-4525 Description: nonlinear regression
Authors: Liberman, Ellen; Reddy, Prasad; Gazdar, Celia; Peterkofsky, Alan Title: The Escherichia coli Adenylate Cyclase Complex Source: J. Biol. Chem. 260 (1985) 4075-4081 Description: for studies involving the effect of varying ATP conc. on adenylated cyclase activity, data were fit to Hill equation.
Authors: Litterst, Charles L.; Roth, Jeri S.; Kelly, James A. Title: Distribution, Elimination, Metabolism, and Bioavailability of Hexamethylenebisacetamide in Rats Source: Inv. New Drugs 3 (1985) 263-272 Description: plasma conc. HMBA in time fit to 2-compartment model
Authors: Lucignani, G.; Nehlig, A.; Blasberg, R.; Patlak, C.S.; Anderson, L.; Fieschi, C.; Fazio, F.; Sokoloff, L. Title: Metabolic and Kinetic Considerations in the Use of [125-I] HIPDM for Quantitative Measurement of Regional Cerebral Blood Flow Source: J. Cereb. Bl. Fl. 5 (1985) 86-96 Description: fit rate constants for [125-I] HIPDM
Authors: Luthin, G.R.; Wolfe, B.B. Title: Characterization of [3H] pirenzepine binding to muscarinic cholinergic receptors solubilized from rat brain Source: J. Pharm. Exp. 234 (1985) 37-44
Authors: Lynch, Christopher J.; Blackmore, Peter F.; Charest, Robert; Exton, John H. Title: The Relationships Between Receptor Binding Capacity for Norepinephrine, Angiotensin II, and Vasopressin and Release of Inositol Triphosphate, Ca2+ Mobilization, and Phosphorylase Activation in Rat Liver Source: Mol. Pharm. 28 (1985) 93-99 Description: all data from concentration-response and binding experiments were calculated, curve-fitted, and plotted with MLAB
Authors: Lynch, Christopher J.; Charest, Robert; Blackmore, Peter F.; Exton, John H. Title: Studies on the Hepatic Alpha-1-Adrenergic Receptor Source: J. Biol. Chem. 260 (1985) 1593-1600 Description: Scatchard plots of conc. dependence of [3-H] prazosin binding were analyzed with MLAB.
Authors: Lynch, Christopher J.; Charest, Robert; Bocckino, Stephen B.; Exton, John H.; Blackmore, Peter F. Title: Inhibition of Hepatic Alpha-1-Adrenergic Effects and Binding by Phorbol Myristate Acetate Source: J. Biol. Chem. 260 (1985) 2844-2851 Description: Binding parameters were determined using nonlinear curve fitting.
Authors: Macalady, Donald L.; Wolfe, N. Lee Title: Effect of Sediment Sorption and Abiotic Hydrolyses. 1. Organophosphorothioate Esters Source: J. Agric. Food Chem. 33 (1985) 167-173 Description: values for neutral hydrolysis rate constants of chlorpyrifos were determined based on 4 lnear coupled differential rate equations.
Authors: Marini, M.A.; Evans, W.J.; Berger, R.L. Title: Use of the Twin-Cell Differential Titration Calorimeter for Binding Studies. I. EDTA and its Calcium Complex Source: J. Biochem. Biophys. Meth. 10 (1985) 273-285 Description: both potentiometric and thermal curves have pK' as common parameter; fit simultaneously
Authors: Marini, Mario A.; Evans, William J.; Morris, Nancy M. Title: Calorimetric and Potentiometric Studies on the Binding of Calcium by Phytic Acid Source: J. Appl. Biochem. 7 (1985) 180-191 Description: potentiometric and calorimetric titrations were analyzed.
Authors: Mattera, Fafael; Pitts, Barry J.R.; Entman, Mark L.; Birnbaumer, Lutz Title: Guanine Nucleotide Regulation of a Mammalian Myocardial Muscarinic Receptor System Source: J. Biol. Chem. 260 (1985) 7410-7421 Description: Scatchard plots, Hill coefficients, Adair-Pauling approach
Authors: McCarthy, J.F.; Jimenez, B.D. Title: Reduction in Bioavailability to Bluegills of Polycyclic Aromatic Hydrocarbons Bound to Dissolved Humic Material Source: Env. Tox. Chem. 4 (1985) 511-521 Description: two compartment model for fish and water, bound and free PAHs
Authors: McCarthy, J.F.; Jimenez, B.D.; Barbee, T. Title: Effect of Dissolved Humic Material on Accumulation of Polycyclic Aromatic Hydrocarbons: Structure-Activity Relationships Source: Aquat. Tox. 7 (1985) 15-24 Description: bioaccumulation, Michaelis-Menten kinetics.
Authors: Monks, Anne; Marquez, Victor E.; Mao, David T.; Cysyk, Richard L. Title: Uptake of 2-Beta-D-Ribofuranosylthiazole-4-Carboxamide (Tiazofurin) and Analogues by the Facilitated Transport Mechanism of Erythrocytes Source: Cancer Lett. 28 (1985) 1-8 Description: Kinetic parameters for transport and inhibition of transport were calculated from least squares fit of data to modified Michaelis Menten equation.
Authors: Morris, Stephen J.; Bradley, Diane; Blumenthal, Robert Title: The Use of Cobalt Ions as a Collisional Quencher to Probe Surface Charge Stability of Fluorescently Labeled Bilayer Vesicles Source: Biochim. Biophys. Acta 818 (1985) 365-372 Description: fluorescence quenching data, change in fluorescence fit to functions with exponential factors
Authors: Morris, S.J.; Gibson, C.C.; Smith, P.D.; Greif, P.G.; Stirk, C.W.; Bradley, D.; Haynes, D.H.; Blumenthal, R. Title: Rapid kinetics of Ca2+ induced fusion of phosphatidylserine/ phosphatidylethanolamine visicles. The effect of bilayer curvature on leakage Source: J. Biol. Chem. 260 (1985) 4122-4127
Authors: Morrissey, Philip J.; Sharrow, Susan O.; Kohno, Yoichi; Berzofsky, Jay A.; Singer, Alfred Title: Correlation of Intrathymic Tolerance with Intrathymic Chimerism in Neonatally Tolerized Mice Source: Transplantation 40 (1985) 68-72 Description: Computer enhanced resolution and curve-smoothing of immunofluorescence profiles.
Authors: Moyer, James D.; Karle, Jean M.; Malinowsky, Nancy; Marquez, Victor E.; Salom, Mohammed A.; Malspeis, Louis; Cysyk, Richard L. Title: Inhibition of Uridine Kinase and the Salvage of Uridine by Modified Pyrimidine Nucleosides Source: Mol. Pharm. 28 (1985) 454-460 Description: Michaelis Menten equation for competitive inhibition
Authors: Nashed, Nashaat T.; Michaud, Dennis P.; Levin, Wayne; Jerina, Donald M. Title: Properties of Liver Microsomal Cholesterol 5,6-Oxide Hydrolase Source: Arch. Biochem. Biophys. 241 (1985) 149-162 Description: fit parameters in Michaelis Menten equation
Authors: Ohata, Masahiro, Fredericks, Wendy R.; Neuwelt, Edward A.; Sundaram, Uma; Rapoport, Stanley I. Title: [3-H] Methotrexate Loss from the Rat Brain Following Enhanced Uptake by Osmotic Opening of the Blood-Brain Barrier Source: Canc. Res. 45 (1985) 1092-1096 Description: least squares fit of exponential model to brain concentration in time to get half-life
Authors: Ohnhaus, E.E.; McManus, M.E.; Scharz, D.M.; Thorgeirsson, S.S. Title: Kinetics of Sparteine Metabolism in Rat and Rabbit Liver Microsomes Source: Biochem. Pharm. 34 (1985) 439-440 Description: Michaelis Menten kinetics
Authors: Osborne, J.C.; Bengtsson-Olivecrona, G.; Lee, N.S.; Olivecrona, T. Title: Studies on Inactivation of Lipoprotein Lipase: Role of the Dimer to Monomer Dissociation Source: Biochem. 24 (1985) 5606-5611
Authors: Osborne, J.S.; Stanley, S.J.; Moss, J. Title: Kinetic Mechanisms of two NAD: arginine ADP-ribosyltransferases: the Soluble, Salt-stimulated Transferase from Turkey Erythrocytes and Choleragen, a Toxin from Vibro cholerae Source: Biochem. 24 (1985) 5235-5240
Authors: Pang, K. Sandy; Kong, Philomena; Terrell, Julia A.; Billings, Ruth E. Title: Metabolism of Acetaminophen and Phenacetin by Isolated Rat Hepatocytes Source: Drug Metab. 13 (1985) 42-50 Description: The kinetic differences in the extents of sulfation of acetominophen as a generated and preformed metabolite may be explained. predictive time course.
Authors: Penniman, C.A.; Mathieson, A.C. Title: Photosynthesis of Gracilaria tikuahiae McLachlan (Gigartinales, Rhodophyta) from the Great Bay Estuary, New Hampshire Source: Botanica Marina 28 (1985) 427-435. Description: fit of exponential model of photosynthesis efficiency to laboratory measurements.
Authors: Perez, Pilar; Bluestone, Jeffrey A.; Stephany, David A.; Segal, David M. Title: Quantitative Measurements of the Specificity and Kinetics of Conjugate Formation Between Cloned Cytotoxic T Lymphocytes and Splenic Target Cells by Dual Parameter Flow Cytometry Source: J. Immunol. 134 (1985) 478-485 Description: computations and data fitting performed with MLAB
Authors: Phillips, Robert S.; Miles, Edith Wilson; Cohen, Louis A. Title: Differential Inhibition of Tryptophan Synthase and of Tryptophanase by the Two Diastereomers of 2,3-Dihydro-L-Tryptophan Source: J. Biol. Chem. 260 (1985) 14665-14670 Description: MLAB, 340nm absorbance vs time at 40 second intervals for pre-steady state data analyzed with MLAB.
Authors: Piantadosi, Steven Title: A Model of Growth with First-Order Birth and Death Rates Source: Comp. Biomed. Res. 18 (1985) 220-232 Description: population dynamics modeled with odes
Authors: Pikal, M.J. Title: Use of laboratory data in freeze drying process design: heat and mass transfer coefficients and the computer simulation of freeze drying Source: PDA J. Pharm. Sci. Tech. 39 (1985) 115-139
Authors: Pocchiari, M.; Munson, P.J.; Costa, T.; Gajdusek, D.C.; Gibbs, C.J., Jr. Title: Serotoninergic System in Scrapie-Infected Hamsters Source: J. Neurochem. 44 (1985) 862-868 Description: Michaelis Menten parameters fit with MLAB and LIGAND
Authors: Poretsky, L.; Grigorescu, F.; Seibel, M.; Moses, A.C.; Flier, J.S. Title: Distribution and Characterization of Insulin and Insulin-Like Growth Factor I Receptors in Normal Human Ovary Source: J. Clin. Endo. Metab. 61 (1985) 728-734 Description: Insulin binding data analyzed with MLAB.
Authors: Rahman, Aquilur; Smith, Frederick P.; Luc, Phuong-Van T.; Woolley, Paul V. Title: Phase I Study and Clinical Pharmacology of 6-Diazo-5-Oxo-L-Norleucine (DON) Source: Inv. New Drugs 3 (1985) 369-374 Description: Prophet drug modeling integrated with MLAB was used to fit plasma disappearance data for both intact drug and total radioactivity
Authors: Rechthand, E.; Smith, Q.R.; Rapoport, S.I. Title: Facilitated Transport of Glucose from Blood into Peripheral Nerve Source: J. Neurochem. 45 (1985) 957-964
Authors: Redmond, T.M.; Wiggert, B.; Robey, F.A.; Yen, N.N.; Lewis, M.S.; Lee, L.; Chader, G.J. Title: Isolation and Characterization of Monkey Interphotoreceptor Retinoid-Binding Protein, a Unique Extracellular Matrix Component of the Retina Source: Biochem. 24 (1985) 787-793
Authors: Robinson-White, Audrey; Baylin, Stephen B.; Olivecrona, Thomas; Beaven, Michael A. Title: Binding of Diamine Oxidase Activity to Rat and Guinea Pig Microvascular Endothelial Cells Source: J. Clin. Inv. 76 (1985) 93-100 Description: curve-fitting 2 or 3 Michaelis Menten components
Authors: Rothman, Richard B.; Bowen, Wayne D.; Herkenham, Miles; Jacobson, Arthur E.; Rice, Kenner C.; Pert, Candace B. Title: A Quantitative Study of [3-H] D-Ala2-D-Leu5-Enkephalin Binding to Rat Brain Membranes Source: Mol. Pharm. 27 (1985) 399-408 Description: fit data to 2 site competitive binding model, F-test
Authors: Rothman, R.B.; Danks, J.A.; Jacobson, A.E.; Burke, T.R.; Rice, K.C. Title: Leucine enkephalin noncompetitively inhibits the binding of [3 H]naloxone to the opiate mu-recognition site: Evidence for delta-mu binding-site interactions in vivo Source: Neuropeptides 6 (1985) 351-363
Authors: Sabljic, Aleksandar Title: Calculation of Retention Indices by Molecular Topology Chlorinated Benzenes Source: J. Chrom. A 319 (1985) 1-8
Authors: Sayer, Jane M.; Yagi, Haruhiko; van Bladeren, Peter J.; Levin, Wayne; Jerina, Donald M. Title: Stereoselectivity of Microsomal Epoxide Hydrolase toward Diol Epoxides and Tetrahydroepoxides Derived from Benz-[alpha]-anthracene Source: J. Biol. Chem. 260 (1985) 1630-1640 Description: Michaelis Menten equation
Authors: Schloss, John V.; Van Dyk, Drew E.; Vasta, Julia F.; Kutny, Rusty M. Title: Purification and Properties of Salmonella typhimurium Acetolactate Synthase Isozyme II from Escherichia coli HB101/pDU9 Source: Biochem. 24 (1985) 4952-4959 Description: kinetic data were fit to Michaelis Menten equations
Authors: Schwartz, Rochelle D.; Jackson, Jane A.; Weigert, David; Skolnick, Phil; Paul, Steven M. Title: Characterization of Barbituate-stimulated Chloride Efflux from Rat Brain Synaptoneurosomes Source: J. Neurosci. 5 (1985) 2963-2970 Description: the efflux of 36-Cl- measured between 5 and 300 sc can best be fit to a single exponential decay curve
Authors: Segev, I.; Fleshman, J.W.; Miller, J.P.; Bunow, B. Title: Modeling the Electrical Behavior of Anatomically Complex Neurons Using a Network Analysis Program: Passive Membrane Source: Biol. Cybern. 53 (1985) 27-40 Description: used SPICE from EE and CS departments at Berkeley
Authors: Sellers, J.R. Title: Mechanism of the phosphorylation-dependent regulation of smooth muscle heavy meromyosin Source: J. Biol. Chem. 260 (1985) 15815-15819
Authors: Senear, Donald F.; Betts, Graham; Bernhard, Sidney A. Title: Multiple Ion-Dependent and Substrate-Dependent Na+/K+-ATPase Conformational States. Transient and Steady-State Kinetic Studies Source: Biochem. 24 (1985) 6789-6798 Description: curve-fitting with MLAB
Authors: Siebens, Arthur W.; Kregenow, Floyd M. Title: Volume-Regulatory Responses of Amphiuma Red Cells in Anisotonic Media: The Effect of Amiloride Source: J. Gen. Physiol. 86 (1985) 527-564 Description: Kinetic analysis of Na uptake as a function extracellular Na was performed by using the method of least squares fit of data to linear transfer of Michaelis Menten equation assuming rapid equilibrium.
Authors: Smal, Jean; Closset, Jean; Hennen, Georges; de Meyts, Pierre Title: Receptor-Binding and Down-Regulatory Properties of 22000-Mr Human Growth Hormone and Its Natural 20000-Mr Variant on Im-9 Human Lymphocytes Source: Biochem. J. 225 (1985) 283-289 Description: Analysis of binding data performed using MLAB
Authors: Smith, Q.R.; Takasato, Y.; Sweeney, D.J.; Rapoport, S.I. Title: Regional Cerebrovascular Transport of Leucine as Measured by the In Situ Brain Perfusion Technique Source: J. Cereb. Bl. Fl. 5 (1985) 300-311
Authors: Stone, Audrey Larack; Park, Juliana Y.; Martenson, Russell E. Title: Low-Ultraviolet Circular Dichroism Spectroscopy of Oligopeptides 1-95 and 96-168 Derived from Myelin Base Protein of Rabbit Source: Biochem. 24 (1985) 6666-6673 Description: To determine the conformation of the oligo peptides the best fits of various matrices (each composed of 4 model CD spectra) to the experimental CD curve.
Authors: Summers, Michael F.; Byrd, R. Andrew; Gallo, Kathleen A.; Samson, Carie J.; Zon, Gerald; Egan, William Title: Nuclear Magnetic Resonance and Circular Dichroism Studies of a Duplex-Single Stranded Hairpin Loop Equilibrium for the Oligodeoxyribonucleotide Sequence d(CGCGATTCGCG) Source: Nucleic Acids Res. 13 (1985) 6375-6386 Description: pre-exchange lifetime was gotten from least squares fit to exponential or linear function.
Authors: Thomson, A.E.R.; Vaughan-Smith, S.; Peel, W.E.; Wetherley-Mein, G. Title: The Intrinsic Radiosensitivity of Lymphocytes in Chronic Lymphocytic Leukaemia, Quantitatively Determined Independently of Cell Death Rate Factors Source: Int. J. Radiat. Biol. 48 (1985) 943-961
Authors: Takasato, Yoshio; Momma, Serji; Smith, Quentin R. Title: Kinetic Analysis of Cerebrovascular Isoleucine Transport from Saline and Plasma Source: J. Neurochem. 45 (1985) 1013-1020 Description: best fit values for Vmax, Km, and Kd were obtained fro isoleucine by fitting PA - Vmax/(Km+Cpf)+Kd to the saline perfusion data with weighted nonlinear least squares.
Authors: Thraves, Peter; Mossman, Kenneth L.; Brennan, Terrance; Dritschilo, Anatoly Title: Radiosensitization of Human Fibroblasts by 3-Aminobenzamide: An Inhibitor of Poly(ADP-Ribosylation) Source: Radiation Res. 104 (1985) 119-127 Description: fit survival curves S = (1-(1-exp(-D/D0))^n), Student's t
Authors: van Bladeren, Peter J.; Sayer, Jane M.; Ryan, Dene E.; Thomas, Paul E.; Levin, Wayne; Jerina, Donald M. Title: Differential Stereoselectivity of Cytochromes P-450b and P-450c in the Formation of Naphthalene and Anthracene 1,2-Oxides Source: J. Biol. Chem. 260 (1985) 10226-10235 Description: enzyme reaction kinetics, fit ordinary differential equations.
Authors: Van Lier, R.B.L. Title: The Use of Monkey Percutaneous Absorption Studies Source: Dermal Exposure Related to Pesticide Use, Chapter 6 (1985) pages 81-91, ACS Symposium Series
Authors: Verschuure, J.; Wijngaart, W.S.I.M.; Brocaar, M.P.; Nagels, M.M. Title: Methods of Analysis of Large Numbers of Audiograms Source: Audiology 24 (1985) 2-14 Description: curve fitting andiograms as hyperbolic tangent functions
Authors: Waldenlind, E.; Ross, S.B.; Saaf, J.; Ekbom, K.; Wetterberg, L. Title: Concentration and uptake of 5-hydroxytryptamine in platelets from cluster headache and migraine patients Source: Cephalalgia 5 (1985) 45-54
Authors: Wallace, S.M.; Chan, L.Y. Title: In vitro interaction of aminoglycosides with beta-lactam penicillins Source: Antimicrob. Ag. and Chem. 28 (1985) 274-281
Authors: Yu, L.C.; Steven, A.C.; Naylor, G.R.S.; Gamble, R.C.; Podolsky, R.J. Title: Distribution of Mass in Relaxed Frog Skeletal Muscle and its Redistribution Upon Activation Source: Biophys. J. 47 (1985) 311-321 Description: intensities of reflection peaks found using MLAB.
Authors: Almeida, O.F.; Lincoln, G.A. Title: Reproductive photorefractoriness in rams and accompanying changes in the patterns of melatonin and prolactin secretion Source: Biol. Reprod. 30 (1984) 143-158
Authors: Arnold, Susan T.; Jayaram, Hiremagalur N.; Harper, Gregory R.; Litterst, Charles L.; Malspeis, Louis; Desouza, John J.V.; Stoubus, Alfred E.; Ahluwalia, Gupreet S.; Wilson, Yvonne A.; Cooney, David A.; Johns, David G. Title: The Disposition and Metabolism of Tiazofurin in Rodents, Rabbits, and Dogs Source: Drug Metab. 12 (1984) 165-173 Description: 3 compartment model
Authors: Bai, Stephen A.; Abramson, Fred P. Title: Effects of Chlorpromazine on the Disposition and Beta-Andrenergic Blocking Activity of Propranolol in the Dog Source: J. Pharm. Biopharm. 12 (1984) 333-349 Description: kinetic analysis of DR-1 vs time date, statistics
Authors: Bissonnette, B.M.; Collen, M.J.; Adachi, H.; Jensen, R.T.; Gardner, J.D. Title: Receptors for Vasoactive Intestinal Peptide and Secretin on Rat Pancreatic Acini Source: Am. J. Physiol. 246 (1984) G710-G717 Description: data in figure 3 were fit to a model having 4 classes of binding sites using MLAB
Authors: Braatz, J.A.; Hua, D.T.; Princier, G.L. Title: A Solid-Phase, Enzyme-Linked Immunosorbent Assay for a Human Lung Tumor-Associated Antigen Source: JNCI 72 (1984) 841-846
Authors: Bristow, Michael R.; Ginsburg, Robert; Laser, Jeffrey A.; McAuley, Bruce J.; Minobe, Wayne Title: Tissue Response Selectivity of Calcium Antagonists is not Due to Heterogeneity of [3-H]-nitrendipine Binding Sites Source: Br. J. Pharm. 82 (1984) 309-320 Description: calculated dissociation constant and maximum binding constant using MLAB
Authors: Chen, Chu; Applegate, Kenneth; King, Weiling C.; Glomset, John A.; Norum, Kaare R.; Gjone, Egil Title: A Study of the Small Spherical High Density Lipoproteins of Patients Afflicted with Familial Lecithin: Cholesterol Acyltransferase Deficiency Source: J. Lipid Res. 25 (1984) 269-282 Description: gel scans in optical density vs. diameter, fit to sum of Gaussians
Authors: Connolly, Stuart; Lebsack, Cynthia; Winkle, Roger A.; Harrison, Donald C.; Kates, Robert E. Title: Propafenore Disposition Kinetics in Cardiac Arrhythmia Source: Clin. Pharm. Ther. 36 (1984) 163-168 Description: 2 and 3 compartment model of plasma concentration
Authors: Crettaz, Marco; Kahn, C. Ronald Title: Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells Source: Diabetes 33 (1984) 477-485 Description: Scatchard analysis
Authors: Dow, D.D.; Gill, B.J. Title: Environmental vs Social Factors as determinants of growth in nestlings of a communally breeding bird Source: Oecologia 63 (1984) 370-375 Description: fit of growth of wing, bill, torso, and weight measurements to 3-parameter logistic and asymptotic regression
Authors: Dower, Steven K.; Ozato, Keiko; Segal, David M. Title: The Interaction of Monoclonal Antibodies with MHC Class I Antigens on Mouse Spleen Cells Source: J. Immunol. 132 (1984) 751-758 Description: two-site binding model
Authors: Dritschilo, A.; Brennan, T.; Weichselbaum, R.R.; Mossman, K.L. Title: Response of Human Fibroblasts to Low Dose Rate Gamma Irradiation Source: Radiation Res. 100 (1984) 387-395 Description: survival curves
Authors: Egorin, Merrill J.; Van Echo, David A.; Tipping, Stuart J.; Olman, Eve A.; Whitacre, Margaret Y.; Thompson, Bruce W.; Aisner, Joseph Title: Pharmacokinetics and Dosage Reduction of cis-Diammine (1,1-cyclobutanedicarboxylato) Platinum in Patients with Impaired Renal Function Source: Canc. Res. 44 (1984) 5432-5438 Description: fit sum of 2 exponentials
Authors: Eliard, Pierre H.; Rousseau, Guy G. Title: Thermodynamics of Steroid Binding to the Human Glucocorticoid Receptor Source: Biochem. J. 218 (1984) 395-404 Description: 2nd order kinetics, ode rate equations
Authors: Ermentrout, G. Bard Title: Period Doublings and Possible Chaos in Neural Models Source: SIAM J. Appl. Math. 44 (1984) 80-95 Description: Gear-Adams solver in MLAB
Authors: Eun, H.M.; Miles, E.W. Title: Reaction of Phenylglyoxal and {p-hydroxyphenyl} glyoxal with Arginines and Cysteines in the alpha-Subunit of Tryptophan Synthase Source: Biochem. 23 (1984) 6484-6491
Authors: Fellini, S.A.; Hascall, V.C.; Kimura, J.H. Title: Localization of proteoglycan core protein in subcellular fractions isolated from rat chondrosarcoma chondrocytes Source: J. Biol. Chem. 259 (1984) 4634-4641
Authors: Franklin, P.H.; Hoss, W. Title: Opiates Stimulate Low Km GTPase in Brain Source: J. Neurochem. 43 (1984) 1132-1135
Authors: Garner, M.H.; Garner, W.H.; Spector, A. Title: Kinetic cooperativity change after H2O2 modification of (Na,K)-ATPase Source: J. Biol. Chem. 259 (1984) 7712-7718
Authors: Graves, P.M.; Carter, R.; Keystone, J.S.; Seeley, D.C., Jr. Title: Drug Sensitivity and Isoenzyme Type in Cloned Lines of Plasmodium falciparum Source: Am. J. Trop. Med. Hyg. 33 (1984) 212-219 Description: fit log-logistic distribution to effect of drug
Authors: Grigorescu, Florin; Flier, Jeffrey S.; Kahn, C. Ronald Title: Defect in Insulin Receptor Phosphorylation in Erythrocytes and Fibroblasts Associated with Severe Insulin Resistance Source: J. Biol. Chem. 259 (1984) 15003-15006 Description: fit logistic equation to competition-inhibition curves.
Authors: Horwitz, Barry; Duara, Ranjan; Rapoport, Stanley I. Title: Intercorrelations of Glucose Metabolic Rates Between Brain Regions: Application to Healthy Males in a State of Reduced Sensory Input Source: J. Cereb. Bl. Fl. 4 (1984) 484-499 Description: figure 3 is a matrix of statistically significant partial correlation coefficients made with MLAB
Authors: Hughes, L.T.; Cohen, J.S.; Szabo, A.; Niu, C.H.; Matsuura, S. Title: Carbon-13 NMR Studies of the Molecular Dynamics of Selectively Carbon-13 Enriched Ribonuclease Complexes Source: Biochem. 23 (1984) 4390-4394
Authors: Huguenin, Philipp N.; Jayaram, Hiremagalur N.; Kelley, James A. Title: Reverse Phase HPLC Determination of 5,6 Dihydro-5-Azacytidine in Biological Fluids Source: J. Liq. Chrom. 7 (1984) 1433-1453 Description: initial pharmacokinetic parameters of DHAC were calculated from rat plasma concentration. 2 compartment open model, biexponential model
Authors: Kessler, R.M.; Goble, J.C.; Bird, J.H.; Girton, M.E.; Doppman, J.L.; Rapoport, S.I.; Baranger, J.A. Title: Measurement of Blood-Brain Barrier Permeability with Positron Emission Tomography and [68-Ga] EDTA Source: J. Cereb. Bl. Fl. 4 (1984) 323-328 Description: brain concentration as linear combination of (1-exp(-ai*t))
Authors: Ketelslegers, Jean-Marie; Pirens, Guy; Maghuin-Rogister, Guy; Hennen, Georges; Frere, Jean-Marie Title: The Choice of Erroneous Models of Hormone-Receptor Interactions: A Consequence of Illegitimate Utilization of Scatchard Graphs Source: Biochem. Pharm. 33 (1984) 707-710 Description: Scatchard plots, hormone receptor models, differential equation models
Authors: Kettner, C.A.; Shenvi, A.B. Title: Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G., and chymotrypsin by peptide boronic acids Source: J. Biol. Chem. 259 (1984) 15106-15114
Authors: Kinsella, James; Cujdik, Timothy; Sacktor, Bertram Title: Na+ H+ Exchange in Isolated Renal Brush-Border Membrane Vesicles in Response to Metabolic Acidosis Source: J. Biol. Chem. 259 (1984) 13224-13227 Description: Eadie-Scatchard plot data fit to Hill equation.
Authors: Klecker, Raymond W., Jr.; Collins, Jerry M. Title: Quantification of Tiazofurin in Plasma by High Performance Liquid Chromotography Source: J. Chrom. B 307 (1984) 361-369 Description: bi- and tri-exponential equations for concentration-time data
Authors: Lagakos, S.W.; Schoenfeld, D.A. Title: Properties of Proportional-Hazards Score Tests Under Misspecified Regression Models Source: Biometrics 40 (1984) 1037-1048
Authors: LaRossa, Robert A.; Schloss, John V. Title: The Sulfonylurea Herbicide Sulfonaturon Methyl Is an Extremely Potent and Selective Inhibitor of Acetolactate Synthase in Salmonella typhimurium Source: J. Biol. Chem. 259 (1984) 8753-8757 Description: fit Michaelis Menten parameters
Authors: Lewis, Marc S.; Carmassi, Franco; Chung, Soo Il Title: Cooperative Association of Plasminogen with Fibrinogen Source: Biochem. 23 (1984) 3874-3879 Description: ultracentrifuge scans digitized and analyzed with MLAB
Authors: Macalady, D.L.; Wolfe, N.L. Title: Abiotic Hydrolysis of Sorbed Pesticides Source: Treatment and Disposal of Pesticide Wastes, Chapter 14 (1984) pages 221-244, Volume 259, ACS Symposium Series
Authors: Maes, M.; Underwood, L.E.; Gerard, G.; Ketelslegers, J.M. Title: Relationship Between Plasma Sonetomedin-C and Liver Somatogenic Binding Sites in Neonatal Rats During Malnutrition and After Short and Long Term Refeeding Source: Endocrin. 115 (1984) 786-792 Description: specific binding data analyzed with MLAB
Authors: Marti, G.E.; Marini, M.A.; Sreenathan, B.R. Title: Characterization of Phenolic Ionizations in Horse Heart Cytochrome c Source: Biochem. 23 (1984) 6649-6654 Description: Experimental tyrosyl ionization curves, titration curves fit
Authors: McManus, M.E.; Minchin, R.F.; Sanderson, N.; Schwartz, D.; Johnson, E.F.; Thorgeirsson, S.S. Title: Metabolic processing of 2-acetylaminofluorene by microsomes and six highly purified cytochrome P-450 forms from rabbit liver Source: Carcinogenesis 5 (1984) 1717-1723
Authors: Newton, Dianne L.; Oldewurtel, Mary D.; Krinks, Marie H.; Shiloach, Joseph; Klee, C.B. Title: Agonist and Antagonist Properties of Calmodulin Fragments Source: J. Biol. Chem. 259 (1984) 4419-4426 Description: Michaelis Menten parameters
Authors: Noel, F.; Godfraind, T. Title: Heterogeneity of Ouabain Specific Binding Sites and (Na+ and K+)-ATPase Inhibition in Microsomes from Rat Heart Source: Biochem. Pharm. 33 (1984) 47-53 Description: Scatchard and log concentration-effect plots, Hill equation
Authors: Osborne, J.C.; Schaefer, E.J.; Powell, G.M.; Lee, N.S.; Zech, L.A. Title: Molecular properties of radioiodinated apolipoprotein A-I Source: J. Biol. Chem. 259 (1984) 347-353
Authors: Phelan, Michael; Gray, Irving Title: Modification of Glyceraldehyde-3-Phosphate Dehydrogenase, EC 1.2.1.12, Isolated from Rainbow Trout During Acclimation at 5 or 15 degrees C--I. Changes in the activity of individual muscle isolates as evidence for variable adaptive responses Source: Comp. Biochem. Physiol. B Comp. Biochem. 79 (1984) 135-138 Description: nonlinear regression analysis of data points generated by enzyme activity assays, Michaelis Menten
Authors: Phelan, Michael; Boykins, R.; Gray, Irving Title: Modification of Glyceraldehyde-3-Phosphate Dehydrogenase, EC 1.2.1.12, Isolated from Rainbow Trout During Acclimation at 5 or 15 degrees C--II. Biochemical characterization of G3PDH muscle isolates Source: Comp. Biochem. Physiol. B Comp. Biochem. 79 (1984) 139-146 Description: nonlinear regression analysis of data points generated by enzyme activity assays, Michaelis Menten
Authors: Phillips, Robert S.; Parniak, Michael A.; Kaufman, Seymour Title: The Interaction of Aromatic Amino Acids with Rat Liver Phenylalanine Hydroxylase Source: J. Biol. Chem. 259 (1984) 271-277 Description: direct fit of Michaelis Menten equation
Authors: Phillips, R.S.; Parniak, M.A.; Kaufman, S. Title: Spectroscopic Investigation of Ligand Interaction with Hepatic Phenylalanine Hydroxylase: Evidence for a Conformational Change Associated with Activation Source: Biochem. 23 (1984) 3836-3842
Authors: Pikal, M.J.; Roy, M.L.; Shah, S. Title: Mass and heat transfer in vial freeze-drying of pharmaceuticals: Role of the vial Source: J. Pharm. Sci. 73 (1984) 1224-1237
Authors: Rahman, Aquilur; Goodman, Anita; Foo, Wayne; Harvey, Jimmie; Smith, Frederick P.; Schein, Philip S. Title: Clinical Pharmacology of Daunorubicin in Phase I Patients with Solid Tumors: Development of an Analytical Methodology for Daunorubicin and Its Metabolites Source: Semin. Oncol. 11 (1984) 36-44 Description: fit plasma concentration-time data to triexponential function.
Authors: Rothman, Richard B.; Bowen, Wayne D.; Bykov, Victor; Schumacher, Uwe K.; Pert, Candace B.; Jacobson, Arthur E.; Burke, Terrence R., Jr.; Rice, Kenner C. Title: Preparation of Rat Brain Membranes Greatly Enriched with Either Type I Delta or Type II Delta Opiate Binding Sites Using Site Directed Alkylating Agents: Evidence for a Two-Site Allosteric Model Source: Neuropeptides 4 (1984) 201-215 Description: saturation binding
Authors: Rothman, Richard B.; Shumacher, Uwe K.; Pert, Candace B. Title: Effect of Beta-FNA on Opiate Delta Receptor Binding Source: J. Neurochem. 43 (1984) 1197-1200 Description: Scatchard plots, saturation studies
Authors: Sabljic, Aleksandar Title: Calculation of Retention Indices by Molecular Topology: Chlorinated Alkanes Source: J. Chrom. A 314 (1984) 1-12 Description: Single and multiple linear regression analysis
Authors: Sabljic, A. Title: Predictions of the Nature and Strength of Soil Sorption of Organic Pollutants by Molecular Topology Source: J. Agric. Food Chem. 32 (1984) 243-246
Authors: Schloss, John V.; Emptage, Mark H.; Cleland, W.W. Title: pH Profiles and Isotope Effects for Aconitases from Saccharomycopsis lipolytica, Beef Heart, and Beef Liver. alpha-Methyl-cis-aconitate and threo-DS-alpha-Methylisocitrate as Substrates Source: Biochem. 23 (1984) 4572-4580 Description: Michaelis Menten parameters
Authors: Schurmeyer, T.H.; Avgerinos, P.C.; Gold, P.W.; Gallucci, W.T.; Tomai, T.P.; Cutler, G.B., Jr.; Loriaux, D.L.; Chrousos, G.P. Title: Human Corticotropin-Releasing Factor in Man: Pharmacokinetic Properties and Dose-Response of Plasma Adrenocorticotropin and Cortisol Secretion Source: J. Clin. Endo. Metab. 59 (1984) 1103-1108 Description: mono- and bi-exponential fits of CRF plasma concentration
Authors: Scott, T.L.; Shamoo, A.E. Title: Distinction of the roles of the two high-affinity calcium sites in the functional activities of the Ca 2+ ATPase of sarcoplasmic reticulum Source: Eur. J. Biochem. 143 (1984) 427-436
Authors: Segal, David M.; Stephany, David A. Title: The Mechanism of Intercellular Aggregation: I. The Kinetics of the Fe Gamma Receptor-Mediated Aggregation of P388D1 Cells with Antibody-Coated Lymphocytes at 4 Degrees C Source: J. Immunol. 132 (1984) 1924-1930 Description: contour graphs, fit exponential model
Authors: Sills, M.A.; Wolfe, B.B.; Frazer, A. Title: Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex Source: J. Pharm. Exp. 231 (1984) 480-487
Authors: Smith, Quentin R.; Rapoport, Stanley I. Title: Carrier-Mediated Transport of Chloride Across the Blood-Brain Barrier Source: J. Neurochem. 42 (1984) 754-763 Description: fit plasma concentration of tracer at different time after injection to linear combination of exponentials
Authors: Smith, Quentin R.; Takasato, Yoshio; Rapoport, Stanley I. Title: Kinetic Analysis of L-leucine Transport Across the Blood-Brain Barrier Source: Brain Res. 311 (1984) 167-170 Description: Michaelis Menten parameters
Authors: Steven, Alasdair C.; Hainfeld, James F.; Trus, Benes L.; Steinert, Peter M.; Wall, Joseph S. Title: Radial Distributions of Density within Macromolecular Complexes Determined from Dark-field Electron Micrographs Source: PNAS 81 (1984) 6363-6367 Description: analysis and graphics of one dimensional traces using MLAB
Authors: Strobl, Jeannine S.; Kasid, Atton; Huff, Karen K.; Lippman, Marc E. Title: Kinetic Alterations in Estrogen Receptors Associated with Estrogen Receptor Processing in Human Breast Cancer Cells Source: Endocrin. 115 (1984) 1116-1124 Description: dissociation curves analyzed using MLAB
Authors: Sweeting, Linda M.; Becker, Edwin D. Title: A Carbon-13 Nuclear Magnetic Resonance Spin-Lattice Relaxation Study of Hydrogen Bonding in 2-Methyl-2-Propanol. Relaxation Mechanisms Source: J. Phys. Chem. 88 (1984) 6075-6080 Description: curve-fit to find T1, k, M0
Authors: Takasato, Yoshio; Rapoport, Stanley I.; Smith, Quentin R. Title: An in Situ Brain Perfusion Technique to Study Cerebrovascular Transport in the Rat Source: Am. J. Physiol. 247 (1984) H484-H493 Description: biexponential model for femoral arterial concentrations of 14-C antipyrine.
Authors: van Schravendijk, Christiaan; Hooghe-Peters, Elisabeth L.; De Meyts, Pierre; Pipeleers, Daniel G. Title: Identification and Characterization of Insulin Receptors on Foetal-Mouse Brain Cortical Cells Source: Biochem. J. 220 (1984) 165-172 Description: apparent affinity constants obtained using a model for 2 class sites
Authors: Velasquez, D.J.; Morrow, P.E. Title: Estimation of Guinea Pig Tracheobronchial Transport Rates using Compartmental Model Source: Exp. Lung Res. 7 (1984) 163-176 Description: modelled spatial zones in tracheal passage, characterized by varying diameter as compartments in compartmental model
Authors: Wahlund, Lars-Olof; Saaf, Jan; Ross, Suante B.; Wetterberg, Lennart Title: Activation of Monoamine Oxidase by High Molecular Weight Fractions of Human Plasma Source: Acta Physiol. Scand. 120 (1984) 337-341 Description: kinetic parameters Km, Vmax determined
Authors: Wahlund, L.-O.; Saaf, J.; Ross, S.B.; Wetterberg, L.; Smedby, Y. Title: Kinetic Aspects of Human Platelet Monoamine Oxidase Thermolability Source: Acta Physiol. Scand. 122 (1984) 97-102
Authors: Waldenlind, E.; Saaf, J.; Ekbom, K.; Ross, S.; Wahlund, L.O.; Wetterberg, L. Title: Kinetics and thermolability of platelet monamine oxidase in cluster headache and migraine Source: Cephalalgia 4 (1984) 125-134
Authors: Weerasuriya, Ananda; Spangler, Robert A.; Rapoport, Stanley I.; Taylor, Robert E. Title: AC Impedance of the Perineurium of the Frog Sciatic Nerve Source: Biophys. J. 46 (1984) 167-174 Description: impedance data analyzed by nonlinear least squares curve fitting technique
Authors: Weir, R.L.; Padgett, W.; Daly, J.W.; Anderson, J.M. Title: Interaction of Anticonvulsant Drugs with Adenosine Receptors in the Central Nervous System Source: Epilepsia 25 (1984) 492-498 Description: characteristics of the [3-H] CHA binding were estimated directly using nontransformed data. single and dual site models fitted
Authors: Yanagishita, M.; Hascall, V.C. Title: Metabolism of proteoglycans in rat ovarian granulosa cell culture. Multiple intracellular degradative pathways and the effect of chloroquine Source: J. Biol. Chem. 259 (1984) 10270-10283
Authors: Zelenka, Peggy S.; Vu, Ngoc-Diep Title: Correlation Between Phosphatidylinositol Degradation and Cell Division in Embryonic Chicken Lens Epithelia Source: Dev. Biol. 105 (1984) 325-329 Description: per cent labelled nuclei in central region of embryonic chicken lens epithelium vs. average decay rate fit with MLAB
Authors: Zimm, Solomon; Collins, Jerry M.; Curt, Gregory A.; O'Neill, Dondra; Poplack, David G. Title: Cerebrospinal Fluid Pharmacokinetics of Intraventricular and Intravenous Aziridinylbenzoquinone Source: Canc. Res. 44 (1984) 1698-1701 Description: monoexponential function fit to CSF disppearance curves following AZQ adminstration
Authors: Zimm, Solomon; Collins, Jerry M.; Miser, James; Chatterji, Dulal; Poplack, David G. Title: Cytosine Arabinoside Cerebrospinal Fluid Kinetics Source: Clin. Pharm. Ther. 35 (1984) 826-830 Description: biexponential model Ara-C CSF disapperance curves
Authors: Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Ozkan, Gunay; Egan, William; Shao, Kai-liu Title: NMR Spectroscopic Studies of Intermediary Metabolites of Cyclophosphamide Source: J. Med. Chem. 27 (1984) 466-485 Description: fit 31-P NMR data to kinetic model.
Authors: Aitken, Susan C.; Lippman, Marc E. Title: Hormonal Regulation of de Novo Pyrimidine Synthesis and Utilization in Human Breast Cancer Cells in Tissue Culture Source: Canc. Res. 43 (1983) 4681-4690 Description: acetate labelling kinetics
Authors: Armand, J.P.; Maquet, J.P.; LeRoy, A.F. Title: Cerebrospinal Fluid-Platinum Kinetics of Cisplatin in Man Source: Canc. Treat. Rpts. 67 (1983) 1035-1037 Description: platinum concentration in plasma as a function of time modelled as sum of two exponentials
Authors: Aronoff, George R.; Pottratz, Scott T.; Brier, Michael E.; Walker, Naomi E.; Fineberg, Naomi S.; Glant, Michael D.; Luft, Friedrich C. Title: Aminoglycoside Accumulation Kinetics in Rat Renal Parenchyma Source: Antimicrob. Ag. and Chem. 23 (1983) 74-78 Description: performed pharmacokinetic analysis
Authors: Ask, Per; Levitan, Herbert; Robinson, Peter J.; Rapoport, Stanley I. Title: Peripheral Nerve as an Osmometer: Role of Perineurium in Frog Sciatic Nerve Source: Am. J. Physiol. 244 (1983) C75-C81 Description: fit by nonlinear least squares to experimentally observed trans. charges.
Authors: Bai, Stephen A.; Abramson, Fred P. Title: Interaction of Phenobarbital with Propranolol in the Dog Source: J. Pharm. Exp. 224 (1983) 62-67 Description: DR-1 vs time data were analyzed using MLAB
Authors: Berg, G.G.; Smith, B.S. Title: Distribution and Elimination of Ingested Mercuric Oxide in Mice Source: J. Am. Col. Tox. 2 (1983) 307-317 Description: weighted least squares fit to 3 compartment model
Authors: Botto, R.E.; Coxon, B. Title: Nitrogen-15 Nuclear Magnetic Resonance Spectroscopy of Neomycin B and Related Aminoglycosides Source: JACS 105 (1983) 1021-1028
Authors: Braatz, J.A.; Hua, D.T.; Princler, G.L. Title: Serum levels of a human lung tumor-associated antigen using an improved radioimmunoassay Source: Canc. Res. 43 (1983) 110-113
Authors: Bunke, C.M.; Aronoff, G.R.; Brier, M.E.; Sloan, R.S.; Luft, F.C. Title: Cefazolin and cephalexin kinetics in continuous ambulatory peritoneal dialysis Source: Clin. Pharm. Ther. 33 (1983) 66-72
Authors: Burch, Patrick G.; Starski, Donald R. Title: The Role of Metabolism and Protein Binding in Thiopental Anesthesia Source: Anesthesiology 58 (1983) 146-152 Description: 3 compartment mamillary model using least squares regression
Authors: Calzone, F.J.; Angerer, R.C.; Gorovsky, M.A. Title: Regulation of protein synthesis in Tetrahymena. Quantitative estimates of the parameters determining the rates of protein synthesis in growing, starved, and starved-deciliated cells Source: J. Biol. Chem. 258 (1983) 6887-6898
Authors: Chen, C.; Knop, R.H.; Cohen, J.S. Title: Adriamycin Inhibits the B to Z Transition of poly(dGm5dc) Source: Biochem. 22 (1983) 5468-5471
Authors: Clay, John R.; Shlesinger, Michael F. Title: Effects of External Cesium and Rubidium on Outward Potassium Currents in Squid Axons Source: Biophys. J. 42 (1983) 43-53 Description: linear regression of current voltage relation
Authors: Closset, Jean; Smal, Jean; Gomez, Francoise; Hennen, Georges Title: Purification of the 22000- and 20000-Molecular Weight Forms of Human Somatotropin and Characterization of Their Binding to Liver and Mammary Binding Sites Source: Biochem. J. 214 (1983) 885-892 Description: Scatchard analysis and parallel-line assays
Authors: Curt, Gregory A.; Kelley, James A.; Kufta, Conrad V.; Smith, Barry H.; Kornblith, Paul L.; Young, Robert C.; Collins, Jerry M. Title: Phase II and Pharmacokinetic Study of Aziridinylbenzoquinone [2,5-Diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone, Diaziquone, NSC 182986] in High-Grade Gliomas Source: Canc. Res. 43 (1983) 6102-6105 Description: 2-compartment, bi-exponential model
Authors: Datiles, M.B.; Kador, P.F.; Fukui, H.N.; Hu, T.S.; Kinoshita, J.H. Title: Corneal re-epitheliazation in galactosemic rats Source: Inv. Ophthal. Vis. Sci. 24 (1983) 563-569
Authors: Dunn, Joseph A.; Blumberg, Peter M. Title: Specific Binding of [20-3H] 12-Deoxyphorbol 13-Isobutyrate to Phorbol Ester Receptor Subclasses in Mouse Skin Particulate Preparations Source: Canc. Res. 43 (1983) 4632-4637 Description: specific binding characteristics of [3H] DPB and [3H]PDBU were determined using the curve fit modelling program MLAB
Authors: Finet, M.; Godfraind, Theophile; Noel, F. Title: The Inotropic Effect of Ouabain and its Antagonism by Dihydroouabain in Rat Isolated Atria and Ventricles in Relation to Specific Binding Sites Source: Br. J. Pharm. 80 (1983) 751-759 Description: Scatchard analysis, student's t test
Authors: Finley, J.; Ireton, D.; Schleidt, W.M.; Thompson, T.A. Title: A New Look at the Features of Mallard Courtship Displays Source: Animal Behav. 31 (1983) 348-354 Description: 3D graphics
Authors: Fram, R.J.; Egan, E.M.; Kufe, D.W. Title: Accumulation of Leukemia Cell DNA Strand Breaks with Adriamycin and Cytosine Arabinoside Source: Leuk. Res. 7 (1983) 243-249 Description: fit decreasing exponential
Authors: Froehlich, Jeffrey P.; Hobbs, Ann S.; Albers, R. Wayne Title: Evidence for Parallel Pathways of Phosphoenzyme Formation in the Mechanism of ATP Hydrolysis by Electrophorus Na,K-ATPase Source: Curr. Topics in Membr. and Trans. 19 (1983) 513-535 Description: simulations of time course of phosphoenzyme formation of Pi release carried out with MLAB
Authors: Gasiewicz, Thomas A.; Geiger, Lee E.; Rucci, George; Neal, Robert A. Title: Distribution, Excretion, and Metabolism of 2,3,7,8-Tetrachloro dibenzo-p-dioxin in C57BL/6J, DBA/2J, and BGD2F1/J Mice Source: Drug Metab. 11 (1983) 397-403 Description: multiexponential models with nonlinear least squares fit
Authors: Greene, Raymond F.; Collins, Jerry M.; Jenkins, Jean F.; Speyer, James L.; Myers, Charles E. Title: Plasma Pharmacokinetics of Adriamycin and Andriamycinol: Implications for the Design of in Vitro Experiments and Treatment Protocols Source: Canc. Res. 43 (1983) 3417-3421 Description: biexponential model for Adriamycin plasma concentration
Authors: Grigorescu, Florin; White, Morris F.; Kahn, C. Ronald Title: Insulin Binding and Insulin-Dependent Phosphorylation of the Insulin Receptor Solubilized from Human Erythrocytes Source: J. Biol. Chem. 258 (1983) 13708-13716 Description: MLAB used to analyze insulin-binding data, Hill-Sipps model, 4 parameter logistic equation.
Authors: Hobbs, Ann S.; Albers, R. Wayne; Froehlich, Jeffrey P. Title: Effects of Oligomycin on the Partial Reactions of the Sodium Plus Potassium-stimulated Adenosine Triphosphatase Source: J. Biol. Chem. 258 (1983) 8163-8168 Description: kinetic data were analyzed by computer simulation using MLAB
Authors: Jackson, Meyer B.; Wong, Brandon S.; Morris, Catherine E.; Lecar, Harold; Christian, Clifford N. Title: Successive Openings of the Same Acetylcholine Receptor Channel are Correlated in Open Time Source: Biophys. J. 42 (1983) 109-114 Description: curve fit sum of 2 exponentials
Authors: Jahnke, Ulrike; Heilmeyer, Ludwig M.G., Jr. Title: Ca2+ and Mg2+-Dependent Complex Formation of Tropomyosin with Phosphotroponin (P1TI2C) or Dephosphotroponin (TI2C) Source: Eur. J. Biochem. 133 (1983) 591-597 Description: degree of tropomysosin aggregation was calculated from sedimentation equation by fitting data. ultracentrifuge
Authors: Kates, Robert E.; Keefe, Deborah L.; Winkle, Roger A. Title: Lorcainide Disposition Kinetics in Arrhythmia Patients Source: Clin. Pharm. Ther. 33 (1983) 28-34 Description: 3 compartment model
Authors: Kaye, T.S.; Egorin, M.J.; Riggs, C.E.; Olman, E.A.; Chou, F.E.; Salcman, M. Title: The plasma pharmacokinetics and tissue distribution of dimethyl sulfoxide in mice Source: Life Sci. 33 (1983) 1223-1230
Authors: Kerr, Ian G.; Jolivet, Jacques; Collins, Jerry M.; Drake, James C.; Chabner, Bruce A. Title: Test Dose for Predicting High-Dose Methotrexate Infusions Source: Clin. Pharm. Ther. 33 (1983) 44-51 Description: kinetics parameters in biexponential model
Authors: Lee, N.S.; Brewer, H.B.; Osborne, J.S. Title: Beta-2 glycoprotein I. Molecular properties of an unused apolipoprotein, apolipoprotein H Source: J. Biol. Chem. 258 (1983) 4765-4770
Authors: LiMuti, C.; Bell, J.E. Title: A steady-state random-order mechanism for the oxidative deamination of norvaline by glutamate dehydrogenase Source: Biochem. J. 211 (1983) 99-107
Authors: Lipman, D.J.; Wilbur, W.J. Title: Contextual constraints on synonymous codon choice Source: J. Molec. Biol. 163 (1983) 363-376
Authors: Maes, M.; De Hertogh, R.; Watrin-Granger, P.; Ketelslegers, J.M. Title: Ontogeny of Liver Somatotropic and Lactogenic Binding Sites in Male and Female Rats Source: Endocrin. 113 (1983) 1325-1332 Description: curvilinear Scatchard plots derived using MLAB
Authors: Maes, Marc; Ketelsleger, Jean Marie; Underwood, Louis E. Title: Low Plasma Somatomedin-C in Streptozotocin-Induced Diabetes Mellitus Source: Diabetes 32 (1983) 1060-1069 Description: scatchard plots dereived and analyzed for different binding models
Authors: Major, Pierre P.; Agarwal, Ram P.; Kufe, Donald W. Title: Clinical Pharmacology of Arabinofuranosyladenine in Combination with Deoxycoformycin Source: Canc. Chem. Pharm. 10 (1983) 125-128 Description: plasma concentration of ara-A were fitted to exponentially decreasing function, 1 compartment model
Authors: Marchaud, E.; Grigorescu, F.; Buysschaert, M.; De Meyts, P.; Ketelslegers, J.M.; Brems, H.; Nathan, M.C.; Lambert, A.E. Title: The Hypoglycemic Effect of a Sulfonylurea (Gliclazide) in Moderate Type II Diabetes and Glucose Intolerance is not Accompanied by Changes in Insulin Action and Insulin Binding to Erythrocytes Source: Mol. Physiol. 4 (1983) 83-93
Authors: McManus, Michael E.; Minchin, Rodney F.; Sanderson, Nancy; Wirth, Peter J.; Thorgeirsson, Snorri S. Title: Kinetics of N- and C-Hydroxylations of 2-Acetylaminofluorene in Male Sprague-Dawley Rat Liver Microsomes: Implications for Carcinogenesis Source: Canc. Res. 43 (1983) 3720-3724 Description: Michaelis-Menten equation parameters
Authors: McManus, M.E.; Minchin, R.F.; Sanderson, N.D.; Wirth, P.J.; Thorgeirsson, S.S. Title: Kinetic Evidence for the Involvement of Multiple Forms of Human Liver Cytochrome P-450 in the Metabolism of Acetylamino Fluorene Source: Carcinogenesis 4 (1983) 693-697 Description: general Michaelis Menten model.
Authors: Micetich, Kenneth; Zwelling, Leonard A.; Kohn, Kurt W. Title: Quenching of DNA: Platinum (II) Monoadducts as a Possible Mechanism of Resistance to cis-Diamminedichloroplatinum (II) in L1210 Cells Source: Canc. Res. 43 (1983) 3609-3613 Description: best fit of kinetic parameters to exponential model
Authors: Michaud, D.P.; Gupta, S.C.; Whalen, D.L.; Sayer, J.M.; Jerina, D.M. Title: Effects of pH and Salt Concentration on the Hydrolysis of a Benzo[alpha]pyrene 7,8-diol-9,10-epoxide Catalyzed by DNA and Polyadenylic Acid Source: Chem. Biol. Int. 44 (1983) 41-52 Description: Michaelis Menten saturation curves
Authors: Mico, Bruce A.; Branch, Richard V.; Pohl, Lance R. Title: Formation of Electrophilic Chlorine from Carbon Tetrachloride. Involvement of Cytochrome P-450 Source: Biochem. Pharm. 32 (1983) 2357-2359 Description: Vmax, Km calculations by unweighted nonlinear least squares regression. concentration of carbon tet vs. rate of electrophile chlorine formation
Authors: Mossman, Kenneth L. Title: Quantitative Radiation Dose-Response Relationships for Normal Tissues in Man. II. Response of the Salivary Glands During Radiotherapy Source: Radiation Res. 95 (1983) 392-398 Description: fit 2 parameter function for dose-response data.
Authors: Newton, Dianne L.; Burke, Terrance R., Jr.; Rice, Kenner C.; Klee, Claude B. Title: Calcium Ion-Dependent Covalent Modification of Calmodulin with Norchlorpromazine Isothiocyanate Source: Biochem. 22 (1983) 5472-5476 Description: competitive inhibition, velocity of reaction
Authors: Nossal, R.; Weiss, G.H.; Nandi, P.K.; Lippoldt, R.E.; Edelhoch, H. Title: Sizes and Mass Distributions of Clathrin-Coated Vesicles from Bovine Brain Source: Arch. Biochem. Biophys. 226 (1983) 593-603 Description: ultracentrifuge data analysis
Authors: Nowak, Thaddeus S., Jr.; Albright, Elizabeth B.; Munro, Hamish N. Title: Inhibition of Aminoacyl-tRNA Synthetases by p-Chloroamphetamine and its Role in Protein Synthesis Inhibition Source: Arch. Biochem. Biophys. 225 (1983) 722-730 Description: dissociation constant for various enzyme-substrate and enzyme-inhibitor complexes were numerically evaluated by fitting rate law to experimental data.
Authors: Pato, M.D.; Adelstein, R.S. Title: Characterization of a Mg2+ dependent phosphatase from turkey gizzard smooth muscle Source: J. Biol. Chem. 258 (1983) 7055-7058
Authors: Pato, M.D.; Adelstein, R.S. Title: Purification and characterization of a multisubunit phosphate from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation Source: J. Biol. Chem. 258 (1983) 7047-7054
Authors: Reddy, K.V.; Hendler, Richard W. Title: Complete Analysis of the Cytochrome Components of Beef Heart Mitochondria in Terms of Spectra and Redox Properties Source: J. Biol. Chem. 258 (1983) 8568-8581 Description: Nernst equation
Authors: Roberts, Roderick K.; Grice, Jeffrey; McGuffie, Christine; Heilbronn, Lillian Title: Oral Contraceptive Steroids Impair the Elimination of Theophylline Source: J. Lab. Clin. Med. 101 (1983) 821-825 Description: fit concentration vs time to exponentially decreasing function
Authors: Robison, W.G.; Kador, P.F.; Kinoshita, J.H. Title: Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor Source: Science 221 (1983) 1177-1179
Authors: Rothman, Richard B. Title: Analysis of Binding Surfaces: A Methodology Appropriate for the Investigation of Complex Receptor Mechanisms and Multiple Neurotransmitter Receptors Source: Neuropeptides 4 (1983) 41-44 Description: ligand and inhibitor bind to 2 binding sites
Authors: Sabol, S.L.; Liang, C.M.; Dandekar, S.; Kranzler, L.S. Title: In vitro biosynthesis and processing of immunologically identified methionine-enkephalin precursor protein Source: J. Biol. Chem. 258 (1983) 2697-2704
Authors: Sara, V.R.; Hall, K.; Misaki, M.; Fryklund, L.; Christensen, N.; Wetterberg, L. Title: Ontogenesis of Somatomedin and Insulin Receptors in the Human Fetus Source: J. Clin. Inv. 71 (1983) 1084-1094 Description: 1st order kinetics
Authors: Schulz, Pierre; Turner-Tamiyasu, Kathleen; Smith, Gabrielle; Giacomini, Kathleen M.; Blaschke, Terrence F. Title: Amitriptyline Disposition in Young and Elderly Normal Men Source: Clin. Pharm. Ther. 33 (1983) 360-366 Description: biexponential model to get half-life
Authors: Segal, David M.; Dower, Steven K.; Titus, Julie A. Title: The FcR-Mediated Endocytosis of Model Immune Complexes by Cells from the P338D1 Mouse Macrophage Line Source: J. Immunol. 130 (1983) 130-137 Description: 1st order kinetics
Authors: Silber, B.M.; Holford, N.H.; Riegelman, S. Title: Dose dependent elimination of propranolol and its major metabolites in humans Source: J. Pharm. Sci. 72 (1983) 725-735
Authors: Steven, Alasdair; Hainfeld, James F.; Trus, Benes L.; Wall, Joseph S.; Steinert, Peter M. Title: The Distribution of Mass in Heteropolymer Intermediate Filaments Assembled in Vitro Source: J. Biol. Chem. 258 (1983) 8323-8329 Description: experimental histograms modelled as sums of Gaussians
Authors: Steven, Alasdair C.; Hainfeld, James F.; Trus, Benes L.; Wall, Joseph S.; Steinert, Peter M. Title: Epidermal Keratin Filaments Assembled in Vitro Have Masses-per-Unit-Length that Scale According to Average Subunit Mass Source: J. Cell Biol. 97 (1983) 1939-1944 Description: statistical analysis and graphics
Authors: Steven, Alasdair C.; Hainfeld, James F.; Wall, Joseph S.; Steer, Clifford J. Title: Mass Distributions of Coated Vesicles Isolated from Liver and Brain: Analysis by Scanning Transmission Electron Microscopy Source: J. Cell Biol. 97 (1983) 1714-1723 Description: Photographic records of stained gels were scanned with densitometer, Kolmogorov-Smirnov test, graphics
Authors: Stevens, James; Jakoby, William B. Title: Cysteine Conjugate Beta-Lyase Source: Mol. Pharm. 23 (1983) 761-765 Description: exponential model
Authors: Takei, Hidenori; Fredericks, Wendy R.; London, Edythe D.; Rapoport, Stanley I. Title: Cerebral Blood Flow and Oxidative Metabolism in Conscious Fischer-344 Rats of Different Ages Source: J. Neurochem. 40 (1983) 801-805 Description: concentration of 14-C-iodoantipyrine measured during intravenous infusion
Authors: Tobacman, L.S.; Korn, E.D. Title: The kinetics of actin nucleation and polymerization Source: J. Biol. Chem. 258 (1983) 3207-3214
Authors: Tozer, Thomas N.; Gambertoglio, John G.; Furst, Daniel E.; Avery, Denis S.; Holford, Nicholas H.G. Title: Volume Shifts and Protein Binding Estimates Using Equilibrium Dialysis: Application to Prednisolone Binding in Humans Source: J. Pharm. Sci. 72 (1983) 1442-1446 Description: binding parameters estimated with MLAB
Authors: Valet, Scot B.; Schwartz, Robert H.; Brooks, John G. Title: Pharmacokinetics of Theophylline and Bioavailability of a Sustained Release Theophylline Preparation in Patients with Cystic Fibrosis Source: Ann. Allergy 50 (1983) 161-165 Description: 2 compartment model for theophyline distributions
Authors: van Bohemen, Charles G.; Eliard, Pierre H.; Rousseau, Guy G. Title: Control by Calcium Ions of Steroid Binding to the Glucocorticoid Receptor Source: Mol. Physiol. 4 (1983) 95-110 Description: Equilibrium binding curves
Authors: van Zuiden, Paul E.A.; Erickson, Sandra K.; Cooper, Allen D. Title: Effect of Removal of Lipoproteins of Different Composition on Hepatic 3-hydroxy-3-methylglutaryl coenzyme A Reductase Activity and Hepatic Very Low Density Lipoprotein Secretion Source: J. Lipid Res. 24 (1983) 418-428 Description: 125I labelled lipoprotein, slope, y-intercept, and half-life.
Authors: Vu, Van T.; Bai, Stephen A.; Abramson, Fred P. Title: Interactions of Phenobarbitol with Propranolol in the Dog. 2. Bioavailability, Metabolism, and Pharmacokinetics Source: J. Pharm. Exp. 224 (1983) 55-61 Description: log absorbance vs time fitted to line
Authors: Wahlund, L.O.; Smedby, Y.; Saaf, J.; Schulmans, A.; Ross, S.B.; Wetterberg, L. Title: Influence of Hemodialysis on Monoamine Oxidase Kinetics in Platelets from Chronic Schizophrenic Patients Source: Artificial Organs 7 (1983) 334-339
Authors: Wilbur, W.J.; Lipman, A.J. Title: Rapid similarity searches of nucleic acid and protein data banks Source: PNAS 80 (1983) 726-730
Authors: Wolfenden, R.; Williams, R. Title: Affinities of Phosphoric Acids, Esters, and Amides for Solvent Water Source: JACS 105 (1983) 1028-1031
Authors: Zaharko, Daniel S.; Covey, Joseph M. Title: Modulation of Deoxycytidine Metabolism in Vivo with High-Dose Thymidine in Mice Source: JNCI 71 (1983) 1033-1039 Description: half-life from per cent dose per ml of plasma vs time
Authors: Zelenka, Peggy S. Title: Phosphatidylcholine and Phosphatidylethanolamine Metabolism During Lens Fiber Cell Formation Source: Biochim. Biophys. Acta 752 (1983) 145-152 Description: linear ordinary differential equation fit
Authors: Zimm, Solomon; Collins, Jerry M.; O'Neill, Dondra; Chabner, Bruce; Poplack, David G. Title: Inhibition of First-Pass Metabolism in Cancer Chemotherapy: Interaction of 6-Mercaptopurine and Allopurinol Source: Clin. Pharm. Ther. 34 (1983) 810-817 Description: plasma concentration fit to bi- and tri-exponential models
Authors: Abramson, Fred P. Title: Methadone Plasma Protein Binding: Alterations in Cancer and Displacement from alpha-1-acid Glycoprotein Source: Clin. Pharm. Ther. 32 (1982) 652-658 Description: least squares fit of AAG/methadone binding data
Authors: Aitken, Susan C.; Lippman, Marc E. Title: Hormonal Regulation of Net DNA Synthesis in MCF-7 Human Breast Cancer Cells in Tissue Culture Source: Canc. Res. 42 (1982) 1727-1735 Description: 32-P in Acid soluble pool vs. time, labelling kinetics
Authors: Aizenbud, Boris M.; Gershon, Nahum D. Title: Diffusion of Molecules on Biological Membranes of Nonplanar Form Source: Biophys. J. 38 (1982) 287-293 Description: 3D graphics
Authors: Alving, Barbara M.; Chung, Soo Il; Murano, Genesio; Tang, Douglas B.; Finlayson, J.S. Title: Rabbit Fibrinogen: Time Course of Constituent Chain Production in Vivo Source: Arch. Biochem. Biophys. 217 (1982) 1-9 Description: kinetic data, 2-terms: (1-exp(-a(t-t0)))
Authors: Aronoff, George R.; Sloan, Rebecca S.; Luft, Friedrich C. Title: Pharmacokinetics of Moxalactam in Patients with Normal and Impaired Renal Function Source: J. Infect. Dis. 145 (1982) 365-369 Description: n compartment model
Authors: Bachur, Nicholas R.; Collins, Jerry M.; Kelley, James A.; van Echo, David A.; Kaplan, Richard S.; Whitacre, Margaret Title: Diaziquone, 2,5 diaziridinyl-3,6-biscarboethoxyamino-1,4-benzo quinone, Plasma and Cerebrospinal Fluid Kinetics Source: Clin. Pharm. Ther. 31 (1982) 650-655 Description: postinfusion plasma conc. fit to biexponential model
Authors: Bikle, David D.; Peck, Carl C.; Holford, Nicholas H.G.; Zolock, David T.; Morrissey, Robert L. Title: Pharmacokinetics and Pharmacodynamics of 1,25-Dihydroxyvitamin D3 in the Chick Source: Endocrin. 111 (1982) 939-946 Description: weighted least squares fit of system of odes
Authors: Bozzato, Richard P.; Tinker, David O. Title: Effects of Membrane Fluidity and Identification of the Rate-Limiting Step in the Protein-Mediated Phosphatidylcholine Exchange Reaction Source: Can. J. Biochem. 60 (1982) 409-418 Description: curve fitting to experimental data, function with two exponentials
Authors: Braatz, J.A.; Scharfe, T.R.; Princler, G.L.; McIntire, K.R. Title: Characterization of a human lung tumor-associated antigen and development of a radioimmunoassay Source: Canc. Res. 42 (1982) 849-855
Authors: Chen, Raymond F. Title: Fluorescence Lifetimes: Effect of Precision of Relaxation Times from Fluorescence Depolarization Data Source: Anal. Lett. 15 (1982) 1383-1392 Description: MLAB used for calculations and graphics.
Authors: Clay, John R.; Shlesinger, Michael F. Title: Delayed Kinetics of Squid Axon Potassium Channels do not Always Superpose After Time Translation Source: Biophys. J. 37 (1982) 677-680 Description: Hodgkin Huxley model
Authors: Cooper, Allen D.; Shrewsbury, M. Adeline; Erickson, Sandra K. Title: Comparison of Binding and Removal of Remnants of Triglyceride-Rich Lipoproteins of Intestinal and Hepatic Origin by Rat Liver in Vitro Source: Am. J. Physiol. 243 (1982) G389-G395 Description: 125I labelled hepatic VLDL in serum vs time as biexponential decay model
Authors: Creaven, Patrick J. Title: The Clinical Pharmacology of VM26 and VP16-213: A Brief Overview Source: Canc. Chem. Pharm. 7 (1982) 133-140 Description: bi and tri exponential fit of plasma concentrations
Authors: Czerlinski, G.H. Title: The spontaneous magnetization of nickel Source: J. Biol. Phys. 10 (1982) 189-198
Authors: Egorin, M.J.; Van Echo, D.; Fox, B.M.; Whitacre, M.; Bachur, N.R. Title: Plasma Kinetics of Aclacinomycin A and Its Major Metabolites in Man Source: Canc. Chemot. Pharm. 8 (1982) 41-46 Description: nonlinear regression least squares fit of sums of 1,2,3 exponentials
Authors: Elchisak, M.A.; Polinsky, R.J.; Ebert, M.H.; Kopin, I.J. Title: Kinetics of Homovanillic Acid and Determination of Its Production Rate in Humans Source: J. Neurochem. 38 (1982) 380-385 Description: nonlinear regression least squares fit of sums of 1,2,3 exponentials
Authors: Ellis, J.; Hoss, W. Title: Competitive interaction of gallamine with multiple muscarinic receptors Source: Biochem. Pharm. 31 (1982) 873-876
Authors: Evans, W.J.; McCourtney, E.J.; Shrager, R.I. Title: Titration Studies of Phytic Acid Source: JAOCS 59 (1982) 189-191 Description: n-site Adair-type binding
Authors: Fisk, Cherie L.; Becker, Edwin D.; Miles, H. Todd; TJ Pinnavia Title: Self-Structured Guanosine 5'-Monophosphate. A 13-C and 1-H Magnetic Resonance Study Source: JACS 104 (1982) 3307-3314 Description: least squares regression to find T1
Authors: Giacomini, Kathleen M.; Swezey, Sarah E.; Turner-Tamiyasu, Kathleen; Blaschke, Terrence Title: The Effect of Saturable Binding to Plasma Proteins on the Pharmacokinetic Properties of Disopyramide Source: J. Pharm. Biopharm. 10 (1982) 1-14 Description: mono- and bi-exponential equation, nonlinear least squares fit
Authors: Hasegawa, Jiro; Lin, Emil T.; Williams, Roger L.; Sorgel, Fritz; Benet, Leslie Z. Title: Pharmacokinetics of Triamterene and Its Metabolite in Man Source: J. Pharm. Biopharm. 10 (1982) 507-523 Description: compartmental models
Authors: Ho, Yen-sen; Lewis, Marc; Rosenberg, Martin Title: Purification and Properties of a Transcriptional Activator Source: J. Biol. Chem. 257 (1982) 9128-9134 Description: ultracentrifuge data, concentration distributions analyzed using MLAB
Authors: Hobbs, Ann S. Title: Comparative Effects of External Monovalent Cations on Sodium Pump Activity and Ouabain Inhibition Rates in Squid Giant Axon Source: J. Physiol. 331 (1982) 567-576 Description: rate of binding was determined graphically using MLAB
Authors: Issekutz, T.; Chu, E.; Geha, R.S. Title: Antigen presentation by human beta cells: T cell proliferation induced by Epstein Barr virus beta lymphoblastoid cells Source: J. Immunol. 129 (1982) 1446-1450
Authors: Kadoma, Masaaki; Froehlich, Jeffrey; Reeves, John; Sutko, John Title: Kinetics of Sodium Ion-Induced Calcium(2+) Release in Calcium 2+ Loaded Cardiac Sarcolenmal Vesicles: Determination of Initial Velocities by Stopped-Flow Spectrophotometry Source: Biochem. 21 (1982) 1914-1918 Description: Hill equation parameters
Authors: Keefe, Deborah L.; Kates, Robert E. Title: Myocardial Disposition and Cardiac Pharmacodynamics of Verapamil in the Dog Source: J. Pharm. Exp. 220 (1982) 91-96 Description: 3 compartment model of plasma concentration vs. time
Authors: Kerr, I.G.; Lippman, M.E.; Jenkins, J.; Myers, C.E. Title: Pharmacology of 13-cis-retinoic acid in humans Source: Canc. Res. 42 (1982) 2069-2073
Authors: Lee, Y.C.; Wolff, J. Title: Two opposing effects of calmodulin on microtubule assembly depend on the presence of microtubule associated proteins Source: J. Biol. Chem. 257 (1982) 6306-6310
Authors: Lyon, Ellen Sue; Jakoby, William B. Title: Arylamine N-Methyltranferase Source: J. Biol. Chem. 257 (1982) 7531-7535 Description: kinetic constants
Authors: Martin, C.J.; Marini, M.A. Title: Ionization behavior of proteins. I. Spectral titration of the tyrosyl groups of chymotrypsinogen and nitrated-chymotrypsinogen Source: Biopolymers 21 (1982) 1657-1666
Authors: Martin, C.J.; Marini, M.A. Title: Ionization behavior of proteins. II. Chymotrypsinogen and its group-modified derivatives: Study of their ionization characteristics by potentiometric and calorimetric titration Source: Biopolymers 21 (1982) 1667-1685
Authors: McManus, Michael E.; Long, Matti A.; Stuart, Karen; Strong, John Title: Activation of Misonidazole by Rat Liver Microsomes and Purified NADPH-Cytochrome C Reductase Source: Biochem. Pharm. 31 (1982) 547-552 Description: fitting data to rate equations for competitive, non-competitive, mixed, and uncompetitive inhibition mechanisms
Authors: McPhie, P Title: Swine Pepsinogen Folding Intermediates are Highly Structured, Motile Molecules Source: Biochem. 21 (1982) 5509-5515
Authors: Miller-Podraza, H.; Fishman, P.H. Title: Translocation of Newly Synthesized Gangliosides to the Cell Surface Source: Biochem. 21 (1982) 3265-3270
Authors: Milne, G.W.A.; Fisk, C.L.; Heller, Stephen R.; Potenzone, Rudolph, Jr. Title: Environmental Uses of the NIH-EPA Chemical Information System Source: Science 215 (1982) 371-375 Description: MLAB as part of information system.
Authors: Mitchell, Richard R.; Gupta, Narendra K. Title: Variability of Radionuclide Clearance Parameter Estimates Source: Comp. Biomed. Res. 15 (1982) 387-403 Description: estimate parameters in washout and washin exponential models
Authors: Mohanakrishnan, P.; Chignell, C.F. Title: Ion-Specific Electrode Study of Copper Binding to Serum Albumins Source: J. Pharm. Sci. 71 (1982) 1180-1182 Description: Nernst equation
Authors: Moore, T.J.; Williams, G.H. Title: Angiotensin II receptors on human platelets Source: Circ. Res. 51 (1982) 314-320 Description: Scatchard plot
Authors: Morrow, P.E.; Gibb, F.R.; Beiter, H.; Amato, F.; Yuile, C.; Kilpper, R.W. Title: Pulmonary Retention of Coal Dusts Source: Ann. Occup. Hyg. 26 (1982) 291-307 Description: compartmental model
Authors: Morrow, P.E.; Yuile, C.L. Title: The disposition of coal dusts in the lungs and tracheobronchial lymph nodes of dogs Source: Toxicol. Sci. 2 (1982) 300-305
Authors: Mossman, Kenneth L. Title: Quantitative Radiation Dose-Response Relationships for Normal Tissues in Man. I. Gustatory tissue response during photon and neutron radiotherapy Source: Radiation Res. 91 (1982) 265-274 Description: LD50 determined by curve-fitting
Authors: Mudd, C.; Berger, R.L.; Hopkins, H.P.; Friauf, W.S.; Gibson, C. Title: An optimized differential heat conduction solution microcalorimeter for thermal kinetic measurements Source: J. Biochem. Biophys. Meth. 6 (1982) 179-203
Authors: Nelson, R.L. Title: The Comparative Clinical Pharmacology and Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Human Patients With Cancer Source: Med. Ped. Onc. 10 (1982) 115-127 Description: linear differential equations, 3 and 4 compartment models
Authors: Ohata, M.; Takei, H.; Fredericks, W.R.; Rapoport, S.I. Title: Effects of Immobilization Stress on Cerebral Blood Flow and Cerebrovascular Permeability in Spontaneously Hypertensive Rats Source: J. Cereb. Bl. Fl. 2 (1982) 373-379 Description: bi-exponential plus constant model of blood concentration in time
Authors: Pang, K. Sandy; Waller, Lewis; Horning, Marjorie G.; Chan, Kenneth K. Title: Metabolite Kinetics: Formation of Acetominophen from Deuterated and Nondeuterated Phenacetin and Acetanilide on Acetaminophen Sulfation Kinetics in the Perfused Rat Liver Preparation Source: J. Pharm. Exp. 222 (1982) 14-19 Description: simulated concentration of drug and metabolite species in lever vs. time
Authors: Parr, Gary R.; Taniuchi, Hiroshi Title: A Thermodynamic Study of Ordered Complexes of Cytochrome c Fragments Source: J. Biol. Chem. 257 (1982) 10103-10111 Description: dissociation constants obtained using MLAB from temperature fluorescence titration measurements and Richardo Vithayathil equation.
Authors: Porter, E. Victoria; Chasey, Bruce M.; Holmlund, Chester E. Title: Purification and Kinetic Characterization of a Specific Glucokinase from Streptococcus mutans OMZ270 Cells Source: Biochim. Biophys. Acta-Protein Struct. and Molec. Enzym. 709 (1982) 178-186 Description: Lineweaver Burk method
Authors: Ramacciotti, Carla; Pretorius, Harold T.; Line, Bruce R.; Goldman, Joel M.; Robbins, Jacob Title: Ablation of Nonalignment Thyroid Remnants with Low Doses of Radioactive Iodine: Concise Communication Source: J. Nucl. Med. 23 (1982) 483-489 Description: expected radiation exposure to body from radioiodine calcuated with MLAB
Authors: Rapoport, Stanley I.; Fitzhugh, Richard; Pettigrew, Karen D.; Sundaram, Uma; Ohno, Kikuo Title: Drug Entry into and Distribution Within Brain and Cerebrospinal Fluid: [14-C] Urea Pharmacokinetics Source: Am. J. Physiol. 242 (1982) R339-R348 Description: pharmacokinetics
Authors: Rhee, Sue Goo; Ubom, Gregory A.; Hunt, John B.; Chock, P.B. Title: Catalytic Cycle of the Biosynthetic Reaction Catalyzed by Adenylated Glutamine Synthetase from Escherichia Coli Source: J. Biol. Chem. 257 (1982) 289-297 Description: curve-fitting, integration, and simulation. first order rate equations, odes.
Authors: Richards, R. Henry; Vreman, Hendrik J.; Zager, Philip; Feldman, Charles; Blaschke, Terrance Title: Acetate Metabolism in Normal Human Subjects Source: Am. J. Kid. Dis. 2 (1982) 47-57 Description: 1st order and nonlinear compartmental models fit to infusion-postinfusion plasma acetate data
Authors: Ritzman, R.F.; Lee, J.M.; Fields, J.Z. Title: Modification of morphine induced change in striatal [3H]-spiroperidol binding and stereotype behavior by cyclo (Leu-Gly) Source: Life Sci. 30 (1982) 1573-1580
Authors: Roberts, D.E.; Scher, A.M. Title: Effect of tissue anisotropy on extracellular potential fields in canine myocardium in situ Source: Circ. Res. 50 (1982) 342-351
Authors: Sayer, J.M.; Lehr, R.E.; Whalen, D.L.; Yagi, H.; Jerina, D.M. Title: Structure-Reactivity Indices for the Hydrolysis of Diol Epoxides of Polycyclic Aromatic Hydrocarbons Source: Tetr. Let. 23 (1982) 4431-4434 Description: least squares slopes and intercepts for log km rate constants and reactivity indices for hydrolysis of region diol epoxides
Authors: Schilsky, Richard L.; Kelley, James A.; Ihde, Daniel C.; Howser, Dianne M.; Cordes, Rosemarie S.; Young, Robert C. Title: Phase I Trial and Pharmacokinetics of Aziridinylbenzoquinone (NSC 182986) in Humans Source: Canc. Res. 42 (1982) 1582-1586 Description: AZQ concentration vs. time fit to biexponential model
Authors: Setty, O.H.; Hendler, Richard W. Title: Interference of Electron Donors in the Measurement of the Proton Gradient and Membrane Potential by Flow Dialysis Source: J. Biochem. Biophys. Meth. 7 (1982) 35-46 Description: All computations and graphic art were performed using MLAB
Authors: Shoemaker, D.D.; McManus, M.E.; Hoerauf, R.; Strong, J.M. Title: Studies on the O-Demethylation of Misonidazole by Rat Liver Microsomes Source: Canc. Treat. Rpts. 66 (1982) 1343-1347 Description: Michaelis-Menten equation parameters
Authors: Shrager, Richard I.; Hendler, Richard W. Title: Titration of Individual Components in a Mixture with Resolution of Difference Spectra, pKs, and Redox Transitions Source: Anal. Chem. 54 (1982) 1147-1152 Description: Henderson-Hasselbach, Nernst, Adair models.
Authors: Silber, Bernie; Holford, Nicholas H.G.; Riegelman, Sidney Title: Stereoselective Disposition and Glucuronidation of Propranolol in Humans Source: J. Pharm. Sci. 71 (1982) 699-704 Description: Michaelis Menten constants, use root function
Authors: Silbergeld, E.K.; Anderson, S.M.; Morris, S.J. Title: Interactions of erythrosin B (U.S. F,D&C Red 3) with rat cortical membranes Source: Life Sci. 31 (1982) 957-969
Authors: Silverton, J.V.; Linen, W.; Miles, H.T. Title: 2-Amino-8-methyladenosine 5'-Monophosphate Dihydrate. A Nucleotide with Syn C4'-Exo Conformation and 'Triple-Stranded' Packing Source: JACS 104 (1982) 1081-1089 Description: extinction correction of the Zachariasen type was evaluated using MLAB
Authors: Singh, S.; Gelband, H.; Mehta, A.V.; Kessler, K.; Casta, A.; Pickoff, A.S. Title: Procainamide elimination kinetics in pediatric patients Source: Clin. Pharm. Ther. (1982) 607-511
Authors: Steven, A.C.; Wall, J.; Hainfeld, J.; Steinert, P.M. Title: Structure of Fibroblastic Intermediate Filaments: Analysis by Scanning Transmission Electron Microscopy Source: PNAS 79 (1982) 3101-3105 Description: relative frequencies of measurement vs. linear mass density in kDal/nm fit to sum of gaussians.
Authors: Thomas, David J.; Fisher, Henry L.; Hall, Larry L.; Mushak, Paul Title: Effects of Age and Sex on Retention of Mercury by Methyl Mercury-Treated Rats Source: Toxicol. and Appl. Pharm. 62 (1982) 445-454 Description: decay corrected data on whole body retention of Hg were fitted to single or multiexponential functions
Authors: Tinker, David O.; Low, Rosita Title: Thermodynamics of Mixing of Dipalmitoyl Phosphatidylcholine and Egg Phosphatidylcholine in Hydrated Bilayers Source: Can. J. Biochem. 60 (1982) 538-548 Description: splined cubic polynomial interpolation formula, Simpson's rule, differential scanning calorimetry of aqueous mixtures fit to nonlinear function of temperature.
Authors: Wanwimolruk, S.; Birkett, D.J.; Brooks, P.M. Title: Protein binding of GP53,633: A basic nonsteroidal anti-inflammatory drug Source: Biochem. Pharm. 31 (1982) 3737-3743
Authors: Wood, Alexander W.; Sayer, Jane M.; Neumark, Harold L.; Yagi, Haruhiko; Michaud, Dennis P.; Jerina, Donald M.; Conney, A.H. Title: Mechanism of the Inhibition of Mutagenicity of a Benzo[alpha]pyrene 7,8-diol 9,10-epoxide by Riboflavin 5'-phosphate Source: PNAS 79 (1982) 5122-5126
Authors: Wood, William I.; Felsenfeld, Gary Title: Chromatin Structure of the Chicken Beta-Globulin Gene Region Source: J. Biol. Chem. 257 (1982) 7730-7736 Description: curvefit
Authors: Zon, G.; Szu, S.C.; Egan, W.; Robbins, J.D.; Robbins, J.B. Title: Hydrolytic stability of pneumococcal group 6 (type 6A and 6B) capsular polysaccharides Source: Infect. Immun. 37 (1982) 89-103
Authors: Adelstein, R.S.; Klee, C.B. Title: Purification and characterization of smooth muscle myosin light chain kinase Source: J. Biol. Chem. 256 (1981) 7501-7509
Authors: Aronstam, R.S.; Eldefrawi, A.T.; Pessah, I.N.; Daly, J.W.; Albuquerque, E.X.; Eldefrawi, M.E. Title: Regulation of [3H] perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor Source: J. Biol. Chem. 256 (1981) 2843-2850
Authors: Aronstam, R.S.; Witkop, B. Title: Anatoxin-a interactions with cholinergic synaptic molecules Source: PNAS 78 (1981) 4639-4643 Description: binding isotherms and exponential decay curve fit
Authors: Behe, M.; Zimmerman, S.; Felsenfeld, G. Title: Changes in the Helical Repeat of Poly(dG-m5dC).Poly(dG-m5dC) and Poly(dG-dC).Poly(dG-dC) Associated with the B-Z Transition Source: Nature 293 (1981) 233-235 Description: autocorrelation analysis and fitting tracings to a single damped sinusoidal curve
Authors: Bunn, Paul A., Jr.; Edelson, Richard; Ford, Sharon S.; Shackney, Stanley E. Title: Patterns of Cell Proliferation and Cell Migration in the Sezary Syndrome Source: Blood 57 (1981) 452-463 Description: least squares curve fit
Authors: Campbell, M.C.W.; Hughes, A. Title: An Analytic, Gradient, Index Schematic Lens and Eye for the Rat Which Predicts Aberration for Finite Pupils Source: Vis. Res. 21 (1981) 1129-1148 Description: curve fitting
Authors: Carlisle, David M.; Blaschke, Terrence F. Title: Vitamin K1, Vitamin K1 Epoxide, and Warfarin Interrelationships in the Dog Source: Biochem. Pharm. 30 (1981) 2931-2936 Description: biexponential model for plasma concentration-time data
Authors: Cheng, Sheue-yann; Rakhit, Gupa; Erard, Francois; Robbins, Jacob; Chignell, Colin F. Title: A Spin Label Study of the Thyroid Hormone-Binding Sites in Human Plasma Thyroxine Transport Proteins Source: J. Biol. Chem. 256 (1981) 831-836 Description: least squares curve fit
Authors: Collins, Jerry M. Title: Inert Gas Exchange of Subcutaneous and Intraperitoneal Gas Pockets in Piglets Source: Resp. Physiol. 46 (1981) 391-404 Description: fitting odes
Authors: Cushman, S.W.; Noda, D.; Salens, L.B. Title: Adipose cell size-function relationships: insulin binding and degradation Source: Am. J. Physiol. Endo. Metab. 240 (1981) E166-E174
Authors: Czernichow, P.; Vandalem, J.L.; Hennen, G. Title: Transient Neonatal Hyperthyrotropinemia: A Factitious Syndrome Due to the Heterophilic Antibodies in the Plasma of Infants and Their Mothers Source: J. Clin. Endo. Metab. 53 (1981) 387-393 Description: Scatchard plots and analysis
Authors: Dower, Steven K.; DeLisi, Charles P.; Titus, Julie A.; Segal, David M. Title: Mechanisms of Binding of Multivalent Immune Complexes to Fc Receptors. 1. Equilibrium Binding Source: Biochem. 20 (1981) 6326-6334 Description: ligand binding model
Authors: Dower, Steven K.; Segal, David M. Title: C1q Binding to Antibody-Coated Cells: Predictions From a Simple Multivalent Binding Model Source: Mol. Immunol. 18 (1981) 823-829 Description: finding root of sixth-power equation.
Authors: Dower, Steven K.; Titus, Julie A.; DeLisi, Charles; Segal, David M. Title: Mechanism of Binding of Multivalent Immune Complexes to Fc Receptors. 2. Kinetics of Binding Source: Biochem. 20 (1981) 6335-6340 Description: biexponential model for dissociation reaction, bi-(1-exponential) model for association reactions.
Authors: Duffel, Michael W.; Jakoby, William B. Title: On the Mechanism of Aryl Sulfotransferase Source: J. Biol. Chem. 256 (1981) 11123-11127 Description: kinetics
Authors: Eldefrawi, M.E.; Warnick, J.E.; Schofield, G.G.; Albuquerque, E.X.; Eldefrawi, A.T. Title: Interaction of impramine with the ionic channel of the acetylcholine receptor of motor end plate and electric organ Source: Biochem. Pharm. 30 (1981) 1391-1394
Authors: French, Robert J.; Shoukimas, Jonathan J. Title: Blockage of Squid Axon Potassium Conductance by Internal Tetra-N-Alkylammonium Ions of Various Sizes Source: Biophys. J. 34 (1981) 271-291 Description: analysis and curve-fitting
Authors: Gangji, D.; Poplack, D.G.; Schwarde, J.; Wood, J.H.; Strong, J.M. Title: Misonidazole blood and cerebrospinal fluid kinetics in monkeys following intravenous and intrathecal administration Source: Eur. J. Cancer 17 (1981) 29-34
Authors: Gladner, J.A.; Lewis, M.S.; Chung, S.I. Title: Molecular properties of lamprey fibrinogen Source: J. Biol. Chem. 256 (1981) 1772-1781
Authors: Green, F.J.; Lavelle, K.J.; Aronoff, G.R.; Vander Zanden, J.; Brier, G.L. Title: Management of Amkacin Overdose Source: Am. J. Kid. Dis. 1 (1981) 110-112 Description: biexponential decay model
Authors: Holford, Nicholas H.G.; Coates, Peter E.; Guentert, Theodore W.; Riegelman, Sidney; Sheiner, Lewis B. Title: The Effect of Quinidine and its Metabolites on the Electrocardiogram and Systolic Time Intervals: Concentration-Effect Relationships Source: Br. J. Clin. Pharm. 11 (1981) 187-195 Description: 2-compartment model of plama quinidine concentration data
Authors: Ihde, Daniel C.; Dutcher, John S.; Young, Robert C.; Cordes, Rosemarie S.; Barlock, Audrey L.; Hubbard, Susan M.; Jones, Roy B.; Boyd, Michael R. Title: Phase I Trial of Pentamethylmelamine: A Clinical and Pharmacologic Study Source: Canc. Treat. Rpts. 65 (1981) 753-762 Description: 2- and 3-compartment models
Authors: Kaiser, B.A.; Potter, D.E.; Bryant, R.E.; Vreman, H.J.; Weiner, M.W. Title: Acid-base changes and acetate metabolism during routine and high-efficiency hemodialysis in children Source: Kidney Int. 19 (1981) 70-79
Authors: Karpetsky, Timothy P.; Shriver, Kren K.; Levy, Carl C. Title: Poly(adenylic acid) in Small Amounts, Free or Covalently Linked to Substrate, Protects RNA from Hydrolysis by Ribonuclease Source: Biochem. J. 193 (1981) 311-324 Description: curve-fit Michaelis-Menten equation
Authors: Kates, Robert E.; Keefe, Deborah L.D.; Schwarz, Janice; Harapat, Sandra; Kirsten, Edward B.; Harrison, Donald C. Title: Verapamil Disposition Kinetics in Chronic Atrial Fibrilation Source: Clin. Pharm. Ther. 30 (1981) 44-51 Description: 3-compartment model
Authors: Kelley, J.A.; Chong, E.D.S. Title: Reverse Phase HPLC Determination of Azq in Biological Fluids Source: J. Liq. Chrom. 4 (1981) 1855-1867
Authors: Landrum, P.F.; Crosby, D.G. Title: The Disposition of p-Nitroanisole by the Sea Urchin, Strongylocentrotus purpuratus Source: Ecotox. and Env. Safety 5 (1981) 225-239 Description: 2-compartment model
Authors: Marini, M.A.; Martin, C.J.; Forlani, L. Title: Analysis of the Potentiometric Titration of Reduced Horse Heart Cytochrome c Source: Biopolymers 20 (1981) 2243-2252 Description: fit pK ionization constants
Authors: Marini, M.A.; Martin, C.J.; Berger. R.L.; Forlani, L. Title: Analysis of the ionization constants and heats of ionization of reduced and oxidized horse heart cytochrome c Source: Biopolymers 20 (1981) 2253-2261
Authors: McHale, A.; Coughlan, M.P. Title: The cellulolytic system of Talaromyces emersonii. Purification and characterization of the extracellular and intracellular beta-glucosidases Source: Biochim. Biophys. Acta-Enzymology (1981) 152-159
Authors: Morris, Catherine; Lecar, Harold Title: Voltage Oscillations in the Barnacle Giant Muscle Fiber Source: Biophys. J. 35 (1981) 193-213 Description: Hodgkin-Huxley equations
Authors: Nagainis, Monica Palcic; Pu, Wenshi; Cheng, Behling; Taylor, Keith E.; Schmidt, Donald E., Jr. Title: Effects of pH and Sulfhydryl Specific Reagents on 4-Fumarylacetoacetate Fumarylhydrolase Source: Biochim. Biophys. Acta-Enzymology 657 (1981) 203-211 Description: pKa values from fitting log V vs ph curves
Authors: Ohata, M.; Fredericks, W.R.; Sundaram, U.; Rapoport, S.I. Title: Effects of Immobilization Stress on Regional Cerebral Blood Flow in the Conscious Rat Source: J. Cereb. Bl. Fl. 1 (1981) 187-194 Description: rising arterial whole blood concentration of 14-C-iodoantipyrine measured during intravenous infusion plotted vs time and fit to biexponential model, brain concentration fit to more complicated model involving exponentials.
Authors: Ohata, M.; Sundaram, U.; Fredericks, W.R.; London, E.D.; Rapoport, S.I. Title: Regional Cerebral Blood Flow During Development and Ageing of the Rat Brain Source: Brain 104 (1981) 319-332 Description: least squares fit of brain concentration data
Authors: Pang, K. Sandy; Koster, Henk; Halsema, Ina C.M.; Scholtens, Egbert; Mulder, Gerard J. Title: Aberrant Pharmacokinetics of Harmol in the Perfused Rat Liver Preparation: Sulfate and Glucuronide Conjugations Source: J. Pharm. Exp. 219 (1981) 134-140 Description: Michaelis-Menten equation
Authors: Parker, Diana S.; Davis, Austine; Taniuchi, Hiroshi Title: Further Study of the Conformation of Nuclease-(1-126) in Relation to Intrinsic Enzymatic Activity Source: J. Biol. Chem. 256 (1981) 4557-4569 Description: modified Lineweaver Burk equation
Authors: Parr, Gary R.; Taniuchi, Hiroshi Title: Ordered Complexes of Cytochrome c Fragments Source: J. Biol. Chem. 256 (1981) 125-132 Description: curve fit relaxation times vs. concentration
Authors: Parsegian, V. Adrian; Weiss, George H. Title: Spectroscopic Parameters for Computation of van der Waals Forces Source: J. Coll. Int. Sci. 81 (1981) 285-289 Description: fit e-prime and e-double prime in Kramers-Kronig relation.
Authors: Pincus, M.R.; DeLisi, C.; Rendell, M. Title: Ligand binding to multiple equivalent sites with steric hindrance Source: Biochim. Biophys. Acta-General Subjects 675 (1981) 392-396
Authors: Pretorius, Harold T.; Nandi, Pradip K.; Lippoldt, Roland E.; Johnson, Michael L.; Keen, James H.; Pastan, Ira; Edelhoch, Harold E. Title: Molecular Characterization of Human Clathrin Source: Biochem. 20 (1981) 2777-2782 Description: sedimentation equilibrium data analysis
Authors: Roberts, R.K.; Grice, J.; Wood, L.; Petroff, V.; McGuffie, C. Title: Cimetidine Impairs the Elimination of Theophylline and Antipyrine Source: Gastroent. 81 (1981) 19-21 Description: area under curve, two tailed t-test
Authors: Ross-Lee, L.M.; Eadie, M. J.; Hooper, W.D.; Bochner, F. Title: Single-Dose Pharmacokinetics of Metoclopramide Source: Eur. J. Clin. Pharm. 20 (1981) 465-471 Description: bi- and tri-exponential model
Authors: Sawhney, Vinod K.; Gregory, Peter B.; Swezey, Sarah E.; Blaschke, Terrence Title: Furosemide Disposition in Cirrhotic Patients Source: Gastroent. 81 (1981) 1012-1016 Description: biexponential model of plasma concentration data
Authors: Shindo, H.; Wooten, J.B.; Zimmerman, S.B. Title: Geometry of the Phosphodiester Backbone in the A Form of Desoxyribonucleic Acid Determined by Phosphorous-31 Nuclear Magnetic Resonance Spectroscopy Source: Biochem. 20 (1981) 745-750
Authors: Shoemaker, D.D.; Ayers, O.C.; D'Anna, M.E.; Cysyk, R.L. Title: Studies on the disposition of 2,3 dihydro-1H- imidazo[1,2-b]pyrazole in rodents Source: Eur. J. Cancer 17 (1981) 391-396
Authors: Sligo, Jennifer H.; Charles, Bruce G.; Ravenscroft, Peter J. Title: Oral Bioavailability of Theophylline from Hydroalcoholic and Alcohol-free Preparations Source: Med. J. Austr. 2 (1981) 410-411 Description: biexponential function plasma conc. of theophylline
Authors: Smith, M.T.; Eadie, M.J.; O'Rourke Brophy, T. Title: The pharmacokinetics of midazolam in man Source: Eur. J. Clin. Pharm. 19 (1981) 271-278
Authors: Swann, Alan C.; Albers, R. Wayne Title: Temperature Effects on Cation Affinities of the (Na+,K+)-ATPase of Mammalian Brain Source: Biochim. Biophys. Acta 644 (1981) 36-40 Description: parameters of equations used to fit experimental data
Authors: Titus, Julie A.; Sharrow, Susan O.; Connolly, Janet M.; Segal, David M. Title: Fc (IgG) Receptor Distribution in Homogeneous and Heterogeneous Cell Populations by Flow Microfluorometry Source: PNAS 78 (1981) 519-523 Description: linear regression of mean fluorescence vs IgG subunits bound per cell
Authors: Vavra, K.J.; Pederson, D.S.; Gorovsky, M.A. Title: Nuclease sensitivity of chromatin containing active genes: kinetic analyses utilizing continuous elution of digestion products from an ultra filtration cell Source: Nucleic Acids Res. 9 (1981) 5825-5844
Authors: Woolley, Paul V., III; Luc, Phuong Van T.; Rahman, Aquilur; Korsmeyer, Susan J.; Smith, Frederick P.; Schein, Philip S. Title: Phase I Trial and Clinical Pharmacology of 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea Source: Canc. Res. 41 (1981) 3896-3900 Description: post-infusion data fit to 2-compartment model
Authors: Aronoff, George R.; Szwed, James J.; Nelson, Robert L.; Maneus, Edwin L.; Kleit, Stuart A. Title: Hypoxanthine-Arabinoside Pharmacokinetics After Adenine Arabinoside Administration to a Patient with Renal Failure Source: Antimicrob. Ag. and Chem. 18 (1980) 212-214 Description: plasma concentration- time data fit to multi-exponential decay model
Authors: Bina, Minou; Sturtevant, Julian M.; Stein, Arnold Title: Stability of DNA in Nucleosomes Source: PNAS 77 (1980) 4044-4047 Description: excess heat capacity vs temp in degrees C fit to sum of Gaussians.
Authors: Bunow, B. Title: Cellular enzymology: The steady-state kinetics of compartmentalized enzymes Source: J. Theor. Biol. (1980) 611-627
Authors: Chikira, Makato; Kon, Hideo; Smith, Kevin M. Title: Concentration- and Solvent-Dependent Electron Spin Resonance Signals and Dimer Formation of High-Spin Iron (III) Porphyrins Source: JCS Dalton (1980) 526-534 Description: calculation and simulation of dimer esr spectra
Authors: Choie, David D.; del Campo, Anthony A.; Guarino, Anthony M. Title: Subcellular Localization of cis-Dichlorodiammineplatinum (II) in Rat Kidney and Liver Source: Toxicol. and Appl. Pharm. 55 (1980) 245-252 Description: estimate half-life of tissue platinum in kidney and liver
Authors: Cole, K.S. Title: Digital operations can be deceptive. Squid giant axon membrane Source: Biophys. J. 31 (1980) 433-434
Authors: Crouch, Thomas H.; Klee, Claude B. Title: Positive Cooperative Binding of Calcium to Bovine Brain Calmodulin Source: Biochem. 19 (1980) 3692-3698 Description: ultracentrifuge data analysis
Authors: Davies, P.J.A.; Wallach, D.; Willingham, M.; Pastan, I.; Lewis, M.S. Title: Self-Association of Chicken Gizzard Filamin and Heavy Merofilamin Source: Biochem. 19 (1980) 1366-1372
Authors: DeLisi, C.; Boyle, M.; Borros, T. Title: Analysis of the colloid osmotic step of complement- mediated immune hemolysis Source: J. Immunol. 125 (1980) 2055-2062
Authors: Dubois, Michel; Sato, Susumu; Lees, David E.; Bull, Joan M.; Smith, Rosalie; White, Billy G.; Moore, Henry; Macnamara, Thomas E. Title: Electroencephalographic Changes During Whole Body Hyperthermia in Humans Source: EEG and Clin. Neurophys. 50 (1980) 486-495 Description: 3D net graphics of spectral intensity over duration of hypothermia
Authors: Dutcher, John S.; Jones, Roy B.; Boyd, Michael R. Title: A Sensitive and Specific Assay for Pentamethylmelamine in Plasma: Applicability to Clinical Studies Source: Canc. Treat. Rpts. 64 (1980) 99-104 Description: 2-compartment model
Authors: Eldefrawi, M.E.; Eldefrawi, A.T.; Aronstam, R.S.; Maleque, M.A.; Warnick, J.E.; Albuquerque, E.X. Title: [3H] phencyclidine: a probe for the ionic channel of the nicotinic receptor Source: PNAS 77 (1980) 7458-7462 Description: nonlinear least squares regression
Authors: Erlichman, Charles; Strong, John M.; Chabner, Bruce A. Title: Application of a Simple Competitive Protein-Binding Assay Technique to the Pharmacokinetics of N-(Phosphonacetyl)-L-Aspartate in Humans Source: Canc. Res. 40 (1980) 1902-1906 Description: Scatchard analysis, 2 compartment model
Authors: Gandour, R.D.; Coyne, M.; Stella, V.J.; Schowen, R.L. Title: Proton Inventory of Phthalic Anhydride Hydrolysis. Comments on Analysis of Proton-Inventory Data Source: J. Org. Chem. 45 (1980) 1733-1737
Authors: Giacomini, Kathleen M.; Giacomini, John C.; Swezey, Sarah E.; Harrison, Donald C.; Nelson, Wendel L.; Burke, Terrence R., Jr.; Blaschke, Terrence Title: The Stereoselective Disposition of Disopyramide in the Dog Source: J. Cardiovasc. Pharm. 2 (1980) 825-832 Description: 2 compartment model, clearance rates
Authors: Goldberg, Itzhak D.; Stemerman, Michael B.; Ransil, Bernard J.; Fuhro, Robert L. Title: In Vivo Aortic Muscle Cell Growth Kinetics Source: Circ. Res. 47 (1980) 182-189 Description: intimal growth curves fit to appropriate function
Authors: Gorman, Jeffrey J.; Folk, J.E. Title: Structural Features of Glutamine Substrates for Human Plasma Factor XIIIa (Activated Blood Coagulation Factor XIII) Source: J. Biol. Chem. 255 (1980) 419-427 Description: Michaelis-Menten equation
Authors: Graves, S.W.; Fox, J.A.; Babior, B.M. Title: Deamination of 2-aminopropanol by Ethanolamine Ammonia- lyase, an Ado Cbl-requiring enzyme. Kinetics and Isotope Effects for the R and S Enantiomers of the Substrate Source: Biochem. 19 (1980) 3630-3633
Authors: Greco, William R.; Hakala, Marie T. Title: Cellular Pharmacokinetics of Lipophilic Diamino Pyrimidine Antifolates Source: J. Pharm. Exp. 212 (1980) 39-46 Description: plasma concentration curves fit to mono- or bi-exponential decay curves, Michaelis Menten equation
Authors: Greco, William R.; Hakala, Marie T. Title: Biochemical Pharmacology of Lipophilic Diaminopyrimidine Antifolates in Mouse and Human Cells in Vitro Source: Mol. Pharm. 18 (1980) 521-528 Description: nonlinear regression
Authors: Grouse, L.D.; Schrier, B.K.; Letendre, C.H.; Zubairi, M.Y.; Nelson, P.G. Title: Neuroblastoma differentiation involves both the disappearance of old and the appearance of new poly (A)+ messenger RNA sequences in polyribosomes Source: J. Biol. Chem. 255 (1980) 3871-3877
Authors: Grossman, Z.; Asofsky, R.; DeLisi, C. Title: The dynamics of antibody secreting cell production: regulation of growth and oscillations in the response to T-independent antigens Source: J. Theor. Biol. 84 (1980) 49-92
Authors: Gullo, John J.; Litterst, Charles L.; Maguire, Patrick J.; Sikic, Branimir I.; Hoth, Daniel F.; Woolley, Paul V., III Title: Pharmacokinetics and Protein Binding of cis-Dichlorodiammine Platinum (II) Administered as a One Hour or as a Twenty Hour Infusion Source: Canc. Chem. Pharm. 5 (1980) 21-26 Description: 1 and 2 compartment models
Authors: Guttman, Rita; Lewis, Stephen; Rinzel, John Title: Control of Repetitive Firing in Squid Axon Membrane as a Model for a Neuroneoscillator Source: J. Physiol. 305 (1980) 377-395 Description: transient trajectories computed using differential equation solver
Authors: Hemmings, B.A. Title: Purification and properties of the phospho and dephospho forms of yeast NAD-dependent glutamate dehydrogenase Source: J. Biol. Chem. 255 (1980) 7925-7932
Authors: Hobbs, Ann S.; Albers, R. Wayne; Froehlich, Jeffrey P. Title: Potassium-Induced Changes in Phosphorylation and Dephosphorylation of (Na+ K+)-ATPase Observed in the Transient State Source: J. Biol. Chem. 255 (1980) 3395-3402 Description: curve fitting.
Authors: Hobbs, Ann S.; Froehlich, Jeffrey P.; Albers, R. Wayne Title: Inhibition by Vanadate of the Reactions Catalyzed by the (Na+ K+)-Stimulated ATPase Source: J. Biol. Chem. 255 (1980) 5724-5727 Description: single exponential fits of phosphorylation of (Na+ K+)-ATPase after equilibration with various concentrations of vanadate vs time.
Authors: Hunston, D.L.; Zakin, J.L. Title: Flow-Assisted Degradation in Dilute Polystyrene Solutions Source: Polymer Eng. Sci. 20 (1980) 517-523 Description: loss of drag reduction through mechanical degradation modeled by exponential function.
Authors: Ikeda, S.R.; Aronstam, R.S.; Eldefrawi, M.E. Title: Nature of regional and chemically-induced differences in the binding properties of muscarinic acetylcholine receptors from rat brain Source: Neuropharm. 19 (1980) 575-585
Authors: Jackson, Meyer B.; Berkowitz, Steven A. Title: Nucleation and the Kinetics of Microtubule Assembly Source: PNAS 77 (1980) 7302-7305 Description: fit thermodynamic parameters in system of odes
Authors: Johnson, Michael L.; Lippoldt, Roland E.; Gershengorn, Marvin C.; Robbins, Jacob; Edelhoch, Harold Title: Molecular Transitions of Human Thyroxine-Binding Globulin Source: Arch. Biochem. Biophys. 200 (1980) 288-295 Description: bi-exponential decay model
Authors: Karpetsky, Timothy; Shriver, Kren K.; Levy, Carl C. Title: Covalent Linkage of Poly(A) to RNA Produces a Molecule Altered in Both Structure and Susceptibility to Ribonuclease-Mediated Hydrolysis Source: J. Biol. Chem. 255 (1980) 2713-2721 Description: thermodynamic parameters-standard enthalpies and entropies, experimental results for melting various polynucleotides, measure absorbance at 260nm vs reciprocal of temperature in degrees K.
Authors: Kates, Robert E.; Jaillon, Patrice Title: A Model to Describe Myocaridal Drug Disposition in the Dog Source: J. Pharm. Exp. 214 (1980) 31-36 Description: 3 compartment model, differential equations
Authors: Kates, Robert E.; Jaillon, Patrice; Rubenson, David S.; Winkle, Roger A. Title: Intravenous N-Acetylprocainamide Disposition Kinetics in Coronary Artery Disease Source: Clin. Pharm. Ther. 28 (1980) 52-57 Description: 3 compartment model
Authors: Keller, Charles A.; Doherty, Richard A. Title: Lead and Calcium Distributions in Blood, Plasma, and Milk of the Lactating Mouse Source: J. Lab. Clin. Med. 95 (1980) 81-89 Description: 2- and 3-compartment exponential models
Authors: Keller, Charles A.; Doherty, Richard A. Title: Distribution and Excretion of Lead in Young and Adult Female Mice Source: Env. Res. 21 (1980) 217-228 Description: whole body retention fit to tri-exponential decay, linear regression
Authors: Kris-Etherton, P.M.; Cooper, A.D. Title: Studies on the Etiology of the Hyperlipemia in Rats Fed an Atherogenic Diet Source: J. Lipid Res. 21 (1980) 435-442 Description: fit linear, exponential models
Authors: Land, Charles E.; Boice, John D.; Shore, Ray E.; Norman, James E.; Tokunaga, M. Title: Breast Cancer Risk from Low-Dose Exposures to Ionizing Radiation: Results of Parallel Analysis of Three Exposed Populations of Women Source: JNCI 65 (1980) 353-376 Description: fit dose-response data to product of quadratic and gaussian
Authors: LeBlond, D.J.; Ashendel, C.L.; Wood, W.A. Title: Determination of enzyme kinetic parameters by continuous addition of substrate to a single reaction mixture and analysis by a tangent- slope procedure: I. Analysis of the method using computed progress curves Source: Anal. Biochem. 104 (1980) 355-369
Authors: Levine, R.F.; Bunn, P.A., Jr.; Hazzard, K.C.; Schlan, M.L. Title: Flow Cytometric Analysis of Megakaryocyte Ploidy. Comparison with Feulgen Microdensitometry and Discovery that 8N is the Dominant Ploidy Class in Guinea Pig and Monkey Marrow Source: Blood 56 (1980) 210-217 Description: fit gaussian to experimental frequency distribution
Authors: Levy, Carl C.; Karpetsky, Timothy Title: The Purification and Properties of Chicken Liver RNase Source: J. Biol. Chem. 255 (1980) 2153-2159 Description: values of kinetic constants were obtained by fitting reciprocal of enzyme activity equation to data.
Authors: Litterst, Charles L. Title: In Vitro Hepatic Drug Metabolism and Microsomal Enzyme Induction in Genetically Obese Rats Source: Biochem. Pharm. 29 (1980) 289-296 Description: linear regression of enzyme specific activity vs. substrate concentration
Authors: Marini, M.A.; Marti, G.E.; Berger, R.L.; Martin, C.J. Title: Potentiometric Titration Curves of Oxidized and Reduced Horse Heart Cytochrome c Source: Biopolymers 19 (1980) 885-898 Description: titration curves
Authors: Martin, C.J.; Sreenathan, B.R.; Marini, M.A. Title: Differential equation systems for heat-loss corrections of isoperibolic microcalorimeters: A computer-modeling approach Source: Biopolymers 19 (1980) 2047-2065
Authors: Mendelson, Carole R.; Johnston, John M. Title: Estrogen Binding in Human Fetal Lung Tissue Cytosol Source: Endocrin. 106 (1980) 368-374 Description: fit binding affinity and conc. of binding sites
Authors: Milne, G.W.A.; Heller, S.R. Title: NIH/EPA Chemical Information System Source: J. Chem. Inf. Comput. Sci. 20 (1980) 204-211 Description: MLAB as part of chemical information system.
Authors: Nandi, Pradip K.; Pretorius, Harold T.; Lippoldt, Roland E.; Johnson, Michael L.; Edelhoch, Harold Title: Molecular Properties of the Reassembled Coat Protein of Coated Vesicles Source: Biochem. 19 (1980) 5917-5921 Description: ultracentrifuge-sedimentation equilibrium data analysis
Authors: Nelson, R.L.; Dyke, R.W.; Root, M.A. Title: Comparative Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Patients with Cancer Source: Canc. Treat. Revs. 7 supplement (1980) 17-24 Description: 3 compartment open model, differential equation
Authors: Newton, Carol M. Title: Biomathematics in Oncology: Modeling of Cellular Systems Source: Ann. Rev. Biophys. Bioeng. 9 (1980) 541-579 Description: review of computer programs
Authors: Ohno, K.; Chiueh, C.C.; Burns, E.M.; Pettigrew, K.D.; Rapoport, S.I. Title: Cerebrovascular Integrity in Protein-Deprived Rats Source: Brain Res. Bull. 5 (1980) 251-255 Description: fit brain concentration data with exponential function
Authors: Osborne, J.C.; Powell, G.M.; Brewer, H.B. Title: Analysis of the mixed association between human apolipoproteins A-I and A-II in aqueous solution Source: Biochim. Biophys. Acta-Molec. Cell Bio. (1980) 559-571
Authors: Pang, K. Sandy; Gillette, James R. Title: Metabolite Pharmacokinetics: Methods for Simultaneous Estimates of Elimination Rate Constants of a Drug and its Metabolite Source: Drug Metab. 8 (1980) 39-43 Description: simulation of decay of a precursor and its metabolite
Authors: Parr, Gary R.; Taniuchi, Hiroshi Title: An Investigation of Ordered Complex Formation with Chemically Modified Fragments of Cytochrome c Source: J. Biol. Chem. 255 (1980) 2616-2623 Description: dimerization equilibrium constants from Pasternack equation.
Authors: Poduslo, J.F.; Rodbard, D. Title: Molecular weight estimation using sodium dodecyl sulfate-pore gradient electrophoresis Source: Anal. Biochem. 101 (1980) 394-406
Authors: Rafferty, C.N.; Muellenberg, C.G.; Shichi, H. Title: Tryptophan in Bovine Rhodopsin: its Content, Spectral Properties, and Environment Source: Biochem. 19 (1980) 2145-2151
Authors: Rapoport, S.I.; Klee, W.A.; Pettigrew, K.D.; Ohno, K. Title: Entry of Opioid Peptides into the Central Nervous System Source: Science 207 (1980) 84-86 Description: fit plasma and brain concentrations vs time to exponential models.
Authors: Roberts, Rowena L.; Szaniszlo, Paul J. Title: Yeast-Phase Cell Cycle of the Polymorphic Fungus Wangiella dermatitidis Source: J. Bacteriol. 144 (1980) 721-731 Description: fit sum of gaussians to experimental frequency distribution
Authors: Rubin, P.; Jackson, G.; Blaschke, T. Title: Studies on the Clinical Pharmacology of Prazosin. II. The Influence of Indomethacin and of Propranolol on the Action and Disposition of Prazosin Source: Br. J. Clin. Pharm. 10 (1980) 33-39 Description: fit plasma concentration-time data to monoexponential decay
Authors: Sabol, S.L. Title: Storage and secretion of beta-endorphin and related peptides by mouse pituitary tumor cells: Regulation by glucocorticoids Source: Arch. Biochem. Biophys. 203 (1980) 37-48
Authors: Shindo, H.; Wooten, J.B.; Pheiffer, B.H.; Zimmerman, S.B. Title: Nonuniform Backbone Conformation of Deoxyribonucleic Acid Indicated by Phosphorous-31 Nuclear Magnetic Resonance Chemical Shift Anisotropy Source: Biochem. 19 (1980) 518-526
Authors: Siddic, Zahid H.; Mimnaugh, Edward G.; Trush, Michael A.; Gram, Theodore E. Title: The Effect of Vitamin A Deficiency on Hepatic, Renal and Pulmonary Glutathione S-Transferase Activities in the Rat Source: Biochem. J. 188 (1980) 889-893 Description: fit Michaelis Menten equation, Km, Vmax
Authors: Silbergeld, E.K.; Hruska, R.E.; Miller, L.P.; Eng, N. Title: Effects of Lead In Vivo and In Vitro on GABAergic Neurochemistry Source: J. Neurochem. 34 (1980) 1712-1718
Authors: Strobl, Jeannine; Monaco, Marie E.; Lippman, Marc E. Title: The Role of Intracellular Equilibria and the Effects of Antiestrogens on Estrogen-Receptor Dissociation Kinetics from Perfused Cultures of Human Breast Cancer Cells Source: Endocrin. 107 (1980) 450-460 Description: fit dissociation curves to mono- and bi-phasic exponential decay functions
Authors: Sumida, Michihiro; Wang, Taitzer; Schwartz, Arnold; Younkin, Casey; Froehlich, Jeffrey P. Title: The Ca2+-ATPase Partial Reactions in Cardiac and Skeletal Sarcoplasmic Reticulum Source: J. Biol. Chem. 255 (1980) 1497-1503 Description: fit to sum of exponentially decreasing functions
Authors: Swann, A.C.; Albers, R. Wayne Title: (Na+,K+)-ATPase of Mammalian Brain: Differential Effects on Cation Affinities of Phosphorylation by ATP and Acetylphosphate Source: Arch. Biochem. Biophys. 203 (1980) 422-427 Description: computer simulations.
Authors: Swann, Alan C.; Marini, James L.; Sheard, Michael H.; Maas, James W. Title: Effects of Chronic Dietary Lithium on Activity and Regulation of (Na+,K+)-Adenosine Triphosphate in Rat Brain Source: Biochem. Pharm. 29 (1980) 2819-2823 Description: fit Hill coefficients.
Authors: Thakur, Ajit; Munson, Peter J.; Hunston, Donald L.; Rodbard, David Title: Characterization of Ligand-Binding Systems by Continuous Affinity Distributions of Arbitrary Shape Source: Anal. Biochem. 103 (1980) 240-254 Description: curve fitting.
Authors: Tinker, David O.; Low, Rosita; Lucassen, Maria Title: Heterogenous Catalysis by Phospholipase A2: Mechanism of Hydrolysis of Gel Phase Phosphatidylcholine Source: Can. J. Biochem. 58 (1980) 898-912 Description: fitting of experimental data to kinetic models using MLAB, three models.
Authors: Trepman, E.; Chen, R.F. Title: Fluorescence stopped-flow study of the o-phthaldialdehyde reaction Source: Arch. Biochem. Biophys. 204 (1980) 524-532
Authors: Turner, N.H.; Murday, J.S.; Rameker, D.E. Title: Quantitative Determination of Surface Composition of Sulfur Bearing Anion Mixtures by Auger Electron Spectroscopy Source: Anal. Chem. 52 (1980) 84-92 Description: fit linear combination of lineshape functions
Authors: Upton, R.A.; Thiercelin, J.F.; Guentert, T.W.; Sansom, L.; Powell, J.R.; Coates, P.E., Riegelman, S. Title: Evaluation of the absorption from some commercial sustained-release theophylline products Source: J. Pharm. Biopharm. 8 (1980) 131-149
Authors: Vallerga, S.; Covacci, R.; Pottala, E.W. Title: Artificial Cone Repsonses: A Computer-Driven Hardware Model Source: Vis. Res. 20 (1980) 453-457 Description: reconstruction of cone responses as odes
Authors: Vreman, Hendrik J.; Assomul, Vinod M.; Kaiser, Bruce A.; Blaschke, Terrance F.; Weiner, Michael W. Title: Acetate Metabolism and Acid-Base Homeostasis During Hemodialysis- Influence of Dialyzer Efficiency and Rate of Acetate Metabolism Source: Kidney Int. 18 (1980) S12-S16 Description: 1st order and nonlinear compartmental models fit to plasma acetate concentrations
Authors: Zelenka, Peggy S. Title: Changes in Phosphatidylinositol Metabolism During Differentiation of Lens Epithelial Cells into Lens Fiber Cells in the Embryonic Chick Source: J. Biol. Chem. 255 (1980) 1296-1300 Description: ode model in which derivative of radioactivity counts is proportional to specific activity of precursor and radioactivity.
Authors: Zweier, J.L. Title: Electron paramagnetic resonance studies of the binding of copper to conalbumin. Probes of the structure and properties of the metal and anion binding sites Source: J. Biol. Chem. 255 (1980) 2782-2789
Authors: Abramson, J.J.; Shamoo, A.E. Title: Anionic detergents as divalent cation ionophores across black lipid membranes Source: J. Membrane Biol. 50 (1979) 241-255
Authors: Baumann, Gerhard Title: Metabolic Clearance Rates of Isohormones of Human Growth Hormone in Man Source: J. Clin. Endo. Metab. 49 (1979) 495-499 Description: 2 and 3 compartment exponential models
Authors: Berg, G.G.; Miles, E.F. Title: Mechanisms of Inhibition of Active Transport ATPases by Mercurials Source: Chem. Biol. Int. 27 (1979) 199-219 Description: transformations, curve-fitting, plotting
Authors: Bina-Stein, Minou; Thoren, Marilyn; Salzman, Norman; Thomson, John A. Title: Rapid Sequence Determination of Late Simian Virus 40 16S mRNA Leader by Using Inhibitions of Reverse Transcriptase Source: PNAS 76 (1979) 731-735 Description: non-linear regression, mobilities of DNA markers were fitted to a polynomial
Authors: Bjornsson, Thorir D.; Meffin, Peter J.; Swezey, Sarah; Blaschke, Terrence F. Title: Clofibrate Displaces Warfarin from Plasma Proteins Source: J. Pharm. Exp. 210 (1979) 316-321 Description: best-fit of biexponential decay function
Authors: Bjornsson, Thorir D.; Meffin, Peter J.; Swezey, Sarah; Blaschke, Terrence F. Title: Effects of Clofibrate and Warfarin Alone and in Combination on the Disposition of Vitamin K Source: J. Pharm. Exp. 210 (1979) 322-326 Description: best-fit of biexponential decay function
Authors: Boice, J.D.; Land, C.E.; Shore, R.E.; Norman, J.E.; Tokunaga, M. Title: Risk of breast cancer following low-dose radiation exposure Source: Radiology 131 (1979) 589-597
Authors: Boobis, Susan W.; Chignell, Colin F. Title: Effect of Protein Concentration on the Binding of Drugs to Human Serum Albumin. I. Sulfadiazine, Salicylate, and Phenylbutazone Source: Biochem. Pharm. 28 (1979) 751-756 Description: Scatchard analysis
Authors: Bunow, Barry; Line, Bruce R.; Horton, Martha R.; Weiss, George H. Title: Regional Ventilatory Clearance by Xenon Scintigraphy: A Critical Evaluation of Two Estimation Procedures Source: J. Nucl. Med. 20 (1979) 703-710 Description: parameter estimation using curve-fitting
Authors: Butrimovitz, Gerald P.; Purdy, William C. Title: Resolution of Age-Dependent Reference Intervals: Polynomial Regression Methodology with Applicability to Plasma Zinc Levels in Childhood Population Source: Clin. Biochem. 12 (1979) 33-36 Description: polynomial regression
Authors: Chen, Betty; Chrambach, Andreas; Rodbard, David Title: Continuous Optical Scanning in Polyacrylamide Gel Electrophoresis: Estimation of the Apparent Diffusion Coefficient of Beta-Lactoglobulin B Source: Anal. Biochem. 97 (1979) 120-130 Description: non-linear least squares curve fit
Authors: Cheng, Sheue-yann; Morone, Stefania; Robbins, Jacob Title: Effect of Deglycosylation on the Binding and Immunoreactivity of Human Thyroxine-Binding Globulin Source: J. Biol. Chem. 254 (1979) 8830-8835 Description: Michaelis-Menten equation
Authors: Davis, Austine; Parr, Gary R.; Taniuchi, Hiroshi Title: A Kinetic Study of the Folding of Nuclease B. A Possible Precursor of Staphyloccocal Nuclease A Source: Biochim. Biophys. Acta 578 (1979) 505-510 Description: kinetic rate constants by curve-fitting
Authors: Di Chiro, Giovanni D.; Arimitsu, Tetsuo; Brooks, Rodney A.; Morganthaler, David G.; Johnston, Gerald S.; Jones, A. Eric; Keller, Mark R. Title: Computed Tomography Profiles of Periventricular Hypodensity in Hydrocephalus and Leukoencephalopathy Source: Radiology 130 (1979) 661-666 Description: curve fitting to piece-wise constant/exponential function
Authors: Edelhoch, Harold; Irace, Gaetano; Johnson, Michael L.; Michot, Jean Luc; Nunez, Jacques Title: The Effects of Thioureylene Compounds (Goitrogens) on Lactoperoxidase Activity Source: J. Biol. Chem. 254 (1979) 11822-11830 Description: fit data to odes.
Authors: Elchisak, M.A.; Polinsky, R.J.; Ebert, M.H.; Modlin, L.T.; Kopin, I.J. Title: Kinetics of Homovanillic Acid and Determination of its Production Rate in the Rhesus Monkey Source: Life Sci. 24 (1979) 1493-1502 Description: decline in serum concentration in time fit to polyexponential functions
Authors: Finbloom, D.S.; Plotz, P.H. Title: Studies of reticuloendothelial function in the mouse with model immune complexes: I. serum clearance and tissue uptake in normal C3H mice Source: J. Immunol. 123 (1979) 1594-1599
Authors: Finbloom, D.S.; Plotz, P.H. Title: Studies of reticuloendothelial function in the mouse with model immune complexes: II. serum clearance, tissue uptake, and reticuloendothelial saturation in NZB/W mice Source: J. Immunol. 123 (1979) 1600-1603
Authors: Ginder, Gordon D.; Wood, William I.; Felsenfeld, Gary Title: Isolation and Characterization of Recombinant Clones Containing the Chicken Adult beta-Globulin Gene Source: J. Biol. Chem. 254 (1979) 8099-8102 Description: least squares curve-fitting
Authors: Greco, William R.; Hakala, Marie T. Title: Evaluation of Methods for Estimating the Dissociation Constant of Tight Binding Enzyme Inhibitors Source: J. Biol. Chem. 254 (1979) 12104-12109 Description: MLAB used for study.
Authors: Grouse, L.D.; Letendre, C.H.; Schrier, B.K. Title: Sequence complexity and frequency distribution of poly [A]-containing message RNA sequences from the glioma cell line C6 Source: J. Neurochem. 33 (1979) 583-585
Authors: Guarino, A.M.; Arnold, S.T. Title: Xenobiotic Transport Mechanisms and Pharmacokinetics in the Dogfish Shark Source: Pesticide and Xenobiotic Metabolism in Aquatic Organisms, Chapter 15 (1979) pages 233-258, ACS Symposium Series, volume 99.
Authors: Heller, S.R.; Milne, G.W. Title: Use of the NIH-EPA Chemical Information System in Support of the Toxic Substances Control Act Source: Monitoring Toxic Substances, Chapter 16 (1979) pages 255-280. ACS Symposium Series, volume 94.
Authors: Hoffer, J.A.; Stein, R.B.; Gordon, T. Title: Differential Atrophy of Sensory and Motor Fibers Following Section of Cat Peripheral Nerves Source: Brain Res. 178 (1979) 347-361 Description: curve fit exponential plus constant function
Authors: Hruska, Robert E.; Kennedy, Shawn; Silbergeld, Ellen K. Title: Quantitative Aspects of Normal Locomotion in Rats Source: Life Sci. 25 (1979) 171-180 Description: curve fit quadratic and logarithmic functions
Authors: Jaillon, Patrice; Rubin, Peter; Yee, YinGail; Ball, Robert; Kates, Robert; Harrison, Donald; Blaschke, Terrence Title: Influence of Congestive Heart Failure on Prazosin Kinetics Source: Clin. Pharm. Ther. 25 (1979) 790-794 Description: blood prazosin conc-time fit to monexponential decay function
Authors: Jennrich, Robert I.; Ralston, Mary L. Title: Fitting Nonlinear Models to Data Source: Ann. Rev. Biophys. Bioeng. 8 (1979) 195-238 Description: review of curve-fitting programs
Authors: Klee, Claude B.; Crouch, Thomas H.; Krinks, Marie H. Title: Subunit Structure and Catalytic Properties of Bovine Brain Ca2+-Dependent Cyclic Nucleotide Phosphodiesterase Source: Biochem. 18 (1979) 722-729 Description: Michaelis Menten equation
Authors: Knott, Gary D. Title: MLAB - A Mathematical Modeling Tool Source: Comp. Meth. Prog. Biomed. 10 (1979) 271-280
Authors: Lafferman, J.A.; Silbergeld, E.K. Title: Erythrosin B inhibits dopamine transport in rat caudate synaptosomes Source: Science 205 (1979) 410-412
Authors: Land, Charles E.; McGregor, Douglas H. Title: Breast Cancer Incidence Among Atomic Bomb Survivors: Implication for Radiobiologic Risk at Low Doses Source: JNCI 62 (1979) 17-21 Description: curve-fit quadratic times gaussian
Authors: Liacouras, A.S.; Anderson, E.P. Title: Uridine-Cytidine Kinase IV. Kinetics of the Competition Between 5-Azacytidine and the Two Natural Substrates Source: Mol. Pharm. 15 (1979) 331-340 Description: modified michaelis-menten equation
Authors: Marimont, R.B.; Shapiro, M.B. Title: Nearest neighbor searches and the curse of dimensionality Source: IMA J. Appl. Math. 24 (1979) 59-70
Authors: Marino, D.F.; Wolfe, F.; Ingle, J.D. Title: Determination of Cobalt by Lophine Chemiluminescence Source: Anal. Chem. 51 (1979) 2051-2053
Authors: Meffin, P.J.; Robert, E.W.; Winkle, R.A.; Harapat, S.; Peters, F.A.; Harrison, D.C. Title: Role of concentration-dependent plasma protein binding in disopyramide disposition Source: J. Pharm. Biopharm. 7 (1979) 29-46
Authors: Michot, Jean Luc; Nunez, Jacques; Johnson, Michael L.; Irace, Gaetano; Edelhoch, Harold Title: Iodide Binding and Regulation of Lactoperoxidase Activity Toward Thyroid Goitrogens Source: J. Biol. Chem. 254 (1979) 2205-2209 Description: curve-fitting odes
Authors: Morrow, P.E.; Gibb, F.R.; Better, H.; Kilpper, R.W. Title: Pulmonary Retention of Neuron-Activated Coal Dust Source: Arch. Env. Health 34 (1979) 178-183 Description: curve-fit sum of exponentials
Authors: Neil, E. Andrew; Meffin, Peter J.; Gregory, Peter B.; Blaschke, Terrence F. Title: Enhanced Bioavailability and Decreased Clearance of Analgesics in Patients with Cirrhosis Source: Gastroent. 77 (1979) 96-102 Description: blood conc.-time data fit to biexponential decay function
Authors: Nelson, R.L.; Dyke, R.W.; Root, M.A. Title: Clinical Pharmacokinetics of Vindesine Source: Canc. Chem. Pharm. 2 (1979) 243-246 Description: fiting odes
Authors: Ohno, K.; Pettigrew, K.D.; Rapoport, S.I. Title: Local Cerebral Blood Flow in the Conscious Rat as Measured with 14-C-Antipyrine, 14-C-Iodoantipyrine, and 3-H-Nicotine Source: Stroke 10 (1979) 62-67 Description: 14-C-Antipyrine or 14-C-Iodoantipyrine in plasma vs. time, fit to triexponential model.
Authors: Pang, K.S.; Gillete, J.R. Title: Sequential first-pass elimination of a metabolite derived from a precursor Source: J. Pharm. Biopharm. 7 (1979) 275-290
Authors: Pang, K. Sandy; Stobl, Kristina; Gillette, James R. Title: A Method for the Estimation of the Fraction of a Precursor that is Converted to a Metabolite in Rat in Vivo with Phenacetin and Acetominophen Source: Drug Metab. 7 (1979) 366-372 Description: half-lives found by curve-fitting
Authors: Pesek, J.J.; Blair, B.A. Title: Determination of C8 and Heavier Molecular Weight Alkylbenzenes in Petroleum Source: Anal. Chem. 51 (1979) 2048-2050
Authors: Pollard, H.B; Shindo, H.; Creutz, C.E.;Pazoles, C.J.; Cohen, J.S. Title: Internal pH and state of ATP in adrenergic chromaffin granules determined by 31-P nuclear magnetic resonance spectroscopy Source: J. Biol. Chem. 254 (1979) 1170-1177
Authors: Raiford, D.S.; Fisk, C.L.; Becker, E.D. Title: Calibration of Methanol and Ethylene Glycol Nuclear Magnetic Resonance Thermometers Source: Anal. Chem. 51 (1979) 2050-2051
Authors: Rakhit, Gupa; Chignell, Colin F. Title: A Spin Label Study of Horseradish Peroxidase Source: Biochim. Biophys. Acta-Protein Struct. 580 (1979) 108-119 Description: curve-fitting and graphics
Authors: Rapoport, Stanley I.; Ohno, Kikuo; Pettigrew, Karen D. Title: Blood-Brain Barrier Permeability in Senescent Rats Source: J. Gerontol. 34 (1979) 162-169 Description: multiexponential decay curve fit for plasma concentration of 14-C, brain concentration fit to more complicated exponential function.
Authors: Rapoport, S.I.; Ohno, K.; Pettigrew, K.D. Title: Drug Entry Into Brain Source: Brain Res. 172 (1979) 354-359 Description: 3 or 4 term exponential function fit to plasma concentration data.
Authors: Rapoport, Stanley I.; Pettigrew, Karen D. Title: A Heterogenous, Pore-Vesicle Membrane Model for Protein Transfer from Blood to Cerebrospinal Fluid at the Choroid Plexus Source: Microvascular Research 18 (1979) 105-119 Description: permeability coefficient of a solute of radius, a, function of a, fit to data.
Authors: Reichstein, E.; Korn, E.D. Title: Acanthamoeba profilin: A protein of low molecular weight from Acanthamoeba castellanii that inhibits actin nucleation Source: J. Biol. Chem. 254 (1979) 6174-6179
Authors: Richman, Paul G.; Klee, Claude B. Title: Specific Perturbation by Ca2+ of Tyrosyl Residue 138 of Calmodulin Source: J. Biol. Chem. 254 (1979) 5372-5376 Description: Henderson-Hasselbach equations
Authors: Rubin, Peter; Yee, Yin-Gail; Anderson, Malcolm; Blaschke, Terrence Title: Prazosin First-Pass Metabolism and Hepatic Extraction in the Dog Source: J. Cardiovasc. Pharm. 1 (1979) 641-647 Description: fit biexponential function
Authors: Sabol, S.L.; Nirenberg, M. Title: Regulation of adenylate cyclase of neuroblastoma X glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alphareceptors Source: J. Biol. Chem. 254 (1979) 1913-1920
Authors: Sinha, B.K.; Chignell, C.F. Title: The synthesis and use of spin-labeled analogs of biotin in the study of avidin Source: Methods Enzym. 62 (1979) 295-308
Authors: Swann, Alan C.; Albers, R. Wayne Title: (Na+,K+)-Adenosine Triphosphate of Mammalian Brain Source: J. Biol. Chem. 254 (1979) 4540-4544 Description: curve-fitting, simulations
Authors: Tack, Brian F.; Morris, Sam C.; Prahl, James W. Title: Third Component of Human Complement: Structural Analysis of the Polypeptide Chains of C3 and C3b Source: Biochem. 18 (1979) 1497-1503 Description: ultracentrifuge data analysis, linear regression
Authors: Tanabe, K.; Bohn, E.W.; Wilson, S.H. Title: Steady State Kinetics of Mouse DNA Polymerase Beta Source: Biochem. 18 (1979) 3401-3406 Description: kinetic constants evaluated by curve-fitting
Authors: Thakur, Ajit K.; Rodbard, David Title: Graphical Aids to Interpretation of Scatchard Plots and Dose-Response Curves Source: J. Theor. Biol. 80 (1979) 383-403 Description: curve-fitting
Authors: Tinker, David O.; Wei, Jane Title: Heterogeneous Catalysis by Phospholipase A2: Formulation of a Kinetic Description of Surface Effects Source: Can. J. Biochem. 57 (1979) 97-106 Description: ode rate equations fit to data.
Authors: Williams, Leah A.; Piatigorsky, Joram Title: Comparative and Evolutionary Aspects of delta-Crystallin in the Vertebrate Lens Source: Eur. J. Biochem. 100 (1979) 349-357 Description: least squares fit
Authors: Adelman, William J.; French, Robert J. Title: Blocking of the Squid Axon Potassium Channel by External Caesium Ions Source: J. Physiol. 276 (1978) 13-25 Description: non linear least squares curve-fitting
Authors: Ahmad, F.; McPhie, P. Title: Thermodynamics of the Denaturation of Pespinogen by Urea Source: Biochem. 17 (1978) 241-246
Authors: Ahmad, F.; McPhie, P. Title: Spectrophotometric titration of phenolic groups of pepsin Source: Biochim. Biophys. Acta-Protein Struct. 537 (1978) 247-254
Authors: Allen, Larry M. Title: Comparison of Uptake and Binding of Two Epipodophyllotoxin Glucopyramosides, 4'-Demethyl Epipodophyllotoxin Thenylidene-Beta-D-Glucoside and 4'-Demethyl Epipodophyllotoxin Ethylidene-Beta-D-Glucoside, in the L1210 Leukemia Cell Source: Canc. Res. 38 (1978) 2549-2554 Description: kinetics of transport VM-26 and VP-16 using MLAB nonlinear least squares of efflux of VM26 and VP-16.
Authors: Auer, Henry E.; Thompson, Thomas N. Title: Actinomycin D-deoxynucleotide Interactions: Binding Isotherms at the Benzenoid and Quinoid Portions of the Drug Source: PNAS 75 (1978) 4729-4733 Description: curve-fitting
Authors: Berger, Robert L. Title: Some Problems Concerning Mixers and Detectors for Stopped Flow Kinetic Studies Source: Biophys. J. 24 (1978) 2-20 Description: determined correct rate constants to make kinetic data fit curve.
Authors: Bina-Stein, Minou Title: Folding of 140-Base Pair Length DNA by a Core of Arnine-Rich Histones Source: J. Biol. Chem. 253 (1978) 5213-5219 Description: digitized melt data analysis
Authors: Boone, R.F.; Moss, B. Title: Sequence complexity and relative abundance of vaccinia virus mRNA's synthesized in vivo and in vitro Source: J. Virol. 26 (1978) 554-569
Authors: Brigham, Brian A.; Bunn, Paul A.; Minna, John D.; Cohen, Martin H.; Ihde, Daniel C.; Shackney, Stanley E. Title: Growth Rates of Small Cell Bronchogenic Carcinomas Source: Cancer 42 (1978) 2880-2886 Description: fit tumor growth data to exponential model
Authors: Bunow, B. Title: Chemical reactions and membranes: A macroscopic basis for facilitated transport, chemiosmosis, and active transport. I: linear analysis Source: J. Theor. Biol. 75 (1978) 51-78
Authors: Bunow, B. Title: Chemical reactions and membranes: A macroscopic basis for active transport. II: non-linear aspects Source: J. Theor. Biol. 75 (1978) 79-96
Authors: Carnahan, J.E.; Jenner, E.L.; Wat, E.K.W. Title: Prevention of Ozone Injury to Plants by a New Protectant Chemical Source: Phytopathology 68 (1978) 1225-1229 Description: least squares fit of data to dose response function
Authors: Cigorraga, Selva B.; Dufau, Maria L.; Catt, Kevin J. Title: Regulation of Luteinizing Hormone Receptors and Steroidogenesis in Gonadotropin-desensitized Leydig Cells Source: J. Biol. Chem. 253 (1978) 4297-4304 Description: Scatchard analysis, solving odes
Authors: Coppola, Richard; Tabor, Richard; Buchsbaum, Monte S. Title: Signal to Noise Ratio and Response Variability Measurements in Single Trial Evoked Potentials Source: EEG and Clin. Neurophys. 44 (1978) 214-222 Description: curve-fitting and simulations
Authors: Darvey, Ivan G.; Walker, E. J. Title: A Procedure for Obtaining Initial Estimates of Parameters Appearing in Steady-State Rate or Equilibrium Binding Equations Source: Can. J. Biochem. 56 (1978) 697-701 Description: weighted least squares fit with continued fractions
Authors: Deibler, Gladys E.; Driscoll, Bernard F.; Kies, Marian W. Title: Immunochemical and Biochemical Studies Demonstrating the Identity of a Bovine Spinal Cord Protein (SCP) and a Basic Protein of Bovine Peripheral Myelin (BF) Source: J. Neurochem. 30 (1978) 401-412 Description: best fit analysis of CD curves
Authors: DeLean, A.; Munson, P.J.; Rodbard, D. Title: Simultaneous Analysis of Families of Sigmoidal Curves: Application to Bioassay, Radioligand Assay, and Physiological Dose-Response Curves Source: Am. J. Physiol. 235 (1978) E97-E102 Description: fit logistic, doesn't use MLAB
Authors: Dufau, Maria L.; Horner, Kathleen A.; Hayashi, Keiko; Tsuruhara, Tsuneo; Conn, P. Michael; Catt, Kevin J. Title: Actions of Choleragen and Gonadotropin in Isolated Leydig Cells Source: J. Biol. Chem. 253 (1978) 3721-3729 Description: Scatchard analysis, fitting odes
Authors: Eaton, William A.; Hanson, Louise Karle; Stephens, P.J.; Sutherland, J.C.; Dunn, J.B.R. Title: Optical Spectra of Oxy- and Deoxyhemoglobin Source: JACS 100 (1978) 4991-5003 Description: fit spectra to sum of gaussians
Authors: Elchisak, M.A.; Polinsky, R.J.; Ebert, M.H.; Powers, K.J.; Kopin, Irwin J. Title: Contribution of Plasma Homovanillic Acid (HVA) to Urine and Cerebrospinal Fluid HVA in the Monkey and its Pharmacokinetic Disposition Source: Life Sci. 23 (1978) 2339-2347 Description: nonlinear least squares fitting, bi-exponential function
Authors: Emlen, Wodruff; Mannik, Mart Title: Kinetics and Mechanisms for Removal of Circulating Single Stranded DNA in Mice Source: J. Exp. Med. 147 (1978) 684-699 Description: clearance kinetics curve analysis
Authors: Formisano, S.; Brewer, H.B.; Osborne, J.C. Title: Effect of pressure and ionic strength on the self-association of Apo-A-I from the human high density lipoprotein complex Source: J. Biol. Chem. 253 (1978) 354-359
Authors: Formisano, Silvestro; Johnson, Michael L.; Edelhoch, Harold Title: Effects of Hofmeister Salts on the Self-Association of Glucagon Source: Biochem. 17 (1978) 1468-1473 Description: best fit of titration curves
Authors: Hantgan, R.R.; Taniuchi, H. Title: Conformational dynamics in cytochrome c. A fragment exchange study Source: J. Biol. Chem. 253 (1978) 5373-5380
Authors: Heck, H.A.; Maloney, K.; Anbar, M. Title: Long-term urinary excretion of methaqualone in a human subject Source: J. Pharm. Biopharm. 6 (1978) 111-122
Authors: Hobbs, Ann S.; Dunham, Philip B. Title: Interactions of External Alkali Metal Ions with the Na-K Pump of Human Erythrocytes Source: J. Gen. Physiol. 72 (1978) 381-402 Description: best fit solutions to Hill equation
Authors: Israel, M.A.; Martin, M.A.; Takemoto, K.K.; Howley, P.M.; Naronson, S.A.; Solomon, D.; Khoury, P.M. Title: Evaluation of normal and neoplastic human tissue for BK virus Source: Virol. 90 (1978) 187-196 Description: best fit solutions to Hill equation
Authors: Johnson, Michael J.; Formisano, Silvestro; Edelhoch, Harold Title: Self-association of Glucagon as Measured by the Optical Properties of Rhodamine 6G Source: J. Biol. Chem. 253 (1978) 1353-1356 Description: least squares fit to find equilibrium constants
Authors: Kafka, M.S.; Blumenthal, R.; Walker, G.A.; Pollard, H.B. Title: Dopamine-beta-hydroxylase-Induced Changes in the Electrical Conductance of Biomolecular Lipid Membranes Source: Mol. Membr. Biol. 1 (1978) 279-295 Description: Scatchard analysis, best fits
Authors: Kahn, C. Ronald; Goldfine, Ira D.; Neville, David M., Jr.; De Meyts, Pierre Title: Alterations in Insulin Binding Induced by Charges in Vitro in the Levels of Glucocorticoids and Growth Hormone Source: Endocrin. 103 (1978) 1054-1066 Description: Scatchard analysis, best fits
Authors: Ketelslegers, Jean-Marie; Catt, Kevin J. Title: Follitropin Receptors in Rat Testis. Characterization with Enzymatically 125-I-Labeled Human Follitropin Source: Biochim. Biophys. Acta 541 (1978) 360-371 Description: binding data were corrected for maximum binding activity of tracer and analyzed with MLAB.
Authors: Ketelslegers, J.M.; Hetzel, W.D.; Sherins, Richard J.; Catt, K.J. Title: Developmental Changes in Testicular Gonadotropin Receptors: Plasma Gonadotropins and Plasma Testosterone in the Rat Source: Endocrin. 103 (1978) 212-222 Description: Scatchard plots, linear and non-linear regression
Authors: Lipkin, J.; Sachs-Lipkin, B. Title: Database Development and Analysis for the Social Historian; The Educational Status of the Beneficed Clergy of the Diocese of Hereford 1289-1539 Source:Computers and the Humanities 12 (1978) 113-125 Description:graphs made with MLAB
Authors: Maghuin-Rogister, Guy; Closset, Jean; Combarnous, Yves; Hennen, Georges; Dechanne, Charles; Ketelslegers, Jean-Marie Title: Study of Follitropin Receptors in Testis Using a Homologous System Source: Eur. J. Biochem. 86 (1978) 121-131 Description: Scatchard analysis
Authors: Mittag, Thomas W.; Tormay, A.; Massa, T. Title: Heterogeneity of Acetylcholine Receptors in Denervated Muscle. Interactions of Receptors with Immunoglobin from Patients with Myasthenia Gravis Source: Mol. Pharm. 14 (1978) 60-68 Description: linear and non-linear regression
Authors: Ohno, K.; Pettigrew, K.D.; Rapoport, S.I. Title: Lower Limits of Cerebrovascular Permeability to Nonelectrolytes in the Conscious Rat Source: Am. J. Physiol. 235 (1978) H299-H307 Description: nonlinear regression of plasma concentration-time curves
Authors: Owen, J.F.; Teegarden, K.J.; Shanks, H.R. Title: Optical properties of the sodium-tungsten bronzes and tungsten trioxide Source: Phys. Rev. B 18 (1978) 3827-3837
Authors: Pang, K. Sandy; Gillette, James R. Title: Kinetics of Metabolite Formation and Elimination in the Perfused Rat Liver Preparation: Differences Between the Elimination of Preformed Acetaminophen and Acetaminophen Formed from Phenacetin Source: J. Pharm. Exp. 207 (1978) 178-194 Description: predicted time-course for decay of [14-C]-phenacetin and the appearance of [14-C]-acetaminophen
Authors: Pelsor, Francis R.; Allen, Larry M.; Creaven, Patrick J. Title: Multicompartment Pharmacokinetic Model of 4'-Demethylepipodophyllo Toxin 9-(4,6-0-Ethylidene-beta-D-glucopyranoside) in Humans Source: J. Pharm. Sci. 67 (1978) 1106-1108 Description: non-linear least squares regression
Authors: Podesta, E.J.; Dufau, M.L.; Catt, K.J. Title: Cyclic Adenosine 3',5'-Monophosphate Dependent Protein Kinase of Rat Leydig Cells: Physical Characteristics of Two Holoenzymes and Their Subunits Source: Biochem. 17 (1978) 1566-1573 Description: Scatchard analysis, ode fitting
Authors: Qasba, P.K.; Chakrabartty, P.K. Title: Purification and properties of two forms of rat alpha-lactal bumin Source: J. Biol. Chem. 253 (1978) 1167-1173
Authors: Ramu, A.; Fusner, J.E.; Blaschke, T.; Glaubiger, D.L. Title: Probenecid Inhibition of Methotrexate-Cerebrospinal Fluid Pharmacokinetics in Dogs Source: Canc. Treat. Rpts. 62 (1978) 1465-1470 Description: regression
Authors: Ramu, Avner; Glaubiger, Daniel; Ramu, Nili P.; Eldridge, Noreen; Blaschke, Terrence Title: Probenecid Inhibition of Methotrexate Excretion from Cerebrospinal Fluid in Dogs Source: J. Pharm. Biopharm. 6 (1978) 389-397 Description: fit CSF MTX concentration to biexponential decay function
Authors: Ramu, Avner; Rosenbaum, James; Blaschke, Terrence F. Title: Disposition of Acetone Following Acute Acetone Intoxication Source: Western J. Med. 129 (1978) 429-432 Description: disappearance curves fit to get 1/2-life, nonlinear regression
Authors: Resnik, Judith A.; Malaba, Franco E.; Colburn, Theodore R.; Murray, George C.; Smith, T.G., Jr. Title: A Novel Rapid Scanning Microspectophotometer and its Use in Measuring Rhodopsin Photoproduct and Pathways and Kinetics in Frog Retinas Source: J. Opt. Soc. Am. 68 (1978) 937-948 Description: multiexponential model
Authors: Rhee, S.G.; Park, R.; Chock, P.B.; Stadtman, E.R. Title: Allosteric Regulation of Monocyclic Interconvertible Enzyme Cascade Systems: Use of Escherichia coli Glutamine Synthetase as an Experimental Model Source: PNAS 75 (1978) 3138-3142 Description: simulated curves
Authors: Shindo, H.; Egan, W.; Cohen, J.S. Title: Studies of individual carboxyl groups in proteins by carbon 13 nuclear magnetic resonance spectroscopy Source: J. Biol. Chem. 253 (1978) 6751-6755
Authors: Sperling, Richard; Furie, Barbara C.; Blumenstein, Michael; Keyt, Bruce; Furie, Bruce Title: Metal Binding Properites of gamma-Carboxyglutamic Acid Source: J. Biol. Chem. 253 (1978) 3898-3906 Description: fit titration data
Authors: Stoller, Ronald G.; Myers, Charles E.; Chabner, Bruce A. Title: Analysis of Cytidine Deaminase and Tetrahydrouridine Interaction by Use of Ligand Techniques Source: Biochem. Pharm. 27 (1978) 53-59 Description: rate constants for binding by curve-fitting
Authors: Swann, A.C.; Albers, R.W. Title: Sodium and potassium ion-dependent adenosine triphosphatase of mammilian brain interactions of magnesium ions with the phosphotase site Source: Biochim. Biophys. Acta-Enzymology (1978) 215-227
Authors: Tinker, David O.; Purdon, A. David; Wei, Jane; Mason, Eileen Title: Kinetics of Hydrolysis of Dispersions of Saturated Phosphatidylcholines by Crotalus atrox Phospholipase A2' Source: Can. J. Biochem. 56 (1978) 552-558 Description: reaction progress curves fit to cubic equation in time.
Authors: Wood, William I.; Peterson, David O.; Bloch, Konrad Title: Subunit Structure of Mycobacterium smegmatis Fatty Acid Synthetase Evidence for Identical Multifunctional Polypeptide Chains Source: J. Biol. Chem. 253 (1978) 2650-2655 Description: graphs
Authors: Abe, Takashi; Chung, Soo Il; DiAugustine, Richard P.; Folk, J.E. Title: Rabbit Liver Transglutaminase: Physical, Chemical, and Catalytic Properties Source: Biochem. 16 (1977) 5495-5501 Description: Michaelis Menten constants
Authors: Blumenthal, R.; Winstein, J.N.; Sharrow, S.O.; Henkart, P. Title: Liposome-lymphocyte interaction: saturable sites for transfer and intracellular release of liposome contents Source: PNAS 74 (1977) 5603-5607
Authors: Catterall, W.A. Title: Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model. Source: J. Biol. Chem. 252 (1977) 8669-8676
Authors: Chock, P.B.; Stadtman, E.R. Title: Superiority of Interconvertible Enzyme Cascades in Metabolic Regulation: Analysis of Multicyclic Systems Source: PNAS 74 (1977) 2766-2770 Description: curve-fitting and graphics
Authors: Donnelly, Cynthia H.; Murphy, Dennis L. Title: Substrate- and Inhibitor-Related Characteristics of Human Platelet Monoamine Oxidase Source: Biochem. Pharm. 26 (1977) 853-858 Description: Michalis constants
Authors: Fenton, John W., II; Fasco, Michael J.; Stacknow, Anne B.; Aronson, David L.; Young, Andrew M.; Finlayson, John S. Title: Human Thrombosis: Production, Evaluation, and Properties of Alpha-Thrombin Source: J. Biol. Chem. 252 (1977) 3587-3598 Description: curve-fitting
Authors: Fitzhugh, R. Title: A model of optimal voluntary muscular control Source: J. Math. Biol. 4 (1977) 203-236
Authors: Fjellstedt, Thorsten A.; Schlesselman, James J. Title: A Simple Statistical Method for Use in Kinetic Analysis Based on Lineweaver-Burk Plots Source: Anal. Biochem. 80 (1977) 224-238 Description: Michaelis-Menten eqtn, statistics, used calculator-not MLAB
Authors: Formisano, Silvestro; Johnson, Michael L.; Edelhoch, Harold Title: Thermodynamics of the Self-Association of Glucagon Source: PNAS 74 (1977) 3340-3344 Description: curve-fitting
Authors: Gross, Michael; Whetzel, Norma K.; Folk, J.E. Title: Amine Binding Sites in Acyl Intermediates of Transglutaminases Source: J. Biol. Chem. 252 (1977) 3752-3759 Description: curve-fitting
Authors: Heck, H.A.; Dyer, R.L.; Scott, A.C.; Anbar, M. Title: Determination and Disposition of Trifluralin in the Rat. Separation by Sequential High-Pressure Liquid Chromotography and Quantitation by Field Ionization Mass Spectrometry Source: J. Agric. Food Chem. 25 (1977) 901-908
Authors: Heller, S.R.; Milne, G.W.A.; Feldman, R.J. Title: A Computer-Based Chemical Information System Source: Science 195 (1977) 253-259 Description: MLAB as part of chemical information system.
Authors: Hendler, R.W. Title: Automated Electrode Potentiometry of Potassium Ferricyanide and Respiratory Components Source: Anal. Chem. 49 (1977) 1914-1918 Description: Nernst equation.
Authors: Highet, Robert J.; Chou, Feng-te E. Title: The Dependence of Phenol-Dienone Tautomerism Upon the Hydrogen Bonding Characteristics of the Solvent: 3,5-Dipyrrolidinophenol Source: JACS 99 (1977) 3538-3539 Description: linear regression
Authors: Hodgkin, A.L.; O'bryan, Paul M. Title: Internal Recording of the Early Receptor Potential in Turtle Cones Source: J. Physiol. 267 (1977) 737-766 Description: curve-fitting to exponential model
Authors: Humphrey, Richard L.; Karpetsky, Timothy P.; Neuwelt, Edward A.; Levy, Carl C. Title: Levels of Serum Ribonuclease as an Indicator of Renal Insufficiency in Patients with Leukemia Source: Canc. Res. 37 (1977) 2015-2022 Description: curve-fitting
Authors: Johnson, C.L.; Mizoguchi, H. Title: The interaction of histimine and guanylnucleotides with cardiac adenylate cyclase and its relationship to cardiac contractility Source: J. Pharm. Exp. 200 (1977) 174-186
Authors: Karpetsky, Timothy P.; Humphrey, Richard L.; Levy, Carl C. Title: Influence of Renal Insufficiency on Levels of Serum Ribonuclease in Patients with Multiple Myeloma Source: JNCI 58 (1977) 875-880 Description: units RNase activity per ml per min fit to A+B/(C (ml/min)).
Authors: Klee, Claude B.; LaJohn, Lawrence E.; Kirk, Kenneth L.; Cohen, Louis A. Title: 2-Fluorourocanic Acid, A Potent Reversible Inhibitor of Urocanase Source: Biochem. Biophys. Res. Comm. 75 (1977) 674-681 Description: least squares fit of model with kinetic constants
Authors: Knights, Ralph J.; Gross, Michael; Folk, J.E. Title: Identification and Quantitative Analysis of Alkyl Isocyanates as Their Urea Derivatives Source: Anal. Biochem. 77 (1977) 176-184 Description: ode fits
Authors: Liang, S.M.; Winter, C.G. Title: Digitonin-induced changes in subunit arrangement in relation to some in vitro activities of the (Na+,K+)-ATPase Source: J. Biol. Chem. 252 (1977) 8278-8284
Authors: Milne, G.W.A.; Heller, S.R. Title: The NIH-EPA Chemical Information System Source: Computer-Assisted Structure Elucidation, Chapter 3 (1977) ACS Symposium Series, volume 54, pages 26-45.
Authors: Mittelstaedt, W.; Still, G.S.; Duerbeck, H.; Fuehr, F. Title: Extraction and Identification of the Major Metabolite of [carbonyl-C14] methabenzthiazuron After Degradation in the soil Source: J. Agric. Food Chem. 25 (1977) 908-912
Authors: Norton, Larry; Simon, Richard Title: Growth Curve of an Experimental Solid Tumor Following Radiotherapy Source: JNCI 58 (1977) 1735-1741 Description: curve-fitting odes
Authors: Osborne, J.C.; Bronzert, T.J.; Brewer, H.B. Title: Self-association of apo-C-I from the human high density lipoprotein complex Source: J. Biol. Chem. 252 (1977) 5756-5760
Authors: Parsegian, V.A.; Weiss, G.H.; Shrader, M.E. Title: Macroscopic Continuum Model of Influence of Hydrocarbon Contaminant on Forces Causing Wetting of Gold by Water Source: J. Coll. Int. Sci. 61 (1977) 356-360 Description: curve-fitting
Authors: Rao, K. Gurudath; Becker, Edwin D.; Rao, C.N.R. Title: Effect of Lithium Ion on the Torsional Barrier in Amides Source: JCS Chem. Comm. 1977 (1977) 350-351 Description: digitized NMR spectra, curve-fitting, Arrhenius plots, Gutowsky-Holm equation
Authors: Sokoloff, Louis; Reivich, M.; Kennedy, C.; DesRosiers, M. H.; Patlak, C.S.; Pettigrew, K.D.; Sakurada, O.; Shinohara, M. Title: The [14-C] Deoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization: Theory, Procedure, and Normal Values in the Conscious and Anesthetized Albino Rat Source: J. Neurochem. 28 (1977) 897-916 Description: least square fit of rate constants in compartmental model
Authors: Stadtman, E.R.; Chock, P.B. Title: Superiority of Interconvertible Enzyme Cascades in Metabolic Regulation: Analysis of Monocyclic Systems Source: PNAS 74 (1977) 2761-2765 Description: fit parameters in steady state solutions of chemical kinetics rate differential equations.
Authors: Taniuchi, Hiroshi; Parker, Diana S.; Bohnert, Janice L. Title: Study of Equilibration of the System Involving Two Alternative, Enzymatically Active Complementing Structures Simultaneously Formed from Two Overlapping Fragments of Staphylococcal Nuclease Source: J. Biol. Chem. 252 (1977) 125-140 Description: least squares fit
Authors: Taylor, Hope C.; Chaiken, Irwin M. Title: Active Site Ligand Binding by an Inactive Ribonuclease S Analogue Source: J. Biol. Chem. 252 (1977) 6991-6994 Description: fit elution data to Michaelis-Menten equation
Authors: Tsuruhara, Tsuneo; Dufau, Maria L.; Cigorraga, Selva; Catt, Kevin J. Title: Hormonal Regulation of Testicular Luteinizing Hormone Receptors Effects of Cyclic AMP and Testosterone Responses in Isolated Leydig Cells Source: J. Biol. Chem. 252 (1977) 9002-9009 Description: Scatchard analysis of binding data
Authors: Weiss, Gary B.; Anderson, W. French Title: The Problem of Nuclease Activity in Nucleic Acid Hybridization Reactions. Theoretical Considerations Source: Biophys. Chem. 6 (1977) 337-344 Description: system of odes representing competition of nucleic acid digestion and hybridization was solved
Authors: Wiggert, Barbara; Bergsma, Donald R.; Helmsen, Ralph J.; Alligood, James; Lewis, Marc; Chader, Gerald J. Title: Retinol Receptors in Corneal Epithelium, Stroma, and Endothelium Source: Biochim. Biophys. Acta-Protein Struct. 491 (1977) 104-113 Description: least squares parameter estimation, odes
Authors: Wiggert, B.; Bergsma, D.R.; Lewis, M.; Chader, G.J. Title: Vitamin A Receptors: Retinol Binding in Neural Retina and Pigment Epithelium Source: J. Neurochem. 29 (1977) 947-954
Authors: Wiggert, B.; Russell, P.; Lewis, M.; Chader, G. Title: Differential binding to soluble nuclear receptors and effects on cell viability of retinol and retinoic acid in cultured retinoblastoma cells Source: Biochem. Biophys. Res. Comm. 79 (1977) 218-225 Description: curve-fitting odes
Authors: Winslow, Robert M.; Swenberg, Mei-Lie; Berger, Robert L.; Shrager, Richard I.; Luzzana, Massimo; Samaja, Michele; Bernardi, Luigi Rossi Title: Oxygen Equilibrium Curve of Normal Human Blood and Its Evaluation by Adair's Equation Source: J. Biol. Chem. 252 (1977) 2331-2337 Description: curve-fitting odes
Authors: Wolfe, N. Lee; Zepp, Richard G.; Gordon, John A.; Baughman, George L.; Cline, David M. Title: Kinetics of Chemical Degradation of Malathion in Water Source: Env. Sci. Tech. 11 (1977) 88-93 Description: rate constants obtained by curve-fitting
Authors: Baumann, Gerhard; Hodges, Gary Title: Lack of in Vivo Transformation of Human Growth Hormone to Its Activated Isohormonesin Peripheral Tissues of the Rhesus Monkey Source: J. Clin. Endo. Metab. 43 (1976) 1009-1014 Description: 2 compartmental exponential model
Authors: Bina-Stein, Minou; Stein, Arnold Title: Allosteric Interpretation of Mg2+ Binding to the Denaturable Escherichia coli tRNA Glu2 Source: Biochem. 15 (1976) 3912-3917 Description: curve-fitting
Authors: Brown, E.M.; Aurbach, G.D. Title: Beta-Andrenergic receptor interactions. Characterization of iodohydroxybenzylpindolol as a specific ligand Source: J. Biol. Chem. 251 (1976) 1232-1238
Authors: Callis, James; Hoehn, Holger Title: Flow-Fluorometric Diagnosis of Euploid and Aneuploid Human Lymphocytes Source: Am. J. Hum. Genetics 28 (1976) 577-584 Description: fit to sum of gaussians
Authors: Chaiken, Irwin M.; Taylor, Hope C. Title: Analysis of Ribonuclease-Nucleotide Interactions by Quantitative Affinity Chromatography Source: J. Biol. Chem. 251 (1976) 2044-2048 Description: fit data to relation involving elution volume, void volume, dissociation constants.
Authors: Craine, Jonathan E.; Peterkofsky, Alan Title: Studies on Arginyl-tRNA Synthetase from Escherichia coli B Dual Roles of Metals in Enzyme Catalysis Source: J. Biol. Chem. 251 (1976) 241-246 Description: fit to Michaelis Menten equation
Authors: Creaven, P.J.; Cohen, M.H.; Allen, L.M. Title: Methotrexate Plasma Decay Kinetics: Possible Alteration in Patients Undergoing Gut Sterilization Source: Br. J. Cancer 34 (1976) 571-575 Description: fit mono- and bi-exponential functions
Authors: Egan, William Title: Intermolecular Association in Adenosine 5'-Monophosphate. An 2-H Nuclear Magnetic Resonance Investigation Source: JACS 98 (1976) 4091-4093 Description: analysis of (eta, T1, [AMP]) data sets in terms of monomer-dimer equilibrium.
Authors: Gillin, Francis D.; Nossal, Nancy G. Title: Control of Mutation Frequency by Bacteriophage T4 DNA Polymerase Source: J. Biol. Chem. 251 (1976) 5225-5232 Description: find Km and Vmax by fitting DNA polymerase assays
Authors: Harosi, Ferenc I. Title: Spectral Relations of Core Pigments in Goldfish Source: J. Gen. Physiol. 68 (1976) 65-80 Description: curve-fitting sums of gaussians
Authors: Karkowsky, A.M.; Bergamini, M.V.; Orlowski, M. Title: Kinetic studies of sheep kidney gamma-glutanyl transpeptidase Source: J. Biol. Chem. 251 (1976) 4736-4743
Authors: Keen, J.H.; Habig, W.H.; Jakoby, W.B. Title: Mechanism for the several activities of the glutathione S-transferases Source: J. Biol. Chem. 251 (1976) 6183-6188
Authors: Lewis, Marc S.; Knott, Gary D. Title: Simulation Studies of Self-Associating Systems: Discrimination Between Specific and Isodemic Associations Source: Biophys. Chem. 5 (1976) 171-183
Authors: Murphy, Dennis L.; Donnelly, Cynthia H.; Miller, Leonard; Wyatt, Richard J. Title: Platelet Monamine Oxidase in Chronic Schizophrenia Source: Arch. Gen. Psych. 33 (1976) 1377-1381 Description: Michaelis constants and maximum velocities by curve-fitting
Authors: Nelson, R.L. Title: The Utility of Pharmacokinetics to the Pharmaceutical Industry Source: J. Clin. Pharm. 16 (1976) 565-569 Description: reviews packages including NONLIN, MLAB
Authors: Nelson, Robert L.; Allen, Larry M.; Creaven, Patrick J. Title: Pharmacokinetics of Divided-Dose Ifosfamide Source: Clin. Pharm. Ther. 19 (1976) 365-370 Description: fit plasma decay of unchanged ifosfamide
Authors: Olofsson, S.O.; Fager, G.; Gustafson, A. Title: Studies on Human Serum High-Density Lipoproteins: VI. Studies on a Cholesterol Ester-Releasing Reaction in Vitro Source: Scand. J. Clin. Lab. Inv. 259 (1976) 632-635 Description: data fitted to form of damped linear oscillators
Authors: Paris, D.F.; Lewis, D.L. Title: Accumulation of methoxychlor by microorganisms isolated from aqueous systems Source: Bull. Env. Cont. & Toxic. 15 (1976) 24-32
Authors: Parsegian, V. Adrian; Brenner, Stephen L. Title: The Role of Long Range Forces in Ordered Arrays of Tobacco Mosaic Virus Source: Nature 259 (1976) 632-635 Description: data fitted to form of damped linear oscillators
Authors: Protzel, Alberto; Sridhara, S.; Levenbook, Leo Title: Ribosomal Replacement and Degradation During Metamorphosis of the Blowfly, Calliphora vicina Source: Insect Biochem. 6 (1976) 571-578 Description: constant plus exponential fit
Authors: Rhee, S.G.; Chock, P.B. Title: Mechanistic Studies of Glutamine Synthetase from Escherichia coli: Kinetic Evidence for Two Reaction Intermediates in Biosynthetic Reaction Source: PNAS 73 (1976) 476-480 Description: curve-fitting and graphics
Authors: Rhee, S.G.; Chock, P.B. Title: Mechanistic Studies of Glutamine Synthetase from Escherichia coli: Kinetics of ADP and Orthophosphate Binding to the Unadenylated Enzyme Source: Biochem. 15 (1976) 1755-1760
Authors: Shindo, H.; Cohen, J.S. Title: Nuclear magnetic resonance titration curves of histidine ring protons. Ribonuclease S-peptide and S-proteins Source: J. Biol. Chem. 251 (1976) 2648-2652
Authors: Shinohara, Toshimichi; Piatigorsky, Joram Title: Quantitation of Delta-Crystallin Messenger RNA During Lens Induction in Chick Embryos Source: PNAS 73 (1976) 2808-2812 Description: Linear regression using MLAB, molecules of Delta-Crystallin mRNA per lens cell vs. time.
Authors: Shizuta, Y.; Shizuta, H.; Gallo, M.; Davies, P.; Pastan, I. Title: Purification and properties of filamin, and actin binding protein from chicken gizzard Source: J. Biol. Chem. 251 (1976) 6562-6567
Authors: Tack, B.F.; Prahl, J.W. Title: Third Component of Human Complement: Purification from Plasma and Physiochemical Characterization Source: Biochem. 15 (1976) 4513-4521 Description: linear least squares fit.
Authors: Tsien, R.W.; Weingart, R. Title: Isotropic Effect of Cyclic AMP in Calf Ventricular Muscle Studied by a Cut End Method Source: J. Physiol. 260 (1976) 117-119 Description: fit to sum of two error functions
Authors: Wee, V.T.; Sinha, B.K.; Taylor, P.W.; Chignell, C.F. Title: Interaction of spin-labeled bisquaternary ammonium ligands with acetylcholinesterase Source: Mol. Pharm. 12 (1976) 667-677
Authors: White, F.H. Title: Studies on Secondary Structure in Chicken Egg-White Lysozyme after Reductive Cleavage of Disulphide Bonds Source: Biochem. 15 (1976) 2906-2912
Authors: Wingard, L.B.; Cook, D.R. Title: Pharmacodynamics of tubocurarine in humans Source: Br. J. Anaesth. 48 (1976) 839-845
Authors: Winslow, Robert M.; Swenberg, Mei-Lei; Gross, Erhard; Chervenick, Paul A.; Buchman, Robert R.; Anderson, W. French Title: Hemoglobin McKees Rocks (Alpha2 Beta2 145 Tyr->Term) Source: J. Clin. Inv. 57 (1976) 772-781 Description: curve fit hemolysate data, Pressure of O2 versus O2 content data.
Authors: Zelenka, Peggy; Piatigorsky, Joram Title: Reiteration Frequency of delta-Crystallin DNA in Lens and Non-lens Tissues of Chick Embryos Source: J. Biol. Chem. 251 (1976) 4294-4298 Description: graphics and curve-fitting
Authors: Allen, Larry M.; Creaven, Patrick J. Title: Comparison of the Human Pharmacokinetics of VM-26 and VP-16, Two Antineoplastic Epipodophyllotoxin Glucopyranoside Derivatives Source: Eur. J. Cancer 11 (1975) 697-707 Description: renal clearances evaluated using MLAB.
Authors: Allen, Larry M.; Creaven, Patrick J. Title: Pharmacokinetics of Ifosfamide Source: Clin. Pharm. Ther. 17 (1975) 492-498 Description: MLAB fit parameters in ode model to data.
Authors: Binstock, L.; Adelman, W.J.; Senft, J.P.; Lecar, H. Title: Determination of the resistance in series with the membranes of giant axons Source: J. Membrane Biol. 21 (1975) 25-47
Authors: Bridges, R.B.; Palumbo, M.P.; Wittenberger, C.L. Title: Purification and properties of an NADP-specific 6-phosphogluconate dehydrogenase from Streptococcus faecalis Source: J. Biol. Chem. 250 (1975) 6093-6100
Authors: Carhart, R.E.; Johnson, S.M.; Smith, D.H.; Buchanan, B.G.; Dromey, R.G.; Lederberg, J. Title: Networking and a Collaborative Research Community: a Case Study Using the DENDRAL Programs Source: Computer Networking and Chemistry, Chapter 13 (1975) ACS Symposium Series, volume 19 pages 192-218
Authors: Catt, K.J.; Dufau, Maria L.; Neaves, William B.; Walsh, Patrick C.; Wilson, Jean D. Title: LH-hCG Receptors and Testosterone Content During Differentiation of the Testes in the Rabbit Embryo Source: Endocrin. 97 (1975) 1157-1165 Description: curve-fitting binding curves
Authors: Chignell, Colin F.; Starkweather, Donnas K.; Sinha, Birandra K. Title: A Spin Label Study of Egg White Avidin Source: J. Biol. Chem. 250 (1975) 5622-5630 Description: ESR spectra manipulated in the form of matrices
Authors: Chou, J.Y.; Singer, M.F.; McPhie, P. Title: Kinetic studies on the phosphorolysis of polynucleotides by polynucleotide phosphorylase Source: J. Biol. Chem. 250 (1975) 508-514
Authors: Cohen, J.S.; Shindo, H. Title: Nuclear magnetic resonance titration curves of histidine ring protons: Conformational transition affecting three of the histidine residues of ribonuclease Source: J. Biol. Chem. 250 (1975) 8874-8881
Authors: Detwiler, Peter B.; Fuortes, M.G.F. Title: Responses of Hair Cells in the Statocyst of Hermissenda Source: J. Physiol. 251 (1975) 107-129 Description: curve-fitting
Authors: Dunn, Ben M.; Chaiken, Irwin M. Title: Relationship Between Alpha-Helical Propensity and Formation of the Ribonuclease-S Complex Source: J. Mol. Biol. 95 (1975) 497-511 Description: constant amount of RNAase-S-(21-124) was assayed with increasing portions of synthetic-(1-15) peptides. The resulting curves were fit to equation 5 by non-linear least square procedure.
Authors: Ehrenstein, Gerald; Gilbert, Daniel L.; Lipicky, Raymond Title: Does Phospholipid Flip-Flop Affect Axon Potassium Channels? Source: Biophys. J. 15 (1975) 847-849 Description: curve fit hyperbolic secant functions to experimental points
Authors: Gillin, Frances D.; Nossal, Nancy G. Title: T4 DNA Polymerase Has a Lower Apparent Km For Deoxynucleoside Triphosphates Complementary Rather Than Noncomplementary to the Template Source: Biochem. Biophys. Res. Comm. 64 (1975) 457-464 Description: Michaelis constants.
Authors: Gross, Michael; Whetzel, Norma K.; Folk, J.E. Title: The Extended Active Site of Guinea Pig Liver Transglutaminase Source: J. Biol. Chem. 250 (1975) 4648-4655 Description: curve-fitting
Authors: Hayes, M.B.; Hagenmaier, H.; Cohen, J.S. Title: Nuclear magnetic resonance titration curves of histidine ring protons. Human metmyoglobin and the effects of azide on human, horse, and sperm whale metmyglobins Source: J. Biol. Chem. 250 (1975) 7461-7472
Authors: Hendler, Richard W.; Towne, David W.; Shrager, Richard I. Title: Redox Properties of b-Type Cytochromes in Escherichia Coli and Rat Liver Mitochondria and Techniques for Their Analysis Source: Biochim. Biophys. Acta-Bioenergetics 376 (1975) 42-62 Description: accumulated data was analyzed by MLAB.
Authors: Ketelslegers, Jean-Marie; Knott, Gary D.; Catt, Kevin J. Title: Kinetics of Gonadotropin Binding by Receptors of the Rat Testis. Analysis by a Nonlinear Curve-Fitting Method Source: Biochem. 14 (1975) 3075-3083 Description: curve-fitting odes
Authors: Ketley, Jeanne N.; Habig, William H.; Jakoby, William B. Title: Binding of Nonsubstrate Ligands to the Glutathione S-Transferases Source: J. Biol. Chem. 250 (1975) 8670-8673 Description: curves for experimental points calculated
Authors: Klee, Claude B.; Kirk, Kenneth L.; Cohen, Louis A.; McPhie, Peter Title: Histidine Ammonia-lyase: The Use of 4-Fluorohistidine in Identification of the Rate-Determining Step Source: J. Biol. Chem. 250 (1975) 5033-5040 Description: estimate kinetic constants by fitting data.
Authors: Latoure, R.; Alvarez, O.; Ehrenstein, G.; Espinoza, M.; Reyes, J. Title: The Nature of the Voltage-Dependent Conductance of the Hemocyanin Channel Source: J. Membrane Biol. 25 (1975) 163-182 Description: curve-fitting
Authors: McPhie, P. Title: The alkaline transition of swine pepsinogen Source: Biophys. Chem. 9 (1975) 281-287
Authors: Reuss, M.; Gnieser, J.; Reng, H.G.; Wagner, F. Title: Extended culture of Candida boidnii on methanol Source: Eur. J. Appl. Micro. Biotech. (1975) 295-305
Authors: Swann, A.C.; Albers, R.W. Title: Sodium + potassium-activated ATPase of mammalian brain regulation of phosphate activity Source: Biochim. Biophys. Acta-Biomembranes 382 (1975) 437-456
Authors: Taniuchi, Hiroshi; Bohnert, Janice L. Title: The Mechanism of Stabilization of the Structure of Nuclease-T' by Binding of Ligands Source: J. Biol. Chem. 250 (1975) 2388-2394 Description: best fit of algebraic equations
Authors: Blumenthal, R.; Shamoo, A.E. Title: Ionophore material derived from eel membrane preparations Source: J. Membrane Biol. 19 (1974) 141-162 Description: curve-fitting and graphics
Authors: Chung, Soo Il; Lewis, Marc S.; Folk, J.E. Title: Relationships of the Catalytic Properties of Human Plasma and Platelet Transglutaminases (Activated Blood Coagulation Factor XIII) to Their Subunit Structures Source: J. Biol. Chem. 249 (1974) 940-950 Description: curve-fitting and graphics
Authors: Di Chiro, G.; Timins, E.L.; Jones, A.E.; Johnston, G.S.; Hammock, M.K.; Swann, S.J. Title: Radionuclide scanning and microangiography of evolving and completed brain infarction: a correlative study in monkeys Source: Neurology 24 (1974) 418-423
Authors: Dunn, B.M.; Anfinsen, C.B.; Shrager, R.I. Title: Kinetics of Woodward's reagent K hydrolysis and reaction with Staphylococcal Nuclease Source: J. Biol. Chem. 249 (1974) 3717-3723
Authors: Gross, M.; Folk, J.E. Title: Activity of guinea pig liver transglutamase toward ester analogs of amide substrates Source: J. Biol. Chem. 249 (1974) 3021-3025
Authors: Lewis, Marc S.; Krieg, Laura C.; Kirk, William D. Title: The Molecular Weight and Detergent Binding of Bovine Rhodopsin Source: Exp. Eye Res. 18 (1974) 29-40 Description: curve-fitting and graphics
Authors: Lipkin, B.S.; Lipkin, L.E. Title: Textural parameters related to nuclear maturation in the granulocytic leukocytic series Source: J. Hist. and Cytochem. 22 (1974) 583-593
Authors: Marini, Mario A.; Martin, Charles J.; Berger, Robert L.; Forlani, Luciano Title: A Proposed Solution for the Determination of the Ionization Constants of Sets of Ionizing Groups in Proteins Source: Biopolymers 13 (1974) 891-902 Description: curve-fitting
Authors: Schrecker, A.W.; Smith, R.G.; Gallo, R.C. Title: Comparative inhibition of purified DNA polymerases from murine leukemia virus and human lymphocytes by 1-beta-D- arabinofuranosylcytosine 5' triphosphate Source: Canc. Res. 34 (1974) 286-292
Authors: Adelman, William J.; Palti, Yoram; Senft, Joseph P. Title: Potassium Ion Accumulation in a Periaxonal Space and its Effect on the Measurement of Membrane Potassium Ion Conductance Source: J. Membrane Biol. 13 (1973) 387-410 Description: least squares curve fit
Authors: Albers, R.W.; Koval, G.J. Title: Sodium-potassium-activated adenosine triphosphate of electrophorous electric organ: VIII. Monovalent cation sites regulating phosphotase activity Source: J. Biol. Chem. 248 (1973) 777-784
Authors: Cleland, W.W.; Gross, M.; Folk, J.E. Title: Inhibition patterns obtained where an inhibitor is present in constant proportion to variable substrate Source: J. Biol. Chem. 248 (1973) 6541-6542
Authors: Cooper, Herbert L. Title: Analysis of Precursor Pool Labeling Kinetics Without Pool Size Measurements: A Computer Assisted Approach Source: Anal. Biochem. 53 (1973) 49-63 Description: ode curve fitting
Authors: Dunn, Ben M.; DiBello, Carlo; Anfinsen, Christian B. Title: The pH Dependence of the Steady State Kinetic Parameters for Staphylococcal Nuclease-catalyzed Hydrolysis of Deoxythymidine-3'-phosphate-5'-p-nitro-phenylphosphate in H2O and D2O Source: J. Biol. Chem. 248 (1973) 4769-4774 Description: curve-fitting
Authors: Fitzhugh, R.; Cole, K.S. Title: Voltage and Current Clamp Transients with Membrane Dielectric Loss Source: Biophys. J. 13 (1973) 1125-1140 Description: numerical integration of odes
Authors: Fleisch, J.H.; Krzan, M.C.; Titus, E. Title: Pharmacologic receptor activity of rabbit aorta: effect of dithiothreitol and N-ethylmaleimide Source: Circ. Res. 33 (1973) 284-290
Authors: Fleisch, J.H.; Titus, E. Title: Effect of local anesthetics on pharmacologic receptor systems of smooth muscle Source: J. Pharm. Exp. 186 (1973) 44-51
Authors: Freedman, M.H.; Lyerla, J.R.; Chaiken, I.M.; Cohen, J.S. Title: Carbon-13 Nuclear-Magnetic-Resonance Studies on Selected Amino Acids, Peptides, and Proteins Source: Eur. J. Biochem. 32 (1973) 215-226
Authors: Gross, Michael; Folk, J.E. Title: Mapping of the Active Sites of Transglutaminases. I. Activity of the Guinea Pig Liver Enzyme Toward Aliphatic Amides Source: J. Biol. Chem. 248 (1973) 1301-1306 Description: kinetic experiments reciprocal velocities plotted vs reciprocal substrate concentrations, fit to models.
Authors: Gross, Michael; Folk, J.E. Title: Mapping of the Active Sites of Transglutaminases. II. Activity of the Guinea Pig Liver Enzyme Toward Methylglutamine Peptide Derivatives Source: J. Biol. Chem. 248 (1973) 6534-6540 Description: reciprocal plots fit to models.
Authors: Pommier, Jacques; Sokoloff, Louis; Nunez, Jacques Title: Enzymatic Iodination of Protein: Kinetics of Iodine Formation and Protein Iodination Catalyzed by Horse-Radish Peroxidase Source: Eur. J. Biochem. 38 (1973) 497-506 Description: curve-fitting
Authors: Rodbard, D.; Weiss, G.H. Title: Mathematical Theory of Immunoradiometric (labeled antibody) Assays Source: Anal. Biochem. 52 (1973) 10-44 Description: curve-fitting
Authors: Chung, S.I.; Folk, J.E. Title: Kinetic studies with transglutaminases: The human blood enzymes (Activated Coagulation Factor XIII) and the guinea pig hair follicle enzyme Source: J. Biol. Chem. 247 (1972) 2798-2807
Authors: Cooper, Herbert L. Title: Studies on RNA Metabolism During Lymphocyte Activation Source: Transplant Rev. 11 (1972) 3-38 Description: nonlinear least squares fit
Authors: Glossmann, H; Neville, DM Title: Phlorizin receptors in isolated kidney brush border membranes Source: J. Biol. Chem. 247 (1972) 7779-7789
Authors: Statland, B.E.; Louderback, A.L. Title: Nonlinear regression analysis approach for determining "true" lactate dehydrogenase activity in serum with the centrifugal analyzer ("rotochem") Source: Clin. Chem. 18 (1972) 845-849 |